School of Medicine
Showing 1-91 of 91 Results
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Philip Beachy
The Ernest and Amelia Gallo Professor, Professor of Urology, of Developmental Biology and, by courtesy, of Chemical and Systems Biology
Current Research and Scholarly InterestsFunction of Hedgehog proteins and other extracellular signals in morphogenesis (pattern formation), in injury repair and regeneration (pattern maintenance). We study how the distribution of such signals is regulated in tissues, how cells perceive and respond to distinct concentrations of signals, and how such signaling pathways arose in evolution. We also study the normal roles of such signals in stem-cell physiology and their abnormal roles in the formation and expansion of cancer stem cells.
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Gill Bejerano
Professor of Developmental Biology, of Computer Science, of Pediatrics (Genetics) and of Biomedical Data Science
Current Research and Scholarly Interests1. Automating monogenic patient diagnosis.
2. The genomic signatures of independent divergent and convergent trait evolution in mammals.
3. The logic of human gene regulation.
4. The reasons for sequence ultraconservation.
5. Cryptogenomics to bridge medical silos.
6. Cryptogenetics to debate social injustice.
7. Managing patient risk using machine learning.
8. Understanding the flow of money in the US healthcare system. -
Alistair Boettiger
Associate Professor of Developmental Biology
Current Research and Scholarly InterestsMy lab focuses on investigating the role of three-dimensional genome organization in regulating gene expression and in shaping cell fate specification during development. We pursue this with advanced single-molecule imaging and transgenics.
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Sarah Bowling
Assistant Professor of Developmental Biology
Current Research and Scholarly InterestsThe Bowling lab focuses on understanding lineage formation and tissue growth in mammalian development during normal and perturbed embryogenesis. We use a combination of next-generation tools and classical embryological approaches to uncover mechanisms of plasticity and resilience during mammalian embryo development, with the aim of using this knowledge to extend our understanding of regeneration and developmental diseases.
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James K. Chen
Jauch Professor and Professor of Chemical and Systems Biology, of Developmental Biology and of Chemistry
Current Research and Scholarly InterestsOur laboratory combines chemistry and developmental biology to investigate the molecular events that regulate embryonic patterning, tissue regeneration, and tumorigenesis. We are currently using genetic and small-molecule approaches to study the molecular mechanisms of Hedgehog signaling, and we are developing chemical technologies to perturb and observe the genetic programs that underlie vertebrate development.
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Gerald Crabtree
David Korn, MD, Professor of Pathology and Professor of Developmental Biology
Current Research and Scholarly InterestsChromatin regulation and its roles in human cancer and the development of the nervous system. Engineering new methods for studying and controlling chromatin and epigenetic regulation in living cells.
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Margaret T. Fuller
Reed-Hodgson Professor of Human Biology, Katharine Dexter McCormick and Stanley McCormick Memorial Professor and Professor of Genetics and of Obstetrics/Gynecology (Reproductive and Stem Cell Biology)
Current Research and Scholarly InterestsRegulation of self-renewal, proliferation and differentiation in adult stem cell lineages. Developmental tumor suppressor mechanisms and regulation of the switch from proliferation to differentiation. Cell type specific transcription machinery and regulation of cell differentiation. Developmental regulation of cell cycle progression during male meiosis.
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Christina Gangemi
Postdoctoral Scholar, Developmental Biology
BioDr Christina Gangemi received her undergraduate degree from Monash University (2016) specialising in molecular biology and biochemistry. She became an Undergraduate Research Opportunities Program Scholar (2016) and completed her Honours thesis (2017) at the Australian Regenerative Medicine Institute (ARMI), Monash University. She later joined Professor Harald Janovjak’s group at ARMI (2018) as a research assistant before completing her doctorate degree (2019-2023) where she studied optical approaches to promote pancreatic beta cell regeneration. Key achievements from this work include establishing an automated image analysis approach to quantify islet proliferation assays, designing a modular light-emitting diode shelving system for ex vivo and in vitro illumination of primary islets, generating a new assay to test cyclin-dependent kinase 6 (CDK6) function (a known beta cell proliferation driver), and exploring the effects of photoswitchable pdDronpa domains when engineered into CDK6. During her candidature, she was awarded a Juvenile Diabetes Research Foundation Australia PhD Top-Up Scholarship. In 2023 she undertook a Postdoctoral Research Associate role in the Janovjak group at Flinders University and has recently joined Professor Seung Kim's group at Stanford University.
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Lauren Goins
Assistant Professor of Developmental Biology
Current Research and Scholarly InterestsThe Goins lab aims to understand how cells make decisions. Our research focuses on how young, immature blood stem cells, with the potential to become many different cell types, choose between these cell fates.
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Daniel Jarosz
Associate Professor of Chemical and Systems Biology and of Developmental Biology
Current Research and Scholarly InterestsMy laboratory studies conformational switches in evolution, disease, and development. We focus on how molecular chaperones, proteins that help other biomolecules to fold, affect the phenotypic output of genetic variation. To do so we combine classical biochemistry and genetics with systems-level approaches. Ultimately we seek to understand how homeostatic mechanisms influence the acquisition of biological novelty and identify means of manipulating them for therapeutic and biosynthetic benefit.
