School of Humanities and Sciences
Showing 301-345 of 345 Results
Professor of Biology (Hopkins Marine Station)
Current Research and Scholarly InterestsNeurobiology, signal transduction
Professor of Biomedical Data Science and, by courtesy, of Statistics
Current Research and Scholarly InterestsMy research interest includes
(1) Survival Analysis and Semiparametric Modeling;
(2) Resampling Method ;
(3) Meta Analysis ;
(4) High Dimensional Data Analysis;
(5) Precision Medicine for Disease Diagnosis, Prognosis and Treatment.
Professor of Biomedical Data Science and of Statistics
Current Research and Scholarly InterestsMy research is in applied statistics and biostatistics. I specialize in computer-intensive methods for regression and classification, bootstrap, cross-validation and statistical inference, and signal and image analysis for medical diagnosis.
Professor of Genetics, of Biology and, by courtesy, of Chemistry
Current Research and Scholarly InterestsWe develop chemogenetic and optogenetic technologies for probing and manipulating protein networks, cellular RNA, and the function of mitochondria and the mammalian brain. Our technologies draw from enzyme engineering, directed evolution, chemical biology, organic synthesis, high-resolution microscopy, genetics, and computational analysis.
Assistant Professor of PhysicsOn Leave from 09/01/2020 To 08/31/2021
Current Research and Scholarly InterestsProfessor Tompkins’s research focuses on understanding the relationships which govern matter’s most fundamental constituents. As a member of the ATLAS experiment at the Large Hadron Collider (LHC), she utilizes the world’s highest energy person-made particle collisions in order to understand the mechanism that gives particles mass, whether or not our current model of elementary particle interactions is a complete description of nature, and if dark matter can be produced and studied in colliders.
In order to search for the exceedingly rare interactions which may provide insight to these questions, the LHC will produce a blistering rate of 50 to 80 proton-proton collisions every 25 nanoseconds in 2015 and beyond. Professor Tompkins works on the design and implementation of custom electronics which will improve the ATLAS experiment’s ability to pick out the collisions which produce the Higgs bosons, dark matter particles and other rare events out of the deluge of ordinary interactions. Her group focuses on particles called heavy flavor fermions, the most massive particles not responsible for mediating interactions. Because they are so heavy, they may have a special connection to the origin of mass or physics beyond our current models of particle interactions.
She is additionally a member of the Light Dark Matter Experiment (LDMX), a proposed experiment to produce and detect dark matter in the laboratory utilizing an accelerated beam of electrons.
Job and Gertrud Tamaki Professor in the School of Humanities and Sciences, Emeritus
BioBorn in Philadelphia, Pennsylvania, Barry Trost began his university training at the University of Pennsylvania (BA, 1962) and completed his Ph.D. in Chemistry at the Massachusetts Institute of Technology (1965). He moved directly to the University of Wisconsin, where he was promoted to Professor of Chemistry and subsequently Vilas Research Professor. He joined the faculty at Stanford as Professor of Chemistry in 1987 and became Tamaki Professor of Humanities and Sciences in 1990. In addition to serving multiple visiting professorships, Professor Trost was presented with a Docteur honoris causa of the Université Claude-Bernard (Lyon I), France, and in 1997 a Doctor Scientiarum Honoris Causa of the Technion, Haifa, Israel. In recognition of his innovations and scholarship in the field of organic synthesis, Professor Trost has received the ACS Award in Pure Chemistry, ACS Award for Creative Work in Synthetic Organic Chemistry, Arthur C. Cope Scholar Award, and the Presidential Green Chemistry Challenge Award, among many others. Professor Trost has been elected a Fellow of the American Academy of Arts and Sciences, American Chemical Society, and American Association for the Advancement of Science, and a member of the National Academy of Sciences, and served as Chairman of the NIH Medicinal Chemistry Study Section. He has held over 125 special university lectureships and presented over 270 Plenary Lectures at national and international meetings. He has published two books and over 950 scientific articles. He edited a major compendium entitled Comprehensive Organic Synthesis consisting of nine volumes and serves on the editorial board for Science of Synthesis and Reaxys.
The Trost Group’s research program revolves around the theme of synthesis, including target molecules with potential applications as novel catalysts, as well as antibiotic and antitumor therapies. The work comprises two major activities: 1) developing the tools, i.e., the reactions and reagents, and 2) creating the proper network of reactions to make complex targets readily available from simple starting materials.
Efforts to develop "chemists' enzymes" – non-peptidic transition metal based catalysts that can perform chemo-, regio-, diastereo-, and especially enantioselective reactions – focus close attention to the question of atom economy to minimize waste, energy, and consumption of raw materials.
