Bio-X
Showing 561-580 of 1,157 Results
-
Roger Kornberg
Mrs. George A. Winzer Professor of Medicine
Current Research and Scholarly InterestsWe study the regulation of transcription, the first step in gene expression. The main lines of our work are 1) reconstitution of the process with more than 50 pure proteins and mechanistic analysis, 2) structure determination of the 50 protein complex at atomic resolution, and 3) studies of chromatin remodelling, required for transcription of the DNA template in living cells
-
Jeffrey R. Koseff
William Alden Campbell and Martha Campbell Professor in the School of Engineering and Professor of Oceans, Emeritus
BioJeff Koseff, founding co-director of the Stanford Woods Institute for the Environment, is an expert in the interdisciplinary domain of environmental fluid mechanics. His research falls in the interdisciplinary domain of environmental fluid mechanics and focuses on the interaction between physical and biological systems in natural aquatic environments. Current research activities are in the general area of environmental fluid mechanics and focus on: turbulence and internal wave dynamics in stratified flows, coral reef and sea-grass hydrodynamics, the role of natural systems in coastal protection, and flow through terrestrial and marine canopies. Most recently he has begun to focus on the interaction between gravity currents and breaking internal waves in the near-coastal environment, and the transport of marine microplastics. Koseff was formerly the Chair of Civil and Environmental Engineering, and the Senior Associate Dean of Engineering at Stanford, and has served on the Board of Governors of The Israel Institute of Technology, and has been a member of the Visiting Committees of the Civil and Environmental Engineering department at Carnegie-Mellon University, The Iowa Institute of Hydraulic Research, and Cornell University. He has also been a member of review committees for the College of Engineering at the University of Michigan, The WHOI-MIT Joint Program, and the University of Minnesota Institute on the Environment. He is a former member of the Independent Science Board of the Bay/Delta Authority. He was elected a Fellow of the American Physical Society in 2015, and received the Richard Lyman Award from Stanford University in the same year. In 2020 he was elected as a Fellow of the California Academy of Sciences. Koseff also served as the Faculty Athletics Representative to the Pac-12 and NCAA for Stanford until July 2024.
-
Nishita Kothary, MD
Professor of Radiology (Interventional Radiology)
Current Research and Scholarly InterestsInterventional Oncology: Percutaneous and transarterial interventions for diagnosis and treatment of primary and metastatic tumors (lung, liver and renal)
Research Interest:
Gastrointestinal and Hepatic Oncology -
Sanmi Koyejo
Associate Professor of Computer Science
BioSanmi Koyejo is an Assistant Professor in the Department of Computer Science at Stanford University and an adjunct Associate Professor at the University of Illinois at Urbana-Champaign. He leads the Stanford Trustworthy AI Research (STAIR) lab, which develops measurement-theoretic foundations for trustworthy AI systems, spanning AI evaluation science, algorithmic accountability, and privacy-preserving machine learning, with applications to healthcare and scientific discovery. His research on AI capabilities evaluation has challenged conventional understanding in the field, including work on measurement frameworks cited in the 2024 Economic Report of the President.
Koyejo has received the Presidential Early Career Award for Scientists and Engineers (PECASE), Skip Ellis Early Career Award, Alfred P. Sloan Research Fellowship, NSF CAREER Award, and multiple outstanding paper awards at flagship venues, including NeurIPS and ACL. He has delivered keynote presentations at major conferences, including ECCV and FAccT. He serves in key leadership roles, including Board President of Black in AI, Board of Directors of the Neural Information Processing Systems Foundation, and other leadership positions in professional organizations advancing AI research and broadening participation in the field. -
Fredric Kraemer
Gerald M. Reaven, MD, Professor of Endocrinology, Emeritus
Current Research and Scholarly InterestsOur research interests are in the general area of cellular lipid and lipoprotein metabolism. The work is aimed primarily at understanding the mechanisms regulating cholesterol and triglyceride accumulation in cells. We utilize a variety of techniques from cell biology, biochemistry, and molecular biology.
-
Sheri Krams
Senior Associate Dean, Graduate Education and Postdoctoral Affairs and Professor of Surgery (Abdominal Transplantation)
Current Research and Scholarly InterestsResearch Interests: 1) NK Cell Responses to EBV, 2) Exosomes in Immune Responses, 3) Plasmacytoid Dendritic Cell-Mediated Graft Prolongation, 4)Transplant Immunology
-
Elliot J. Krane
Professor of Anesthesiology, Perioperative and Pain Medicine (Pediatric Anesthesia) at the Stanford University Medical Center, Emeritus
Current Research and Scholarly InterestsThe management of pain in children using intraspinal opioids, regional anesthetics, and novel analgesic agents; cerebral and osmolar complications of diabetic ketoacidosis in children.
-
Mark Krasnow
Paul and Mildred Berg Professor
Current Research and Scholarly Interests- Lung development and stem cells
- Neural circuits of breathing and speaking
- Lung diseases including lung cancer
- New genetic model organism for biology, behavior, health and conservation -
Alan M. Krensky, M.D.
