Bio-X


Showing 1-79 of 79 Results

  • Michele Calos

    Michele Calos

    Professor of Genetics, Emerita

    Current Research and Scholarly InterestsMy lab is developing innovative gene and stem cell therapies for genetic diseases, with a focus on gene therapy and regenerative medicine.

    We have created novel methods for inserting therapeutic genes into the chromosomes at specific places by using homologous recombination and recombinase enzymes.

    We are working on 3 forms of muscular dystrophy.

    We created induced pluripotent stem cells from patient fibroblasts, added therapeutic genes, differentiated, and engrafted the cells.

  • David Camarillo

    David Camarillo

    Associate Professor of Bioengineering and, by courtesy, of Neurosurgery and of Mechanical Engineering

    BioDavid B. Camarillo is Associate Professor of Bioengineering, (by courtesy) Mechanical Engineering and Neurosurgery at Stanford University. Dr. Camarillo holds a B.S.E in Mechanical and Aerospace Engineering from Princeton University, a Ph.D. in Mechanical Engineering from Stanford University and completed postdoctoral fellowships in Biophysics at the UCSF and Biodesign Innovation at Stanford. Dr. Camarillo worked in the surgical robotics industry at Intuitive Surgical and Hansen Medical, before launching his laboratory at Stanford in 2012. His current research focuses on precision human measurement for multiple clinical and physiological areas including the brain, heart, lungs, and reproductive system. Dr. Camarillo has been awarded the Hellman Fellowship, the Office of Naval Research Young Investigator Program award, among other honors including multiple best paper awards in brain injury and robotic surgery. His research has been funded by the NIH, NSF, DoD, as well as corporations and private philanthropy. His lab’s research has been featured on NPR, the New York Times, The Washington Post, Science News, ESPN, and TED.com as well as other media outlets aimed at education of the public.

  • Emmanuel Candes

    Emmanuel Candes

    Barnum-Simons Chair of Math and Statistics, and Professor of Statistics and, by courtesy, of Electrical Engineering

    BioEmmanuel Candès is the Barnum-Simons Chair in Mathematics and Statistics, a professor of electrical engineering (by courtesy) and a member of the Institute of Computational and Mathematical Engineering at Stanford University. Earlier, Candès was the Ronald and Maxine Linde Professor of Applied and Computational Mathematics at the California Institute of Technology. His research interests are in computational harmonic analysis, statistics, information theory, signal processing and mathematical optimization with applications to the imaging sciences, scientific computing and inverse problems. He received his Ph.D. in statistics from Stanford University in 1998.

    Candès has received several awards including the Alan T. Waterman Award from NSF, which is the highest honor bestowed by the National Science Foundation, and which recognizes the achievements of early-career scientists. He has given over 60 plenary lectures at major international conferences, not only in mathematics and statistics but in many other areas as well including biomedical imaging and solid-state physics. He was elected to the National Academy of Sciences and to the American Academy of Arts and Sciences in 2014.

  • Robson Capasso, MD

    Robson Capasso, MD

    Professor of Otolaryngology - Head & Neck Surgery (OHNS) and, by courtesy, of Psychiatry and Behavioral Sciences (Sleep Medicine)

    Current Research and Scholarly InterestsClinically relevant outcomes for OSA Surgery.
    Wearables and Digital Health Technologies for Sleep.
    Innovative approaches for OSA Management.
    Innovation in Sleep and Otolaryngology

  • Andres Cardenas

    Andres Cardenas

    Assistant Professor of Epidemiology and Population Health and, by courtesy, of Pediatrics

    BioI am an environmental epidemiologist and serve as an Assistant Professor in the Department of Epidemiology and Population Health at Stanford University. I joined the faculty at Stanford School of Medicine in 2022.

    My research focuses on characterizing molecular and epigenetic biomarkers and the extent to which these alterations contribute to disease risk throughout the life course. My group utilizes computational approaches to investigate environmental chemical mixtures, biological aging markers and fetal epigenetic programming. We have several studies looking at chemical and non-chemical stressors in early-life and subsequent health including; neurodevelopment, obesity and immune function.

    My research examines the intersection of chemical and social environments in shaping health and disease.

  • Jan Carette

    Jan Carette

    Professor of Microbiology and Immunology

    Current Research and Scholarly InterestsOur research focuses on the identification of host genes that play critical roles in the pathogenesis of infectious agents including viruses. We use haploid genetic screens in human cells as an efficient approach to perform loss-of-function studies. Besides obtaining fundamental insights on how viruses hijack cellular processes and on host defense mechanisms, it may also facilitate the development of new therapeutic strategies.

  • Matteo Cargnello

    Matteo Cargnello

    Associate Professor of Chemical Engineering

    BioMatteo Cargnello received his Ph.D. in Nanotechnology in 2012 at the University of Trieste, Italy, under the supervision of Prof. Paolo Fornasiero, and he was then a post-doctoral scholar in the Chemistry Department at the University of Pennsylvania with Prof. Christopher B. Murray before joining the Faculty at Stanford University in January 2015. He is currently Associate Professor of Chemical Engineering and, by courtesy, of Materials Science and Engineering and Silas Palmer Faculty Scholar. Dr. Cargnello is the recipient of several awards including the Sloan Fellowship in 2018, the Mitsui Chemicals Catalysis Science Award for Creative Work in 2020, and the Early Career Award in Catalysis from the ACS Catalysis Division in 2022. The general goals of the research in the Cargnello group pertain to solving energy and environmental challenges. The group focuses on capture and conversion of carbon dioxide, emission control and reduction of methane and hydrocarbon emissions in the atmosphere, sustainable chemical practices through electro- and photocatalysis, sustainable production of hydrogen, and chemical recycling of plastics.

  • Suzan L Carmichael, PhD, MS

    Suzan L Carmichael, PhD, MS

    Professor (Research) of Pediatrics (Neonatology), of Obstetrics & Gynecology (Maternal Fetal Medicine) and, by courtesy, of Epidemiology and Population Health

    Current Research and Scholarly InterestsDr. Carmichael is a perinatal and nutritional epidemiologist and Professor of Pediatrics and Obstetrics and Gynecology at the Stanford University School of Medicine.