Synthetic efficiency raises the question of metal catalyzed cycloadditions to rings other than six-membered. A general strategy is evolving for a "Diels-Alder" equivalent for formation of five, seven, nine, etc. membered carbo- and heterocyclic rings.
An exciting new direction derives from the molecular gymnastics acetylenes undergo in the presence of transition metals. Additional specific goals include cycloisomerization to virtually all types of ring sizes and systems with particularly versatile juxtaposition of functionality.
Palladium and ruthenium catalysts represent a major part of the lab's efforts, in order to invent new synthetic processes together with new opportunities for selectivity complementary to that obtained using other metal complexes. Main group chemistry, especially involving silicon, zinc, and sulfur, also offers many opportunities for new reaction design. Rational design of novel catalysts for asymmetric additions to carbonyl and imine groups are an exciting thrust.From these new synthetic tools evolve new synthetic strategies towards complex natural products. Targets include β-lactam antibiotics, ionophores, steroids and related compounds (e.g., Vitamin D metabolites), alkaloids, nucleosides, carbohydrates, and macrolide, terpenoid, and tetracyclic antitumor and antibiotic agents.
The Dean and Virginia Morrison Professor of Population Studies
Current Research and Scholarly InterestsStochastic dynamics of human and natural populations; prehistoric societies; probability forecasts including sex ratios, mortality, aging and fiscal balance; life history evolution.
Professor of Mathematics
Current Research and Scholarly InterestsAlgebraic geometry and related subjects. For a complete publication list, see my publication page http://math.stanford.edu/~vakil/preprints.html rather than the list here.
Robert Grimmett Professor in Mathematics
Current Research and Scholarly InterestsMy research concentrates on topics in two broad areas of applications of microlocal analysis in which, partly with collaborators, I introduced new ideas in recent years: non-elliptic linear and non-linear partial differential equations (PDE), typically concerning wave propagation or other related phenomena, and inverse problems for X-ray type transforms along geodesics and related problems for determining the metric tensor from boundary measurements.
Clifford G. Morrison Professor in Population and Resource Studies, Senior Fellow at the Woods Institute for the Environment and Professor, by courtesy, of Earth System ScienceOn Leave from 04/01/2021 To 06/30/2021
Current Research and Scholarly InterestsVitousek's research interests include: evaluating the global cycles of nitrogen and phosphorus, and how they are altered by human activity; understanding how the interaction of land and culture contributed to the sustainability of Hawaiian (and other Pacific) agriculture and society before European contact; and working to make fertilizer applications more efficient and less environmentally damaging (especially in rapidly growing economies)
Professor of Physics, Emeritus
Current Research and Scholarly InterestsProbes (accretion disks, ...) of black holes, sources and detectors of gravitational radiation, theories of gravitation, anthropic cosmological principle.
Professor of Biology
Current Research and Scholarly InterestsOur current focus is on maize anther development to understand how cell fate is specified. We discovered that hypoxia triggers specification of the archesporial (pre-meiotic) cells, and that these cells secrete a small protein MAC1 that patterns the adjacent soma to differentiate as endothecial and secondary parietal cell types. We also discovered a novel class of small RNA: 21-nt and 24-nt phasiRNAs that are exceptionally abundant in anthers and exhibit strict spatiotemporal dynamics.
BioChristopher Walsh is a consulting professor to the Stanford University Department of Chemistry and an advisor to the Stanford ChEM-H institute. He was the Hamilton Kuhn Professor of Biological Chemistry and Molecular Pharmacology at Harvard Medical School from 1987 to 2013, when he took emeritus status. He has had extensive academic leadership experience, including Chairmanship of the MIT Chemistry Department and of the HMS Biological Chemistry & Molecular Pharmacology Department, as well as serving as President and CEO of the Dana Farber Cancer Institute. At Stanford he has taught short courses including Posttranslational Modifications of Proteins: Expanding Nature’s Inventory (Chem 187/287) and also Antibiotics: Mechanisms and Resistance.
Dr. Walsh’s research has focused on enzymes and enzyme inhibitors, with specialization on antibiotics and biosynthesis of other biologically and medicinally active natural products. He and his group authored 810 research papers, and four books: Enzymatic Reaction Mechanisms (1979); Antibiotics: Origins, Actions, Resistance (2003); Posttranslational Modification of Proteins: Expanding Nature’s Inventory (2005); and Antibiotics: Challenges, Mechanisms, Opportunities (2016).
Dr. Walsh is a member of the U.S. National Academy of Sciences, the U.S. National Academy of Medicine, the American Academy of Arts and Sciences, the American Philosophical Society, and a co-recipient of the 2010 Welch Prize in Chemistry. At Harvard and MIT he taught biochemistry, chemical biology, and pharmacology to medical students and graduate students and organic chemistry to undergraduates.