Shelagh Galligan Professor in the School of Medicine, Emeritus
Current Research and Scholarly InterestsMechanisms and therapies for infection, cancer, autoimmunity and transplantation.
-
Siddharth Krishnan
Assistant Professor of Electrical Engineering, and by courtesy, of Bioengineering and of Materials Science and Engineering
Current Research and Scholarly InterestsThe Krishnan Lab develops bioelectronic devices, tools and systems for closed loop disease management. Our work is divided into the following broad areas:
1. Biohybrid electronics for therapy and sensing: we combine living cells as functional parts of implantable devices, leveraging their ability to produce complex biologic therapeutics in a constitutive or triggerable manner, and their ability to sense their complex dynamic environment. These efforts are focused on developed functional cures for diseases like Type I Diabetes and other conditions requiring the regular infusion of proteins, peptides or antibody drugs.
2. Digital drug release systems for particulate forms of biologic drugs: Many complex protein and peptide drugs are not stable in solution, thereby frustrating the ability to delivery them through pumps and autoinjectors. This need is particularly acute for drugs that need to be administered as emergency rescue therapies, such as glucagon in the context of type 1 Diabetes. We develop implantable, miniaturized microelectromechanical devices that can store particulate (powders, pills) forms of these drugs and release them in a close loop manner based on wireless inputs from sensors.
3. Wearable sensors: Wearables to detect biophysical (temperature, flow, cardiac activity) and biochemical markers of health are gaining importance for closed-loop disease management and personalized medicine. We design hardware for on-chip molecular profiling based on sampling biofluids in noninvasive or minimally invasive formats.
4. New wireless power architectures for implantable bioelectronics: We develop high-power, high-efficiency strongly coupled power harvesting system to power battery-free implant systems. -
Thomas M. Krummel, MD, FACS/FAAP
Emile Holman Professor, Emeritus
Current Research and Scholarly InterestsSurgical Innovation, Simulation and Virtual Reality in Surgical Education, Fetal Healing-Cellular and Biochemical Mechanisms
-
Ellen Kuhl
Catherine Holman Johnson Director of Stanford Bio-X, Walter B Reinhold Professor in the School of Engineering, Professor of Mechanical Engineering and, by courtesy, of Bioengineering
Current Research and Scholarly Interestscomputaitonal simulation of brain development, cortical folding, computational simulation of cardiac disease, heart failure, left ventricular remodeling, electrophysiology, excitation-contraction coupling, computer-guided surgical planning, patient-specific simulation
-
Anshul Kundaje
Associate Professor of Genetics and of Computer Science
Current Research and Scholarly InterestsWe develop statistical and machine learning frameworks to model gene regulation and decipher the genetic and molecular basis of disease
-
Calvin Kuo
Maureen Lyles D'Ambrogio Professor
Current Research and Scholarly InterestsWe study cancer biology, intestinal stem cells (ISC), and angiogenesis. We use primary organoid cultures of diverse tissues and tumor biopsies for immunotherapy modeling, oncogene functional screening and stem cell biology. Angiogenesis projects include blood-brain barrier regulation, stroke therapeutics and anti-angiogenic cancer therapy. ISC projects apply organoid culture and ko mice to injury-inducible vs homeostatic stem cells and symmetric division mechanisms.
-
Christin S Kuo
Assistant Professor of Pediatrics (Pulmonary Medicine)
BioDr. Kuo is a physician-scientist with expertise in single-cell genomics and pulmonary medicine. She has made pioneering contributions to pulmonary neuroendocrine cell (PNEC) biology by developing innovative strategies that established the first comprehensive framework for understanding the molecular and cellular diversity of normal PNECs and their roles in health and disease. Her discoveries have laid the foundation for this emerging field and her contributions are recognized internationally.
PNECs are exceedingly rare lung epithelial cells with specialized airway sensory, secretory, and stem cell functions. These neurosensory cells are thought to monitor airway oxygen, chemicals, mechanical deformation, infection, and injury, and serve as sentinels that signal this sensory information locally in the lung, to the brain through synapses with pulmonary sensory neurons and potentially globally throughout the body via secretion of myriad local signals and hormones. PNECs are also known to play critical roles in the control of breathing, cough, and respiratory physiology. Among their diverse physiologic functions, their response to injury has been most intensively studied in murine models and they are a cell of origin for high grade lung neuroendocrine tumors.
Dr. Kuo performed the first comprehensive anatomical mapping and lineage tracing studies of PNECs in mice which generated a foundational understanding of PNEC development (Kuo and Krasnow, Cell 2015). She also led single cell transcriptomic profiling studies that revealed a surprising diversity in PNEC sensors and signals (Kuo et al, eLife 2022). PNECs express over 25 different sensory receptor genes ("sensors") and over 40 different neuropeptide and peptide hormone genes ("signals"). Her scRNA-seq analysis of PNECs revealed a remarkable number and diversity of PNEC neuropeptide signals and their predicted cellular targets both within the lung and to innervating sensory neurons (Kuo et al., 2022, eLife).
