School of Medicine
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Assistant Professor of Pediatrics (Critical Care)
Current Research and Scholarly InterestsMy laboratory is focused on understanding the cellular mechanisms which mediate end-organ failure in pediatric sepsis. Our current work focuses on determining the role of altered mitochondrial dynamics in sepsis-induced multi-organ dysfunction syndrome (MODS). Specifically, we focus on understanding the mechanisms that mediate derangements in mitochondrial fission and autophagy in sepsis.
Kimberly Glenn Professor and Professor of Political Science
BioJens Hainmueller is the Kimberly Glenn Professor in Political Science and Director of Graduate Studies of the Department of Political Science at Stanford University. He is the Faculty Co-Director of the Stanford Immigration Policy Lab that is focused on the design and evaluation of immigration and integration policies and programs.
His research interests include immigration, statistical methods, political economy, and political behavior. He has published over 65 articles, many of them in top general science journals and top field journals in political science, statistics, economics, and business. He has also published three open source software packages and his research has received awards and funding from the Carnegie Corporation, the Russell Sage Foundation, the Robin Hood Foundation, the National Science Foundation, the Swiss SNF, the American Political Science Association, Schmidt Futures, the Society of Political Methodology, the National Bureau of Economic Research, and the Midwest Political Science Association.
Hainmueller received his PhD from Harvard University and also studied at the London School of Economics, Brown University, and the University of Tübingen. Before joining Stanford, he served on the faculty of the Massachusetts Institute of Technology.
Professor of Pediatrics (Neonatology) and, by courtesy, of Obstetrics and Gynecology
Current Research and Scholarly Interests1. development of hospital operations centers coupled with sophisticated simulation capabilities
2. re-creation of near misses and adverse events
3. optimizing human and system performance during resuscitation
4. optimizing pattern recognition and situational awareness at the bedside
5. evaluation and optimization of debriefing
6. patient simulator design
Scott S. Hall, Ph.D
Professor of Psychiatry and Behavioral Sciences (Interdisciplinary Brain Sciences)
Current Research and Scholarly InterestsMy primary area of scholarly and clinical interest is the pathogenesis of problem behaviors shown by individuals diagnosed with intellectual and developmental disabilities (IDD), particularly those with neurogenetic forms of IDD, such as fragile X syndrome, Cornelia de Lange syndrome and Prader-Willi syndrome. My work aims to both advance understanding of these disorders and to identify effective new treatment approaches for pediatric and adult patient populations by state-of-the-art methodologies, such as brain imaging, eye tracking and functional analysis to determine how environmental and biological factors affect the development of aberrant behaviors in these syndromes. The end goal of my research is to create patient-specific methods for treating the symptoms of these disorders.
Sr Research Scholar, School of Medicine - Biomedical Ethics
BioMeghan Halley, PhD, MPH, is a Senior Research Scholar in the Center for Biomedical Ethics (SCBE) at Stanford University. She completed her doctorate in medical anthropology from Case Western Reserve University in 2012, and additional training in health services research at the Palo Alto Medical Foundation Research Institute from 2012 through 2016. Her current research focuses at the intersection of the ethics and economics of new genomic technologies. Her current projects include examining ethical issues related to sustainability and governance of patient data and relationships when large clinical genomic studies transition to new models of funding; ethnographic work exploring how diverse stakeholders perceive value in the use of genome sequencing for diagnosis of rare diseases; and the development of new measures for assessing patient-centered outcomes in pediatric rare diseases.
Professor of Psychiatry and Behavioral Sciences
Current Research and Scholarly InterestsPrincipal Investigator
Infrastructure to facilitate discovery of autism genes
The purpose of this project is to facilitate the discovery of the genes that contribute autism by maintaining an infrastructure which research groups studying the genetics of autism can work collaboratively. This will be
accomplished through workshops, a Virtual Private Network, and access to a database that includes phenotype and genotype data from all participating groups.
A California Population-Based Twin Study of Autism
This will address several fundamental questions: (1) What is the heritability of autism (2) What is the contribution of genetic factors to variation in symptom dimensions? (3) Is there a continuum between the quantitative neurocognitive traits and clinical disorder? (4) What proportion of the variance in the neurocognitive traits is accounted for by genetic and non-genetic factors?
