Stanford University
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Lynette Cegelski
Monroe E. Spaght Professor of Chemistry and Professor, by courtesy, of Chemical Engineering
Current Research and Scholarly InterestsResearch in the Cegelski laboratory is driven by the need to uncover and define the chemistry that underlies outstanding challenges in human health, the environment, and sustainability. Beyond discovery, we use chemistry as a tool to innovate and create solutions to these pressing problems. The laboratory is highly interdisciplinary, designing experimental approaches to understand how complex biological systems are built, organized, and controlled, and then perturb and influence assembly processes. The lab develops new methods and uniquely leverages: (1) small molecules in new biochemical assay development, chemical genetics approaches, and therapeutic discovery in infectious diseases, (2) fluorescence and electron microscopy coupled to analytical HPLC, mass spectrometry, and complementary biochemical techniques, and (3) spectroscopy, particularly solid-state NMR, to uncover new “dark matter” and define chemistry in insoluble, heterogeneous and complex assemblies relevant to human health, plants, and the ocean.
Long-standing efforts in the laboratory focus on defining mechanisms underlying bacterial biofilm formation and identifying new antibiotic and anti-virulence strategies, including advancing therapeutic candidates for the most difficult-to-treat infections. Through these efforts, we uncovered a new chemical structure in nature: phosphoethanolamine (pEtN) cellulose. Cellulose is the most abundant biopolymer on earth and this discovery provided the first experimental validation of a naturally produced chemically modified cellulose. We are developing alternatively modified celluloses and polysaccharides and advancing new solutions for ecofriendly, sustainably sourced, and recyclable materials. Collectively, our projects span disciplines from molecular structure and assembly chemistry to living microbial communities and natural marine systems, while aiming to translate fundamental discoveries into therapeutic and materials solutions. -
Rahul Chajwa
Basic Life Research Scientist
Current Research and Scholarly InterestsMy HFSP project is focussed on understanding the birth, life and death of marine snow. A predictive understanding of the hydrodynamic, biotic, and non-equilibrium aspects of this sinking microbial ecosystem is a notoriously challenging and globally relevant problem and is the central theme of my research at Stanford University. I’m applying my training as a physicist to shed light on the dynamical aspects of microbial life in the ocean, and to contribute insights that can help mitigate the negative impact of human activities on global climate; something I feel strongly about.
