Bio-X
Showing 781-790 of 1,080 Results
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Guillem Pratx
Associate Professor of Radiation Oncology (Radiation Physics)
Current Research and Scholarly InterestsThe Physical Oncology Lab is interested in making a lasting impact on translational cancer research by building novel physical tools and methods.
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David Prince
Edward F. and Irene Thiele Pimley Professor of Neurology and the Neurological Sciences, Emeritus
Current Research and Scholarly InterestsExperiments examine
1)intrinsic properties of neuronal membranes; actions of neurotransmitters that regulate neocortical and thalamic excitability
2) chronic epileptogenesis following cortical injury; changes in intracortical connectivity and receptors;
3) effects of early injury and activity on cortical development/maldevelopment Electrophysiological, anatomical and pharmacological techniques employed.
4. prophylaxis of postraumatic epilepsy
5. Neocortical interneuronal function/modulation -
John R. Pringle
Professor of Genetics
Current Research and Scholarly InterestsMuch of our research exploits the power of yeast as an experimentally tractable model eukaryote to investigate fundamental problems in cell and developmental biology such as the mechanisms of cell polarization and cytokinesis. In another project, we are developing the small sea anemone Aiptasia as a model system for study of the molecular and cellular biology of dinoflagellate-cnidarian symbiosis, which is critical for the survival of most corals but still very poorly understood.
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Jonathan Pritchard
Bing Professor of Population Studies, Professor of Genetics and Biology
Current Research and Scholarly InterestsWe are interested in a broad range of problems at the interface of genomics and evolutionary biology. One current focus of the lab is in understanding how genetic variation impacts gene regulation and complex traits. We also have long-term interests in using genetic data to learn about population structure, history and adaptation, especially in humans.
FOR UP-TO-DATE DETAILS ON MY LAB AND RESEARCH, PLEASE SEE: http://pritchardlab.stanford.edu -
Carla Pugh, MD, PhD
Thomas Krummel Professor
Current Research and Scholarly InterestsThe Technology Enabled Clinical Improvement (T.E.C.I.) Center is a multidisciplinary team of researchers dedicated to the design and implementation of advanced engineering technologies that facilitate data acquisition relating to clinical performance.
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Elisabetta Viani Puglisi
Associate Professor (Research) of Structural Biology
Current Research and Scholarly InterestsViral infections and subsequent host response depend on multiple RNA-protein interaction. My research focuses on the structural and functional characterization of RNA-protein complexes involved in viral infection. Current research aims to understand how the Human Immunodeficiency Virus (HIV) initiates its replication upon host infection. We use NMR spectroscopy and x-ray crystallography to study the structure of the initiation complex, formed by a host tRNA and HIV genomic RNA, coupled with biochemical and biophysical methods to understand functional properties. The goal of this research is to gain a molecular view of HIV replication initiation, and use this information to develop new therapeutic approaches to combat HIV.
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Joseph (Jody) Puglisi
Jauch Professor and Professor of Structural Biology
Current Research and Scholarly InterestsThe Puglisi group investigates the role of RNA in cellular processes and disease. We investigate dynamics using single-molecule approaches. Our goal is a unified picture of structure, dynamics and function. We are currently focused on the mechanism and regulation of translation, and the role of RNA in viral infections. A long-term goal is to target processes involving RNA with novel therapeutic strategies.
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Lei (Stanley) Qi
Associate Professor of Bioengineering
BioDr. Lei (Stanley) Qi is an Associate Professor of Bioengineering, an Institute Scholar at Sarafan ChEM-H, and a Chan Zuckerberg Biohub Investigator. He earned B.S. in Physics and Mathematics from Tsinghua University and Ph.D. in Bioengineering from UC Berkeley. Before joining the Stanford faculty in 2014, Dr. Qi was a Systems Biology Faculty Fellow at UCSF.
Dr. Qi is a pioneer in CRISPR technology development, particularly in the areas of epigenetic regulation and chromatin DNA imaging. He invented the first nuclease-deactivated Cas9 (dCas9) system for targeted gene regulation in living cells. His lab has since expanded the CRISPR-dCas toolbox, including new tools and variants like hyperCas12a and the compact CasMINI. These new technologies have enabled CRISPRi and CRISPRa for targeted gene repression and activation in various cells and organisms, large-scale genetic perturbation screens, and precision epigenetic editing in primary cells. His lab also developed technologies for dynamic chromatin DNA imaging in live cells (LiveFISH), 3D genome structure manipulation (CRISPR-GO), and multiplexed transcriptome engineering (MEGA).
Dr. Qi has used these new technologies to make key discoveries in epigenetics, such as the synergistic functions of enhancer elements in cancer gene regulation, metabolic pathways in T cell dysfunction, and novel antivirals against RNA viruses. Dr. Qi’s current research explores synthetic biology, epigenetics, immune cell engineering, and innovative targets for gene therapy in immunology and neurobiology.