Center for Integrating Ethics in Genetics Research(Cho)
The goal of this project is to serve as a center of excellence in neurogenetics research, to develop a national model for bench, to bedside research ethics consultation, and to provide training opportunity in biomedical ethics.
Gene, Brain and Behavior in Turner Syndrome(Reiss)
The primary objective of this project is to use advanced, multi-modal magnetic resonance imaging (MRI) techniques, analyses of X chromosome parent-of-origin and cognitive-behavioral assessment to elucidate the effects of monosomy and X-linked imprinting on neurodevelopment and neural function in a large cohort of young girls with Turner syndrome, pre-estrogen replacement.
Project F: Genomic Analysis in narcolepsy cataplexy
The goal of the project is to locate genes outside the HLA region that influence susceptibility to narcolepsy. In order to localize these genes we will carry out a linkage and association study in the most extensive world-wide collection of DNAs from well-characterized patients with narcolepsy and their families.
Marron and Mary Elizabeth Kendrick Professor of Pediatrics and Professor, by courtesy, of Epidemiology and Population Health and of Psychiatry and Behavioral Sciences
Current Research and Scholarly InterestsResearch focuses on developmental, cognitive and psychosocial factors involved in adolescents’ and young adults’ health-related decision-making, perceptions of risk and vulnerability, health communication and risk behavior. My research has focused on understanding and reducing health risk behaviors such as tobacco use, alcohol and marijuana use, risky driving, and risky sexual behavior.
Professor of Anesthesiology, Perioperative and Pain Medicine (Pediatric) and of Pediatrics (Critical Care)
Current Research and Scholarly InterestsDr. Hammer's primary research interests are pediatric pharmacology and perioperative care of children undergoing cardiac surgery. He has numerous funded research projects in these areas, including an NIH grant for $4.3 million to study the pharmacology of sodium nitroprusside, a drug commonly used for blood pressure control in the operating room and ICU. Dr. Hammer has two other NIH grants and other ongoing research projects in the area of pediatric pharmacology.
Lawrence Crowley, M.D., Endowed Professor of Child Health
Current Research and Scholarly InterestsHis research and clinical work focuses on the development of interventional techniques for fetal and neonatal treatment of congenital heart disease, pulmonary, vascular physiology, and the neurologic impact of open-heart surgery. He developed and pioneered the unifocalization procedure, in which a single procedure is used to repair a complex and life-threatening congenital heart defect rather than several staged open-heart surgeries as performed by other surgeons.
Clinical Assistant Professor, Pediatrics
Current Research and Scholarly InterestsA bad latch means maternal excruciating pain, ineffective milk transfer with subsequent weight loss, hypoglycemia, higher risk of hyperbilirubinemia and dehydration fever.All of the above led to early cessation of breastfeeding; 46% of mothers who initiate exclusive breastfeeding stop within the first 12 weeks because of difficult latch. I developed a latch tutorial focusing on step-by step-in striations for achieving an effective, non-painful latch.
Antonio Hardan, M.D.
Professor of Psychiatry and Behavioral Sciences
Current Research and Scholarly InterestsThe neurobiology of autism
Neuroimaging in individuals with autism
Psychopharmacological treatment of children and adults with autism and/or developmental disorders
The neurobiology and innovative interventions of several neurogenic disorders including DiGeorge Syndrome (Velocardiofacial syndrome; 22q11.2 mutations), PTEN mutations, and Phelan McDermid Syndrome (22q13 mutations).
Assistant Professor of Neurobiology
Current Research and Scholarly InterestsOur laboratory studies the mechanisms by which highly complex behaviors are mediated at the neuronal level, mainly focusing on the example of dynamic social interactions and the neural circuits that drive them. From dyadic interactions to group dynamics and collective decision making, the lab seeks a mechanistic understanding for the fundamental building blocks of societies, such as cooperation, empathy, fairness and reciprocity.
Phillip M. Harter, M.D.
Associate Professor (Teaching) of Emergency Medicine, Emeritus
Current Research and Scholarly InterestsMedical Education, particularly the role of simulation (part-task trainers, human patient simulators and virtual reality) in the education of medical students and residents. Also, the use of the internet for distance learning in health care professions.