    Her team is committed to finding ways to improve maternal and infant health outcomes and equity by leading research that identifies effective leverage points for change, from upstream 'macro' social and structural factors, to downstream clinical factors (eg, related to care and morbidities) through a collaborative research approach that integrates epidemiologic approaches with community engagement and systems thinking.

    Exposure themes include social context, nutrition, care, environmental contaminants and genetics. Outcome themes include severe maternal morbidity, stillbirth, birth defects, and preterm delivery. She is particularly interested in understanding the intersectionality of these varied types of exposures and outcomes and how they interact to impact health and health disparities, for the mother-baby dyad.

    Please see the team web-site for further information!
    https://med.stanford.edu/carmichaellab.html

  • Victor G. Carrión

    Victor G. Carrión

    John A. Turner Endowed Professor for Child and Adolescent Psychiatry

    Current Research and Scholarly InterestsExamines the interplay between brain development and stress vulnerability via a multi-method approach that includes psychophysiology, neuroimaging, neuroendocrinology and phenomenology. Treatment development that focuses on individual and community-based interventions for stress related conditions in children and adolescents that experience traumatic stress.

  • Dennis R Carter

    Dennis R Carter

    Professor of Mechanical Engineering, Emeritus

    Current Research and Scholarly InterestsProfessor Carter studies the influence of mechanical loading upon the growth, development, regeneration, and aging of skeletal tissues. Basic information from such studies is used to understand skeletal diseases and treatments. He has served as President of the Orthopaedic Research Society and is a Fellow of the American Institute for Medical and Biological Engineering.

  • Karen Casciotti

    Karen Casciotti

    Associate Dean for Facilities and Shared Labs, Professor of Oceans, of Earth System Science and Senior Fellow at the Woods Institute for the Environment

    Current Research and Scholarly InterestsProfessor in Oceans and ESS, focus on marine chemistry and biogeochemistry.

  • Lynette Cegelski

    Lynette Cegelski

    Professor of Chemistry and, by courtesy, of Chemical Engineering

    Current Research and Scholarly InterestsOur research program is inspired by the challenge and importance of elucidating chemical structure and function in complex biological systems and the need for new strategies to treat infectious diseases. The genomics and proteomics revolutions have been enormously successful in generating crucial "parts lists" for biological systems. Yet, for many fascinating systems, formidable challenges exist in building complete descriptions of how the parts function and assemble into macromolecular complexes and whole-cell factories. We have introduced uniquely enabling problem-solving approaches integrating solid-state NMR spectroscopy with microscopy and biochemical and biophysical tools to determine atomic- and molecular-level detail in complex macromolecular assemblies and whole cells and biofilms. We are uncovering new chemistry and new chemical structures produced in nature. We identify small molecules that influence bacterial assembly processes and use these in chemical genetics approaches to learn about bacterial cell wall, amyloid and biofilm assembly.

    Translationally, we have launched a collaborative antibacterial drug design program integrating synthesis, chemical biology, and mechanistic biochemistry and biophysics directed at the discovery and development of new antibacterial therapeutics targeting difficult-to-treat bacteria.

  • Chris Chafe

    Chris Chafe

    Duca Family Professor

    BioChris Chafe is a composer, improvisor, and cellist, developing much of his music alongside computer-based research. He is Director of Stanford University's Center for Computer Research in Music and Acoustics (CCRMA). In 2019, he was International Visiting Research Scholar at the Peter Wall Institute for Advanced Studies The University of British Columbia, Visiting Professor at the Politecnico di Torino, and Edgard-Varèse Guest Professor at the Technical University of Berlin. At IRCAM (Paris) and The Banff Centre (Alberta), he has pursued methods for digital synthesis, music performance and real-time internet collaboration. CCRMA's jacktrip project involves live concertizing with musicians the world over. Online collaboration software and research into latency factors continue to evolve. An active performer either on the net or physically present, his music reaches audiences in sometimes novel venues. An early network project was a simultaneous five-country concert was hosted at the United Nations in 2009. Chafe’s works include gallery and museum music installations which are now into their second decade with “musifications” resulting from collaborations with artists, scientists and MD’s. Recent work includes the Earth Symphony, the Brain Stethoscope project (Gnosisong), PolarTide for the 2013 Venice Biennale, Tomato Quintet for the transLife:media Festival at the National Art Museum of China and Sun Shot played by the horns of large ships in the port of St. Johns, Newfoundland.

  • Page Chamberlain

    Page Chamberlain

    Professor of Earth and Planetary Sciences and of Earth System Science

    Current Research and Scholarly InterestsResearch
    I use stable and radiogenic isotopes to understand Earth system history. These studies examine the link between climate, tectonics, biological, and surface processes. Projects include: 1) examining the terrestrial climate history of the Earth focusing on periods of time in the past that had CO 2-levels similar to the present and to future projections; and 2) addressing how the chemical weathering of the Earth's crust affects both the long- and short-term carbon cycle. Field areas for these studies are in the Cascades, Rocky Mountains, Sierra Nevada, the European Alps, Tibet and the Himalaya and the Southern Alps of New Zealand.

    International Collaborations
    Much of the research that I do has an international component. Specifically, I have collaborations with: 1) the Senckenberg Biodiversity and Climate Research Center in Frankfurt Germany as a Humboldt Fellow and 2) the Chinese University of Geosciences in Bejiing China where I collaborate with Professor Yuan Gao.

    Teaching
    I teach courses at the undergraduate and graduate level in isotope biogeochemistry, Earth system history, and the relationship between climate, surface processes and tectonics.

    Professional Activities
    Editor American Journal of Science; Co-Director Stanford Stable Isotope Biogeochemistry Laboratory (present);Chair, Department of Geological and Environmental Sciences (2004-07); Co-Director Stanford/USGS SHRIMP Ion microprobe facility (2001-04)

  • Fu-Kuo Chang

    Fu-Kuo Chang

    Professor of Aeronautics and Astronautics

    BioProfessor Chang's primary research interest is in the areas of multi-functional materials and intelligent structures with particular emphases on structural health monitoring, intelligent self-sensing diagnostics, and multifunctional energy storage composites for transportation vehicles as well as safety-critical assets and medical devices. His specialties include embedded sensors and stretchable sensor networks with built-in self-diagnostics, integrated diagnostics and prognostics, damage tolerance and failure analysis for composite materials, and advanced multi-physics computational methods for multi-functional structures. Most of his work involves system integration and multi-disciplinary engineering in structural mechanics, electrical engineering, signal processing, and multi-scale fabrication of materials. His recent research topics include: Multifunctional energy storage composites, Integrated health management for aircraft structures, bio-inspired intelligent sensory materials for fly-by-feel autonomous vehicles, active sensing diagnostics for composite structures, self-diagnostics for high-temperature materials, etc.

