School of Medicine
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Assistant Professor of Cardiothoracic Surgery
Current Research and Scholarly InterestsOur lab aims to understand the biomechanics that govern a wide spectrum of congenital heart defects, and how those biomechanics change with contemporary operative repair strategies. We simulate operations virtually via CFD, and in ex vivo and in vivo animal models, and analyze how the changes we make alter fluid flow, pressure, and stresses throughout the system. We hope that these experiments can impact and optimize existing techniques that translate quickly to the operating room.
Sean Mackey, M.D., Ph.D.
Redlich Professor, Professor of Anesthesiology, Perioperative, and Pain Medicine and, by courtesy, of Neurology
Current Research and Scholarly InterestsMultiple NIH funded projects to characterize CNS mechanisms of human pain. Comparative effectiveness of cognitive behavioral therapy and chronic pain self-management within the context of opioid reduction (PCORI funded). Single session pain catastrophizing treatment: comparative efficacy & mechanisms (NIH R01). Development and implementation of an open-source learning healthcare system, CHOIR (http://choir/stanford.edu), to optimize pain care and innovative research in real-world patients.
Associate Professor of Molecular and Cellular Physiology
Current Research and Scholarly InterestsMolecular mechanisms of ion chnanels & transporters studied by integration of structural and electrophysiological methods.
Professor (Research) of Microbiology and Immunology
Current Research and Scholarly InterestsI'm interested in immune monitoring of T cell responses to chronic pathogens and cancer, and the correlation of T cell response signatures with disease protection.
Professor of Medicine (Cardiovascular Medicine)
BioClinical Focus: Cardiovascular Medicine: Atrial Fibrillation; Chronic CAD; ACS;
My primary research interest is the design and conduct of multicenter clinical trials and analyses of important clinical cardiac issues using large patient databases. My research focuses on novel anticoagulation agents for the treatment of acute coronary syndromes and atrial fibrillation, the study of agents targeted to protect the myocardium during reperfusion therapy for acute myocardial infarction, and the evaluation of cardiovascular safety of diabetic therapies. I am also interested in the methodology of clinical trials. Current research activities include standardization of the definition of myocardial infarction used in clinical trials, the adjudication of suspected clinical endpoint events by Clinical Event Committees (CEC), and the efficient operational conduct of large multinational clinical trials.
Administrative Focus: Associate Dean, Clinical Research School of Medicine; Vice Chair of Clinical Research Department of Medicine; Director Stanford Center for Clinical Research; Member of the Stanford IRB
1985 Stanford University, BS Chemistry
1989 University of Washington, MD
1993 University of Arizona, Internship/Residency/Chief Residency
1996 Duke University, Fellowship in Cardiology
1996 Duke University, Faculty in Cardiology
2013 Stanford University, Faculty Cardiovascular Medicine
Richard D. Mainwaring
Clinical Professor, Cardiothoracic Surgery
Current Research and Scholarly InterestsProfessional Interests: Pediatric cardiovascular surgery, surgery for adults with congenital heart disease
Academic Staff - Hourly - CSL, Medicine - Cardiovascular Medicine
BioDr. Anurag Mairal is an Adjunct Professor of Medicine and the Director, Global Outreach Programs at Stanford Byers Center for Biodesign, Stanford University. He is also a Faculty Fellow and Lead for Technology Innovation and Impact at Center for Innovation in Global Health. In these roles, he leads initiatives focused on applying the biodesign process to resource-constrained settings globally. Further, he facilitates opportunities for students, faculty and fellows at Stanford to work on global healthcare needs. He is founding co-Director for MED 232, Global Health: Scaling Health Technology Innovations in Low Resource Settings, and was part of the founding faculty team for BIOE 371, Global Biodesign: Medical Technology in an International Context, graduate-level courses offered to engineering, business, and medical students at Stanford University. Earlier, he served as Associate Director for the Stanford-India Biodesign and Singapore-Stanford Biodesign programs. He serves as the Founding Chair of BME IDEA APAC, a community of medtech innovation programs in Asia Pacific, partnering closely with the industry and academia in the region. He is also an Honorary Professor at University of Cape Town, South Africa. Concurrently, he is a co-founder and Executive Vice President of Orbees Medical, a SF Bay Area-based strategy consulting firm serving global healthcare industry, with a focus on medtech, pharmaceutical, and digital health industry.
