School of Medicine
Showing 1-50 of 193 Results
Clinical Professor, Obstetrics & Gynecology - General
BioDr. Wachtel has been practicing general obstetrics and gynecology for 38 years and has personally delivered over 6,000 babies. He continues to have an active practice in general ob/gyn, serving as a Clinical Professor. He is a nationally recognized expert in patient safety, peer review and data driven quality improvement and has served numerous roles in the field and lectured nationally and internationally. Dr. Wachtel is the Assistant Secretary for the American College of Obstetricians and Gynecologists (ACOG) and currently serves on the ACOG National Executive Board and Executive Committee. He is the immediate Past Chair for ACOG District IX (the state of California) and also previously served for three years on the ACOG national Executive Board. He also serves on the Executive Committee for the California Maternal Quality Care Collaborative and is an Expert Medical Reviewer for the Medical Board of California.
Associate Professor (Research) of Surgery (Health Services Research Unit)
BioTodd Wagner is an Associate Professor in the Department of Surgery at Stanford University. He studies health information, efficiency and value, and health care access. He is particularly interested in developing learning health care systems that provide high value care. In addition to his role at Stanford, he Directs the Health Economics Resource Center and is the Associate Director for the Center for Innovation to Implementation, both at the Palo Alto VA. He also co-directs the VA/NCI Big Data Fellowship.
Professor of Photon Science and of Structural Biology
Current Research and Scholarly InterestsUbiquitin signaling: structure, function, and therapeutics
Ubiquitin is a small protein modifier that is ubiquitously produced in the cells and takes part in the regulation of a wide range of cellular activities such as gene transcription and protein turnover. The key to the diversity of the ubiquitin roles in cells is that it is capable of interacting with other cellular proteins either as a single molecule or as different types of chains. Ubiquitin chains are produced through polymerization of ubiquitin molecules via any of their seven internal lysine residues or the N-terminal methionine residue. Covalent interaction of ubiquitin with other proteins is known as ubiquitination which is carried out through an enzymatic cascade composed of the ubiquitin-activating (E1), ubiquitin-conjugating (E2), and ubiquitin ligase (E3) enzymes. The ubiquitin signals are decoded by the ubiquitin-binding domains (UBDs). These domains often specifically recognize and non-covalently bind to the different ubiquitin species, resulting in distinct signaling outcomes.
We apply a combination of the structural (including protein crystallography, small angle x-ray scattering, cryo-electron microscopy (Cryo-EM) etc.), biocomputational and biochemical techniques to study the ubiquitylation and deubiquitination processes, and recognition of the ubiquitin chains by the proteins harboring ubiquitin-binding domains. Current research interests including SARS-COV2 proteases and their interactions with polyubiquitin chains and ubiquitin pathways in host cell responses, with an ultimate goal of providing strategies for effective therapeutics with reduced levels of side effects.
Protein self-assembly processes and applications.
The Surface layers (S-layers) are crystalline protein coats surrounding microbial cells. S-layer proteins (SLPs) regulate their extracellular, self-assembly by crystallizing when exposed to an environmental trigger. We have demonstrated that the Caulobacter crescentus SLP readily crystallizes into sheets both in vivo and in vitro via a calcium-triggered multistep assembly pathway. Observing crystallization using a time course of Cryo-EM imaging has revealed a crystalline intermediate wherein N-terminal nucleation domains exhibit motional dynamics with respect to rigid lattice-forming crystallization domains. Rate enhancement of protein crystallization by a discrete nucleation domain may enable engineering of kinetically controllable self-assembling 2D macromolecular nanomaterials. In particular, this is inspiring designing robust novel platform for nano-scale protein scaffolds for structure-based drug design and nano-bioreactor design for the carbon-cycling enzyme pathway enzymes. Current research focuses on development of nano-scaffolds for high throughput in vitro assays and structure determination of small and flexible proteins and their interaction partners using Cryo-EM, and applying them to cancer and anti-viral therapeutics.