John A. Overdeck Professor, Professor of Statistics and of Biomedical Data Sciences
Current Research and Scholarly InterestsFlexible statistical modeling for prediction and representation of data arising in biology, medicine, science or industry. Statistical and machine learning tools have gained importance over the years. Part of Hastie's work has been to bridge the gap between traditional statistical methodology and the achievements made in machine learning.
Melanie Hayden Gephart
Professor of Neurosurgery and, by courtesy, of Neurology
BioI am a brain tumor neurosurgeon, treating patients with primary and metastatic brain tumors. I treat patients with malignant and benign tumors, including glioma, brain metastases, meningioma, and vestibular schwannomas. I direct the Stanford Brain Tumor Center and the Stanford Brain Metastasis Consortium, collaborative unions of physicians and scientists looking to improve our understanding and treatment of brain tumors. My laboratory seeks greater understanding of the mechanisms driving tumorigenesis and disease progression in malignant brain tumors. We study how rare cancer cell populations survive and migrate in the brain, inadvertently supported by native brain cells. We develop novel cell free nucleic acid biomarkers to track brain cancer treatment response, relapse, and neurotoxicity. Our bedside-to-bench-to-bedside research model builds on a foundation of generously donated patient samples, where we test mechanisms of brain cancer growth, develop novel pre-clinical models that reliably recapitulate the human disease, and facilitate clinical trials of new treatments for patients with brain cancer.
Florette K. Gray Hazard
Professor of Pathology and of Pediatrics
Current Research and Scholarly InterestsMy scholarly pursuits are primarily focused on the study of death and disease in the pediatric population. It is through this work that I am able to explore fundamental concepts of neoplasia, such as histogenesis and mutagenesis, while utilizing a variety of investigational techniques.
John P. Hegarty II
Clinical Assistant Professor, Psychiatry and Behavioral Sciences
BioI am a neuroscientist and Principal Investigator of the Stanford Clinical Neuroscience (CNS) Lab in the Department of Psychiatry and Behavioral Sciences as well as Director of Neuroimaging for the Autism and Developmental Disorders Research Program at Stanford. My innovative research studies clinical aspects of cognitive and behavioral neuroscience, with a special focus on examining the neural circuitry associated with important brain-behavior relationships that may underlie different psychological and psychiatric domains in autistic children, adolescents, and adults. The ultimate goal of this research is to improve our understanding of the development of different cognitive and behavioral skills in order to develop mechanistically driven interventions that will improve precision medicine for mental health. Biologically based diagnosis and treatment are extremely limited for most psychological and psychiatric conditions but also critically needed to increase early identification and improve treatment outcomes, especially for neurodevelopmental disorders in which early intervention is the most beneficial. My early career research has primarily focused on clinical neuroscience using neuroimaging (e.g., MRI & EEG) to examine the effects of different drugs and behavioral interventions on the brain, especially for developing biomarkers for improving treatment planning and monitoring biological changes in response to single dose and clinical trials.
My primary contributions to science thus far fall within these major categories: 1) identifying the neural correlates of individual differences in cognition and behavior, 2) developing new interventions and investigating the neurobiological substrates of response to treatment, 3) examining different factors that contribute to brain development, 4) summarizing and increasing accessibility to autism-related research, and 5) methods development for neuroimaging studies. My earliest research investigated the neurobiology of alexithymia, dyslexia, and stress using structural and functional magnetic resonance imaging to test theories of the mechanisms that contribute to differences in cognition and behavior. My subsequent dissertation research, in which I began to focus on neurodevelopmental disorders, examined the neural correlates of response to beta-blockers in autistic adults and also assessed the contribution of cerebellar circuits to the autism phenotype. During my postdoctoral training, I have developed further skills for working with children in multiple clinical research settings, especially for using advanced neuroimaging approaches to examine important brain-behavior relationships. This includes a recent K99/R00 from the National Institute of Child Health and Human Development (NCT04278898 & NCT05664789) that will assess the neurobiology of restricted and repetitive behaviors in autistic children and examine the efficacy and target engagement of a novel nutritional supplement and investigational drug, N-acetylcysteine (NAC), in the brain. You can find more information about our NAC studies at https://redcap.link/NACandAutism.