Dr. Mairal has an extensive background in medical technology development and commercialization, collaborating with partners in the U.S., India, China, and other emerging markets to advance product development, manufacturing, and distribution. Recently, he took a sabbatical for two years to take a senior leadership role at PATH, a major global health nonprofit based in Seattle. In this role, he oversaw research and development, commercialization, and implementation of technologies in PATH’s medical devices, diagnostics, and digital health divisions. Previously, he held several positions at Johnson & Johnson, including Business Development Director and Product Director for structural heart, cardiology, and peripheral vascular products at Cordis. Before joining J&J, he was a Group Leader and a Process Development Manager at Membrane Technology and Research (MTR). At MTR, he was responsible for business development, strategic alliances, and product development in the bioseparations area. An active mentor to entrepreneurs and industry professionals, he serves as the chair of PATH’s Bay Area Leadership Council, board member at EPPIC Global Network and IIT Bombay Heritage Foundation and advisory board member at D-Rev and Sewa International.
Dr. Mairal earned a PhD in chemical engineering from the University of Colorado at Boulder and an MBA from the Haas School of Business at the University of California at Berkeley. He also holds an MS in chemical engineering from the Indian Institution of Technology in Mumbai and a BS in chemical engineering from National Institute of Technology, Raipur. Dr. Mairal was a post-doctoral fellow at the University of Twente, Netherlands and at University of Michigan, Ann Arbor. At BerkeleyHaas, he was a founding co-Chairman of the South Asia Business Conference and Chair of the Biotech Panel for the Asia Business Conference. His work has been published in more than 30 publications, and he has seven issued patents.
Boston Scientific Applied Biomedical Engineering Professor and Professor of Bioengineering
Current Research and Scholarly InterestsDr. Josh Makower is the Boston Scientific Applied Bioengineering Professor of Medicine and of Bioengineering at the Stanford University Schools of Medicine and Engineering and the Director of the Stanford Byers Center for Biodesign, the program he co-founded with Dr. Paul Yock twenty years ago. Josh helped create the fundamental structure of the Center’s core curriculum and is the chief architect of what is now called “The Biodesign Process.” Over the past 20 years since Josh and Paul founded Biodesign, this curriculum and the associated textbook has been used at Stanford and across the world to train hundreds of thousands of students, faculty and industry leaders on the Biodesign process towards the advancement of medical innovation for the improvement of patient care. Josh has practiced these same techniques directly as the Founder & Executive Chairman of ExploraMed, a medical device incubator, creating 9 companies since 1995. Transactions from the ExploraMed portfolio include NeoTract, acquired by Teleflex, Acclarent, acquired by J&J, EndoMatrix, acquired by C.R. Bard & TransVascular, acquired by Medtronic. Other ExploraMed/NEA ventures include Moximed, NC8 and Willow. Josh is also a Special Partner at NEA where he supports the healthcare team and medtech/healthtech investing practice. Josh serves on the boards of Allay Therapeutics, Revelle Aesthetics, Setpoint Medical, DOTS Technologies, Eargo, ExploraMed, Intrinsic Therapeutics, Moximed, Willow and Coravin. Josh holds over 300 patents and patent applications. He received an MBA from Columbia University, an MD from the NYU School of Medicine, a bachelor’s degree in Mechanical Engineering from MIT. Josh is a Member of the National Academy of Engineering and the College of Fellows of The American Institute for Medical and Biological Engineering and was awarded the Coulter Award for Healthcare Innovation by the Biomedical Engineering Society in 2018.
David J. Maron
C. F. Rehnborg Professor and Professor of Medicine (Stanford Prevention Research Center)
Current Research and Scholarly InterestsDr. Maron is the Co-Chair and Principal Investigator of the ISCHEMIA trial, and Co-Chair of the ISCHEMIA-CKD trial. These large, international, NIH-funded studies will determine whether an initial invasive strategy of cardiac catheterization and revascularization plus optimal medical therapy will reduce cardiovascular events in patients with and without chronic kidney disease and at least moderate ischemia compared to an initial conservative strategy of optimal medical therapy alone.
