Stanford University
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Justin Du Bois
Henry Dreyfus Professor of Chemistry and Professor, by courtesy, of Chemical and Systems Biology
BioResearch and Scholarship
Research in the Du Bois laboratory spans reaction methods development, natural product synthesis, and chemical biology, and draws on expertise in molecular design, molecular recognition, and physical organic chemistry. An outstanding goal of our program has been to develop C–H bond functionalization processes as general methods for organic chemistry, and to demonstrate how such tools can impact the logic of chemical synthesis. A second area of interest focuses on the role of ion channels in electrical conduction and the specific involvement of channel subtypes in the sensation of pain. This work is enabled in part through the advent of small molecule modulators of channel function.
The Du Bois group has described new tactics for the selective conversion of saturated C–H to C–N and C–O bonds. These methods have general utility in synthesis, making possible the single-step incorporation of nitrogen and oxygen functional groups and thus simplifying the process of assembling complex molecules. To date, lab members have employed these versatile oxidation technologies to prepare natural products that include manzacidin A and C, agelastatin, tetrodotoxin, and saxitoxin. Detailed mechanistic studies of metal-catalyzed C–H functionalization reactions are performed in parallel with process development and chemical synthesis. These efforts ultimately give way to advances in catalyst design. A long-standing goal of this program is to identify robust catalyst systems that afford absolute control of reaction selectivity.
In a second program area, the Du Bois group is exploring voltage-gated ion channel structure and function using the tools of chemistry in combination with those of molecular biology, electrophysiology, microscopy and mass spectrometry. Much of this work has focused on studies of eukaryotic Na and Cl ion channels. The Du Bois lab is interested in understanding the biochemical mechanisms that underlie channel subtype regulation and how such processes may be altered following nerve injury. Small molecule toxins serve as lead compounds for the design of isoform-selective channel modulators, affinity reagents, and fluorescence imaging probes. Access to toxins and modified forms thereof (including saxitoxin, gonyautoxin, batrachotoxin, and veratridine) through de novo synthesis drives studies to elucidate toxin-receptor interactions and to develop new pharmacologic tools to study ion channel function in primary cells and murine pain models. -
Monica M. Dua, MD
Clinical Professor, Surgery - General Surgery
Current Research and Scholarly InterestsTechnical aspects of minimally invasive pancreatic and liver surgery
Minimally invasive strategies for the management of pancreatic necrosis
Management of severe acute pancreatitis – academic vs community treatment
Multidisciplinary treatment of HCC; institutional barriers to appropriate referral/ care
Endocrine/exocrine insufficiency after pancreatectomy; volumetric assessment
Natural history and management of pancreatic cysts -
Dawn Duane
Clinical Professor, Pediatric Neurology
Clinical Professor (By courtesy), PediatricsCurrent Research and Scholarly InterestsI am a general pediatric neurologist. My interest is in clinical diagnosis and treatment of common neurologic diseases in pediatric patients and teaching feature doctors, neurologists and pediatric neurologists about pediatric neurology.
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Catherine Duarte
Assistant Professor of Epidemiology and Population Health
BioDr. Catherine Duarte is an Assistant Professor in the Department of Epidemiology & Population Health at Stanford University’s School of Medicine. She received her PhD in Epidemiology from the University of California, Berkeley School of Public Health and her Master of Science in Social and Behavioral Sciences from the Harvard T.H. Chan School of Public Health. Duarte’s work evaluates upstream drivers of overall risk for, and heterogeneity in, lifecourse health. Specifically, she examines how education and legal system policy and practice exposures in early life may shape population health and health inequity, with an emphasis on cognitive aging and dementia outcomes in midlife and older age. In doing so, her work aims to contribute to systems-level interventions designed to support population health and wellbeing for collective thriving.
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Anne Dubin
Endowed Professor of Pediatric Cardiology
Current Research and Scholarly InterestsArrhythmia management in pediatric heart failure, especially resynchronization therapy in congenital heart disease,Radio frequency catheter ablation of pediatric arrhythmias,
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Anthony DuBose
Clinical Associate Professor, Medicine - Primary Care and Population Health
Current Research and Scholarly InterestsSoft tissue musculoskeletal injuries with focus on repetitive strain injuries
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Alfredo Dubra, PhD
Professor of Ophthalmology
Current Research and Scholarly InterestsOur lab seeks to help the early diagnosing and monitoring progression of ocular, vascular, neurodegenerative and systemic diseases through novel non-invasive optical ophthalmic imaging. We pursue this goal through a multidisciplinary approach that integrates optics, computer science, vision science, electrical engineering and other engineering disciplines.
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Piotr Dubrowski
Clinical Instructor, Radiation Oncology - Radiation Physics
BioPiotr Dubrowski is a Canadian trained and board-certified Therapy Medical Physicist. Throughout his career Piotr has had the opportunity to bring several new Cancer Clinics operational from the ground up, where he was able to hone a broad, systems-approach to Radiation Oncology. He was recently promoted to Associate Quality Director of Physics responsible for improving patient safety and workflow/technology improvements across a wide cancer care network. Piotr’s research interests focus mainly on improving the treatment planning process and increasing clinic safety through software development and hardware 3D-print prototyping. Additionally, Piotr has sought out opportunities to give back to the Global community with participation in the Stanford Global Radiation Oncology Outreach efforts expanding education and access to care in Tanzania and Kenya and throughout the developing world via online Radiation Therapy courses.