Director, Geballe Laboratory for Advanced Materials (GLAM), Professor of Materials Science and Engineering and, by courtesy, of Bioengineering and of Chemical Engineering
Current Research and Scholarly InterestsProtein engineering
Wm. LeRoy Heinrichs
Member, Maternal & Child Health Research Institute (MCHRI)
Current Research and Scholarly InterestsSurgical simulation; team-training in virtual environments; online training of healthcare providers in virtual environments; tele-medicine for acute & chronic disease management in virtual environments
Edward C. and Amy H. Sewall Professor in the School of Medicine and Professor of Otolaryngology - Head & Neck Surgery (OHNS)On Partial Leave from 08/01/2023 To 09/30/2023
Current Research and Scholarly InterestsOur research focuses on the inner ear, from its earliest manifestation as one of the cranial placodes until it has developed into a mature and functioning organ. We are interested in how the sensory epithelia of the inner ear that harbor the sensory hair cells develop, how the cells mature, and how these epithelia respond to toxic insults. The overarching goal of this research is to find ways to regenerate lost sensory hair cells in mammals.
Professor of Medicine (Biomedical Informatics), of Biomedical Data Science, of Surgery and, by courtesy, of Epidemiology and Population Health
Current Research and Scholarly InterestsMy background and expertise is in the field of computational biology, with concentration in health services research. A key focus of my research is to apply novel methods and tools to large clinical datasets for hypothesis generation, comparative effectiveness research, and the evaluation of quality healthcare delivery. My research involves managing and manipulating big data, which range from administrative claims data to electronic health records, and applying novel biostatistical techniques to innovatively assess clinical and policy related research questions at the population level. This research enables us to create formal, statistically rigid, evaluations of healthcare data using unique combinations of large datasets.
Senior Associate Dean for Education and Professor of Civil and Environmental Engineering
BioLynn Hildemann's current research areas include the sources and dispersion of airborne particulate matter indoors, and assessment of human exposure to air pollutants.
Prof. Hildemann received BS, MS, and PhD degrees in environmental engineering science from the California Institute of Technology. She is an author on >100 peer-reviewed publications, including two with over 1000 citations each, and another 6 with over 500 citations each. She has been honored with Young Investigator Awards from NSF and ONR, the Kenneth T. Whitby Award from the AAAR (1998), and Stanford's Gores Award for Teaching Excellence (2013); she also was a co-recipient of Atmospheric Environment’s Haagen-Smit Outstanding Paper Award (2001).
She has served on advisory committees for the Bay Area Air Quality Management District and for the California Air Resources Board. She has been an Associate Editor for Environmental Science & Technology, and Aerosol Science and Technology, and has served on the advisory board for the journal Environmental Science & Technology.
At Stanford, Prof. Hildemann has been chair of the Department of Civil & Environmental Engineering, and served as an elected member of the Faculty Senate. She has chaired the School of Engineering Library Committee, the University Committee on Judicial Affairs, and the University Breadth Governance Board.
Professor of Obstetrics and Gynecology (General Gynecology), Emerita
BioPaula J. Adams Hillard, M.D., is Professor of Obstetrics and Gynecology at Stanford University School of Medicine where she serves as Associate Chair for Medical Student Education. She earned a B.S. in Zoology from the University of North Carolina and obtained her M.D. from Stanford University School of Medicine. She completed a residency in OB/Gyn at the University of North Carolina, Chapel Hill. She was on the faculty at the University of Virginia, and served as Professor in the Departments of OB/Gyn and Pediatrics at the Cincinnati Children’s Hospital (CCHMC) /University of Cincinnati Medical Center for 23 years. At CCHMC she was the founder of a postgraduate fellowship training program in Pediatric and Adolescent Gynecology. She currently directs the program in Pediatric and Adolescent Gynecology at the Lucile Packard Children’s Hospital at Stanford.