Douglass M. and Nola Leishman Professor of Cardiovascular Diseases, and Professor of Pediatrics (Cardiology) and of Bioengineering
Current Research and Scholarly InterestsThe Cardiovascular Biomechanics Computation Lab at Stanford develops novel computational methods for the study of cardiovascular disease progression, surgical methods, and medical devices. We have a particular interest in pediatric cardiology, and use virtual surgery to design novel surgical concepts for children born with heart defects.
Clinical Associate Professor, Radiology
BioPayam Massaband received his Bachelors degree in Neuroscience at UCLA in 1998 and MD degree at USC in 2002. Dr. Massaband has been a staff radiologist at the VA Palo Alto since graduating from Radiology residency and fellowship at Stanford in 2010. Dr. Massaband concentrated on imaging of the cardiovascular and musculoskeletal organ systems in fellowship. As chief of the Radiology Service at VA Palo Alto since 2012, he has concentrated on clinical excellence, process improvement and residency education. Dr. Massaband was named the Stanford Radiology Residency Program Director in 2015.
Professor of Microbiology and Immunology, Emeritus
Current Research and Scholarly Interests1. Improvement of our newly discovered cancer prodrug regimen that permits noninvaisve visualization of drug activation. 2. Tracking tumors & cancer metastases using bacterial magnetite and newly developed single-cell tracking by MRI. 3. Molecular basis of bacterial planktonic and biofilm antibiotic resistance on Earth and under space microgravity -- development of new countermeasures; 4. Bioremediation.
Michael V. McConnell, MD, MSEE
Clinical Professor, Medicine - Cardiovascular Medicine
Current Research and Scholarly InterestsMy imaging research has involved clinical and molecular Imaging of cardiovascular disease, with a focus on coronary and vascular diseases, including atherosclerosis, aortic aneurysms, and vascular inflammation.
My prevention research has involved innovative technologies to reduce coronary and vascular disease, including early disease detection plus leveraging mobile health to enhance heart-healthy activities in patients and populations.
Professor of Materials Science and Engineering
BioThe Melosh group explores how to apply new methods from the semiconductor and self-assembly fields to important problems in biology, materials, and energy. We think about how to rationally design engineered interfaces to enhance communication with biological cells and tissues, or to improve energy conversion and materials synthesis. In particular, we are interested in seamlessly integrating inorganic structures together with biology for improved cell transfection and therapies, and designing new materials, often using diamondoid molecules as building blocks.
My group is very interested in how to design new inorganic structures that will seamless integrate with biological systems to address problems that are not feasible by other means. This involves both fundamental work such as to deeply understand how lipid membranes interact with inorganic surfaces, electrokinetic phenomena in biologically relevant solutions, and applying this knowledge into new device designs. Examples of this include “nanostraw” drug delivery platforms for direct delivery or extraction of material through the cell wall using a biomimetic gap-junction made using nanoscale semiconductor processing techniques. We also engineer materials and structures for neural interfaces and electronics pertinent to highly parallel data acquisition and recording. For instance, we have created inorganic electrodes that mimic the hydrophobic banding of natural transmembrane proteins, allowing them to ‘fuse’ into the cell wall, providing a tight electrical junction for solid-state patch clamping. In addition to significant efforts at engineering surfaces at the molecular level, we also work on ‘bridge’ projects that span between engineering and biological/clinical needs. My long history with nano- and microfabrication techniques and their interactions with biological constructs provide the skills necessary to fabricate and analyze new bio-electronic systems.
Molecular materials at interfaces
Self-Assembly and Nucleation and Growth
Professor of Medicine (Cardiovascular)
BioDr. Mercola is Professor of Medicine and Professor in the Stanford Cardiovascular Institute. He completed postdoctoral training at the Dana-Farber Cancer Institute and Harvard Medical School, was on the faculty in the Department of Cell Biology at Harvard Medical School for 12 years, and later at the Sanford-Burnham-Prebys Institute and Department of Bioengineering at the University of California, San Diego before relocating to Stanford in 2015.