Multiscale imaging and technology developments.
Multimodal, multiscale imaging modalities will be developed and integrated to understand how molecular level events of key enzymes and protein network are connected to cellular and multi-cellular functions through intra-cellular organization and interactions of the key machineries in the cell. Larger scale organization of these proteins will be studied by solution X-ray scattering and Cryo-EM. Their spatio-temporal arrangements in the cell organelles, membranes, and cytosol will be further studied by X-ray fluorescence imaging and correlated with cryoEM and super-resolution optical microscopy. We apply these multiscale integrative imaging approaches to biomedical, and environmental and bioenergy research questions with Stanford, DOE national labs, and other domestic and international collaborators.
Professor of Medicine (Oncology) at the Stanford University Medical Center
Current Research and Scholarly InterestsDr. Wakelee's research is focused on clinical trials and translational efforts in patients with lung cancer and other thoracic malignancies such as thymoma and thymic carcinoma. Other interests include translation projects in thoracic malignancies and collaborations with population scientists regarding lung cancer questions.
Rebecca D. Walker
Clinical Associate Professor, Emergency Medicine
Current Research and Scholarly InterestsInterests include international development in emergency care, healthcare disparities, wilderness medicine, human rights, administration
Associate Professor of Pediatrics (Systems Medicine), of Biomedical Data Science and, by courtesy, of Psychiatry and Behavioral Sciences
Current Research and Scholarly InterestsSystems biology for design of clinical solutions that detect and treat disease
Associate Professor of Surgery (Pediatric Surgery) at the Lucile Salter Packard Children's Hospital and, by courtesy, of Bioengineering
Current Research and Scholarly InterestsHealth Technology Innovation
Clinical Assistant Professor, Neurology & Neurological Sciences
BioDr. Walter received her MD from Georgetown University in Washington, DC. She stayed at Georgetown for her internship in Internal Medicine and then moved to New York City to complete her residency in Neurology at the Icahn School of Medicine at Mount Sinai. She went on to pursue a Clinical Neurophysiology Fellowship at Rush University in Chicago, IL, training in both EEG and EMG. Due to her particular interest in Epilepsy she went on to become the first Epilepsy Fellow at Rush University. Dr. Walter provides clinical care to general neurology patients as well as patients with epilepsy and enjoys teaching residents and medical students. She also has a particular interest in dietary treatments for epilepsy and clinical research.
Brian A. Wandell
Isaac and Madeline Stein Family Professor and Professor, by courtesy, of Electrical Engineering, of Ophthalmology and at the Graduate School of Education
Current Research and Scholarly InterestsModels and measures of the human visual system. The brain pathways essential for reading development. Diffusion tensor imaging, functional magnetic resonance imaging and computational modeling of visual perception and brain processes.
Professor of Chemical and Systems Biology and, by courtesy, of Chemistry
Current Research and Scholarly InterestsWe employ an interdisciplinary approach to studies of biological systems, combining synthetic chemistry with biochemistry, cell biology, and structural biology. We invent tools for biology and we are motivated by approaches that enable new experiments with unprecedented control. These new techniques may also provide a window into mechanisms involved in maintaining cellular homeostasis. Protein quality control is a particular interest at present.
Assistant Professor of Radiology and, by courtesy, of Electrical Engineering
BioMy group develops technologies for advanced x-ray and CT imaging, including artificial intelligence for CT acquisition, reconstruction, and image processing; novel system and detector designs; spectral imaging; model-based image reconstruction; and radiation transport methods. I am also the Director of the Zeego Lab and the Tabletop X-Ray Lab.
I completed my PhD in Electrical Engineering at Stanford under the supervision of Dr. Norbert Pelc, developing strategies for maximizing the information content of dual energy CT and photon counting detectors. I then pursued a postdoc at Johns Hopkins with Dr. Jeff Siewerdsen in Biomedical Engineering, developing reconstruction and registration methods for x-ray based image-guided surgery. Prior to returning to Stanford in 2018, I was a Senior Scientist at Varian Medical Systems, developing x-ray/CT methods for image-guided radiation therapy.