She has been active on a number of national medical committees, including chair of the American College Obstetricians and Gynecologists' (ACOG) Committees on Patient Education, Adolescent Health, and Guidelines for Women’s Health; she is a past member of the Gynecologic Practice Committee, the Gynecology Document Review Committee, and the Ethics Committee. She was been an examiner for the American Board of Obstetricians and Gynecologists from 1991-2015. She is a Board Member of the Association of Professors of Gynecology and Obstetrics, and was elected a fellow of the American Gynecological and Obstetrical Society. She is a past president of the North American Society for Pediatric and Adolescent Gynecology, and is an active contributor to the literature in adolescent gynecology and contraception with over 200 journal articles and abstracts published. She serves as Editor-in-Chief of the Journal of Pediatric and Adolescent Gynecology. She is the sole editor of two textbooks: the 5-Minute Consult in Obstetrics and Gynecology (2008) and Practical Pediatric and Adolescent Gynecology (2013). She is the author of over 120 book chapters on women’s health. She has been a consultant and a member of tasks forces and committees for the CDC, the U.S. FDA, the NICHD, the AMA, American Cancer Society, and ACOG. In addition to her work as a member of editorial boards and as an ad hoc reviewer for professional publications, Dr. Hillard has extensive experience with the consumer press. She was a contributing editor to Parents magazine from 1982-1990, writing a monthly column on pregnancy and birth--and currently acts as an editorial consultant to women’s publications such as Good Housekeeping, Family Circle, Woman’s Day, Cosmopolitan, Redbook, Glamour, YM, and Seventeen, as well as ABC News. She is a consultant to and a member of the medical advisory board of Clue, a menstrual cycle tracking app. She has been recognized for her teaching, and has been selected as one of 18 senior faculty master teachers/mentors for medical students at the Stanford University School of Medicine in a formal mentoring program called Educators for CARE: Compassion, Advocacy, Responsibility, and Empathy.
Susan R. Hintz, M.D., M.S. Epi.
Robert L. Hess Family Professor and Professor, by courtesy, of Obstetrics and Gynecology
Current Research and Scholarly Interests1) Early childhood neurodevelopmental outcomes, mortality and morbidities of extremely premature and high-risk infants
2) Use of advanced neuroimaging and other predictors of neurodevelopmental outcomes in high-risk infants, evidence-based interventions to improve outcomes
3) Quality and process improvement throughout the continuum of care
4) Natural history and outcomes of complex fetal anomalies, implementing innovative fetal therapies.
Andrew R. Hoffman
Professor of Medicine (Endocrinology)
Current Research and Scholarly InterestsMechanism of genomic imprinting of insulin like growth factor-2 and other genes.Long range chromatin interactions Role of histone modifications and DNA methylation in gene expression.
Marie Hollenhorst, MD, PhD
Basic Life Science Research Associate, Sarafan ChEM-H
BioDr. Hollenhorst is a physician and scientist with expertise in non-malignant hematology, transfusion medicine, and chemical biology. Dr. Hollenhorst values the one-on-one relationships that she forms with her patients, and strives to deliver the highest quality of care for individuals with blood diseases. Her experience caring for patients drives her to ask scientific questions in the laboratory, where she aims to bring a chemical approach to the study of non-malignant blood disease.
Dr. Hollenhorst pursued combined MD and PhD training at Harvard University, where she received a PhD in Chemical Biology under the mentorship of Professor Christopher T Walsh. She subsequently completed a residency in Internal Medicine at Brigham and Women's Hospital, a fellowship in Transfusion Medicine at Harvard Medical School, and a fellowship in Hematology at Stanford.
Dr. Hollenhorst has an interest in the biology of platelets, which are cellular fragments that help the blood to maintain a healthy balance between bleeding and clotting. Working in the laboratory of Professor Carolyn Bertozzi of Stanford Chemistry, Dr. Hollenhorst is studying sugar molecules found on the surface of platelets that are important in controlling their function and lifespan.
Dr. Hollenhorst's research is supported by an NIH K99 Career Pathway to Independence in Blood Science Award for Physician-Scientists, a Stanford Chemistry, Engineering & Medicine for Human Health Physician-Scientist Fellowship, and a National Blood Foundation Early-Career Scientific Research Grant.
Professor of Statistics
Current Research and Scholarly InterestsOur lab has been developing tools for the analyses of complex data structures, extending work on multivariate data to structured multitable table that include graphs, networks and trees as well as categorical and continuous measurements.