Prof. Mercola is known for identifying many of the factors that are responsible for inducing and forming the heart, including the discovery that Wnt inhibition is a critical step in cardiogenesis that provided the conceptual basis and reagents for the large-scale production of cardiovascular tissues from pluripotent stem cells. He has collaborated with medicinal chemists, optical engineers and software developers to pioneer the use of patient iPSC-cardiomyocytes for disease modeling, safety pharmacology and drug development. His academic research is focused on developing and using quantitative high throughput assays of patient-specific cardiomyocyte function to discover druggable targets for preserving contractile function in heart failure and promoting regeneration following ischemic injury. He co-established drug screening and assay development at the Conrad Prebys Drug Discovery Center (San Diego), which operated as one of 4 large screening centers of the US National Institutes of Health (NIH) Molecular Libraries screening initiative and continues as one of the largest academic drug screening centers.
Prof. Mercola received an NIH MERIT award for his work on heart formation. He holds numerous patents, including describing the invention of the first engineered dominant negative protein and small molecules for stem cell and cancer applications. He serves on multiple editorial and advisory boards, including Vala Sciences, Regencor, The Ted Rogers Centre for Heart Research and the Human Biomolecular Research Institute. His laboratory is funded by the National Institutes of Health (NIH), California Institute for Regenerative Medicine, Phospholamban Foundation and Fondation Leducq.
Sr Res Scientist-Basic Life, Pediatrics - Cardiology
Current Research and Scholarly InterestsDevelopment, maintenance, and repair of the pulmonary circulation
D. Craig Miller, M.D.
Thelma and Henry Doelger Professor of Cardiovascular Surgery, Emeritus
Current Research and Scholarly InterestsCardiac and heart valve disease with experimental laboratory large animal projects focused on the investigation of left ventricular and cardiac mechanics, bioenergetics, and LV and mitral valve physiology and pathophysiology. Current thrust is aimed at understanding the mitral valve and subvalvular mitral apparatus and transmural LV wall strains, thickening, and myolaminar fiber-sheet mechanics.
Clinical research interests include thoracic aortic diseases (aortic dissection, aneurysm) and cardiac valvular disease, including surgical treatment, endovascular thoracic aortic stent-graft repair, mitral valve repair, and valve-sparing aortic root replacement.
Lloyd B. Minor, MD
Carl and Elizabeth Naumann Professorship for the Dean of the School of Medicine, Professor of Otolaryngology - Head & Neck Surgery (OHNS) and, by courtesy, of Neurobiology and of Bioengineering
Current Research and Scholarly InterestsThrough neurophysiological investigations of eye movements and neuronal pathways, Dr. Minor has identified adaptive mechanisms responsible for compensation to vestibular injury in a model system for studies of motor learning. Following his discovery of superior canal dehiscence, he published a description of the disorder’s clinical manifestations and related its cause to an opening in the bone covering of the superior canal. He subsequently developed a surgical procedure to correct the problem.
R. Scott Mitchell
Professor of Cardiothoracic Surgery at the Stanford University Medical Center, Emeritus
Current Research and Scholarly InterestsResearch Interests: Disease of the aorta, congenital and acquired. Treatment of aortic pathology, including development of stent graft systems. Patterns of disease in patients treated with mediastinal radiation. Valvular heart disease, especially aortopathy associated with congenital bicuspid aortic valve.
Professor of Microbiology and Immunology, Emeritus
Current Research and Scholarly InterestsMy research interests focus on the biology and pathogenesis of cytomegalovirus (CMV), an opportunistic pathogen that causes significant disease worldwide. We developed global approaches and produced key insights into the areas of CMV gene regulation, DNA replication and packaging, maturation, impact on the host cell, disease pathogenesis, latency and reactivation, host cell signaling and chemokine system. (NOTE: Research occurs at my Emory University Vaccine Center laboratory in Atlanta, GA)
George D. Smith Professor of Translational Medicine
Current Research and Scholarly InterestsTwo areas: 1. Using rationally-designed peptide inhibitors to study protein-protein interactions in cell signaling. Focus: protein kinase C in heart and large GTPases regulating mitochondrial dynamics in neurodegdenration. 2. Using small molecules (identified in a high throughput screens and synthetic chemistry) as activators and inhibitors of aldehyde dehydrogenases, a family of detoxifying enzymes, and glucose-6-phoshate dehydrogenase, in normal cells and in models of human diseases.