C. Jason Wang, MD, PhD
Associate Professor of Pediatrics (General Pediatrics) at the Lucile Salter Packard Children's Hospital and of Medicine (Primary Care and Outcomes Research)
BioDr. Wang is the Director of Center for Policy, Outcomes and Prevention. Prior to coming to Stanford in 2011, he was a faculty member at Boston University Schools of Medicine and Public Health. His other professional experiences include working as a management consultant with McKinsey and Company and serving as the project manager for Taiwan's National Health Insurance Reform Task-force. His current interests include: 1) COVID-19 related policies; 2) developing tools for assessing and improving the value of healthcare; 3) facilitating the use of mobile technology in improving quality of care; 4) supporting competency-based medical education curriculum, and 5) engaging in healthcare delivery and payment reforms.
Clinical Associate Professor, Anesthesiology, Perioperative and Pain Medicine
BioEllen Wang, MD is a Clinical Associate Professor of Pediatric Anesthesiology and Medical Director of Clinical Informatics for Perioperative Services at Lucile Packard Children’s Hospital Stanford. She is board-certified in Pediatric Anesthesiology and Clinical Informatics, with particular emphasis on EHR enhancement and optimization projects that support surgical, nursing, and pediatric and obstetric anesthesia workflows. She is also Chief of Operations of the Stanford Chariot Program, combining her interest in clinical care, process improvement, data analytics and research with virtual/augmented reality technologies to advance and evolve standards in patient care.
Jack Tzu-Chieh Wang
Instructor, Neurology & Neurological Sciences
Current Research and Scholarly InterestsMy primary research focus is in understanding the molecular mechanisms of axonal degeneration and subsequent failure of axonal regeneration in the CNS. I have identified a critical cellular pathway mediating axonal degeneration following neurological injuries. Modulating this pathway presents a novel therapeutic target to protect vulnerable nerve fibers and enhance functional recovery in a multitude of CNS diseases.
Jennifer Y. Wang, MD
Clinical Assistant Professor, Dermatology
BioDr. Wang is a board-certified dermatologist. She is also a Clinical Assistant Professor of Dermatology at Stanford University School of Medicine.
Dr. Wang is fellowship-trained in dermatopathology. Her clinical interests include medical dermatology and cutaneous oncology, including melanoma, high-risk skin cancer, and cutaneous lymphoma.
Her research interests span the histopathologic characterization of rare skin disorders and improving the detection and treatment of skin cancers. She has received grants to advance applications of the principles of precision medicine in dermatopathology.
Dr. Wang has co-authored articles on uncommon dermatologic conditions, the dermatologic side effects of cancer treatments, and novel histopathologic findings in various diseases of the skin. Her work has appeared in the Journal of the American Academy of Dermatology, Journal of Cutaneous Pathology, American Journal of Dermatopathology, American Journal of Surgical Pathology, and elsewhere.
She has given presentations on topics such as the histopathologic features of a cutaneous lymphoma therapy-related rash, microscopic findings in a rare form of epidermolysis bullosa, and an unusual case of antineutrophil cytoplasmic antibody-associated vasculitis. Dr. Wang has presented at the American Society of Dermatopathology Annual Meeting, Medical Dermatology Society Annual Meeting, World Congress of Cutaneous Lymphoma, and other conferences in the US and worldwide.
Named outstanding volunteer physician by Cardinal Free Clinics, Dr. Wang’s services have included providing annual skin cancer screenings and education to Stanford NCAA student athletes, examining patients with dermatologic conditions at Stanford’s student-run free clinics, and teaching Stanford medical students about dermatology through interactive didactic sessions.