  • Howard Y. Chang, MD, PhD

    Howard Y. Chang, MD, PhD

    Virginia and D. K. Ludwig Professor of Cancer Research, Professor of Genetics and, by courtesy, of Pathology

    Current Research and Scholarly InterestsOur research is focused on how the activities of hundreds or even thousands of genes (gene parties) are coordinated to achieve biological meaning. We have pioneered methods to predict, dissect, and control large-scale gene regulatory programs; these methods have provided insights into human development, cancer, and aging.

  • James Chang, MD

    James Chang, MD

    Johnson and Johnson Professor of Surgery

    Current Research and Scholarly InterestsMy role in research is to apply novel advances in tissue engineering and microsurgery to the clinical problems of hand trauma, peripheral nerve injuries, and congenital hand problems. I am interested in developing new tissues and techniques that will allow optimal reconstruction of form and function to those patients requiring reconstructive surgery.

  • Robert Chang, MD

    Robert Chang, MD

    Associate Professor of Ophthalmology

    Current Research and Scholarly InterestsI'm interested in developing a best in class glaucoma registry, utilizing modern algorithm techniques on imaging, text, and biologic data for precision health predictive analytics in glaucoma diagnosis and treatment, validating new medical devices and technologies, especially portable ones, and working on implementation science

  • Steven D. Chang, MD

    Steven D. Chang, MD

    Robert C. and Jeannette Powell Neurosciences Professor and, by courtesy, of Otolaryngology - Head & Neck Surgery (OHNS) and of Neurology and Neurological Sciences

    Current Research and Scholarly InterestsClinical research includes studies in the treatment of cerebrovascular disorders, such as aneurysms and AVMs, as well as the use of radiosurgery to treat tumors and vascular malformations of the brain and spine.

    Dr. Chang is C0-Director of the Cyberknife Radiosurgery Program.

    Dr. Chang is also the head of the The Stanford Neuromolecular Innovation Program with the goal of developing new technologies to improve the diagnosis and treatment of patients affected by neurological conditions.

  • Akshay Chaudhari

    Akshay Chaudhari

    Assistant Professor (Research) of Radiology (Integrative Biomedical Imaging Informatics at Stanford) and of Biomedical Data Science

    Current Research and Scholarly InterestsDr. Chaudhari is interested in the application of artificial intelligence techniques to all aspects of medical imaging, including automated schedule and reading prioritization, image reconstruction, quantitative analysis, and prediction of patient outcomes. His interests focus on the development and evaluation new self-supervised and representation learning techniques for multi-modal deep learning in healthcare using vision, language, and medical records data

  • Ovijit Chaudhuri

    Ovijit Chaudhuri

    Associate Professor of Mechanical Engineering and, by courtesy, of Bioengineering

    Current Research and Scholarly InterestsWe study the physics of cell migration, division, and morphogenesis in 3D, as well cell-matrix mechanotransduction, or the process by which cells sense and respond to mechanical properties of the extracellular matrices. For both these areas, we use engineered biomaterials for 3D culture as artificial extracellular matrices.

  • Bertha Chen, MD

    Bertha Chen, MD

    Professor of Obstetrics and Gynecology (Gynecology and Gynecologic Specialties/Urogynecology) and, by courtesy, of Urology

    Current Research and Scholarly InterestsDr. Chen’s research examines the molecular causes of urinary incontinence and pelvic floor dysfunction. Recognizing that urinary incontinence linked to demise of smooth muscle sphincter function, she is investigating the potential use of stem cell regeneration to restore muscle capacity.

  • James K. Chen

    James K. Chen

    Jauch Professor and Professor of Chemical and Systems Biology, of Developmental Biology and of Chemistry

    Current Research and Scholarly InterestsOur laboratory combines chemistry and developmental biology to investigate the molecular events that regulate embryonic patterning, tissue regeneration, and tumorigenesis. We are currently using genetic and small-molecule approaches to study the molecular mechanisms of Hedgehog signaling, and we are developing chemical technologies to perturb and observe the genetic programs that underlie vertebrate development.

  • Jonathan H. Chen, MD, PhD

    Jonathan H. Chen, MD, PhD

    Assistant Professor of Medicine (Biomedical Informatics) and of Biomedical Data Science

    Current Research and Scholarly InterestsInformatics solutions ares the only credible approach to systematically address challenges of escalating complexity in healthcare. Tapping into real-world clinical data streams like electronic medical records will reveal the community's latent knowledge in a reproducible form. Delivering this back as clinical decision support will uniquely close the loop on a continuously learning health system.

  • Lu Chen

    Lu Chen

    Professor of Neurosurgery and of Psychiatry and Behavioral Sciences

    Current Research and Scholarly InterestsWhat distinguishes us humans from other animals is our ability to undergo complex behavior. The synapses are the structural connection between neurons that mediates the communication between neurons, which underlies our various cognitive function. My research program aims to understand the cellular and molecular mechanisms that underlie synapse function during behavior in the developing and mature brain, and how synapse function is altered during mental retardation.

  • Xiaoke Chen

    Xiaoke Chen

    Associate Professor of Biology

    Current Research and Scholarly InterestsOur goal is to understand how brain circuits mediate motivated behaviors and how maladaptive changes in these circuits cause mood disorders. To achieve this goal, we focus on studying the neural circuits for pain and addiction, as both trigger highly motivated behaviors, whereas, transitioning from acute to chronic pain or from recreational to compulsive drug use involves maladaptive changes of the underlying neuronal circuitry.

  • Alan G. Cheng, MD

    Alan G. Cheng, MD

    Edward C. and Amy H. Sewall Professor in the School of Medicine, Professor of Otolaryngology - Head & Neck Surgery (OHNS) and, by courtesy, of Pediatrics

    Current Research and Scholarly InterestsActive Wnt signaling maintains somatic stem cells in many organ systems. Using Wnt target genes as markers, we have characterized distinct cell populations with stem cell behavior in the inner ear, an organ thought to be terminally differentiated. Ongoing work focuses on delineating the developing significance of these putative stem/progenitor cells and their behavior after damage.