Stephen B. Montgomery
Associate Professor of Pathology, of Genetics, of Biomedical Data Science and, by courtesy, of Computer Science
Current Research and Scholarly InterestsWe focus on understanding the effects of genome variation on cellular phenotypes and cellular modeling of disease through genomic approaches such as next generation RNA sequencing in combination with developing and utilizing state-of-the-art bioinformatics and statistical genetics approaches. See our website at http://montgomerylab.stanford.edu/
Associate Professor of Biology
Current Research and Scholarly InterestsOur research interests are to elucidate the contribution of chromatin to mechanisms that promote genomic integrity.
Professor of Radiology (Radiological Sciences Lab)
Current Research and Scholarly InterestsMR physics into tissue contrast mechanisms such as diffusion, perfusion, and functional imaging describes the research direction. Applications of cerebral stroke (brain attacks) and neurocognitive disorders are also being developed from these methods
Clinical Associate Professor, Pediatrics - Cardiology
Current Research and Scholarly InterestsArrhythmias in Pediatric and Adult Congenital Heart Disease
Associate Professor of Anesthesiology, Perioperative and Pain Medicine
Current Research and Scholarly InterestsDr. Mudumbai’s research interests focus on 1) optimizing therapeutic strategies and reducing adverse outcomes related to medication management, particularly opioids; and 2) measuring and improving the quality of perioperative and pain management.
Associate Professor of Surgery (Pediatric Surgery)
Current Research and Scholarly InterestsInvestigations of how children's beliefs of health affect their responses to illness.
Professor of Pediatrics (Cardiology), Emeritus
Current Research and Scholarly InterestsDr. Murphy's major interests are in noninvasive cardiology and clinical pediatric and adult congenital cardiac disease. These clinical interests range from imaging of complex cardiac disease in the fetus and newborn to care of the adult with congenital heart disease. He also coordinates the Marfan clinic at LPCH. He is the director of the Adult Congenital Cardiac Clinic at Stanford University Medical Center.
Jonathan N. Myers
Clinical Professor (Affiliated), Medicine - Med/Cardiovascular Medicine
BioDr. Myers is a Health Research Scientist at the Palo Alto VA Health Care System; a Clinical Professor at Stanford University (Affiliated), and a Senior Research Career Scientist Award recipient through the VA Rehabilitation Research and Development Program. His research has focused on primary and secondary prevention, and the clinical applications of exercise testing and rehabilitation in patients with cardiovascular disease and other chronic conditions. He has a lengthy history of studying the epidemiology of cardiopulmonary exercise test responses, physical activity patterns, and other lifestyle factors and their relation to health outcomes. He manages the Veterans Exercise Testing Study (VETS), an ongoing, prospective evaluation of Veteran subjects referred for exercise testing for clinical reasons, designed to address exercise test, clinical, and lifestyle factors and their association with health outcomes.
He earned his bachelor’s degree from the University of California, Santa Barbara, his master's degree from San Diego State University, and his doctorate from the University of Southern California. He has been a board member for many organizations including the American Heart Association (AHA), the American Association of Cardiovascular and Pulmonary Rehabilitation (AACVPR), and the American College of Sports Medicine (ACSM), and serves on the editorial board for 9 journals. He is a recipient of the Michael Pollock Established Investigator Award through the AACVPR, a recipient of the Steven N Blair Award for excellence in physical activity research from the AHA Council on Epidemiology and Prevention and is the 2022 recipient of the American College of Sports Medicine Citation Award. He is a fellow of the AACVPR, ACSM, American College of Cardiology, and the AHA, and has authored and co-authored guidelines on exercise testing and rehabilitation for each of these organizations, including the 2021 editions of the ACSM and AACVPR guidelines.