He has been involved in a variety of venture-based biotechnology companies since 1981, including Genzyme, Immunogen, Leukosite, Millenium, Kosan, Vicuron, Epizyme. Currently he is on the board of directors of Ironwood, and Proteostasis, and the non profits: California Institute for Biomedical Research and Ludwig Institute for Cancer Research. He is a member of the scientific advisory groups at Hua, Abide, Cidara, and Flex Pharma, an advisor to Health Care Ventures and a limited investor in Health Care Ventures, MPM bioventures, Clarus, and the Longwood Venture Funds.
Dr. Walsh is married to Diana Chapman Walsh, who was president of Wellesley College from 1993-2007 and was the founding chair of the board of the Broad Institute of MIT and Harvard. Their daughter Allison Walsh Kurian is an Associate Professor of Medicine at Stanford and co-director of the High Risk Center for women with genetic predisposition to breast and ovarian cancer.
Professor of Statistics
BioGuenther Walther studied mathematics, economics, and computer science at the University of Karlsruhe in Germany and received his Ph.D. in Statistics from UC Berkeley in 1994.
His research has focused on statistical methodology for detection problems, shape-restricted inference, and mixture analysis, and on statistical problems in astrophysics and in flow cytometry.
He received a Terman fellowship, a NSF CAREER award, and the Distinguished Teaching Award of the Dean of Humanities and Sciences at Stanford. He has served on the editorial boards of the Journal of Computational and Graphical Statistics, the Journal of the Royal Statistical Society, the Annals of Statistics, the Annals of Applied Statistics, and Statistical Science. He was program co-chair of the 2006 Annual Meeting of the Institute of Mathematical Statistics and served on the executive committee of IMS from 1998 to 2012.
Professor of Biology, Emeritus
Current Research and Scholarly InterestsEvolutionary adaptive mechanisms, molecules to ecosystems
Robert Eckles Swain Professor in Chemistry and Professor, by courtesy, of Chemical Engineering
BioRobert Eckles Swain Professor in Chemistry Robert Waymouth investigates new catalytic strategies to create useful new molecules, including bioactive polymers, synthetic fuels, and sustainable plastics. In one such breakthrough, Professor Waymouth and Professor Wender developed a new class of gene delivery agents.
Born in 1960 in Warner Robins, Georgia, Robert Waymouth studied chemistry and mathematics at Washington and Lee University in Lexington, Virginia (B.S. and B.A., respectively, both summa cum laude, 1982). He developed an interest in synthetic and mechanistic organometallic chemistry during his doctoral studies in chemistry at the California Institute of Technology under Professor R.H. Grubbs (Ph.D., 1987). His postdoctoral research with Professor Piero Pino at the Institut fur Polymere, ETH Zurich, Switzerland, focused on catalytic hydrogenation with chiral metallocene catalysts. He joined the Stanford University faculty as assistant professor in 1988, becoming full professor in 1997 and in 2000 the Robert Eckles Swain Professor of Chemistry.
Today, the Waymouth Group applies mechanistic principles to develop new concepts in catalysis, with particular focus on the development of organometallic and organic catalysts for the synthesis of complex macromolecular architectures. In organometallic catalysis, the group devised a highly selective alcohol oxidation catalyst that selectively oxidizes unprotected polyols and carbohydrates to alpha-hyroxyketones. In collaboration with Dr. James Hedrick of IBM, we have developed a platform of highly active organic catalysts and continuous flow reactors that provide access to polymer architectures that are difficult to access by conventional approaches.
The Waymouth group has devised selective organocatalytic strategies for the synthesis of functional degradable polymers and oligomers that function as "molecular transporters" to deliver genes, drugs and probes into cells and live animals. These advances led to the joint discovery with the Wender group of a general, safe, and remarkably effective concept for RNA delivery based on a new class of synthetic cationic materials, Charge-Altering Releasable Transporters (CARTs). This technology has been shown to be effective for mRNA based cancer vaccines.
Director, Stanford Institute for Stem Cell Biology and Regenerative Medicine, Virginia & D.K. Ludwig Professor for Clinical Investigation in Cancer Research, Professor of Developmental Biology and, by courtesy, of Biology
Current Research and Scholarly InterestsStem cell and cancer stem cell biology; development of T and B lymphocytes; cell-surface receptors for oncornaviruses in leukemia. Hematopoietic stem cells; Lymphocyte homing, lymphoma invasiveness and metastasis.
