School of Medicine
Showing 51-100 of 252 Results
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Michael W. Gaynon, MD
Clinical Professor, Ophthalmology
Current Research and Scholarly Interests-Retinal Vascular Disease
-Angiogenesis
-Retinopathy of Prematurity
-Sustained Release Drug Delivery Systems -
Sharon Markham Geaghan
Associate Professor of Pathology at the Stanford University Medical Center, Emerita
Current Research and Scholarly InterestsPediatric Hematopathology, Pediatric Laboratory Medicine and Pathology
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Pascal Geldsetzer
Assistant Professor of Medicine (Primary Care and Population Health) and, by courtesy, of Epidemiology and Population Health
BioPascal Geldsetzer is an Assistant Professor of Medicine in the Division of Primary Care and Population Health and, by courtesy, in the Department of Epidemiology and Population Health. He is also affiliated with the Department of Biomedical Data Science, Department of Health Policy, King Center for Global Development, and the Stanford Centers for Population Health Sciences, Innovation in Global Health, and Artificial Intelligence in Medicine & Imaging.
His research focuses on identifying and evaluating the most effective interventions for improving health at older ages. In addition to leading several randomized trials, his methodological emphasis lies on the use of quasi-experimental approaches to ascertain causal effects in large observational datasets, particularly in electronic health record data. He has won an NIH New Innovator Award (in 2022), a Chan Zuckerberg Biohub investigatorship (in 2022), and two NIH R01 grants as Principal Investigator (both in 2023). -
Linda N. Geng, MD, PhD
Clinical Associate Professor, Medicine - Primary Care and Population Health
Current Research and Scholarly InterestsMy scholarly interests are focused on defining, studying, and improving patients' diagnostic journeys. What prolongs the journey to the correct diagnosis and how can we shorten it? With this question in mind, we are exploring crowdsourcing, informatics/AI, health data visualization, and advanced laboratory testing as ways to help tackle the toughest cases in medicine-- complex, rare, and mystery conditions.
With the COVID pandemic, the puzzling and complex illness of post-acute COVID-19 syndrome (PACS) or long COVID came to light. Together with a multidisciplinary group of physicians and researchers, we launched a program here at Stanford to advance the care and understanding of PACS. Our goal is to better understand the natural history, clinical symptomatology, immunological response, risk factors, and subgroup stratification for PACS. We are also actively assessing management strategies that may be effective for heterogeneous PACS symptoms. -
Grace Gengoux
Clinical Professor, Psychiatry and Behavioral Sciences - Child & Adolescent Psychiatry and Child Development
Current Research and Scholarly InterestsDr. Grace Gengoux is Director of the Autism Intervention Clinic and leads an autism intervention research program focused on developing and evaluating promising behavioral and developmental treatments for Autism Spectrum Disorder (ASD).
Dr. Gengoux is also Associate Chair for Faculty Engagement & Well-being and Department Well-being Director in the Department of Psychiatry and Behavioral Sciences, leading the department's Standing Well-being Advisory Committee. -
Mark Genovese
James W. Raitt M.D. Professor, Emeritus
Current Research and Scholarly InterestsClinical trials and interventions in the rheumatic diseases including Rheumatoid Arthritis,Systemic Lupus Erythematosus, Systemic Sclerosis, Osteoarthritis.
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Michael Gensheimer
Clinical Associate Professor, Radiation Oncology - Radiation Therapy
Current Research and Scholarly InterestsIn addition to my clinical research in head and neck and lung cancer, I work on the application of computer science and machine learning to cancer research. I develop tools for analyzing large datasets to improve outcomes and safety of cancer treatment. I developed a machine learning prognostic model using data from around 13,000 patients with metastatic cancer which performs better than traditional models and physicians [PubMed ID 33313792]. We recently completed a prospective randomized study in thousands of patients in which the model was used to help improve advance care planning conversations.