In contrast to the advanced understanding of PNEC development, stem cell, and signaling function in mouse, little is known about human PNECs. To compare the findings of PNEC development, diversity, and function in mouse models to human diseases, her lab recently established a platform to systematically construct a human PNEC atlas. This foundational work created a molecular and anatomic framework for the entire human pulmonary neuroendocrine system and the diseases that are predicted to originate from distinct PNECs. Her lab has recently used this new PNEC atlas combined with single cell transcriptomic approaches to identify the molecular diversity of anatomically and functionally distinct human PNECs.
Dr. Kuo's studies with human models extends her lab’s current research aims to define the diverse neuroendocrine sensory and signaling interactions and the molecules that mediate them to their roles in lung cancer, neuroendocrine proliferative disorders such as diffuse idiopathic neuroendocrine cell hyperplasia (DIPNECH), neuroendocrine cell hyperplasia of infancy (NEHI) and major inflammatory and obstructive pulmonary diseases. Dr. Kuo’s lab engages a network of collaborators to develop and implement clinical protocols and strategically apply cutting-edge technologies to studying minor, but physiologically diverse airway sentinels.
Please visit the research website for additional information and current research areas (https://kuo.stanford.edu). -
WILLIAM T. KUO, MD, FSIR, FCCP, FSVM, FACR, FCIRSE
Professor of Radiology (Interventional Radiology)
Current Research and Scholarly Interests1) LASER-ASSISTED AND COMPLEX IVC FILTER RETRIEVAL
2) CATHETER-DIRECTED THERAPY FOR ACUTE PULMONARY EMBOLISM
3) INTERNATIONAL PE REGISTRY
4) IVC FILTER REGISTRY
5) ENDOVASCULAR TREATMENT OF CAVAL AND DEEP VENOUS THROMBOSIS -
Allison W. Kurian, M.D., M.Sc.
Colleen Haas Chair in the School of Medicine, Professor of Medicine (Oncology) and of Epidemiology and Population Health
Current Research and Scholarly InterestsI aim to understand cancer burden and improve treatment quality at the population level. I have a strong focus on genetic risk assessment and precision oncology. I lead epidemiologic studies of cancer risk factors, clinical trials of novel approaches to genetic testing and cancer risk reduction, and decision analyses of strategies to optimize cancer outcomes.
-
Clete A. Kushida, MD, PhD
Professor of Psychiatry and Behavioral Sciences (Sleep Medicine)
Current Research and Scholarly InterestsDr. Kushida is a neurologist and sleep specialist who directs several NIH- and industry-sponsored research studies, focused on topics such as the physical features and neurocognitive changes associated with the obstructive sleep apnea syndrome, the epidemiology and treatment of restless legs syndrome/periodic limb movement disorder, primary care sleep education and training, and countermeasures for sleep loss.
-
Angelle Desiree LaBeaud
Professor of Pediatrics (Infectious Diseases), Senior Fellow at the Woods Institute for the Environment and Professor, by courtesy, of Epidemiology and Population Health and of Environmental Social Sciences
Current Research and Scholarly InterestsArthropod-borne viruses are emerging and re-emerging infections that are spreading throughout the world. Our laboratory investigates the epidemiology of arboviral infections, focusing on the burden of disease and the long-term complications on human health. In particular, Dr. LaBeaud investigates dengue, chikungunya, and Rift Valley fever viruses in Kenya, where outbreaks cause fever, arthritis, retinitis, encephalitis, and hemorrhagic fever. Our main research questions focus on the risk factors for arboviral infections, the development of diagnostic tests that can be administered in the field to quickly determine what kind of arboviral infection a person has, and the genetic and immunologic investigation of why different people respond differently to the same infection. Our long-term goals are to contribute to a deeper understanding of arboviral infections and their long-term health consequences and to optimize control strategies to prevent these emerging infections. Our laboratory also investigates the effects of antenatal and postnatal parasitic infections on vaccine responses, growth, and development of Kenyan children.
My lab at Stanford supports the field work that is ongoing in Kenya, but we also have several projects that are based locally. We strive to improve diagnostics of arboviral infections and are using Luminex technology to build a new screening assay. We also have created a Luminex based platform to assess vaccine responses against multiple pathogens. -
Amy Ladd, MD
Elsbach-Richards Professor of Surgery, Emerita
Current Research and Scholarly InterestsResearch Interests
1. The kinematics and forces associated with thumb carpometcarpal (CMC) function and pathology
2. The anatomy, microstructure, and immunofluorescent characteristics of the thumb CMC joint
3. Pathomechaniics of CMC arthritis: biomechanical wear, injury, genetic, and environmental causes
4. Biomechanics of the golf swing
5. Archiving, vitalizing, and innovating medical and surgical knowledge, most recently with innovative iBook monographs