School of Engineering
Showing 11-20 of 33 Results
Professor (Research) of Computer Science, Emeritus
BioRichard Fikes has a long and distinguished record as an innovative leader in the development of techniques for effectively representing and using knowledge in computer systems. He is best known as co-developer of the STRIPS automatic planning system, KIF (Knowledge Interchange Format), the Ontolingua ontology representation language and Web-based ontology development environment, the OKBC (Open Knowledge Base Connectivity) API for knowledge servers, and IntelliCorp's KEE system. At Stanford, he led projects focused on developing large-scale distributed repositories of computer-interpretable knowledge, collaborative development of multi-use ontologies, enabling technology for the Semantic Web, reasoning methods applicable to large-scale knowledge bases, and knowledge-based technology for intelligence analysts. He was principal investigator of major projects for multiple Federal Government agencies including the Defense Advanced Research Projects Agency (DARPA) and the Intelligence Community’s Advanced Research and Development Activity (ARDA).
Assistant Professor of Computer Science and of Electrical Engineering
BioChelsea Finn is an Assistant Professor in Computer Science and Electrical Engineering at Stanford University, and the William George and Ida Mary Hoover Faculty Fellow. Professor Finn's research interests lie in the ability to enable robots and other agents to develop broadly intelligent behavior through learning and interaction. Her work lies at the intersection of machine learning and robotic control, including topics such as end-to-end learning of visual perception and robotic manipulation skills, deep reinforcement learning of general skills from autonomously collected experience, and meta-learning algorithms that can enable fast learning of new concepts and behaviors. Professor Finn received her Bachelors degree in Electrical Engineering and Computer Science at MIT and her PhD in Computer Science at UC Berkeley. Her research has been recognized through the ACM doctoral dissertation award, an NSF graduate fellowship, a Facebook fellowship, the C.V. Ramamoorthy Distinguished Research Award, and the MIT Technology Review 35 under 35 Award, and her work has been covered by various media outlets, including the New York Times, Wired, and Bloomberg. Throughout her career, she has sought to increase the representation of underrepresented minorities within CS and AI by developing an AI outreach camp at Berkeley for underprivileged high school students, a mentoring program for underrepresented undergraduates across three universities, and leading efforts within the WiML and Berkeley WiCSE communities of women researchers.
Associate Professor of Bioengineering and of Medicine (Microbiology and Immunology)
Current Research and Scholarly InterestsThe human microbiome is linked to a range of phenotypes in the host, but it remains difficult to test causality and explore the mechanisms of these interactions. Our lab focuses on two research areas that share a common goal of studying host-microbiota interactions at the level of molecular mechanism:
1) Technology development. Much of what we know about biology has been learned by deleting individual genes from mice, worms, flies and yeast. The ability to do single-strain and single-gene deletion in the microbiome would be transformative but does not yet exist. We are developing technology in three areas to make this possible:
Synthetic ecology: There is a pressing need for model systems for the microbiome that are defined, but of an order of complexity that approaches the native state. Key experiments in the field often show that a host phenotype can be transferred to a germ-free mouse via fecal transplant. If these phenomena could be recapitulated with a defined, high-complexity community, then reductionist experiments to probe mechanism would be possible. We are developing the technology required to build highly complex defined communities (100-200 bacterial species), make them stable upon transplantation into mice, and probe their function in vitro and in vivo.
Genetics: It is difficult to probe mechanism without genetics, and genetic tools exist for only ~10% of the bacterial species in the gut and skin microbiome. We are developing technologies that will make it possible to delete and insert genes, and build mutant libraries, in many of the most common bacterial strains in the gut and skin microbiome.
Computation: In previous work from the lab, we have developed computational algorithms that identify small-molecule-producing genes in bacterial genomes. In current work, we are devising algorithms for genome mining that are specific to the microbiome, and new tools for predicting the chemical structures of small molecules from untargeted metabolomics data.
2) Molecular mechanisms. Many of the early findings in microbiome research are correlative or associative. We are applying the tools described above to explore the mechanisms underlying these phenomena:
Small molecules: Our lab has had a long-standing interest in small molecules from the microbiota. These include: 1) host-derived molecules metabolized by the microbiome, like bile acids; 2) characteristic components of the bacterial membrane and cell wall, including LPS and capsular polysaccharides; and 3) hundreds of other diffusible small molecules (e.g., the products of polysaccharide and amino acid metabolism) that are present in the bloodstream at high concentrations. Our work in this area seeks to establish the mechanisms by which these molecules modulate host biology, especially by deleting them one at a time in the background of a complex community; and to discover new microbiome-derived metabolites present in the bloodstream and host tissues.
Ecology of complex communities: Synthetic ecology at the 100+ strain scale is entirely unexplored, and the emergent properties of complex communities are not well understood. Our work in this area seeks to understand basic principles outlined by the following questions: How many meaningful interactions exist in a community of hundreds of strains? What constitutes a niche, molecularly and spatially, and how do strains map to niches? What are the molecular correlates of stability, and how does a community reconfigure in response to a perturbation? How rare or common are stable states, and how predictable is the process by which a consortium will evolve toward a stable state? To what extent do priority effects (early colonists and events) determine the outcome of ecosystem development? Can the results of ecosystem competition be predicted or engineered?
Kumagai Professor in the School of Engineering and Senior Fellow at the Precourt Institute for Energy
BioProfessor Fischer's research goals are to improve the productivity of project teams involved in designing, building, and operating facilities and to enhance the sustainability of the built environment. His work develops the theoretical foundations and applications for virtual design and construction (VDC). VDC methods support the design of a facility and its delivery process and help reduce the costs and maximize the value over its lifecycle. His research has been used by many small and large industrial government organizations around the world.
Professor of Applied Physics and, by courtesy, of Materials Science and Engineering
Current Research and Scholarly InterestsOur research focuses on the study of quantum materials with unconventional magnetic & electronic ground states & phase transitions. Emphasis on design and discovery of new materials. Recent focus on use of strain as a probe of, and tuning parameter for, a variety of electronic states. Interests include unconventional superconductivity, quantum phase transitions, nematicity, multipolar order, instabilities of low-dimensional materials and quantum magnetism.
Assistant Professor of Civil and Environmental Engineering and Center Fellow at the Woods Institute for the Environment
Current Research and Scholarly InterestsThe Fletcher Lab aims to advance water resources management to promote resilient and equitable responses to a changing world.
Sr. Research Scholar
BioJune A. Flora, PhD, is a senior research scientist at Stanford University’s Human Sciences & Technologies Advanced Research Institute (HSTAR) in the Graduate School of Education, and the Solutions Science Lab in the Stanford School of Medicine. June's research focuses on understanding the drivers of human behavior change and the potential of communication interventions. The research is solution focused on behavior change relevant to health and climate change.
Most recently she is studying the role of energy use feedback delivered through motivationally framed online applications; the potential of children and youth delivered energy reduction interventions to motivate parent behavior change, and the effects of entertainment-education interventions to change behavior.
June earned her Ph.D. from Arizona State University in educational psychology. She has held faculty positions at University of Utah and Stanford University.
Assistant Professor of Mechanical Engineering and, by courtesy, of Computer Science
Current Research and Scholarly InterestsHuman Computer Interaction, Haptics, Robotics, Human Centered Design