  • Paul Cheng MD PhD

    Paul Cheng MD PhD

    Assistant Professor of Medicine (Cardiovascular Medicine)

    BioDr. Cheng is a Cardiologist at Stanford University School of Medicine in the Department of Medicine and a member of the Cardiovascular Research Institute. Dr. Cheng received his BEng in Chemical Engineering and BSc in biology at MIT. He subsequently completed his MD/PhD at UCSF working in the Srivastava lab studying how extracellular morphogenic signals affect cardiac development and fate determination of cardiac progenitors. Dr. Cheng completed internal medicine residency and cardiology fellowship at Stanford. His current clinical focus is in amyloidosis and cardio-oncology. During his post doctoral research in the Quertermous lab, he pioneered the application of single cell transcriptomic and epigenetic techniques to study human vascular diseases including atherosclerosis and aneurysm, and applied these techniques to investigate molecular mechanisms behind genetic risk factors for several human vascular diseases including atherosclerosis, and aortopathies such as Marfan's and Loey-Dietz syndrome.

    The Cheng lab takes a patient-to-bench-to-bedside approach to science. The lab focuses on elucidating new pathogenic mechanisms of human vascular diseases through combing human genetics and primary vascular disease tissues, with high-resolution transcriptomic and epigenetic profiling to generate novel hypothesis that are then tested in a variety of in vitro and in vivo models. The lab is focused on two broad questions: (1) understanding the biological underpinning of the differences in diseases propensities of different arterial segments in an individual (i.e. why do you have atherosclerosis and aneurysms in certain segments but not others), and (2) understanding the role of perivascular fibroblast in human vascular diseases.

    Find out more about what the Cheng lab is up to, check out https://chenglab.stanford.edu

  • Mike Cherry

    Mike Cherry

    Professor (Research) of Genetics, Emeritus

    Current Research and Scholarly InterestsMy research involves identifying, validating and integrating scientific facts into encyclopedic databases essential for research and scientific education. Published results of scientific experimentation are a foundation of our understanding of the natural world and provide motivation for new experiments. The combination of in-depth understanding reported in the literature with computational analyses is an essential ingredient of modern biological research.

  • Glenn M. Chertow

    Glenn M. Chertow

    Norman S. Coplon/Satellite Healthcare Professor of Medicine and Professor, by courtesy, of Epidemiology and Population Health and of Health Policy

    Current Research and Scholarly Interestsclinical epidemiology, health services research, decision sciences, clinical trials in acute and chronic kidney disease

  • Emilie Cheung, MD

    Emilie Cheung, MD

    Associate Professor of Orthopaedic Surgery

    Current Research and Scholarly InterestsPyrocarbon humeral head replacement
    Clinical outcome after shoulder replacement
    Clinical outcome after elbow replacement
    Clinical outcomes following complex reconstruction of the shoulder and elbow,
    Bone mineral density in the shoulder,
    3D kinematics of the shoulder girdle after arthroplasty

  • E.J. Chichilnisky

    E.J. Chichilnisky

    John R. Adler Professor, Professor of Neurosurgery and of Ophthalmology and, by courtesy, of Electrical Engineering

    Current Research and Scholarly InterestsFunctional circuitry of the retina and design of retinal prostheses

  • Yueh-hsiu Chien

    Yueh-hsiu Chien

    Professor of Microbiology & Immunology

    Current Research and Scholarly InterestsContribution of T cells to immunocompetence and autoimmunity; how the immune system clears infection, avoids autoimmunity and how infection impacts on the development of immune responses.

  • Gheorghe Chistol

    Gheorghe Chistol

    Assistant Professor of Chemical and Systems Biology

    Current Research and Scholarly InterestsResearch in my laboratory is aimed at understanding how eukaryotes replicate their DNA despite numerous challenges (collectively known as replication stress), and more generally – how eukaryotic cells safeguard genome integrity. Specifically, we are investigating: (i) mechanisms that regulate the activity of the replicative helicase during replication stress, (ii) mechanisms that control the inheritance of epigenetic information during replication, and (iii) mechanisms of ubiquitin-mediated regulation of genome maintenance. We utilize single-molecule microscopy to directly image fluorescently-labeled replication factors and track them in real time in Xenopus egg extracts. I developed this system as a postdoctoral fellow, and used it to monitor how the eukaryotic replicative helicase copes with DNA damage. We plan to further extend the capabilities of this platform to directly visualize other essential replication factors, nucleosomes, and regulatory post-translational modifications like ubiquitin chains. By elucidating molecular mechanisms responsible for maintaining genome stability, we aim to better understand the link between genome instability and cancer, and how these mechanisms can be harnessed to improve disease treatment.

  • Bill Chiu

    Bill Chiu

    Associate Professor of Surgery (Pediatric Surgery)

    BioDr. Chiu obtained his B.S. degree in Biological Sciences and graduated with Honors from Stanford University. After graduating, he received his Medical Degree at Northwestern University Feinberg School of Medicine, where he remained for his internship and General Surgery residency training. Dr. Chiu completed his Pediatric Surgery training at The Children’s Hospital of Philadelphia. He is an Associate Professor at Stanford University School of Medicine where he has an active research program studying innovative approaches to treat patients with neuroblastoma.

  • Wah Chiu

    Wah Chiu

    Wallenberg-Bienenstock Professor and Professor of Bioengineering and of Microbiology and Immunology

    Current Research and Scholarly InterestsMy research includes methodology improvements in single particle cryo-EM for atomic resolution structure determination of molecules and molecular machines, as well as in cryo-ET of cells and organelles towards subnanometer resolutions. We collaborate with many researchers around the country and outside the USA on understanding biological processes such as protein folding, virus assembly and disassembly, pathogen-host interactions, signal transduction, and transport across cytosol and membranes.

