Stanford University
Showing 821-840 of 898 Results
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Jennifer Tremmel
Susan P. and Riley P. Bechtel Medical Director and Associate Professor of Medicine (Cardiovascular Medicine)
Current Research and Scholarly InterestsDr. Tremmel studies sex differences in cardiovascular disease. Current research projects include evaluating sex differences in coronary pathophysiology, young patients presenting with myocardial infarction, the impact of stress on anginal symptoms, chronic total coronary occlusions, and vascular access site complications.
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Jennifer Tsai
Adjunct Clinical Instructor, Pediatrics - Hematology & Oncology
BioJennifer is a researcher in clinical development of novel therapeutics for hematologic diseases. She has a special interest in bone marrow failure and rare pediatric disorders.
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Philip S. Tsao, PhD
Professor (Research) of Medicine (Cardiovascular Medicine)
Current Research and Scholarly InterestsOur primary interests are in the molecular underpinnings of vascular disease as well as assessing disease risk. In addition to targeted investigation of specific signaling molecules, we utilize global genomic analysis to identify gene expression networks and regulatory units. We are particularly interested in the role of microRNAs in gene expression pathways associated with disease.
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Jason Tucciarone, MD, PhD
Assistant Professor of Psychiatry and Behavioral Sciences (General Psychiatry and Psychology)
BioJason Tucciarone MD, PhD is an Assistant Professor with Stanford School of Medicine’s Department of Psychiatry and Behavioral Sciences. As a neuroscientist, he leads a lab interested in biological mechanisms of mental illness and investigating new therapies for mood disorders and addiction. In particular, he is defining new cell types and evolutionary conserved circuits in emotional processing centers of the brain, with the hope of finding new entry points for novel therapeutics. Working with Dr Robert Malenka, he is using optogenetic, chemogenetic, neuroimaging and behavioral approaches in mouse models of addiction to uncover vulnerable brain circuitry in opioid use disorder. Alongside Dr Alan Schatzberg, he is investigating the efficacy of buprenorphine augmentation to IV ketamine infusion at reducing suicidality in treatment resistant depression.
Clinically, he works collaboratively in the department’s Neuropsychiatry clinic and his clinical focus includes treating patients with diverse and complex presentations at the interface of psychiatry and neurology with particular interest in functional neurological disorders. He sees a small cohort of psychotherapy patients in Individual Psychotherapy Clinic. He also works weekend shifts on Stanford’s inpatient psychiatry units.
Prior to training in psychiatry at Stanford’s research residency track Jason received his bachelor’s degree in biology and philosophy from Union College. He spent three years as a Post-Baccalaureate IRTA fellow at the National Institute of Neurological Disorders and Stroke investigating and developing MRI reportable contrast agents to map neuronal connectivity. Following this he entered the Medical Scientist Training Program (MD/PhD) at the State University of NY Stony Brook University. There he completed a doctoral dissertation in neuroscience under the mentorship Dr. Josh Huang at Cold Spring Harbor Laboratory. His thesis work employed mouse genetic dissections of excitatory and inhibitory cortical circuits with a focus on the circuitry of chandelier inhibitory interneurons in prefrontal cortex.
In addition to his research and clinical work, Jason is passionate about teaching, mentorship, and resident clinical supervision. He joined a working group early in his clinical residency to restructure trainee’s neuroscience education. He teaches introductory lectures in the neuroscience of addiction, PTSD, psychosis, and mood disorders. He also leads resident group supervision in their introductory psychodynamic psychotherapy clinical experience. He supervises medical students, residents, and clinical fellows in Neuropsychiatry clinic. Finally, committed to the Stanford clinical community, he leads a support group for Internal Medicine interns and residents. -
Mirko Uljarevic
Clinical Associate Professor, Psychiatry and Behavioral Sciences
BioI am a medically trained researcher focused academic with a background in developmental psychopathology, psychometrics and big data science. My research takes a life-span perspective and is driven by the urgent need to improve outcomes for people with autism and other neuropsychiatric (NPD) disorders and neurodevelopmental conditions (NDD). My primary research interest has focused on combining cutting-edge psychometric procedures and a big data approach to better understand structure of clinical phenotypes across autism and other NPD and NDD and on using this knowledge to improve existing and develop new clinical assessments that are more effective for screening and diagnosis, tracking the natural and treatment-related symptom progression and for use in genetic and neurobiological studies. In addition to my focus on the development of outcome measures, I have collaborated with leading psychopathology researchers and groups in the United States, Europe and Australia on numerous projects spanning a range of topics including genetics, treatment and employment, with a particular focus on understanding risk and resilience factors underpinning poor mental health outcomes in adolescents and adults. Most recently, through several competitively funded projects, I have led the statistical analyses to uncover the latent structure of social and communication and restricted and repetitive behaviors (RRB) clinical phenotypes across NPD and NDD. These findings have enabled us to (i) start capturing and characterizing a highly variable social functioning phenotype across a range of disorders and understanding mechanisms underpinning this variability, (ii) combine phenotypic and genetic units of analyses to advance our understanding of the genetic architecture of RRB, and (iii) focus on identification and characterization of subgroups of individuals that share distinct symptom profiles and demonstrate clinical utility and neurobiological validity. Importantly, this work has provided key information for developing a programmatic line of research aimed at developing novel, comprehensive assessment protocols that combine parent and clinician reports, objective functioning indicators and incorporate state-of-the-art psychometric, mobile and connected technologies and procedures.
