Showing 821-840 of 929 Results
Jean Y. Tang MD PhD
Professor of Dermatology at the Stanford University Medical Center
Current Research and Scholarly InterestsMy research focuses on 2 main areas:
1. Skin cancer:
- New therapeutics to treat and prevent non-melanoma skin cancer, especially by targeting the Hedgehog signaling pathway for BCC tumors
- Genomic analysis of drug-resistant cancers
- Identifying risk factors for skin cancer in the Women's Health Initiative
2. Epidermolysis Bullosa: gene therapy and protein therapy to replace defective/absent Collagen 7 in children and adults with Recessive Dystrophic EB
Associate Professor of Mechanical Engineering, Senior Fellow at the Woods Institute for the Environment and Professor, by courtesy, of Radiology (Precision Health and Integrated Diagnostics)
Current Research and Scholarly InterestsThe long-term goal of Dr. Tang's research program is to harness mass transport in microfluidic systems to accelerate precision medicine and material design for a future with better health and environmental sustainability.
Current research areas include: (I) Physics of droplets in microfluidic systems, (II) Interfacial mass transport and self-assembly, and (III) Applications in food allergy, single-cell wound repair, and the bottom-up construction of synthetic cell and tissues in close collaboration with clinicians and biochemists at the Stanford School of Medicine, UCSF, and University of Michigan.
For details see https://web.stanford.edu/group/tanglab/
William Abraham Tarpeh
Assistant Professor of Chemical Engineering, by courtesy, of Civil and Environmental Engineering and Center Fellow, by courtesy, at the Woods Institute for the Environment
BioReimagining liquid waste streams as resources can lead to recovery of valuable products and more efficient, less costly approaches to reducing harmful discharges to the environment. Pollutants in effluent streams can be captured and used as valuable inputs to other processes. For example, municipal wastewater contains resources like energy, water, nutrients, and metals. The Tarpeh Lab develops and evaluates novel approaches to resource recovery from “waste” waters at several synergistic scales: molecular mechanisms of chemical transport and transformation; novel unit processes that increase resource efficiency; and systems-level assessments that identify optimization opportunities. We employ understanding of electrochemistry, separations, thermodynamics, kinetics, and reactor design to preferentially recover resources from waste. We leverage these molecular-scale insights to increase the sustainability of engineered processes in terms of energy, environmental impact, and cost.
Professor of Energy Resources Engineering
Current Research and Scholarly InterestsEnvironmental fluid mechanics, Applied and computational mathematics, Biomedical modeling.
Assistant Professor of Anesthesiology, Perioperative and Pain Medicine (Adult Pain) at the Stanford University Medical Center
Current Research and Scholarly InterestsMy overall research interest is to understand how the immune system interacts with the nervous system after injury to promote the transition from acute to chronic pain. In my clinical practice I care for patients with persistent pain that often occurs after minor trauma such as fracture or surgery. Using basic science approaches including whole system immune phenotyping with mass cytometry and genetic manipulation of peripheral and central immune cells, we seek to dissect the temporal and tissue-specific contribution of these cells to either promotion or inhibition of healing.
Assistant Professor of Radiology (Pediatric Radiology) at the Stanford University Medical Center
Current Research and Scholarly InterestsOver the past decade there has been tremendous advances in the field of Interventional Oncology with the clinical utilization of multiple new innovative locoregional therapies (i.e. chemoembolization, percutaneous ablation). Looking forward, our ability to superselectively deliver new therapies such as nanoparticles, stem cells and gene therapy will open new pathways for Interventional Radiology into the emerging field of Regenerative Medicine.
Assistant Professor of Neurosurgery at the Stanford University Medical Center
Current Research and Scholarly InterestsThe long-term goal of my research is the repair of damaged corticospinal circuitry. Therapeutic regeneration strategies will be informed by an understanding both of corticospinal motor neuron (CSMN) development and of events occurring in CSMN in the setting of spinal cord injury. MicroRNAs are small, non-coding RNAs that regulate the expression of “suites” of genes. The work in my lab seeks to identify microRNA controls over CSMN development and over the CSMN response to spinal cord injury.
Professor of Biomedical Data Science and of Statistics
Current Research and Scholarly InterestsMy research is in applied statistics and biostatistics. I specialize in computer-intensive methods for regression and classification, bootstrap, cross-validation and statistical inference, and signal and image analysis for medical diagnosis.
Professor of Genetics, of Biology and, by courtesy, of Chemistry
Current Research and Scholarly InterestsWe develop chemogenetic and optogenetic technologies for probing and manipulating protein networks, cellular RNA, and the function of mitochondria and the mammalian brain. Our technologies draw from enzyme engineering, directed evolution, chemical biology, organic synthesis, high-resolution microscopy, genetics, and computational analysis.
Professor of Medicine (Gastroenterology and Hepatology) at the Stanford University Medical Center
Current Research and Scholarly InterestsMy laboratory has been focusing on the mechanism of liver fibrogenesis and the role of hepatocyte cell death in fibrogenic injury. We have demonstrated the intricate link between hepatocyte cell death, generation of apoptotic bodies and their phagocytosis by stellate cells triggering fibrogenic activation. Key to this was the activation of the NADPH oxidase and production of reactive oxidative species inducing stellate cell transdifferentiation and collagen I transcription (Gastroenterology, 2010).
We have expanded our work focusing on the role of non-phagocytic NADPH oxidases including NOX4 in dysregulating insulin responses and precipitating stress signaling in non-alcoholic steatohepatitis. (Gastroenterology, 2015). As patients with type II diabetes mellitus develop more progressive liver disease we are now studying how advanced glycation end products (AGEs) engage RAGE signaling in the liver and NADPH oxidase-mediated redox stress.