I also work on the methods underpinning observational and predictive modeling research. My open source nnet-survival software that allows use of neural networks for survival modeling has been used by researchers internationally. In collaboration with the Stanford Research Informatics Center, I examined how electronic medical record (EMR) survival outcome data compares to gold-standard data from a cancer registry [PubMed ID 35802836]. The EMR data captured less than 50% of deaths, a finding that affects many studies being published that use EMR outcomes data. -
Andrew Gentles
Associate Professor (Research) of Pathology, of Medicine (BMIR) and, by courtesy, of Biomedical Data Science
Current Research and Scholarly InterestsComputational systems biology
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Paul George, MD, PhD
Associate Professor of Neurology and Neurological Sciences (Adult Neurology) and, by courtesy, of Neurosurgery
Current Research and Scholarly InterestsCONDUCTIVE POLYMER SCAFFOLDS FOR STEM CELL-ENHANCED STROKE RECOVERY:
We focus on developing conductive polymers for stem cell applications. We have created a microfabricated, polymeric system that can continuously interact with its biological environment. This interactive polymer platform allows modifications of the recovery environment to determine essential repair mechanisms. Recent work studies the effect of electrical stimulation on neural stem cells seeded on the conductive scaffold and the pathways by which it enhances stroke recovery Further understanding the combined effect of electrical stimulation and stem cells in augmenting neural repair for clinical translational is a major focus of this research going forward.
BIOPOLYMER SYSTEMS FOR NEURAL RECOVERY AND STEM CELL MODULATION:
The George lab develops biomaterials to improve neural recovery in the peripheral and central nervous systems. By controlled release of drugs and molecules through biomaterials we can study the temporal effect of these neurotrophic factors on neural recovery and engineer drug delivery systems to enhance regenerative effects. By identifying the critical mechanisms for stroke and neural recovery, we are able to develop polymeric technologies for clinical translation in nerve regeneration and stroke recovery. Recent work utilizing these novel conductive polymers to differentiate stem cells for therapeutic and drug discovery applications.
APPLYING ENGINEERING TECHNIQUES TO DETERMINE BIOMARKERS FOR STROKE DIAGNOSTICS:
The ability to create diagnostic assays and techniques enables us to understand biological systems more completely and improve clinical management. Previous work utilized mass spectroscopy proteomics to find a simple serum biomarker for TIAs (a warning sign of stroke). Our study discovered a novel candidate marker, platelet basic protein. Current studies are underway to identify further candidate biomarkers using transcriptome analysis. More accurate diagnosis will allow for aggressive therapies to prevent subsequent strokes. -
Marios Georgiadis
Instructor, Radiology
BioMarios is an Instructor of Neuroimaging, part of the Faculty of the Stanford University School of Medicine.
His research focuses mainly on studying brain microstructure using cutting edge imaging (advanced X-ray, MRI, optical, and spatial biology approaches), with a particular focus on Alzheimer's disease hippocampi, neurodegeneration, and a special interest in myelin and iron.
He is also actively involved in projects related to imaging and modeling brain trauma, exosome signatures of neurodegeneration, and imaging the brain using advanced forms of electron and light microscopy.
His current research is being supported by NIH, the Alzheimer's Association, and the American Society of Neuroradiology.
Marios is a mechanical engineer by training (School of Mechanical Engineering, National Technical University of Athens, Greece). His thesis "Closed-loop force control of a haptic surgical simulator", was performed in the Control Systems Lab of Prof. Evangelos Papadopoulos.
In 2011 he obtained his MSc in Biomedical Engineering from ETH Zurich (Swiss Federal Institute of Technology). He performed his thesis in IBM Research on "Advanced pathology using the Microfluidic Probe", under Emmanuel Delamarche and Govind Kaigala, and was awarded the ETH medal for this work.
He completed his PhD in Bone Biomechanics in the lab of Prof. Ralph Muller in ETH Zurich, where he developed X-ray scattering-based methods to investigate bone microstructure in 3D, research that earned him the 2nd Student Award from the European Society for Biomechanics in 2015.
In 2016 he started using imaging methods to study brain microstructure, in the lab of Prof. Markus Rudin, in the Institute for Biomedical Engineering of ETH Zurich. There, he combined X-ray scattering with DTI, histology and CLARITY for studying rodent brain.
In 2017 he joined the MRI Biophysics group of Profs. Els Fieremans and Dmitry Novikov in New York University School of Medicine, to study human and mouse brain microstructure using X-ray scattering and diffusion MRI.
He is in the Translational Neuroimaging lab, headed by Dr Michael Zeineh, since 2019.
His research on myelin in mouse and human brain using X-ray scattering has been supported twice by the Swiss National Science Foundation. -
Daniel Aaron Gerber, MD
Clinical Assistant Professor, Medicine - Cardiovascular Medicine
BioDr. Gerber is a critical care cardiologist and co-director of Stanford's Cardiac ICU. He has dual subspecialty training in cardiovascular and critical care medicine and additional board certification in echocardiography. He completed his residency in internal medicine, fellowship in cardiovascular medicine, and an additional fellowship in critical care medicine at Stanford University and joined as faculty in 2021 as a Clinical Assistant Professor in the Department of Medicine’s Division of Cardiovascular Medicine.
