Stanford University
Showing 1,161-1,180 of 2,469 Results
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Calvin Kuo
Maureen Lyles D'Ambrogio Professor
Current Research and Scholarly InterestsWe study cancer biology, intestinal stem cells (ISC), and angiogenesis. We use primary organoid cultures of diverse tissues and tumor biopsies for immunotherapy modeling, oncogene functional screening and stem cell biology. Angiogenesis projects include blood-brain barrier regulation, stroke therapeutics and anti-angiogenic cancer therapy. ISC projects apply organoid culture and ko mice to injury-inducible vs homeostatic stem cells and symmetric division mechanisms.
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Christin S Kuo
Assistant Professor of Pediatrics (Pulmonary Medicine)
BioDr. Kuo is a physician-scientist with expertise in single-cell genomics and pulmonary medicine. She has made pioneering contributions to pulmonary neuroendocrine cell (PNEC) biology by developing innovative strategies that established the first comprehensive framework for understanding the molecular and cellular diversity of normal PNECs and their roles in health and disease. Her discoveries have laid the foundation for this emerging field and her contributions are recognized internationally.
PNECs are exceedingly rare lung epithelial cells with specialized airway sensory, secretory, and stem cell functions. These neurosensory cells are thought to monitor airway oxygen, chemicals, mechanical deformation, infection, and injury, and serve as sentinels that signal this sensory information locally in the lung, to the brain through synapses with pulmonary sensory neurons and potentially globally throughout the body via secretion of myriad local signals and hormones. PNECs are also known to play critical roles in the control of breathing, cough, and respiratory physiology. Among their diverse physiologic functions, their response to injury has been most intensively studied in murine models and they are a cell of origin for high grade lung neuroendocrine tumors.
Dr. Kuo performed the first comprehensive anatomical mapping and lineage tracing studies of PNECs in mice which generated a foundational understanding of PNEC development (Kuo and Krasnow, Cell 2015). She also led single cell transcriptomic profiling studies that revealed a surprising diversity in PNEC sensors and signals (Kuo et al, eLife 2022). PNECs express over 25 different sensory receptor genes ("sensors") and over 40 different neuropeptide and peptide hormone genes ("signals"). Her scRNA-seq analysis of PNECs revealed a remarkable number and diversity of PNEC neuropeptide signals and their predicted cellular targets both within the lung and to innervating sensory neurons (Kuo et al., 2022, eLife).
In contrast to the advanced understanding of PNEC development, stem cell, and signaling function in mouse, little is known about human PNECs. To compare the findings of PNEC development, diversity, and function in mouse models to human diseases, her lab recently established a platform to systematically construct a human PNEC atlas. This foundational work created a molecular and anatomic framework for the entire human pulmonary neuroendocrine system and the diseases that are predicted to originate from distinct PNECs. Her lab has recently used this new PNEC atlas combined with single cell transcriptomic approaches to identify the molecular diversity of anatomically and functionally distinct human PNECs.
Dr. Kuo's studies with human models extends her lab’s current research aims to define the diverse neuroendocrine sensory and signaling interactions and the molecules that mediate them to their roles in lung cancer, neuroendocrine proliferative disorders such as diffuse idiopathic neuroendocrine cell hyperplasia (DIPNECH), neuroendocrine cell hyperplasia of infancy (NEHI) and major inflammatory and obstructive pulmonary diseases. Dr. Kuo’s lab engages a network of collaborators to develop and implement clinical protocols and strategically apply cutting-edge technologies to studying minor, but physiologically diverse airway sentinels.
Please visit the research website for additional information and current research areas (https://kuo.stanford.edu). -
WILLIAM T. KUO, MD, FSIR, FCCP, FSVM, FACR, FCIRSE
Professor of Radiology (Interventional Radiology)
Current Research and Scholarly Interests1) LASER-ASSISTED AND COMPLEX IVC FILTER RETRIEVAL
2) CATHETER-DIRECTED THERAPY FOR ACUTE PULMONARY EMBOLISM
3) INTERNATIONAL PE REGISTRY
4) IVC FILTER REGISTRY
5) ENDOVASCULAR TREATMENT OF CAVAL AND DEEP VENOUS THROMBOSIS -
Allison W. Kurian, M.D., M.Sc.
Colleen Haas Chair in the School of Medicine, Professor of Medicine (Oncology) and of Epidemiology and Population Health
Current Research and Scholarly InterestsI aim to understand cancer burden and improve treatment quality at the population level. I have a strong focus on genetic risk assessment and precision oncology. I lead epidemiologic studies of cancer risk factors, clinical trials of novel approaches to genetic testing and cancer risk reduction, and decision analyses of strategies to optimize cancer outcomes.
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Clete A. Kushida, MD, PhD
Professor of Psychiatry and Behavioral Sciences (Sleep Medicine)
Current Research and Scholarly InterestsDr. Kushida is a neurologist and sleep specialist who directs several NIH- and industry-sponsored research studies, focused on topics such as the physical features and neurocognitive changes associated with the obstructive sleep apnea syndrome, the epidemiology and treatment of restless legs syndrome/periodic limb movement disorder, primary care sleep education and training, and countermeasures for sleep loss.
