Stanford University
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Katie Fiocca
COLLEGE Lecturer, Civic, Liberal, and Global Education
BioKatie received a PhD in Biology at Drexel University in Philadelphia, PA, researching social insect nutritional physiology and chemical ecology. Additionally she earned a graduate minor in Undergraduate STEM Education through the Drexel Center for the Advancement of STEM Teaching and Learning Excellence.
She began her work at Stanford as an NSF Postdoctoral Research Fellow in the Biology Department, working to better understand the relationship between poison frog prey selection and their toxic ant diet. During her position, she also worked to broaden the participation of diverse identities in science, focusing on partnering with the local Bay Area community, including both students and high school teachers.
Currently, she is a COLLEGE Lecturer in Civic, Liberal, and Global Education with Stanford Introductory Studies. -
David Fiorentino, MD, PhD
Professor of Dermatology
Current Research and Scholarly InterestsFrom a clinical standpoint, I am particularly focused in the care of patients with myositis or systemic sclerosis. We offer clinical trials, including novel, cutting-edge cellular-based (e.g. chimeric antigen receptor, or, CAR T) therapies for these diseases. We are particularly interested in understanding the role of auto antigens in providing windows into disease pathogenesis, as well as their potential direct role of autoantibodies in causing disease.
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Kyla Lynne Fiorey
Life Science Research Professional 1, Urology - Divisions
Current Role at StanfordLife Science Research Professional
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Morris P. Fiorina
Wendt Family Professor and Senior Fellow at the Hoover Institution
BioMorris P. Fiorina is the Wendt Family Professor of Political Science and a Senior Fellow of the Hoover Institution. He received an undergraduate degree from Allegheny College and a Ph.D. from the University of Rochester, and taught at Caltech and Harvard before joining Stanford in 1998. Fiorina has written widely on American politics, with special emphasis on the study of representation, public opinion and elections. He has published numerous articles and written or edited thirteen books, including: Representatives, Roll Calls, and Constituencies; Congress--Keystone of the Washington Establishment; Retrospective Voting in American National Elections; The Personal Vote (coauthored with Bruce Cain and John Ferejohn); Divided Government; Civic Engagement in American Democracy (co-edited with Theda Skocpol), Culture War? The Myth of a Polarized America (with Samuel Abrams and Jeremy Pope), Disconnect: The Breakdown of Representation in American Politics (with Samuel Abrams), Can We Talk: The Rise of Rude, Nasty, Stubborn Politics (co-edited with Dan Shea) and most recently, Unstable Majorities. Fiorina has served on the editorial boards of a dozen journals in Political Science, Political Economy, Law, and Public Policy, and from 1986-1990 served as Chairman of the Board of Overseers of the American National Election Studies. He is an elected member of the American Academy of Arts and Sciences, the American Academy of Political and Social Sciences and the National Academy of Sciences. He has received Career Achievement Awards from the American Political Science Association’s Organized Sections on Elections, Public Opinion, and Voting Behavior, and Political Organizations and Parties.
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Andrew Fire
George D. Smith Professor of Molecular and Genetic Medicine and Professor of Pathology and of Genetics
Current Research and Scholarly InterestsWhile chromosomal inheritance provides cells with one means for keeping and transmitting genetic information, numerous other mechanisms have (and remain to be) discovered. We study novel cellular mechanisms that enforce genetic constancy and permit genetic change. Underlying our studies are questions of the diversity of inheritance mechanisms, how cells distinguish such mechanisms as "wanted" versus "unwanted", and of the consequences and applications of such mechanisms in health and disease.
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Daniel James Firl
Clinical Instructor, Surgery - Abdominal Transplantation
BioDaniel Firl is an abdominal transplant surgery fellow at Stanford Medicine and a surgeon-scientist working at the intersection of hepatobiliary cancer surgery and transplantation. His work centers on patient selection in primary liver cancer — determining which patients are best served by resection and which by transplantation — and on the risk-assessment tools that make that decision more precise.
He is a co-developer of HALT-HCC, a risk model for liver transplantation in hepatocellular carcinoma, and first author of its international validation across more than 4,000 patients. His aim is to make selection between resection and transplantation progressively more sophisticated — sharpening prediction of waitlist and post-transplant outcomes, informing donor selection, and enabling the safe use of grafts that might otherwise be declined — with a particular interest in intrahepatic cholangiocarcinoma and gallbladder cancer, where the role of transplantation is still being defined. He sees the next step as the integration of tumor genomics, bringing the molecular features of each cancer into the models that guide surgical decisions.
Earlier, during postdoctoral training at the Massachusetts General Hospital, he studied the immunology and physiology of kidney xenotransplantation, including the design and long-term function of organs from genetically engineered porcine donors — part of the broader effort to expand the supply of transplantable organs.
Dr. Firl completed general surgery residency at Duke University, where he served as chief resident, and earned his MD with Special Qualifications in Biomedical Research through the research-intensive program at the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University. He holds a bachelor's degree in biochemistry from Boston College.
He is the author of over 30 peer-reviewed articles, with work in Nature, Cell, The Lancet Gastroenterology & Hepatology, Hepatology, and The Lancet Digital Health. He serves as an ad hoc reviewer for journals including The BMJ, Kidney International, the American Journal of Transplantation, JCO Precision Oncology, and Transplantation.
He has received fellowships and grant funding from prestigious organizations during competitive funding opportunities including from: the NIH-NIAID, Howard Hughes Medical Institute, and the American Society of Transplantation. -
Michael Fischbach
Liu (Liao) Family Professor
Current Research and Scholarly InterestsThe microbiome carries out extraordinary feats of biology: it produces hundreds of molecules, many of which impact host physiology; modulates immune function potently and specifically; self-organizes biogeographically; and exhibits profound stability in the face of perturbations. Our lab studies the mechanisms of microbiome-host interactions. Our approach is based on two technologies we recently developed: a complex (119-member) defined gut community that serves as an analytically manageable but biologically relevant system for experimentation, and new genetic systems for common species from the microbiome. Using these systems, we investigate mechanisms at the community level and the strain level.
1) Community-level mechanisms. A typical gut microbiome consists of 200-250 bacterial species that span >6 orders of magnitude in relative abundance. As a system, these bacteria carry out extraordinary feats of metabolite consumption and production, elicit a variety of specific immune cell populations, self-organize geographically and metabolically, and exhibit profound resilience against a wide range of perturbations. Yet remarkably little is known about how the community functions as a system. We are exploring this by asking two broad questions: How do groups of organisms work together to influence immune function? What are the mechanisms that govern metabolism and ecology at the 100+ strain scale? Our goal is to learn rules that will enable us to design communities that solve specific therapeutic problems.
2) Strain-level mechanisms. Even though gut and skin colonists live in communities, individual strains can have an extraordinary impact on host biology. We focus on two broad (and partially overlapping) categories:
Immune modulation: Can we redirect colonist-specific T cells against an antigen of interest by expressing it on the surface of a bacterium? How do skin colonists induce high levels of Staphylococcus-specific antibodies in mice and humans?
Abundant microbiome-derived molecules: By constructing single-strain/single-gene knockouts in a complex defined community, we will ask: What are the effects of bacterially produced molecules on host metabolism and immunology? Can the molecular output of low-abundance organisms impact host physiology?
3) Cell and gene therapy. We have begun two new efforts in mammalian cell and gene therapies. First, we are developing methods that enable cell-type specific delivery of genome editing payloads in vivo. We are especially interested in delivery vehicles that are customizable and easy to manufacture. Second, we have begun a comprehensive genome mining effort with an emphasis on understudied or entirely novel enzyme systems with utility in mammalian genome editing.