Dr. Gerber manages the full spectrum of heart and vascular conditions with a focus on critically ill patients with life-threatening cardiovascular disease. He is active in medical education, teaching introductory echocardiography to Stanford medical students and residents, co-directing the Stanford Critical Care Medicine Critical Care Ultrasound Program, and lecturing nationally on critical care echocardiography and point-of-care ultrasonography at the Society of Critical Care Medicine’s annual congress. Finally, Dr. Gerber’s research interests focus on optimizing cardiac intensive care, including working with the Critical Care Cardiology Trials Network (CCCTN) - a national network of tertiary cardiac ICUs coordinated by the TIMI Study Group - and studying acute mechanical circulatory support techniques to improve patient outcomes and care processes. -
Yael Gernez
Clinical Associate Professor, Pediatrics - Immunology and Allergy
BioMy clinic focuses on solving the molecular puzzles that underlie rare allergic and immunologic diseases to shed light on fundamental principles governing allergy, inflammation and immune system defects. My goal is to find better and safer therapies for my patients with rare diseases that include autoinflammation, autoimmunity and primary immune deficiency. It is important to highlight that every patient requires individualized therapeutic approaches based on their underlying genetic problem and the types and severity of their clinical manifestations. For some patients, a hematopoietic stem cell transplant (HSCT) is curative while for others, a targeted drug therapy, such as a biologic or small molecule agent, is most suitable. In some cases, a truly novel therapy may be required, .e.g., anti-sense oligonucleotide therapy to suppress aberrant gene splicing or adoptive cellular therapy. My passion is to provide the best personalized therapy for our patients with allergy and immunology diseases. This often requires performing very specialized functional assays and in some cases in enlisting laboratories with specific expertise or interest in particular genetic disorders.
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Rabin Gerrah
Clinical Assistant Professor, Cardiothoracic Surgery
BioDr. Rabin Gerrah is a cardiothoracic surgeon and specializes in surgical treatment of heart diseases such as ischemic, valvular, structural and congenital heart diseases. He has been trained at Harvard University and Columbia University Hospitals. Dr. Gerrah has been involved in multiple medical research projects and has patented and developed innovative surgical devices and technologies.
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Margot Gerritsen
Professor of Energy Resources Engineering, Emerita
Current Research and Scholarly InterestsResearch
My work is about understanding and simulating complicated fluid flow problems. My research focuses on the design of highly accurate and efficient parallel computational methods to predict the performance of enhanced oil recovery methods. I'm particularly interested in gas injection and in-situ combustion processes. These recovery methods are extremely challenging to simulate because of the very strong nonlinearities in the governing equations. Outside petroleum engineering, I'm active in coastal ocean simulation with colleagues from the Department of Civil and Environmental Engineering, yacht research and pterosaur flight mechanics with colleagues from the Department of Mechanical and Aeronautical Engineering, and the design of search algorithms in collaboration with the Library of Congress and colleagues from the Institute of Computational and Mathematical Engineering.
Teaching
I teach courses in both energy related topics (reservoir simulation, energy, and the environment) in my department, and mathematics for engineers through the Institute of Computational and Mathematical Engineering (ICME). I also initiated two courses in professional development in our department (presentation skills and teaching assistant training), and a consulting course for graduate students in ICME, which offers expertise in computational methods to the Stanford community and selected industries.
Professional Activities
Senior Associate Dean, School of Earth, Energy and Environmental Sciences, Stanford (from 2015); Director, Institute for Computational and Mathematical Engineering, Stanford (from 2010); Stanford Fellow (2010-2012); Magne Espedal Professor II, Bergen University (2011-2014); Aldo Leopold Fellow (2009); Chair, SIAM Activity group in Geosciences (2007, present, reelected in 2009); Faculty Research Fellow, Clayman Institute (2008); Elected to Council of Society of Industrial and Applied Mathematics (SIAM) (2007); organizing committee, 2008 Gordon Conference on Flow in Porous Media; producer, Smart Energy podcast channel; Director, Stanford Yacht Research; Co-director and founder, Stanford Center of Excellence for Computational Algorithms in Digital Stewardship; Editor, Journal of Small Craft Technology; Associate editor, Transport in Porous Media; Reviewer for various journals and organizations including SPE, DoE, NSF, Journal of Computational Physics, Journal of Scientific Computing, Transport in Porous Media, Computational Geosciences; member, SIAM, SPE, KIVI, AGU, and APS -
Neil Gesundheit
George DeForest Barnett Founders Professor of Medicine and Professor (Teaching) of Medicine (Endocrinology)
Current Research and Scholarly InterestsOur medical education research group is developing and validating the best educational practices to train competent, compassionate, and ethical physicians and physician-scientists. We are studying the use of standardized patients and other modalities to improve clinical skill training and reasoning. We are interested in applying the rigor of clinical investigation to education research.