  • Valerie Chock

    Valerie Chock

    Professor of Pediatrics (Neonatology) and, by courtesy, of Obstetrics and Gynecology (Maternal Fetal Medicine)
    On Partial Leave from 09/16/2024 To 01/19/2025

    Current Research and Scholarly InterestsNeurological monitoring in critically ill infants. Altered hemodynamics in neonates, especially in relation to prematurity, congenital heart disease, and central nervous system injury. Determination of the hemodynamic significance and effects of a patent ductus arteriosus in the preterm infant. Utilizing NIRS (near-infrared spectroscopy) and other technologies for improved monitoring in the NICU.

  • Danny Hung-Chieh Chou

    Danny Hung-Chieh Chou

    Associate Professor of Pediatrics (Endocrinology) and, by courtesy, of Chemical and Systems Biology

    Current Research and Scholarly InterestsOur research program integrates concepts of chemical biology, protein engineering and structure biology to design new therapeutic leads and generate probes to study biological processes. A key focus of our lab is insulin, an essential hormone in our body to reduce blood glucose levels. We generate synthetic libraries of insulin analogs to select for chemical probes, and investigate natural insulin molecules (e.g. from the venom of fish-hunting cone snails!) to develop novel therapeutic candidates. We are especially interested in using chemical and enzymatic synthesis to create novel chemical entities with enhanced properties, and leverage the strong expertise of our collaborators to apply our skill sets in the fields of cancer biology, immunology and pain research. Our ultimate goal is to translate our discovery into therapeutic interventions in human diseases.

  • Constance Chu, MD

    Constance Chu, MD

    Professor of Orthopaedic Surgery (Sports Medicine)

    BioDr. Constance R. Chu is Professor and Vice Chair Research, in the Department of Orthopedic Surgery at Stanford University. She is also Director of the Joint Preservation Center and Chief of Sports Medicine at the VA Palo Alto. Previously, she was the Albert Ferguson Endowed Chair and Professor of Orthopaedic Surgery at the University of Pittsburgh. She is a clinician-scientist who is both principal investigator of several projects funded by the National Institutes of Health and who has been recognized as a Castle-Connelly/US News and World Report “Top Doctor” in Orthopedic Surgery as well as on Becker’s list of Top Knee Surgeons in the United States. Her clinical practice focuses on the knee: primarily restoration and reconstruction of the ACL, menisci and cartilage. She graduated from the U.S. Military Academy at West Point and earned her medical degree from Harvard Medical School.

    As Director of the multi-disciplinary Joint Preservation Center structured to seamlessly integrate the latest advances in biologics, mechanics, and imaging with comprehensive patient centered musculoskeletal and orthopedic care, Dr. Chu aims to develop a new model for health care delivery, research and education with an emphasis on health promotion and prevention. Cornerstones of this program include teamwork and a focus on personalized medicine. A central goal is to transform the clinical approach to osteoarthritis from palliation to prevention. In addition to optimizing clinical operations, outstanding research is critical to developing more effective new treatments. Towards this end, Dr. Chu is leading innovative translational research from bench to bedside in three main areas: quantitative imaging and biomarker development for early diagnosis and staging of joint and cartilage injury and degeneration; cartilage tissue engineering and stem cell based cartilage repair; and molecular and biological therapies for joint restoration and joint rejuvenation. Her research efforts have led to more than 30 professional awards and honors to include a Kappa Delta Award, considered to be the highest research honor in Orthopedic Surgery.

    Dr. Chu also regularly holds leadership and committee positions in major professional organizations such as the American Association of Orthopedic Surgeons (AAOS) and the American Orthopedic Association (AOA). In her subspecialty of Orthopedic Sports Medicine, she is a past President of the Forum Sports Focus Group, a member of the Herodicus Society of leaders in Sports Medicine, and immediate past Chair of the American Orthopedic Society for Sports Medicine (AOSSM) Research Council. She is alumnus of the AOA American, British, Canadian (ABC) and the AOSSM Traveling Fellowships.

  • Gilbert Chu

    Gilbert Chu

    Professor of Medicine (Oncology) and of Biochemistry

    Current Research and Scholarly InterestsAfter shuttering the wet lab, we have focused on: a point-of-care device to measure blood ammonia and prevent brain damage; a human protein complex that juxtaposes and joins DNA ends for repair and V(D)J recombination; and strategies for teaching students and for reducing selection bias in educational programs.

  • Lawrence Chu, MD, MS

    Lawrence Chu, MD, MS

    Professor of Anesthesiology, Perioperative and Pain Medicine (MSD)

    Current Research and Scholarly InterestsI have two lines of research, one involving educational informatics and use of technology in postgraduate medical education and another involving NIH-funded work in patient-oriented clinical research regarding opioid use and physiologic responses associated with acute and chronic exposure in humans.

    For a full description of my educational informatics work, please see my website aim.stanford.edu.

    My clinical research focuses on the study opiate-induced hyperalgesia in patients suffering from chronic pain.

    I am currently conducting an NIH-funded five year double-blinded randomized controlled clinical study (NIGMS award 1K23GM071400-01) that prospectively examines the following hypotheses: 1) pain patients on chronic opioid therapy develop dose-dependent tolerance and/or hyperalgesia to these medications over time, 2) opiate-induced tolerance and hyperalgesia develop differently with respect to various types of pain, 3) opioid-induced hyperalgesia occurs independently of withdrawal phenomena, and 4) opiate-induced tolerance and hyperalgesia develop differently based on gender and/or ethnicity.

    The study is the first quantitative and prospective examination of tolerance and hyperalgesia in pain patients and may have important implications for the rational use of opioids in the treatment of chronic pain.

  • Steven Chu

    Steven Chu

    William R. Kenan Jr. Professor, Professor of Molecular and Cellular Physiology and of Energy Science and Engineering

    Current Research and Scholarly InterestsSynthesis, functionalization and applications of nanoparticle bioprobes for molecular cellular in vivo imaging in biology and biomedicine. Linear and nonlinear difference frequency mixing ultrasound imaging. Lithium metal-sulfur batteries, new approaches to electrochemical splitting of water. CO2 reduction, lithium extraction from salt water

  • Katrin Chua

    Katrin Chua

    Professor of Medicine (Endocrinology, Gerontology and Metabolism)

    Current Research and Scholarly InterestsOur lab is interested in understanding molecular processes that underlie aging and age-associated pathologies in mammals. We focus on a family of genes, the SIRTs, which regulate stress resistance and lifespan in lower organisms such as yeast, worms, and flies. In mammals, we recently uncovered a number of ways in which SIRT factors may contribute to cellular and organismal aging by regulating resistance to various forms of stress. We have now begun to characterize the molecular mechanisms by which these SIRT factors function. In particular, we are interested in how SIRT factors regulate chromatin, the molecular structure in which the DNA of mammalian genomes is packaged, and how such functions may link genome maintenance to stress resistance and aging.