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Andrea Lynn Kussman
Member, Wu Tsai Human Performance Alliance
Current Research and Scholarly InterestsDr. Kussman conducts research on injury prevention and athlete wellness. Specific areas of interest include the female athlete, endurance athletes, bone health, mental health in athletes, exercise as medicine, and medical education. Previous research has included work on the female and male athlete triad, eating disorders in athletes, mental health in athletes, mononucleosis infection in athletes, cardiac complications of COVID-19, and concussion.
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Ian Matthew Kysel
Visiting Scholar, Center for Advanced Study in the Behavioral Sciences
Visiting Scholar, Law AdmissionsBioKysel is currently a Visiting Scholar at Stanford Law School and at the Center for Advanced Study in the Behavioral Sciences. He also holds an appointment as a Clinical Professor of Law at Cornell Law School, where he co-directs its Migration and Human Rights Program and is the founding director of its Transnational Disputes Clinic. In addition, Kysel is a non-resident Fellow at the Zolberg Institute on Migration and Mobility at The New School. Kysel’s research and clinical work primarily focuses on international migration and refugee law and international dispute resolution.
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Angelle Desiree LaBeaud
Professor of Pediatrics (Infectious Diseases), Senior Fellow at the Woods Institute for the Environment and Professor, by courtesy, of Epidemiology and Population Health and of Environmental Social Sciences
Current Research and Scholarly InterestsArthropod-borne viruses are emerging and re-emerging infections that are spreading throughout the world. Our laboratory investigates the epidemiology of arboviral infections, focusing on the burden of disease and the long-term complications on human health. In particular, Dr. LaBeaud investigates dengue, chikungunya, and Rift Valley fever viruses in Kenya, where outbreaks cause fever, arthritis, retinitis, encephalitis, and hemorrhagic fever. Our main research questions focus on the risk factors for arboviral infections, the development of diagnostic tests that can be administered in the field to quickly determine what kind of arboviral infection a person has, and the genetic and immunologic investigation of why different people respond differently to the same infection. Our long-term goals are to contribute to a deeper understanding of arboviral infections and their long-term health consequences and to optimize control strategies to prevent these emerging infections. Our laboratory also investigates the effects of antenatal and postnatal parasitic infections on vaccine responses, growth, and development of Kenyan children.
My lab at Stanford supports the field work that is ongoing in Kenya, but we also have several projects that are based locally. We strive to improve diagnostics of arboviral infections and are using Luminex technology to build a new screening assay. We also have created a Luminex based platform to assess vaccine responses against multiple pathogens. -
Amy Ladd, MD
Elsbach-Richards Professor of Surgery, Emerita
Current Research and Scholarly InterestsResearch Interests
1. The kinematics and forces associated with thumb carpometcarpal (CMC) function and pathology
2. The anatomy, microstructure, and immunofluorescent characteristics of the thumb CMC joint
3. Pathomechaniics of CMC arthritis: biomechanical wear, injury, genetic, and environmental causes
4. Biomechanics of the golf swing
5. Archiving, vitalizing, and innovating medical and surgical knowledge, most recently with innovative iBook monographs -
Subhaneil Lahiri
Physical Sci Res Scientist, Ginzton, E.L. Laboratory
Current Research and Scholarly InterestsOur brains store long term memories by adjusting the strengths of the synapses connecting neurons. The tendency for new memories to overwrite old ones leads to a trade-off between learning and remembering: if synapses are too plastic older memories will be wiped out easily, if they are too rigid it becomes difficult to learn new memories. I am studying theoretical models of synapses to understand how their internal structure can be used to balance these effects and maximize their memory storage.
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Tze Leung Lai
Member, Wu Tsai Neurosciences Institute
Current Research and Scholarly InterestsResearch interests include clinical trial design, cancer biostatistics, survival analysis, adaptation and sequential experimentation, change-point detection and segmentation, stochastic optimization, time series and inference on stochastic processes, hidden Markov models and genomic applications.
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Rayhan A. Lal, MD
Assistant Professor of Medicine (Endocrinology) and of Pediatrics (Endocrinology)
BioI grew up in the east bay area and have had type 1 diabetes for 30+ years. I studied electrical engineering and computer science at U.C. Berkeley (Go Bears!) with the hope of applying my knowledge to diabetes technology. The significance of clinical practice became clear to me after my siblings also developed diabetes. I am devoting my life to advancing the care of diabetes in people of all ages.
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Sanjay Lall
Professor of Electrical Engineering
BioSanjay Lall is Professor of Electrical Engineering in the Information Systems Laboratory and Professor of Aeronautics and Astronautics at Stanford University. He received a B.A. degree in Mathematics with first-class honors in 1990 and a Ph.D. degree in Engineering in 1995, both from the University of Cambridge, England. His research group focuses on algorithms for control, optimization, and machine learning. Before joining Stanford he was a Research Fellow at the California Institute of Technology in the Department of Control and Dynamical Systems, and prior to that he was a NATO Research Fellow at Massachusetts Institute of Technology, in the Laboratory for Information and Decision Systems. He was also a visiting scholar at Lund Institute of Technology in the Department of Automatic Control. He has significant industrial experience applying advanced algorithms to problems including satellite systems, advanced audio systems, Formula 1 racing, the America's cup, cloud services monitoring, and integrated circuit diagnostic systems, in addition to several startup companies. Professor Lall has served as Associate Editor for the journal Automatica, on the steering and program committees of several international conferences, and as a reviewer for the National Science Foundation, DARPA, and the Air Force Office of Scientific Research. He is the author of over 130 peer-refereed publications.