We created and support the Bioconductor package phyloseq for the analyses of microbial ecology data from the microbiome. We have specialized in developing interactive graphical visualization tools for doing reproducible research in biology.
Member, Maternal & Child Health Research Institute (MCHRI)
BioDr. Hong specializes in the treatment of pediatric patients with neurosurgical conditions, with additional specialty training in the treatment of pediatric spinal disorders, including scoliosis. He completed his residency in his home state of Michigan at the Detroit Medical Center, and completed fellowship training at Rady Children's Hospital in San Diego, before becoming a part of Stanford Children's Health.
His clinical interests include brain tumors, epilepsy surgery, idiopathic scoliosis, Chiari malformation, vascular conditions, concussion, and will treat all other conditions within the specialty.
David S. Hong
Associate Professor of Psychiatry and Behavioral Sciences (Interdisciplinary Brain Science Research)
Current Research and Scholarly InterestsDr. Hong is a child and adolescent psychiatrist and clinician-scientist. His responsibilities span clinical care, teaching/mentorship, and research, with a unifying theme of advancing a developmental cognitive framework as applied to psychiatric conditions. Using this core premise, he work encompasses multiple domains: specialized clinical care, fellowship training, research mentorship, and elaborating the role of sex-specific determinants of development, one of the greatest contributors to individual developmental variation.
His lab investigates genetic and hormonal influences underlying sex differences in child psychiatric conditions. Sex has emerged as a critical variable driving differences in the phenomenology, course, and treatment of many mental health disorders. Unfortunately, an understanding of the biological mechanisms driving these effects are limited. By applying innovative neuroimaging and multiomic approaches, Dr. Hong seeks to provide a deeper understanding of the connection between sex-specific effects and complex psychiatric diseases. To do so, research in the Hong Lab focuses on the role of genes on the X and Y chromosomes, as well as circulating sex hormones on brain development, cognition, and behavior. The lab broadly aims to elucidate the changing nature of these mechanisms across various stages of development.
Another area of focus is the implementation of clinical informatics in child psychiatry and the development of digital mental health tools. As co-Director of the Mental Health Technology and Innovation Hub, Dr. Hong is helping to develop clinical and research infrastructure within the Department of Psychiatry and Behavioral Sciences to advance development of mobile mental health resources that will improve efficacy and access to mental health care.
Clinical Professor, Anesthesiology, Perioperative and Pain Medicine
Current Research and Scholarly InterestsPatient Safety and Simulation
Effective Use of Health Care Resources
Professor of Pediatrics (Endocrinology) and of Psychiatry and Behavioral Sciences (Child and Adolescent Psychology)
BioDr. Hood directs NIH- and foundation-funded clinical research aimed at promoting health and quality of life outcomes for people with diabetes. He has expertise and experience with diabetes epidemiology and interventions, study design, methodology, data management, and advanced statistical methods. There are two content threads to his work: 1) construct prevention and treatment programs to address modifiable psychological and family factors that create barriers to optimal diabetes management, and 2) optimize the use of devices and technologies to improve health outcomes. With regard to the first thread, Dr. Hood has successfully implemented depression screening programs in tertiary diabetes and GI clinics within a Quality Improvement framework, and recently completed a large scale clinical trial on a distress prevention program for teens with type 1 diabetes. Dr. Hood manages and analyzes all the data from these studies. From a device and technology standpoint, Dr. Hood coordinates the Human Factors assessments in Drs. Maahs’ and Buckingham’s closed loop studies and is recognized as one of the experts in this area nationally and internationally. In addition, he has implemented Human Factors assessments in national (e.g., T1D Exchange) studies and registries and is the lead psychologist on 2 of the 4 UC4 grants from NIDDK (Hovorka, PI; Bergenstal, PI). These assessments focus on uptake of devices and technologies, and determining strategies to promote uptake and optimize their use. Dr. Hood and his research team have published over 100 scientific articles on these topics and are active presenters at diabetes, behavioral medicine, and advocacy conferences.