Our ultimate goal is to translate our findings and develop novel therapeutic approaches that reverse fibrosis in NASH and improve patient outcomes.
Philip S. Tsao, PhD
Professor (Research) of Medicine (Cardiovascular Medicine)
Current Research and Scholarly InterestsOur primary interests are in the molecular underpinnings of vascular disease as well as assessing disease risk. In addition to targeted investigation of specific signaling molecules, we utilize global genomic analysis to identify gene expression networks and regulatory units. We are particularly interested in the role of microRNAs in gene expression pathways associated with disease.
George D. Smith Professor, Emeritus
Current Research and Scholarly InterestsWe study synaptic communication between brain cells with the goal of understanding neuronal computations and memory mechanisms. Main areas of focus include: presynaptic calcium channels, mechanisms of vesicular fusion and recycling. Modulation of synaptic strength through changes in postsynaptic receptors and dendritic morphology. Signaling that links synaptic activity to nuclear transcription and local protein translation. Techniques include imaging, electrophysiology, molecular biology.
The Dean and Virginia Morrison Professor of Population Studies
Current Research and Scholarly InterestsStochastic dynamics of human and natural populations; prehistoric societies; probability forecasts including sex ratios, mortality, aging and fiscal balance; life history evolution.
Minang (Mintu) Turakhia
Associate Professor of Medicine (Cardiovascular Medicine) at the Palo Alto Veterans Affairs Health Care System
Current Research and Scholarly InterestsDr. Turakhia has an active clinical research program, with funding from AHA, VA, NIH, the medical device industry, and foundations. His research program aims to improve the treatment of heart rhythm disorders, with an emphasis on atrial fibrillation, by evaluating quality and variation of care, comparative and cost-effectiveness of therapies, and risk prediction. Dr. Turakhia has extensive expertise in using large administrative and claims databases for this work. His TREAT-AF retrospective study of over 500,000 patients with newly-diagnosed AF is the largest known research cohort of AF patients. He has served as study PI or chairman of several prominent single- and multicenter trials in atrial fibrillation, investigational devices for electrophysiology procedures, digital health interventions, and sensor technologies.
His other research interests include technology assessment of new device-based therapies and the impact of changing health policy and reform on the delivery of arrhythmia care. Dr. Turakhia is a Fellow of the American Heart Association, American College of Cardiology, and Heart Rhythm Society.
Alexander Eckehart Urban
Assistant Professor of Psychiatry and Behavioral Sciences (Major Laboratories and Clinical Translational Neurosciences Incubator) and of Genetics
Current Research and Scholarly InterestsComplex behavioral and neuropsychiatric phenotypes often have a strong genetic component. This genetic component is often extremely complex and difficult to dissect. The current revolution in genome technology means that we can avail ourselves to tools that make it possible for the first time to begin understanding the complex genetic and epigenetic interactions at the basis of the human mind.
Professor of Medicine (Immunology and Rheumatology)
Current Research and Scholarly InterestsThe long-term research goal of the Utz laboratory is to understand autoimmunity, autoantibodies, and how tolerance is broken and can be reestablished.
Associate Professor of Otolaryngology - Head & Neck Surgery (OHNS) and, by courtesy, of Pediatrics at the Lucile Salter Packard Children's Hospital
BioDr. Tulio A Valdez is a surgeon scientist born and raised in Colombia with a subspecialty interest in Pediatric Otolaryngology. He attended medical school at Universidad Javeriana in Bogota Colombia before undertaking his residency in Otolaryngology, Head and Neck Surgery in Boston. He completed his Pediatric Otolaryngology Fellowship at Texas Children’s Hospital (2007), Houston and obtained his Master’s in Clinical and Translational Research at the University of Connecticut.
Clinically, Dr. Valdez has an interest in airway surgery and swallowing disorders. He has a special interest in the management of sinus disease in cystic fibrosis. Dr. Valdez has co-authored one textbook and numerous book chapters and scientific manuscripts. Dr. Valdez continues his clinical research in these areas, particularly with a focus on aerodigestive disorders.
Scientifically, Dr. Valdez has developed various imaging methods to diagnose otitis media and cholesteatoma a middle ear condition that can lead to hearing loss. He was part of the Laser Biomedical Research Center at Massachusetts Institute of Technology. His research includes novel imaging modalities to better diagnose ear infections one of the most common pediatric problems. His research has now expanded to include better intraoperative imaging modalities in pediatric patients to improve surgical outcomes without the need for radiation exposure.
Dr. Valdez believes in the multi-disciplinary collaborations to tackle medical problems and has co-invented various medical devices and surgical simulation models.
Associate Professor of Computer Science
Current Research and Scholarly InterestsMy primary research interests lie at the intersection of algorithms, learning, applied probability, and statistics. I am particularly interested in understanding the algorithmic and information theoretic possibilities and limitations for many fundamental information extraction tasks that underly real-world machine learning and data-centric applications.
Matt van de Rijn
Sabine Kohler, MD, Professor in Pathology
Current Research and Scholarly InterestsOur research focuses on molecular analysis of human soft tissue tumors (sarcomas) with an emphasis on leiomyosarcoma and desmoid tumors. In addition we study the role of macrophages in range of malignant tumors.
Capucine van Rechem
Assistant Professor of Pathology (Pathology Research)
Current Research and Scholarly InterestsMy long-term interest lies in understanding the impact chromatin modifiers have on disease development and progression so that more optimal therapeutic opportunities can be achieved. My laboratory explores the direct molecular impact of chromatin-modifying enzymes during cell cycle progression, and characterizes the unappreciated and unconventional roles that these chromatin factors have on cytoplasmic function such as protein synthesis.