My areas of clinical interest in endocrinology include disorders of the pituitary, thyroid, and gonad. -
Olivier Gevaert
Associate Professor of Medicine (Biomedical Informatics) and of Biomedical Data Science
Current Research and Scholarly InterestsMy lab focuses on biomedical data fusion: the development of machine learning methods for biomedical decision support using multi-scale biomedical data. We primarily use methods based on regularized linear regression to accomplish this. We primarily focus on applications in oncology and neuroscience.
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Pejman Ghanouni, MD, PhD
Associate Professor of Radiology (Body MRI) and, by courtesy, of Neurosurgery, of Obstetrics and Gynecology and of Urology
BioDr. Ghanouni is a board-certified, fellowship-trained diagnostic radiologist with Stanford Health Care Radiology. He is an associate professor in the Department of Radiology, Division of Body MRI at Stanford University School of Medicine, and by courtesy, of Urology, of Neurosurgery, and of Obstetrics and Gynecology.
Dr. Ghanouni is the director of the Stanford Health Care Minimally Invasive MR Interventional Center (MIMRIC) and the Focused Ultrasound Center of Excellence. He is also chief of the Division of Body MRI at Stanford University School of Medicine.
Dr. Ghanouni is recognized around the world for his extensive expertise in using advanced imaging to diagnose, manage, and treat a wide range of conditions and disorders. As a renowned leader in diagnostic and MRI-guided interventional radiology, Dr. Ghanouni creates a customized care plan for each of his patients.
Dr. Ghanouni’s research interests include the latest advances in MR-guided focused ultrasound techniques to treat essential tremor, Parkinson’s disease, prostate cancer, bone tumors, desmoid tumors, and uterine fibroids. An experienced physician-scientist, Dr. Ghanouni has collaboratively led clinical trials and research initiatives that explore treatments for epilepsy, pancreatic cancer, and several types of tumors. Through these clinical trials, Dr. Ghanouni has helped secure FDA approval for many MR-guided focused ultrasound treatments.
His articles have been published in dozens of peer-reviewed medical journals, including Lancet Oncology, Neurology, Investigative Radiology, European Radiology, Journal of Magnetic Resonance Imaging, Journal of Neurosurgery, New England Journal of Medicine, and Radiology. Dr. Ghanouni has been invited to speak at conferences and symposiums all over the nation and the world, including in Rome, Italy; Tel Aviv, Israel; and Riyadh, Saudi Arabia. He is widely regarded for his groundbreaking research as well as his clinical expertise.
Dr. Ghanouni is a member of several professional organizations, including the International Society for Magnetic Resonance in Medicine, the International Society for Therapeutic Ultrasound, and the European Focused Ultrasound Society.
MR-guided focused ultrasound treatment: https://www.youtube.com/watch?v=3Bwq2YxD9eU -
Laleh Gharahbaghian, MD
Clinical Professor, Emergency Medicine
Current Research and Scholarly InterestsEmergency Ultrasound,
Resident Education,
Interesting Cases,
Visual Diagnosis -
Zahra Ghazi-Askar
Clinical Associate Professor, Emergency Medicine
BioDr. Ghazi-Askar is Assistant Professor of Emergency Medicine and, by courtesy, of Pediatrics and serves as the Director of Pediatric Ultrasound Education in the Department of Emergency Medicine . As an academic clinical educator in with expertise in pediatric and adult point-of-care ultrasound, Dr. Ghazi-Askar's clinical focus is on children and young adults who seek care in the pediatric emergency department. She is specialty-board certified in pediatric emergency medicine.
At a national level, Dr. Ghazi-Askar is the Chair of Point-of-Care Ultrasound subcommittee for the Association of Pediatric Program Directors (APPD), where she is leading the development of an educational curriculum for pediatric residency point-of-care ultrasound.