I am a co-director of the recently established Program for Psychometrics and Measurement-Based Care (https://med.stanford.edu/sppmc.html) that aims to bring together world-leading expertise in clinical science, psychometrics, and big data analytics to bridge the gap between the science of measurement development and clinical practice and bring improvements to both clinical care and research. -
Alexander Eckehart Urban
Associate Professor of Psychiatry and Behavioral Sciences (Major Laboratories and Clinical Translational Neurosciences Incubator) and of Genetics
Current Research and Scholarly InterestsComplex behavioral and neuropsychiatric phenotypes often have a strong genetic component. This genetic component is often extremely complex and difficult to dissect. The current revolution in genome technology means that we can avail ourselves to tools that make it possible for the first time to begin understanding the complex genetic and epigenetic interactions at the basis of the human mind.
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PJ Utz
Professor of Medicine (Immunology and Rheumatology)
Current Research and Scholarly InterestsThe long-term research goal of the Utz laboratory is to understand autoimmunity, autoantibodies, and how tolerance is broken and can be reestablished.
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Tulio Valdez, MD, MSc
Professor of Otolaryngology - Head & Neck Surgery (OHNS) and, by courtesy, of Pediatrics
BioDr. Tulio A Valdez is a surgeon scientist born and raised in Colombia with a subspecialty interest in Pediatric Otolaryngology. He attended medical school at Universidad Javeriana in Bogota Colombia before undertaking his residency in Otolaryngology, Head and Neck Surgery in Boston. He completed his Pediatric Otolaryngology Fellowship at Texas Children’s Hospital (2007), Houston and obtained his Master’s in Clinical and Translational Research at the University of Connecticut.
Clinically, Dr. Valdez has an interest in pediatric sleep apnea. He has a special interest in the management of sinus disease in cystic fibrosis. Dr. Valdez has co-authored one textbook and numerous book chapters and scientific manuscripts. Dr. Valdez continues his clinical research in these areas, particularly with a focus on aerodigestive disorders.
Scientifically, Dr. Valdez has developed various imaging methods to diagnose otitis media and cholesteatoma a middle ear condition that can lead to hearing loss. He was part of the Laser Biomedical Research Center at the Massachusetts Institute of Technology. His research includes novel imaging modalities to better diagnose ear infections one of the most common pediatric problems. His research has now expanded to include better intraoperative imaging modalities in pediatric patients to improve surgical outcomes without the need for radiation exposure.
Dr. Valdez believes in multi-disciplinary collaborations to tackle medical problems and has co-invented various medical devices and surgical simulation models. -
Matt van de Rijn
Sabine Kohler, MD, Professor of Pathology
Current Research and Scholarly InterestsOur research focuses on molecular analysis of human soft tissue tumors (sarcomas) with an emphasis on leiomyosarcoma and desmoid tumors. In addition we study the role of macrophages in range of malignant tumors.
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Keith Van Haren, MD
Assistant Professor of Neurology (Pediatric Neurology) and of Pediatrics
Current Research and Scholarly InterestsOur research team is working to develop new treatments for children at risk of neurodegenerative diseases. We are primarily focused on multiple sclerosis and X-linked adrenoleukodystrophy, two conditions that involve inflammatory and metabolic disruption of the myelin that insulates brain cells. A key area of interest for us is how nutrient deficiencies during childhood may contribute to the disease processes and whether nutritional interventions could play a role in prevention.
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Capucine Van Rechem
Assistant Professor of Pathology (Pathology Research)
Current Research and Scholarly InterestsMy long-term interest lies in understanding the impact chromatin modifiers have on disease development and progression so that more optimal therapeutic opportunities can be achieved. My laboratory explores the direct molecular impact of chromatin-modifying enzymes during cell cycle progression, and characterizes the unappreciated and unconventional roles that these chromatin factors have on cytoplasmic function such as protein synthesis.
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Shreyas Vasanawala, MD/PhD
William R. Brody Professor of Pediatric Radiology and Child Health
Current Research and Scholarly InterestsOur group is focused on developing new fast and quantitative MRI techniques.