Kevin Wang, MD, PhD
Assistant Professor of Dermatology
Current Research and Scholarly InterestsThe Wang lab takes an interdisciplinary approach to studying fundamental mechanisms controlling gene expression in mammalian cells, and how epigenetic mechanisms such as DNA methylation, chromatin modifications, and RNA influence chromatin dynamics to affect gene regulation.
Clinical Associate Professor, Radiation Oncology - Radiation Physics
BioClinical research on Linac and Cyberknife based SRS and SBRT which includes: small field dosimety, machine and patient quality assurance, treatment planning, etc; new QA tool and methodology development; new treatment technology implementation to keeping high standard in patient care.
Clinical Associate Professor, Pediatrics
Current Research and Scholarly InterestsEvaluation and management of the febrile young infant and infections in hospitalized children; promotion of appropriate antibiotic use.
Professor of Emergency Medicine and, by courtesy, of Pediatrics (Hospital Medicine) at the Stanford University Medical Center
Current Research and Scholarly Interests- Disparities in Emergency Medical Services for children.
- Efficacy of novel interventions for pediatric access to care.
- Teaching and supporting community-initiated interventions and programs internationally.
Paul J. Wang, MD
Professor of Medicine (Cardiovascular Medicine) at the Stanford University Medical Center and, by courtesy, of Bioengineering
Current Research and Scholarly InterestsDr. Wang's research centers on the development of innovative approaches to the treatment of arrhythmias, including more effective catheter ablation techniques, more reliable implantable devices, and less invasive treatments. Dr. Wang's clinical research interests include atrial fibrillation, ventricular tachycardia, syncope, and hypertrophic cardiomyopathy. Dr. Wang has active collaborations with Bioengineering, Mechanical Engineering, and Electrical Engineering Departments at Stanford.
Clinical Professor, Psychiatry and Behavioral Sciences
Current Research and Scholarly InterestsBipolar Disorders, Psychopharmacology, Treatment, Anticonvulsants, Mood stabilizers
Shan X. Wang
Leland T. Edwards Professor in the School of Engineering and Professor of Electrical Engineering and, by courtesy, of Radiology (Molecular Imaging Program at Stanford)
Current Research and Scholarly InterestsShan Wang was named the Leland T. Edwards Professor in the School of Engineering in 2018. He directs the Center for Magnetic Nanotechnology and is a leading expert in biosensors, information storage and spintronics. His research and inventions span across a variety of areas including magnetic biochips, in vitro diagnostics, cancer biomarkers, magnetic nanoparticles, magnetic sensors, magnetoresistive random access memory, and magnetic integrated inductors.
Sophia Ying Wang, MD
Assistant Professor of Ophthalmology at the Stanford University Medical Center
Masters Student in Biomedical Informatics, admitted Autumn 2019
Current Research and Scholarly InterestsI use and integrate a wide variety of data sources in my research, spanning both structured and unstructured forms, including national survey datasets, health insurance claims data, patient generated online text, surgical video, and electronic health records. I investigate outcomes of treatments for glaucoma and cataract, as well as other areas of ophthalmology. My focus is developing and applying novel methods for automated extraction of ophthalmic data, especially from free text and video.
Sui Wang, PhD
Assistant Professor of Ophthalmology
Current Research and Scholarly InterestsOur research focuses on understanding the molecular mechanisms that underlie retinal development and diseases. We utilize genetic and genomic tools to uncover how different types of retinal cells, including retinal neurons, glia and the vasculature, respond to developmental cues and disease insults at the epigenomic and transcriptional levels, and how they interact and collectively contribute to the integrity of the retina.
1. Retinal cell fate specification.
We are using genetic tools and methods, such as in vivo plasmid electroporation and CRISPR, to dissect the roles of cis-regulatory elements and transcription factors in controlling retinal cell fate specification.
2. The multicellular responses elicited by diabetes in the retina.
Diabetes can induce multicellular responses in the retina, including vascular lesions, glial dysfunction and neurodegeneration, all of which contribute to retinopathy. We are using diabetic rats as models to investigate the detailed molecular mechanisms underlying the diabetes-induced multicellular responses, and the disease mechanisms of diabetic retinopathy.