Dr. Ghazi-Askar also has expertise in the field of Tele-ultrasound, where she is able to teach point-of-care ultrasound virtually where clinical expertise may otherwise not be available. Here she is able to provide education and health equity when it is most needed. -
Zaniar Ghazizadeh
Affiliate, Department Funds
Fellow in Graduate Medical EducationBioZaniar completed his Internal Medicine training at Yale New Haven Hospital/Yale School of Medicine. He received his medical degree from Tehran University of Medical Sciences and spent a few years as a post-doctoral fellow at Weill Cornell Medicine and Brigham and Women’s Hospital before his residency. His research interest lies in the development of in vitro and in vivo platforms for studying heart regeneration and precision medicine. Zaniar’s work is focused on identifying the mechanisms of cardiac arrhythmias using several experimental systems ranging from genetically engineered animal models to human pluripotent stem cell derived cardiac cell types. His ultimate goal as a clinician-scientist is to utilize this framework for drug discovery and identifying new therapeutic strategies that can prevent or reverse specific arrhythmias.
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Alireza Ghiam, MD, MS
Clinical Associate Professor, Radiation Oncology - Radiation Therapy
BioDr. Ghiam is an American and Canadian Board-Certified Radiation Oncologist with the Stanford Medicine Cancer Center and a Clinical Associate Professor in the Department of Radiation Oncology at Stanford University School of Medicine. After completing an MSc in Molecular Biology & Genetics at the University of Montreal, he completed a residency in Radiation Oncology and fellowship in Head & Neck and GU radiation oncology at the University of Toronto.
He diagnoses and treats various conditions specializing in head & neck cancer, genitourinary malignancies, and metastatic disease. His treatment expertise includes oligometastatic disease, palliative radiation therapy, stereotactic ablative radiotherapy, and proton therapy.
Dr. Ghiam has contributed to the field through his authorship of technology- and biology-based publications and collaboration in clinical trials. He has been recognized by awards from the American Society for Radiation Oncology (ASTRO), the Canadian Association of Radiation Oncology (CARO), and the Universities of Toronto and Pennsylvania. In recognition of his educational work, he received two prestigious teaching awards for teaching residents and medical students. He has presented his research work nationally and internationally and authored and co-authored several papers.
Dr. Ghiam's interest lies in exploring novel AI-powered technologies that can enhance patient outcomes, and bridge health equity gaps in radiation oncology. He is also interested in clinical trials of innovative radiation therapy techniques with a focus on leveraging technology and biology to reduce toxicity and increase precision.
Dr. Ghiam is dedicated to academia, education, and diversity. He is committed to improving patient outcomes and changing the role of supportive care in radiation oncology by promoting quality standards and utilizing palliative radiotherapy to enhance the quality of life for his patients.
Dr. Ghiam practices evidence-based care with compassion and treats his patients as he would his own family. -
Amato J. Giaccia
Jack, Lulu and Sam Willson Professor, Professor of Radiation Oncology, Emeritus
Current Research and Scholarly InterestsDuring the last five years, we have identified several small molecules that kill VHL deficient renal cancer cells through a synthetic lethal screening approach. Another major interest of my laboratory is in identifying hypoxia-induced genes involved in invasion and metastases. We are also investigating how hypoxia regulates gene expression epigenetically.
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Karleen Giannitrapani
Assistant Professor of Medicine (Primary Care and Population Health)
BioIn contrast to bounded teams with static membership, dynamic teaming reflects the common challenge of interdisciplinary healthcare teams with changing rosters. Such dynamic collaboration is critical to addressing multi-faceted problems and individualizing care. At present, off the shelf interventions to improve the way healthcare teams work - often assume static and bounded teams. Dr Giannitrapani intends to leverage design approaches to build a new kind of healthcare “teaming intervention,” which respects the nature of their constantly changing membership and more closely aligns with how healthcare teams actually collaborate. Their expertise includes organizational behavior, building interdisciplinary teams, implementation science, mixed methods-research, quality improvement, pain and palliative care research, and global health.