  • Benjamin I. Chung

    Benjamin I. Chung

    Associate Professor of Urology

    Current Research and Scholarly InterestsRenal cell carcinoma and prostate cancer outcomes research and epidemiology.

  • Karlene Cimprich

    Karlene Cimprich

    Professor of Chemical and Systems Biology and, by courtesy, of Biochemistry

    Current Research and Scholarly InterestsGenomic instability contributes to many diseases, but it also underlies many natural processes. The Cimprich lab is focused on understanding how mammalian cells maintain genomic stability in the context of DNA replication stress and DNA damage. We are interested in the molecular mechanisms underlying the cellular response to replication stress and DNA damage as well as the links between DNA damage and replication stress to human disease.

  • Thomas Clandinin

    Thomas Clandinin

    Shooter Family Professor

    Current Research and Scholarly InterestsThe Clandinin lab focuses on understanding how neuronal circuits assemble and function to perform specific computations and guide behavior. Taking advantage of a rich armamentarium of genetic tools available in the fruit fly, combined with imaging, physiology and analytical techniques drawn from systems neuroscience, we examine a variety of visual circuits.

  • David Clark

    David Clark

    Professor of Anesthesiology, Perioperative and Pain Medicine (MSD)

    BioMy career is dedicated to improving the safety, effectiveness and availability of pain relief. Both the needs and opportunities in these areas are limitless. I have had the good fortune of working as a clinician, teacher and scientist at Stanford University and the Palo Alto VA hospital for more than two decades.

    Much of my time is spent on laboratory, translational and clinical research. In the laboratory, we are pursuing several projects related to the questions of why pain sometimes becomes chronic after injuries and why opioids lose their effectiveness over time. Alterations in endogenous pain control mechanisms and the involvement of the adaptive system of immunity are central to these investigations. We would like to find ways to maximize functional recovery after surgery and other forms of trauma while minimizing the risks of analgesic use. This work involves local, national and international collaborations. Clinical trials work involves establishing the efficacy of novel forms of analgesic therapy as well as the comparative effectiveness of long-established approaches to controlling common forms of pain such as low back pain. This spectrum of pain-related pursuits continues to evolve with the rapid expansion of the field.

  • Michael F. Clarke, M.D.

    Michael F. Clarke, M.D.

    Karel H. and Avice N. Beekhuis Professor of Cancer Biology

    Current Research and Scholarly InterestsDr. Clarke maintains a laboratory focused on two areas of research: i) the control of self-renewal of normal stem cells and diseases such as cancer and hereditary diseases; and ii) the identification and characterization of cancer stem cells. His laboratory is investigating how perturbations of stem cell regulatory machinery contributes to human disease. In particular, the laboratory is investigating epigenetic regulators of self renewal, the process by which stem cells regenerate themselves.

  • Carol Clayberger

    Carol Clayberger

    Professor (Research) of Pediatrics, Emerita

    Current Research and Scholarly InterestsOur group uses molecular biology, biochemistry, and cellular immunology to investigate the activation and effector function of T lymphocytes. Research in the laboratory is currently focused on three areas: granulysin, a lytic molecule expressed late (7-12 days) after T cell activation; identification of correlates of immunity in diseases such as tuberculosis; and tolerance. The long term goal of this work is to develop new ways to treat human disease.

  • William Clusin, MD

    William Clusin, MD

    Associate Professor of Medicine (Cardiovascular Medicine)

    Current Research and Scholarly InterestsCardiac action potentials; tissue culture, voltage, clamp technique; role of calcium in ischemia arrhythmias; coronary, artery disease; myocardial infarction.

  • Maria Inmaculada Cobos Sillero

    Maria Inmaculada Cobos Sillero

    Associate Professor of Pathology

    Current Research and Scholarly InterestsOur lab uses cellular and molecular methods, single-cell technology, and quantitative histology to study human neurodegenerative diseases. Current projects include:

    - Using single-cell RNA-sequencing to understand selective vulnerability and disease progression in human Alzheimer’s disease brain

    - Investigating mechanisms of tau-related neurodegeneration in human brain

    - Studying the neocortical and limbic systems in Diffuse Lewy Body Disease (DLBD) at the single cell level

  • Jennifer R. Cochran

    Jennifer R. Cochran

    Senior Associate Vice Provost for Research, Addie and Al Macovski Professor and Professor of Bioengineering

    Current Research and Scholarly InterestsMolecular Engineering, Protein Biochemistry, Biotechnology, Cell and Tissue Engineering, Molecular Imaging, Chemical Biology

  • Harvey Cohen

    Harvey Cohen

    Deborah E. Addicott - John A. Kriewall and Elizabeth A. Haehl Family Professor of Pediatrics, Emeritus

    Current Research and Scholarly InterestsMy research interests extend from hypothesis-driven studies in biochemistry and cell biology to discovery-driven interests in proteomics and systems biology to clinical treatment of acute lymphoblastic leukemia of children, and pediatric palliative care.

  • Stanley N. Cohen, MD

    Stanley N. Cohen, MD

    Kwoh-Ting Li Professor in the School of Medicine, Professor of Genetics and of Medicine

    Current Research and Scholarly InterestsWe study mechanisms that affect the expression and decay of normal and abnormal mRNAs, and also RNA-related mechanisms that regulate microbial antibiotic resistance. A small bioinformatics team within our lab has developed knowledge based systems to aid in investigations of genes.

