Sarafan ChEM-H
Showing 21-30 of 196 Results
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Bria Castellano
Scientific Program Manager, Sarafan ChEM-H
Current Role at StanfordSarafan ChEM-H* Scientific Program Manager
*Chemistry, Engineering and Medicine for Human Health Research Institute -
Lynette Cegelski
Monroe E. Spaght Professor of Chemistry and Professor, by courtesy, of Chemical Engineering
Current Research and Scholarly InterestsResearch in the Cegelski laboratory is driven by the need to uncover and define the chemistry that underlies outstanding challenges in human health, the environment, and sustainability. Beyond discovery, we use chemistry as a tool to innovate and create solutions to these pressing problems. The laboratory is highly interdisciplinary, designing experimental approaches to understand how complex biological systems are built, organized, and controlled, and then perturb and influence assembly processes. The lab develops new methods and uniquely leverages: (1) small molecules in new biochemical assay development, chemical genetics approaches, and therapeutic discovery in infectious diseases, (2) fluorescence and electron microscopy coupled to analytical HPLC, mass spectrometry, and complementary biochemical techniques, and (3) spectroscopy, particularly solid-state NMR, to uncover new “dark matter” and define chemistry in insoluble, heterogeneous and complex assemblies relevant to human health, plants, and the ocean.
Long-standing efforts in the laboratory focus on defining mechanisms underlying bacterial biofilm formation and identifying new antibiotic and anti-virulence strategies, including advancing therapeutic candidates for the most difficult-to-treat infections. Through these efforts, we uncovered a new chemical structure in nature: phosphoethanolamine (pEtN) cellulose. Cellulose is the most abundant biopolymer on earth and this discovery provided the first experimental validation of a naturally produced chemically modified cellulose. We are developing alternatively modified celluloses and polysaccharides and advancing new solutions for ecofriendly, sustainably sourced, and recyclable materials. Collectively, our projects span disciplines from molecular structure and assembly chemistry to living microbial communities and natural marine systems, while aiming to translate fundamental discoveries into therapeutic and materials solutions. -
Ovijit Chaudhuri
Professor of Mechanical Engineering and, by courtesy, of Bioengineering
Current Research and Scholarly InterestsWe study the physics of cell migration, division, and morphogenesis in 3D, as well cell-matrix mechanotransduction, or the process by which cells sense and respond to mechanical properties of the extracellular matrices. For both these areas, we use engineered biomaterials for 3D culture as artificial extracellular matrices.
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James K. Chen
Jauch Professor and Professor of Chemical and Systems Biology, of Developmental Biology and of Chemistry
Current Research and Scholarly InterestsOur laboratory combines chemistry and developmental biology to investigate the molecular events that regulate embryonic patterning, tissue regeneration, and tumorigenesis. We are currently using genetic and small-molecule approaches to study the molecular mechanisms of Hedgehog signaling, and we are developing chemical technologies to perturb and observe the genetic programs that underlie vertebrate development.
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Danny Hung-Chieh Chou
Associate Professor of Pediatrics (Endocrinology) and, by courtesy, of Chemical and Systems Biology
Current Research and Scholarly InterestsOur research program integrates concepts of chemical biology, protein engineering and structure biology to design new therapeutic leads and generate probes to study biological processes. A key focus of our lab is insulin, an essential hormone in our body to reduce blood glucose levels. We generate synthetic libraries of insulin analogs to select for chemical probes, and investigate natural insulin molecules (e.g. from the venom of fish-hunting cone snails!) to develop novel therapeutic candidates. We are especially interested in using chemical and enzymatic synthesis to create novel chemical entities with enhanced properties, and leverage the strong expertise of our collaborators to apply our skill sets in the fields of cancer biology, immunology and pain research. Our ultimate goal is to translate our discovery into therapeutic interventions in human diseases.