In addition to the Assistant Professor role in Division of Primary Care and Population Health at Stanford University School of Medicine they serve as the quality lead for the section of Palliative Medicine. They are also a Core Investigator at the Center for Innovation to Implementation (Ci2i) in the VA Palo Alto Health Care System and serve as PI or co-investigator on multiple ongoing studies representing over 25 million dollars of competitive government grant funding. They are also a Director of the VA Quality Improvement Resource Center (QuIRC) for Palliative Care, supporting Geriatrics and Extended Care programs for 170 Veterans Affairs facilities nationally. In QuIRC they lead a portfolio of projects on improving the processes that interdisciplinary teams can leverage to improve pain and symptom management among high-risk patients; a specific focus of their work is to bridge the gap of poor palliative care integration in the perioperative period.
They have given hundreds of presentations and have over 70 peer reviewed publications in high quality medical and health services delivery journals such as Medical Care, JAMA Surgery, the Journal of General Internal Medicine, the Journal of Pain and Symptom Management and Pain Medicine. They received a 5-year VA Career Development Award on building better teams across disciplines and was an American Academy of Hospice and Palliative Medicine Research Scholar for related work. -
William Giardino
Assistant Professor (Research) of Psychiatry and Behavioral Sciences (Sleep Medicine)
Current Research and Scholarly InterestsWe aim to decipher the neural mechanisms underlying psychiatric conditions of stress, addiction, and sleep/circadian dysregulation. Our work uses combinatorial technologies for precisely mapping, monitoring, and manipulating neural circuits that regulate emotional states. We are especially focused on the behavioral functions of neuropeptide molecules acting throughout the circuitry of the extended amygdala- particularly in a brain region called the bed nucleus of the stria terminalis (BNST).
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Iris C. Gibbs, MD, FACR, FASTRO
Professor of Radiation Oncology (Radiation Therapy) and, by courtesy, of Neurosurgery
On Leave from 05/01/2024 To 04/22/2025Current Research and Scholarly InterestsDr. Gibbs is a board-certified radiation oncologist who specializes in the treatment of CNS tumors. Her research focuses on developing new radiation techniques to manage brain and spinal tumors in adults and children. Dr. Gibbs has gained worldwide acclaim for her expertise in Cyberknife robotic radiosurgery.
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Erin Gibson
Assistant Professor of Psychiatry and Behavioral Sciences (Sleep Medicine)
Current Research and Scholarly InterestsGlia make up more than half of the cells in the human brain, but we are just beginning to understand the complex and multifactorial role glia play in health and disease. Glia are decidedly dynamic in form and function. Understanding the mechanisms underlying this dynamic nature of glia is imperative to developing novel therapeutic strategies for diseases of the nervous system that involve aberrant gliogenesis, especially related to changes in myelination.
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Rona Giffard
Professor of Anesthesiology, Perioperative and Pain Medicine, Emerita
Current Research and Scholarly InterestsAstrocytes, microglia and neurons interact, and have unique vulnerabilities to injury based on their patterns of gene expression and their functional roles. We focus on the cellular and molecular basis of brain cell injury in stroke. We study the effects of altering miRNA expression, altering levels of heat shock and cell death regulatory proteins. Our goal is to improve outcome by improving mitochondrial function and brain cell survival, and reducing oxidative stress and inflammation.
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Harcharan Gill
Kathryn Simmons Stamey Professor, Emeritus
Current Research and Scholarly InterestsBenign Prostatic Hyperplasia- Evaluation and development of new minimally invasive techniques
Endourology: developing, designing and evaluating new instruments
Bladder cancer: outcomes of treatment
BPH: cryotherapy and HIFU -
Lisa Giocomo
Professor of Neurobiology
Current Research and Scholarly InterestsMy laboratory studies the cellular and molecular mechanisms underlying the organization of cortical circuits important for spatial navigation and memory. We are particularly focused on medial entorhinal cortex, where many neurons fire in spatially specific patterns and thus offer a measurable output for molecular manipulations. We combine electrophysiology, genetic approaches and behavioral paradigms to unravel the mechanisms and behavioral relevance of non-sensory cortical organization. Our first line of research is focused on determining the cellular and molecular components crucial to the neural representation of external space by functionally defined cell types in entorhinal cortex (grid, border and head direction cells). We plan to use specific targeting of ion channels, combined with in vivo tetrode recordings, to determine how channel dynamics influence the neural representation of space in the behaving animal. A second, parallel line of research, utilizes a combination of in vivo and in vitro methods to further parse out ionic expression patterns in entorhinal cortices and determine how gradients in ion channels develop. Ultimately, our work aims to understand the ontogenesis and relevance of medial entorhinal cortical topography in spatial memory and navigation.