3. Molecular tools that allow for cell type-specific labeling and manipulation in vivo.
Cis-regulatory elements, such as enhancers, play essential roles in directing tissue/cell type-specific and stage-specific expression. We are interested in identifying enhancers that can drive cell type-specific expression in the retina and brain, and incorporating them into plasmid or AAV based delivery systems.
Taia T. Wang, MD, PhD, MSCI
Assistant Professor of Medicine (Infectious Diseases) and of Microbiology and Immunology
Current Research and Scholarly InterestsLaboratory of Mechanisms in Human Immunity and Disease Pathogenesis
Studies in our lab are aimed at defining mechanisms in human immunity and disease. We are particularly interested the hypothesis that diversity in antibody-based signaling that arises from diversity in IgG antibodies and their receptors, is a central driver of heterogeneity in human immune functioning and susceptibility to infectious diseases. We are studying how the Fc domain repertoire of an individual impacts the quality of effector cell responses that can be recruited during immune activation and how selectivity of effector responses contributes to immunity and disease.
SARS-CoV-2, dengue viruses, influenza viruses, disease pathogenesis, influenza vaccines
Current clinical studies:
An Open Label Study of IgG Fc Glycan Composition in Human Immunity
Principal Investigator: Taia T. Wang, MD, PhD
Klaus Bensch Professor in Experimental Pathology, Emerita
Current Research and Scholarly InterestsThe main focus of our research is to understand how cells maintain genome integrity by checkpoint mechanisms during chromosome replication.
Tim Wang, M.D.
Clinical Assistant Professor, Orthopaedic Surgery
BioTim Wang, M.D. is an Orthopaedic Surgeon at Stanford Healthcare specializing in Sports Medicine. Dr. Wang sees patients and performs surgeries at the Stanford Medicine Outpatient Center in Redwood City and Stanford Healthcare in Emeryville.
Dr. Wang’s clinical expertise includes the management of sports injuries of the knee, shoulder, and elbow using the most innovative arthroscopic and minimally invasive techniques. He has particular interest in knee cartilage regeneration, cartilage transplantation, and knee ligament reconstruction. He also provides comprehensive shoulder care (including rotator cuff tears and shoulder replacement), as well as treats fractures of the upper and lower extremities.
Originally from Chicago, Dr. Wang recognized his passion for medicine early in his career and committed to the Honors Program in Medical Education at Northwestern University. He continued his training at the Northwestern University Feinberg School of Medicine. In recognition of his academic achievements, Dr. Wang was elected to the Alpha Omega Alpha honors society and also received his medical degree with Distinction in Research. He completed his orthopaedic surgery residency at Stanford University and went on to pursue subspecialty training in Sports Medicine and Shoulder Surgery at the Hospital for Special Surgery in New York, the top ranked Orthopaedic hospital in the nation. While in New York, he served as the Clinical Fellow for the Brooklyn Nets NBA team and Iona College athletics (NCAA DI MAAC). Dr. Wang has participated in the care of countless collegiate and professional athletes. He currently serves as Team Physician for Laney College and Merritt College in Oakland.
FOR MORE INFORMATION, PLEASE GO TO: www.timwangmd.com
Associate Professor of Neurosurgery
Current Research and Scholarly InterestsMechanisms underlying mitochondrial dynamics and function, and their implications in neurological disorders.
Irene Wapnir, MD
Professor of Surgery (General Surgery) at the Stanford University Medical Center
Current Research and Scholarly InterestsClinical trials in operative procedures such as Nipple-sparing mastectomy, arm lymphatic mapping, skin perfusion and Treatments for Breast Cancer, especially local recurrence. Dr. Wapnir is institutional Principal Investigator and Chair for National Surgical Adjuvant Breast and Bowel Project (NSABP) clinical trials. Laboratory and translational research includes exploring the activity of breast iodide transporter in breast cancer brain metastasis.