  • Todd Coleman

    Todd Coleman

    Associate Professor of Bioengineering and, by courtesy, of Electrical Engineering

    BioTodd P. Coleman is an Associate Professor in the Department of Bioengineering, and by courtesy, Electrical Engineering at Stanford University. He received B.S. degrees in electrical engineering (summa cum laude), as well as computer engineering (summa cum laude) from the University of Michigan (Go Blue). He received M.S. and Ph.D. degrees from MIT in electrical engineering and computer science. He did postdoctoral studies at MIT and Mass General Hospital in quantitative neuroscience. He previously was a faculty member in the Departments of Electrical & Computer Engineering and Bioengineering at the University of Illinois, Urbana-Champaign, and the University of California, San Diego, respectively. Dr. Coleman’s research is very multi-disciplinary, using tools from applied probability, physiology, and bioelectronics. Examples include, for instance, optimal transport methods in high-dimensional uncertainty quantification and developing technologies and algorithms to monitor and modulate physiology of the nervous systems in the brain and visceral organs. He has served as a Principal Investigator on grants from the NSF, NIH, Department of Defense, and multiple private foundations. Dr. Coleman is an inventor on 10 granted US patents. He has been selected as a Gilbreth Lecturer for the National Academy of Engineering, a TEDMED speaker, and a Fellow of IEEE as well as the American Institute for Medical and Biological Engineering. He recently served as Chair of the National Academies Standing Committee on Biotechnology Capabilities and National Security Needs.

  • Steven Hartley Collins

    Steven Hartley Collins

    Associate Professor of Mechanical Engineering and, by courtesy, of Bioengineering

    BioSteve Collins is an Associate Professor of Mechanical Engineering at Stanford University, where he teaches courses on design and robotics and directs the Stanford Biomechatronics Laboratory. His primary focus is to speed and systematize the design and prescription of prostheses and exoskeletons using versatile device emulator hardware and human-in-the-loop optimization algorithms (Zhang et al. 2017, Science). Another interest is efficient autonomous devices, such as highly energy-efficient walking robots (Collins et al. 2005, Science) and exoskeletons that use no energy yet reduce the metabolic energy cost of human walking (Collins et al. 2015, Nature).

    Prof. Collins received his B.S. in Mechanical Engineering in 2002 from Cornell University, where he performed undergraduate research on passive dynamic walking robots. He received his Ph.D. in Mechanical Engineering in 2008 from the University of Michigan, where he performed research on the dynamics and control of human walking. He performed postdoctoral research on humanoid robots at T. U. Delft in the Netherlands. He was a professor of Mechanical Engineering and Robotics at Carnegie Mellon University for seven years. In 2017, he joined the faculty of Mechanical Engineering at Stanford University.

    Prof. Collins is a member of the Scientific Board of Dynamic Walking and the Editorial Board of Science Robotics. He has received the Young Scientist Award from the American Society of Biomechanics, the Best Medical Devices Paper from the International Conference on Robotics and Automation, and the student-voted Professor of the Year in his department.

  • Le Cong

    Le Cong

    Assistant Professor of Pathology (Pathology Research) and of Genetics

    Current Research and Scholarly InterestsOur lab develops gene-editing technologies like novel CRISPR systems and large gene insertion techniques for gene&cell therapy. We also leverages these gene-editing tools for single-cell functional screening, to probe molecular mechanisms of cancer and immunological diseases. To accelerate our work, we integrate AI and machine learning to design and evolve gene-editing proteins/RNAs in silico, pushing the frontier that bridges computational and experimental biology.

  • Christos E. Constantinou

    Christos E. Constantinou

    Associate Professor of Urology, Emeritus

    Current Research and Scholarly InterestsMy main recent interest is the application of Biomedical Engineering approaches for the clinical visualization and characterization of the static and dynamic properties of pelvic floor function. This extends to ultrasound Imaging and image processing, construction of computer models and biomechanics analysis of pelvic floor function. It is envisioned that these considerations are important constituents of the clinical evaluation of patients with lower urinary tract dysfunction and urodynamics.

  • Christopher H. Contag

    Christopher H. Contag

    Professor of Pediatrics (Neonatology), Emeritus

    Current Research and Scholarly InterestsWe develop and use the tools of molecular imaging to understand oncogenesis, reveal patterns of cell migration in immunosurveillance, monitor gene expression, visualize stem cell biology, and assess the distribution of pathogens in living animal models of human biology and disease. Biology doesn't occur in "a vacuum" or on coated plates--it occurs in the living body and that's were we look for biological patterns and responses to insult.

  • John P. Cooke, MD, PhD

    John P. Cooke, MD, PhD

    Professor of Medicine (Cardiovascular Medicine), Emeritus

    Current Research and Scholarly InterestsOur translational research program in vascular regeneration is focused on generating and characterizing vascular cells from human induced pluripotential stem cells. We are also studying the therapeutic application of these cells in murine models of peripheral arterial disease. In these studies we leverage our longstanding interest in endothelial signaling, eg by nitric oxide synthase (NOS) as well as by nicotinic cholinergic receptors (nAChR).

  • David N. Cornfield

    David N. Cornfield

    Anne T. and Robert M. Bass Professor of Pediatric Pulmonary Medicine

    Current Research and Scholarly InterestsOver the past 20 years, the Cornfield Laboratory has focused upon basic, translational and clinical research, with a primary focus on lung biology. As an active clinician-scientist, delivering care to acutely and chronically ill infants and children, our lab focuses on significant clinical challenges and tried to use science to craft novel solutions to difficult clinical problems.

  • Steven M. Corsello

    Steven M. Corsello

    Assistant Professor of Medicine (Oncology) and, by courtesy, of Chemical and Systems Biology

    Current Research and Scholarly InterestsOur laboratory operates at the intersection of functional genomics and chemical biology, with the goal of advancing novel molecular mechanisms of cancer inhibition to clinical use. We aim to 1) leverage phenotypic screening and functional genomics to determine novel anti-cancer mechanisms of small molecules, 2) develop new targeted therapy approaches against solid tumors, and 3) build a comprehensive community resource for drug repurposing discovery.

  • Markus Covert

    Markus Covert

    Shriram Chair of the Department of Bioengineering, Professor of Bioengineering and, by courtesy, of Chemical and Systems Biology

    Current Research and Scholarly InterestsOur focus is on building computational models of complex biological processes, and using them to guide an experimental program. Such an approach leads to a relatively rapid identification and validation of previously unknown components and interactions. Biological systems of interest include metabolic, regulatory and signaling networks as well as cell-cell interactions. Current research involves the dynamic behavior of NF-kappaB, an important family of transcription factors.