Dr. Hood also works in clinical and service settings. Dr. Hood is a licensed clinical psychologist and is part of the diabetes care team at Stanford. He is the past chair of the American Diabetes Association’s Behavioral Medicine and Psychology Interest Group and is currently a member of the Research Policy Committee. He was also a member of the ADA’s Call to Congress in March 2017. Dr. Hood is an Associate Editor for both Diabetes Care and Pediatric Diabetes.
Rachel Knight Hopper
Clinical Associate Professor, Pediatrics - Cardiology
Current Research and Scholarly InterestsCurrent research interests include:
PH related to prematurity and bronchopulmonary dysplasia
Right heart failure in children with pulmonary hypertension, imaging and biomarkers
Pulmonary hypertension related to congenital diaphragmatic hernia
Pulmonary vein stenosis in infants and children
Pulmonary hypertension in children with congenital heart disease
Clinical trials in children with PH
Yusuke Hori, MD
Clinical Instructor, Neurosurgery
BioDr. Hori received his MD from Sapporo Medical University, Japan, and during that time he served as a Medical Student Research Fellow in the Department of Pharmacology. He explored the functional role of the SIRT1 gene, a longevity-associated gene, and its association with various conditions such as muscular dystrophy. He also completed a Visiting Student Research Fellowship at the Health Sciences University of Hokkaido and participated in Human Genetics projects focusing on an association between the 27-bp deletion and 538G>A mutation in the ABCC11 Gene.
After graduating from medical school, Dr. Hori completed a neurosurgery residency at National Hospital Organization Okayama Medical Center in Japan. Subsequently, he completed a Stereotactic and Functional Neurosurgery Fellowship and then a Neurosurgical Oncology and Radiosurgery Fellowship at The Cleveland Clinic. He also completed an International Neurosurgery Fellowship at Boston Children's Hospital, Harvard Medical School. In 2022, he moved to Stanford University as a postdoctoral fellow, and under the supervision of Dr. Anca Pasca, he participated in brain organoid research focusing on hypoxic brain injuries.
Since July 2023, Dr. Hori has been working as a Clinical Instructor (Neurosurgical Oncology and Radiosurgery) in the Department of Neurosurgery at Stanford under the supervision of Dr. Steven D. Chang. His clinical interests include malignant brain and spine tumors in both adult and pediatric patients. His clinical research focuses on the application of minimally invasive treatments such as laser interstitial thermal therapy, focused ultrasound, and radiosurgery to treat various neurosurgical conditions. His current lab research aims to develop an organoid model for radiation-induced brain injuries and a high-throughput screening platform to identify novel therapeutic compounds, for which he received a Clinician Educator Grant from Stanford University Maternal and Child Health Research Institute. Outside of medicine, he enjoys playing music including guitar and drums.
Clinical Assistant Professor, Medicine - Immunology & Rheumatology
BioDr. Horomanski specializes in the diagnosis and treatment of rheumatologic diseases. She received her undergraduate degree from Case Western Reserve University, medical degree from Wright State University, and completed her Internal Medicine residency and Rheumatology fellowship at Stanford University. She is the Director of the Stanford Vasculitis Clinic where she manages the complex care of patients with all types of vasculitis and works closely with partners in related specialties. She has a specific interest in clinical trials and a Graduate Certificate in Epidemiology and Clinical Research. Dr. Horomanski also received training in musculoskeletal ultrasound from the USSONAR program and is an integral part of Stanford's Diagnostic and Interventional Musculoskeletal Ultrasound Clinic. Additional areas of research include the application of ultrasound in the study and management of rheumatologic diseases.
Assistant Professor (Research) of Psychiatry and Behavioral Sciences (Interdisciplinary Brain Science Research)
Current Research and Scholarly InterestsOur lab’s research portfolio crosses multiple disciplines including computational neuropsychiatry, cognitive neuroscience, multimodal neuroimaging and neurocognitive rehabilitation. Our computational neuropsychiatry research mainly involves investigating alterations in the organization of connectome in various neurodevelopmental and neurocognitive disorders using state of the art neuroimaging techniques (fMRI, sMRI, DWI, functional NIRS) combined with novel computational methods (graph theoretical and multivariate pattern analyses).