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Anne Villeneuve
Berthold and Belle N. Guggenhime Professor and Professor of Developmental Biology and of Genetics
Current Research and Scholarly InterestsMechanisms underlying homologous chromosome pairing, DNA recombination and chromosome remodeling during meiosis, using the nematode Caenorhabditis elegans as an experimental system. High-resolution 3-D imaging of dynamic reorganization of chromosome architecture. Role of protease inhibitors in regulating sperm activation.
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David Vu
Clinical Associate Professor, Pediatrics - Infectious Diseases
BioDr. Vu is a pediatric infectious diseases specialist who is researching human responses to dengue virus and malaria infections. He performed his undergraduate studies at the University of California, San Diego, and obtained his medical doctorate at the University of Pennsylvania School of Medicine. He trained in general pediatrics at UCSF Benioff Children's Hospital Oakland, and in pediatric infectious diseases at Emory University School of Medicine. His present studies on pediatric dengue and malaria co-infection are supported by an NIAID Career Development Award (K23 AI127909) and a Instructor K Award Support Program Award from the Maternal & Child Health Research Institute and Department of Pediatrics.
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Soichi Wakatsuki
Professor of Photon Science and of Structural Biology
Current Research and Scholarly InterestsUbiquitin signaling: structure, function, and therapeutics
Ubiquitin is a small protein modifier that is ubiquitously produced in the cells and takes part in the regulation of a wide range of cellular activities such as gene transcription and protein turnover. The key to the diversity of the ubiquitin roles in cells is that it is capable of interacting with other cellular proteins either as a single molecule or as different types of chains. Ubiquitin chains are produced through polymerization of ubiquitin molecules via any of their seven internal lysine residues or the N-terminal methionine residue. Covalent interaction of ubiquitin with other proteins is known as ubiquitination which is carried out through an enzymatic cascade composed of the ubiquitin-activating (E1), ubiquitin-conjugating (E2), and ubiquitin ligase (E3) enzymes. The ubiquitin signals are decoded by the ubiquitin-binding domains (UBDs). These domains often specifically recognize and non-covalently bind to the different ubiquitin species, resulting in distinct signaling outcomes.
We apply a combination of the structural (including protein crystallography, small angle x-ray scattering, cryo-electron microscopy (Cryo-EM) etc.), biocomputational and biochemical techniques to study the ubiquitylation and deubiquitination processes, and recognition of the ubiquitin chains by the proteins harboring ubiquitin-binding domains. Current research interests including SARS-COV2 proteases and their interactions with polyubiquitin chains and ubiquitin pathways in host cell responses, with an ultimate goal of providing strategies for effective therapeutics with reduced levels of side effects.
Protein self-assembly processes and applications.
The Surface layers (S-layers) are crystalline protein coats surrounding microbial cells. S-layer proteins (SLPs) regulate their extracellular, self-assembly by crystallizing when exposed to an environmental trigger. We have demonstrated that the Caulobacter crescentus SLP readily crystallizes into sheets both in vivo and in vitro via a calcium-triggered multistep assembly pathway. Observing crystallization using a time course of Cryo-EM imaging has revealed a crystalline intermediate wherein N-terminal nucleation domains exhibit motional dynamics with respect to rigid lattice-forming crystallization domains. Rate enhancement of protein crystallization by a discrete nucleation domain may enable engineering of kinetically controllable self-assembling 2D macromolecular nanomaterials. In particular, this is inspiring designing robust novel platform for nano-scale protein scaffolds for structure-based drug design and nano-bioreactor design for the carbon-cycling enzyme pathway enzymes. Current research focuses on development of nano-scaffolds for high throughput in vitro assays and structure determination of small and flexible proteins and their interaction partners using Cryo-EM, and applying them to cancer and anti-viral therapeutics.
Multiscale imaging and technology developments.
Multimodal, multiscale imaging modalities will be developed and integrated to understand how molecular level events of key enzymes and protein network are connected to cellular and multi-cellular functions through intra-cellular organization and interactions of the key machineries in the cell. Larger scale organization of these proteins will be studied by solution X-ray scattering and Cryo-EM. Their spatio-temporal arrangements in the cell organelles, membranes, and cytosol will be further studied by X-ray fluorescence imaging and correlated with cryoEM and super-resolution optical microscopy. We apply these multiscale integrative imaging approaches to biomedical, and environmental and bioenergy research questions with Stanford, DOE national labs, and other domestic and international collaborators. -
Rebecca D. Walker
Clinical Associate Professor, Emergency Medicine
Current Research and Scholarly InterestsInterests include international development in emergency care, healthcare disparities, wilderness medicine, human rights, administration
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Dennis Wall
Professor of Pediatrics (Clinical Informatics), of Biomedical Data Science and, by courtesy, of Psychiatry and Behavioral Sciences
Current Research and Scholarly InterestsSystems biology for design of clinical solutions that detect and treat disease