  • Tina Cowan

    Tina Cowan

    Professor of Pathology (Clinical) and, by courtesy, of Pediatrics (Genetics)

    Current Research and Scholarly Interestsscreening and diagnosis of patients with inborn errors of metabolism, including newborn screening, development of new testing methods and genotype/phenotype correlations.

  • Gerald Crabtree

    Gerald Crabtree

    David Korn, MD, Professor of Pathology and Professor of Developmental Biology

    Current Research and Scholarly InterestsChromatin regulation and its roles in human cancer and the development of the nervous system. Engineering new methods for studying and controlling chromatin and epigenetic regulation in living cells.

  • Jonas Cremer

    Jonas Cremer

    Assistant Professor of Biology

    Current Research and Scholarly InterestsWe are a highly interdisciplinary research team, joined in our desire to better understand microbial life. To elucidate how bacterial cells accumulate biomass and grow, we work with the model organism Escherichia coli. We further focus on gut bacteria and their interactions with the human host. Our approaches combine quantitative experimentation and mathematical modeling.

  • Craig Criddle

    Craig Criddle

    Professor of Civil and Environmental Engineering, Emeritus

    Current Research and Scholarly InterestsCriddle's interests include microbial biotechnology for the circular economy, including recovery of clean water from used water, renewable energy, valuable materials that can replace fossil-carbon derived materials. Current projects include energy-efficient anaerobic wastewater treatment technology, assessment of new treatment trains that yield high quality water; fossil carbon plastics biodegradation, and biotechnology for production of bioplastics that can replace fossil carbon plastics.

  • Patricia Cross

    Patricia Cross

    Professor (Teaching) of Structural Biology, Emerita

    Current Research and Scholarly InterestsI am not now actively involved in research, but my past endeavors remain central to my position in guiding medical students in their scholarship pursuits.
    The cited publications represent three areas of interest:
    (1) medical student research (Jacobs and Cross)
    (2) women in medicine (Cross and Steward)
    (3) the reproductive physiology of early development (Cross and Brinster)
    Only one publication is listed in this area since the research is not current, but others (in e.g. Nature, DevBiol, ExpCellRes) give a broader picture of my pursuit when at the University of Pennsylvania.

  • Larry Crowder

    Larry Crowder

    Edward Ricketts Provostial Professor, Professor of Oceans, Senior Fellow at the Woods Institute for the Environment and Professor, by courtesy, of Biology

    Current Research and Scholarly InterestsEcology, conservation, fisheries, protected species, ecosystem-based management

  • Alia Crum

    Alia Crum

    Associate Professor of Psychology and, by courtesy, of Medicine (Primary Care & Population Health)
    On Leave from 10/01/2024 To 06/30/2025

    Current Research and Scholarly InterestsOur lab focuses on how subjective mindsets (e.g., thoughts, beliefs and expectations) can alter objective reality through behavioral, psychological, and physiological mechanisms. We are interested in understanding how mindsets affect important outcomes both within and beyond the realm of medicine, in the domains such as exercise, diet and stress. https://mbl.stanford.edu/

  • Bianxiao Cui

    Bianxiao Cui

    Job and Gertrud Tamaki Professor of Chemistry

    Current Research and Scholarly InterestsOur objective is to develop new biophysical methods to advance current understandings of cellular machinery in the complicated environment of living cells. Currently, we are focusing on four research areas: (1) Membrane curvature at the nano-bio interface; (2) Nanoelectrode arrays (NEAs) for scalable intracellular electrophysiology; (3) Electrochromic optical recording (ECORE) for neuroscience; and (4) Optical control of neurotrophin receptor tyrosine kinases.

  • Yi Cui

    Yi Cui

    Fortinet Founders Professor, Professor of Materials Science and Engineering, of Energy Science and Engineering, of Photon Science, Senior Fellow at Woods and Professor, by courtesy, of Chemistry

    BioCui studies fundamentals and applications of nanomaterials and develops tools for their understanding. Research Interests: nanotechnology, batteries, electrocatalysis, wearables, 2D materials, environmental technology (water, air, soil), cryogenic electron microscopy.

  • Catherine Curtin MD

    Catherine Curtin MD

    Professor of Surgery (Plastic & Reconstructive Surgery) and, by courtesy, of Orthopaedic Surgery

    Current Research and Scholarly InterestsMaintaining and optimizing upper limb function in people with spinal cord injury and other nerve disorders.
    Improving pain and general well being after severe hand injuries.
    Improving treatment and recognition of pain.

  • Christina Curtis

    Christina Curtis

    RZ Cao Professor, Professor of Genetics and of Biomedical Data Science

    Current Research and Scholarly InterestsThe Curtis laboratory for Cancer Computational and Systems Biology is focused on the development and application of innovative experimental, computational, and analytical approaches to improve the diagnosis, treatment, and early detection of cancer.

  • Mark Cutkosky

    Mark Cutkosky

    Fletcher Jones Professor in the School of Engineering

    BioCutkosky applies analyses, simulations, and experiments to the design and control of robotic hands, tactile sensors, and devices for human/computer interaction. In manufacturing, his work focuses on design tools for rapid prototyping.

  • Martha S. Cyert

    Martha S. Cyert

    Dr. Nancy Chang Professor

    Current Research and Scholarly InterestsThe Cyert lab is identifying signaling networks for calcineurin, the conserved Ca2+/calmodulin-dependent phosphatase, and target of immunosuppressants FK506 and cyclosporin A, in yeast and mammals. Cell biological investigations of target dephosphorylation reveal calcineurin’s many physiological functions. Roles for short linear peptide motifs, or SLiMs, in substrate recognition, network evolution, and regulation of calcineurin activity are being studied.

  • Agnieszka Czechowicz, MD, PhD

    Agnieszka Czechowicz, MD, PhD

    Assistant Professor of Pediatrics (Stem Cell Transplantation)

    Current Research and Scholarly InterestsDr. Czechowicz’s research is aimed at understanding how hematopoietic stem cells interact with their microenvironment in order to subsequently modulate these interactions to improve bone marrow transplantation and unlock biological secrets that further enable regenerative medicine broadly. This work can be applied across a variety of disease states ranging from rare genetic diseases, autoimmune diseases, solid organ transplantation, microbiome-augmentation and cancer.