School of Medicine
Showing 351-400 of 507 Results
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Theodore Roth
Assistant Professor of Pathology
Current Research and Scholarly InterestsThe Roth Lab develops, applies, and translates scalable genetic manipulation technologies in primary human cells and complex in vivo tissue environments. Working with students, trainees, and staff with backgrounds across bioengineering, genetics, immunology, oncology, and pathology, the lab has developed CRISPR-All, a unified genetic perturbation language able to arbitrarily and combinatorially examine genetic perturbations across perturbation type and scale in primary human cells. Ongoing applications of CRISPR-All in the lab have revealed surprising capacities to synthetically engineer human cells beyond evolved cellular states. These new capacities to perturb human cell’s genetics beyond their evolved functionality drives ongoing work to understand the biology and therapeutic potential of synthetic cell state engineering - in essence learning how to build new human genes tailor made for a specific cell and specific environment to drive previously inaccessible therapeutic cellular functions.
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Atif Saleem
Clinical Assistant Professor (Affiliated), Pathology Clinical
Staff, Pathology Operations supported expensesBioDr. Atif Saleem completed his residency training in Anatomic and Clinical Pathology, followed by fellowships in Hematopathology and Dermatopathology at Stanford. He is board certified in both Anatomic Pathology and Clinical Pathology, Hematopathology, and Dermatopathology. His interests include virus-associated neoplasms, medical education, and global health.
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Darren Salmi
Clinical Associate Professor, Pathology
Current Research and Scholarly InterestsCardiovascular pathology, congenital heart disease, autopsy, medical education
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Matteo Santoro Pharm.D., Ph.D.
Postdoctoral Scholar, Pathology
BioDr. Santoro joined Stanford University in March 2021, focusing his research on Parkinson’s disease, neuronal vulnerability, and identification of therapeutic markers in relation to α-synucleinopathies. Currently under the Supervision of Prof. Thomas Montine, he is working on the development of LRRK2 selective inhibitors. Prior to his arrival at Stanford, he held a position as a clinical monitor at Syneos Health, where he gained key knowledge needed to translate lab-based findings into clinical and commercial applications. Previously, Dr. Santoro held a postdoctoral position at the University of Aberdeen (Scotland, UK), working on amyloid-beta extracts from Alzheimer’s disease patients. During his postdoctoral research, Dr. Santoro designed and optimized a cost-effective and rapid assay for the measurement of toxic amyloid-beta species in human biofluids. In 2017, he obtained his Ph.D. (4-year program) at the University of Aberdeen on Parkinson’s disease (PD), immunology, and behavior. The major findings Ph.D. findings were the following: 1) the characterization of a small protein called HMGB1 as an inflammatory mediator in PD; 2) the motor and non-motor behavioral characterization of three neurotoxin based mouse models of PD, 3) the characterization of the innate immune response in PD through the toll-like receptor signaling pathways 4) evaluation of the effects of chronic systemic inflammation on both resident and infiltrating immune cells in the CNS. In 2012, Dr. Santoro attained his Pharm.D. in chemistry and pharmaceutical technology (5-year program) at the University of Calabria (Italy), during which he undertook an internship at King’s College London (SGDP Centre) and worked for over a year on a rat model of stroke.
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Ansuman Satpathy, MD, PhD
Associate Professor of Pathology
Current Research and Scholarly InterestsOur lab works at the interface of immunology, cancer biology, and genomics to study cellular and molecular mechanisms of the immune response to cancer. In particular, we are leveraging high-throughput genomic technologies to understand the dynamics of the tumor-specific T cell response to cancer antigens and immunotherapies (checkpoint blockade, CAR-T cells, and others). We are also interested in understanding the impact of immuno-editing on the heterogeneity and clonal evolution of cancer.
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Birgitt Schuele
Associate Professor (Research) of Pathology and, by courtesy, of Neurology and Neurological Sciences
Current Research and Scholarly InterestsThe Schuele lab focuses on neurogenetics, human stem cell modeling, and gene therapy approaches to uncover disease mechanisms and pathways involved in neurodegeneration in Parkinson's, Alzheimer's disease and related disorders.
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Robert W. Shafer
Professor (Research) of Medicine (Infectious Diseases) and, by courtesy, of Pathology
Current Research and Scholarly InterestsMy group’s research is on the mechanisms and consequences of virus evolution with a focus on HIV therapy and drug resistance. We maintain a public HIV drug resistance database (http://hivdb.stanford.edu) as a resource for HIV drug resistance surveillance, interpreting HIV drug resistance tests, and HIV drug development. Our paramount goal is to inform HIV treatment and prevention policies by identifying the main factors responsible for the emergence and spread of drug resistance.
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Hua Shan
Professor of Pathology
BioDr. Shan specializes in providing blood transfusion and apheresis treatment to patients with diverse medical problems. She has been practicing transfusion medicine for over twenty five years. Dr. Shan currently serves as the Medical Director of Transfusion Service at Stanford Medical Center. Dr. Shan has also been leading research and education programs in the fields of transfusion safety, optimizing clinical blood transfusion practice and blood availability.
