Wu Tsai Neurosciences Institute
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Professor (Research) of Neurosurgery
Current Research and Scholarly InterestsMy lab is focused on developing novel therapeutic methods against stroke using rodent models. We study protective effect of postconditioning, preconditioning and mild hypothermia. The rationale for studying three means of neuroprotection is that we may discover mechanisms that these treatments have in common. Conversely, if they have differing mechanisms, we will be able to offer more than one treatment for stroke and increase a patients chance for recovery.
Professor of Mechanical Engineering
BioProfessor Zheng received her Ph.D. in Mechanical & Aerospace Engineering from Princeton University (2006), B.S. in Thermal Engineering from Tsinghua University (2000). Prior to joining Stanford in 2007, Professor Zheng did her postdoctoral work in the Department of Chemistry and Chemical Biology at Harvard University. Professor Zheng is a member of MRS, ACS and combustion institute. Professor Zheng received the TR35 Award from the MIT Technology Review (2013), one of the 100 Leading Global Thinkers by the Foreign Policy Magazine (2013), 3M Nontenured Faculty Grant Award (2013), the Presidential Early Career Award (PECASE) from the white house (2009), Young Investigator Awards from the ONR (2008), DARPA (2008), Terman Fellowship from Stanford (2007), and Bernard Lewis Fellowship from the Combustion Institute (2004).
Roseanna N. Zia
Assistant Professor of Chemical Engineering and, by courtesy, of Mechanical Engineering
Current Research and Scholarly InterestsThe Zia group seeks to unite the deeply connected fields of suspension mechanics and cell biology, to show the role of physics in biological cell fitness. With theory and computation we ask:
1. Is Brownian motion alone sufficient to power life-essential processes in biological cells, and how does this connect cell fitness or even to the origin of life?
2. Do colloidal phase transitions really arrest?
3. Can Einstein's fluctuation-dissipation theory be expanded well beyond equilibrium?
J. Bradley Zuchero
Assistant Professor of Neurosurgery
Current Research and Scholarly InterestsGlia are a frontier of neuroscience, and overwhelming evidence from the last decade shows that they are essential regulators of all aspects of the nervous system. The Zuchero Lab aims to uncover how glial cells regulate neural development and how their dysfunction contributes to diseases like multiple sclerosis (MS) and in injuries like stroke.
Although glia represent more than half of the cells in the human brain, fundamental questions remain to be answered. How do glia develop their highly specialized morphologies and interact with neurons to powerfully control form and function of the nervous system? How is this disrupted in neurodegenerative diseases and after injury? By bringing cutting-edge cell biology techniques to the study of glia, we aim to uncover how glia help sculpt and regulate the nervous system and test their potential as novel, untapped therapeutic targets for disease and injury.
We are particularly interested in myelin, the insulating sheath around neuronal axons that is lost in diseases like MS. How do oligodendrocytes- the glial cell that produces myelin in the central nervous system- form and remodel myelin, and why do they fail to regenerate myelin in disease? Our current projects aim to use cell biology and neuroscience approaches to answer these fundamental questions. Ultimately we hope our work will lead to much-needed therapies to promote remyelination in patients.