Francis W. Bergstrom Professor of Chemistry and Professor, by courtesy, of Chemical and Systems Biology
Current Research and Scholarly InterestsMolecular imaging, therapeutics, drug delivery, drug mode of action, synthesis
Professor of Biological Sciences and Dean of the School of Humanities and Sciences, Emeritus
Current Research and Scholarly InterestsAnnual survey of rainbow and brown trout in northern lakes on the North Island of New Zealand. !995-2018, et seq.
Cheriton Family Professor and Professor of Physics and of Education
Current Research and Scholarly InterestsThe Wieman group’s research generally focuses on the nature of expertise in science and engineering, particularly physics, and how that expertise is best learned, measured, and taught. This involves a range of approaches, including individual cognitive interviews, laboratory experiments, and classroom interventions with controls for comparisons. We are also looking at how different classroom practices impact the attitudes and learning of different demographic groups.
Professor of Applied Physics (Research), Emeritus
BioBorn and educated in New York City, he received his AB (1953) and his PhD (1957) from Columbia University. Following a postdoc position at the University of Rochester (1957-59) he continued work in high energy physics and accelerator development at the Cambridge Electron Accelerator at Harvard University (1959-73), serving as Assistant Director. He came to Stanford in 1973 to lead the technical design of the Stanford Synchrotron Radiation Project (SSRP), now SSRL, and served as Deputy Director of the laboratory until his semi-retirement in 1998 (www-ssrl.slac.stanford.edu). He has taught physics at Columbia, Rochester, Harvard, MIT, Northwestern, University of Massachusetts, and Stanford. His 1970’s and 1980’s research developing periodic magnet systems (wigglers and undulators), had a major impact on synchrotron radiation sources and research facilities at Stanford and around the world. Beginning in 1992 he made major contributions to initiating and developing the Linac Coherent Light Source (LCLS), the world’s first X-ray Free Electron Laser. Starting operation in 2009, the LCLS has shifted the major SLAC focus from high energy physics to x-ray sources and research. In 1997 he suggested SESAME, a synchrotron light source involving 9 countries in the Middle East. He has played a major role in the development of this project, on track to start research in 2016 (www.sesame.org.jo). He is now promoting a similar project in Africa. Throughout his adult life he has been an activist in helping dissidents and protecting academic freedom and human rights.
Wing Hung Wong
Stephen R. Pierce Family Goldman Sachs Professor in Science and Human Health and Professor of Biomedical Data Science
Current Research and Scholarly InterestsCurrent interest centers on the application of statistics to biology and medicine. We are particularly interested in questions concerning gene regulation, genome interpretation and their applications to precision medicine.
Associate Professor of Chemistry
Current Research and Scholarly InterestsPolymer Chemistry, Microporous Polymer Membranes, Responsive Polymers, Degradable Polymers, Polymers with Unique Mechanical Behaviors, Polymer Networks, Organic Electronic Materials
Marguerite Blake Wilbur Professor in Natural Science and Professor, by courtesy, of Physics
Current Research and Scholarly InterestsMy research group is exploring a variety of topics that range from the basic understanding of chemical reaction dynamics to the nature of the chemical contents of single cells.
Under thermal conditions nature seems to hide the details of how elementary reactions occur through a series of averages over reagent velocity, internal energy, impact parameter, and orientation. To discover the effects of these variables on reactivity, it is necessary to carry out studies of chemical reactions far from equilibrium in which the states of the reactants are more sharply restricted and can be varied in a controlled manner. My research group is attempting to meet this tough experimental challenge through a number of laser techniques that prepare reactants in specific quantum states and probe the quantum state distributions of the resulting products. It is our belief that such state-to-state information gives the deepest insight into the forces that operate in the breaking of old bonds and the making of new ones.
Space does not permit a full description of these projects, and I earnestly invite correspondence. The following examples are representative:
The simplest of all neutral bimolecular reactions is the exchange reaction H H2 -> H2 H. We are studying this system and various isotopic cousins using a tunable UV laser pulse to photodissociate HBr (DBr) and hence create fast H (D) atoms of known translational energy in the presence of H2 and/or D2 and using a laser multiphoton ionization time-of-flight mass spectrometer to detect the nascent molecular products in a quantum-state-specific manner by means of an imaging technique. It is expected that these product state distributions will provide a key test of the adequacy of various advanced theoretical schemes for modeling this reaction.
Analytical efforts involve the use of capillary zone electrophoresis, two-step laser desorption laser multiphoton ionization mass spectrometry, cavity ring-down spectroscopy, and Hadamard transform time-of-flight mass spectrometry. We believe these methods can revolutionize trace analysis, particularly of biomolecules in cells.
Basic Life Research Scientist
Current Research and Scholarly InterestsCell cycle and cell size control in animal cells