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Tanya Sharma
Postdoctoral Scholar, Pathology
BioTanya's interests span across studying G-Protein Coupled Receptors and the biochemistry of membrane proteins. During her doctoral studies, she worked as a visiting researcher at the National Research Council of Canada, Ottawa (Sussex laboratories) from 2019-2023 uncovering the role of an ancient mating receptor Ste3 in microbial pathogenesis and chemotropism. During her current position at Butcher lab, she is using High Performance Computing (HPC) platforms to guide her search for interesting ligand-receptor interactions. This involves using a combination of computation tools, cell based and analytical chemistry techniques for discovery and validation phase respectively.
Outside of science, she is an avid musician and a singer. -
Jeanne Shen
Associate Professor of Pathology
Current Research and Scholarly InterestsGastrointestinal and pancreatobiliary pathology, with major emphasis on GI and pancreatic neoplasia, inflammatory bowel disease, biodesign innovation, and the application of machine learning to digital pathology.
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Kang Shen
Vincent V.C. Woo Director, Wu Tsai Neurosciences Institute, Frank Lee and Carol Hall Professor and Professor of Biology and of Pathology
Current Research and Scholarly InterestsThe connectivity of a neuron (its unique constellation of synaptic inputs and outputs) is essential for its function. Neuronal connections are made with exquisite accuracy between specific types of neurons. How each neuron finds its synaptic partners has been a central question in developmental neurobiology. We utilize the relatively simple nervous system of nematode C. elegans, to search for molecules that can specify synaptic connections and understand the molecular mechanisms of synaptic as
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Run Zhang Shi
Clinical Associate Professor, Pathology
Current Research and Scholarly InterestsClinical chemistry and therapeutic drug monitoring;
adult and pediatric clinical endocrine testing;
screening, detection and follow up of multiple myeloma;
tumor markers;
clinical utility of tandem mass spectrometry and high resolution mass spectrometry. -
Hiroyuki Shimada
Professor of Pathology and, by courtesy, of Pediatrics
BioHiroyuki Shimada, MD, PhD, FRCPA (Hon), is Professor of Pathology and of Pediatrics at the Stanford University Medical Center. He was born in Tokyo, Japan, and completed MD (1973) and PhD (1982) at the Yokohama City University School of Medicine, Yokohama, Japan, and also completed his pathology training at the Children's Hospital (now the Nationwide Children’s Hospital) and the Ohio State University, Columbus, Ohio, USA (1988). Before moving to the Stanford University in 2019, he was Professor of Pathology (Clinical Scholar) at the University of Southern California Keck School of Medicine and working at the Children’s Hospital Los Angeles.
Dr. Shimada was Chair of the International Neuroblastoma Pathology Committee (1999-2017) and the founder of the International Neuroblastoma Pathology Classification (INPC). As Director of the COG (Children’s Oncology Group) Neuroblastoma Pathology Reference Laboratory (since 2001), he has been actively reviewing pathology samples of ~700 neuroblastoma cases per year from United States, Canada, Australia, and New Zealand. Pathology review results according to the INPC have been providing critical information for patient stratification and protocol assignment in the COG international neuroblastoma clinical trials. -
Richard Sibley
Professor of Pathology, Emeritus
Current Research and Scholarly InterestsImmunologic mechanism of rejection in humans and animal, models of organ transplantation; histological definition of clinical pathology studies of various renal disorders.
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Arend Sidow
Professor of Pathology and of Genetics
Current Research and Scholarly InterestsWe have a highly collaborative research program in the evolutionary genomics of cancer. We apply well-established principles of phylogenetics to cancer evolution on the basis of whole genome sequencing and functional genomics data of multiple tumor samples from the same patient. Introductions to our work and the concepts we apply are best found in the Newburger et al paper in Genome Research and the Sidow and Spies review in TIGS.
More information can be found here: http://www.sidowlab.org -
Oscar Silva
Clinical Assistant Professor, Pathology
BioOscar is an academic hematopathologist who completed anatomic and clinical pathology residency and hematopathology fellowship at Stanford in 2020. Prior to Stanford, he received his MD and PhD from UCLA. His interests include immunology, the pathogenesis and diagnosis of lymphomas, and global health.
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Raymond A. Sobel, M.D.
Professor of Pathology
Current Research and Scholarly InterestsWe study cellular and molecular mechanisms of immune-mediated injury in CNS tissues that are affected in multiple sclerosis (MS). We study: 1) tissues of mice with EAE using histology and immunohistochemistry, 2) cross-recognition of neurons by antibodies against myelin proteolipid protein epitopes, and a distinct oligodendrogliopathy induced in mice by the non-protein amino acid azetidine (Aze), (which is found in the human diet); Aze-induced abnormalities mimic those in MS patient CNS tissues