The ultimate goal of our research is to translate the findings from computational neuropsychiatry research toward developing personalized interventions. We have been developing personalized interventions that integrate computerized cognitive rehabilitation, real-time functional brain imaging and neurofeedback, as well as virtual reality (VR) tailored toward targeted rehabilitation of the affected brain networks in patients with neurocognitive disorders.
Associate Professor of Pathology
BioDr. Howitt is a gynecologic and sarcoma pathologist, with academic interests in gynecologic mesenchymal tumors and morphologic and clinical correlates of molecular alterations in gynecologic neoplasia.
Michael R. Howitt
Assistant Professor of Pathology and of Microbiology and Immunology
Current Research and Scholarly InterestsOur lab is broadly interested in how intestinal microbes shape our immune system to promote both health and disease. Recently we discovered that a type of intestinal epithelial cell, called tuft cells, act as sentinels stationed along the lining of the gut. Tuft cells respond to microbes, including parasites, to initiate type 2 immunity, remodel the epithelium, and alter gut physiology. Surprisingly, these changes to the intestine rely on the same chemosensory pathway found in oral taste cells. Currently, we aim to 1) elucidate the role of specific tuft cell receptors in microbial detection. 2) To understand how protozoa and bacteria within the microbiota impact host immunity. 3) Discover how tuft cells modulate surrounding cells and tissue.
Joe Le Hsu
Assistant Professor of Medicine (Pulmonary and Critical Care)
Current Research and Scholarly InterestsI am interested in understanding the host-pathogen interaction between Aspergillus fumigatus and the lung transplant recipient.
Clinical Associate Professor, Pediatrics - Rheumatology
Current Research and Scholarly InterestsPediatric Systemic Lupus Erythematosus;
Racial/Ethnic Differences in Pediatric Lupus Patients
Professor of Obstetrics and Gynecology (Reproductive and Stem Cell Biology), Emeritus
Current Research and Scholarly InterestsHormonal regulation of ovarian function; gonadotropin receptors and related genes, bioinformatic ananlyses of polypeptide hormones and receptors, follicle recruitment and GDF-9; analysis of oocyte and ovarian-expressed genes.
Ngan F. Huang
Associate Professor of Cardiothoracic Surgery (Cardiothoracic Surgery Research) and, by courtesy, of Chemical Engineering
Current Research and Scholarly InterestsDr. Huang's laboratory aims to understand the chemical and mechanical interactions between extracellular matrix (ECM) proteins and pluripotent stem cells that regulate vascular and myogenic differentiation. The fundamental insights of cell-matrix interactions are applied towards stem cell-based therapies with respect to improving cell survival and regenerative capacity, as well as engineered vascularized tissues for therapeutic transplantation.
Lynne C. Huffman
Professor (Teaching) of Pediatrics (Developmental-Behavioral Pediatrics) and, by courtesy, of Psychiatry and Behavioral Sciences
Current Research and Scholarly InterestsResearch interests and activities include (1) shared decision-making in clinical care; (2) medical education research; (3) the early identification and treatment of behavioral problems, particularly in children with special health care needs; and (4) community-based mental health/educational program evaluation and outcomes measurement.
Professor of Neurology and, by courtesy, of Molecular and Cellular Physiology
Current Research and Scholarly InterestsWe are interested in the neuronal mechanisms that underlie synchronous oscillatory activity in the thalamus, cortex and the massively interconnected thalamocortical system. Such oscillations are related to cognitive processes, normal sleep activities and certain forms of epilepsy. Our approach is an analysis of the discrete components (cells, synapses, microcircuits) that make up thalamic and cortical circuits, and reconstitution of components into in silico computational networks.
Noor A. Hussein
Postdoctoral Scholar, Human Gene Therapy
BioIam a pharmacologist scientist. My experience as a researcher has taught me to seek out new perspectives for exploration and discovery. As a dedicated biological and pharmacological researcher with over 7 years of experience with models of diseases such as cancer both in vitro and in vivo. During my masters and Ph.D. studies, I mastered lots of molecular biology techniques, including cell culture, cytotoxicity assays, western blot, quantitative PCR, immunofluorescence, flow cytometry. I utilized my skills to design experiments finding solutions to common problems in the biomedical field, especially cancer experimental and molecular therapeutics.