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Seung K. Kim M.D., Ph.D.
KM Mulberry Professor, Professor of Developmental Biology, of Medicine (Endocrinology) and, by courtesy, of Pediatrics (Endocrinology)
Current Research and Scholarly InterestsWe study the development of pancreatic islet cells using molecular, embryologic and genetic methods in several model systems, including mice, pigs, human pancreas, embryonic stem cells, and Drosophila. Our work suggests that critical factors required for islet development are also needed to maintain essential functions of the mature islet. These approaches have informed efforts to generate replacement islets from renewable sources for diabetes.
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Stuart Kim
Professor of Developmental Biology, Emeritus
Current Research and Scholarly InterestsMechanisms of Aging in C. elegans and humans.
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David Kingsley
Rudy J. and Daphne Donohue Munzer Professor in the School of Medicine
Current Research and Scholarly InterestsWe use mice, stickleback fish, and humans to study the molecular basis of evolution and common diseases. By combining genetics and genomics, we have identified key DNA changes that control bone formation, limb patterning, hair color, brain evolution, and susceptibility to arthritis, schizophrenia, and bipolar disorder. We find that the same genetic mechanisms are often used repeatedly in nature, providing new insights into the origin of key traits in many different species, including ourselves.
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Kyle Loh
Assistant Professor of Developmental Biology (Stem Cell)
BioHow the richly varied cell-types in the human body arise from one embryonic cell is a biological marvel and mystery. We have mapped how human embryonic stem cells develop into over twenty different human cell-types. This roadmap allowed us to generate enriched populations of human liver, bone, heart and blood vessel cells in a Petri dish from embryonic stem cells. Each of these human cells could regenerate their cognate tissue upon injection into respective mouse models, with relevance to regenerative medicine. In addition to developmental and stem cell biology, we have an emerging interest in exploring deadly biosafety level 4 viruses together with our collaborators.
Kyle attended the County College of Morris and Rutgers, and received his Ph.D. from Stanford (working with Irving Weissman), with fellowships from the Hertz Foundation, National Science Foundation and Davidson Institute for Talent Development. He then continued as a Siebel Investigator, and later, as an Assistant Professor and The Anthony DiGenova Endowed Faculty Scholar at Stanford, where he is jointly appointed in the Department of Developmental Biology and Institute for Stem Cell Biology & Regenerative Medicine. Kyle is a Packard Fellow, Pew Scholar, Human Frontier Science Program Young Investigator and Baxter Foundation Faculty Scholar, and his research has been recognized by the NIH Director's Early Independence Award, Forbes 30 Under 30, Harold Weintraub Graduate Award, Hertz Foundation Thesis Prize and A*STAR Investigatorship. -
Nicole M. Martinez
Assistant Professor of Chemical and Systems Biology and of Developmental Biology
Current Research and Scholarly InterestsThe Martinez lab studies RNA regulatory mechanisms that control gene expression. We focus on mRNA processing, RNA modifications and their roles in development and disease.
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Harley H McAdams
Professor (Research) of Developmental Biology, Emeritus
Current Research and Scholarly InterestsExperimental and theoretical analysis and modeling of genetic regulatory circuits, particularly bacterial regulation and with emphasis on global regulation of Caulobacter crescentus. Bioinformatic analysis of bacterial genomes, global patterns of gene transcription and translation.
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Emmanuel Nsamba
Postdoctoral Scholar, Developmental Biology
BioHere is my google scholar
https://scholar.google.com/citations?user=RKnoiR8AAAAJ&hl=en -
Roeland Nusse
Virginia and Daniel K. Ludwig Professor of Cancer Research
Current Research and Scholarly InterestsOur laboratory studies Wnt signaling in development and disease. We found recently that Wnt proteins are unusual growth factors, because they are lipid-modified. We discovered that Wnt proteins promote the proliferation of stem cells of various origins. Current work is directed at understanding how Wnt signals lead to the proliferation of stem cells and on understanding Wnt signaling during repair and regeneration after tissue injury.
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Ellen Porzig
Professor (Teaching) of Developmental Biology, Emerita
Current Research and Scholarly InterestsEarly Human Developmental Biology:
From Egg to Embryo
Organogenesis: Pattern formation
Sex Determination in Embryogenesis -
Florentine Rutaganira
Assistant Professor of Biochemistry and of Developmental Biology
Current Research and Scholarly InterestsWe use chemical tools to decipher the roles of key signaling networks in choanoflagellates, single-celled organisms that are the closest living relatives of animals. Choanoflagellates produce molecular signals essential for intercellular communication in animals and the presence of these molecules in choanoflagellates suggests that signaling components needed to communicate between cells is evolutionarily ancient. We aim to uncover new understanding of animal development, physiology and disease.
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Jessica B. Sarthi
Program Manager, Department of Developmental Biology
BioMolecular and Cellular Biologist (Ph.D.) with over 10 years of scientific research experience. Accomplished in developing, optimizing, validating and implementing new ideas and technology. Experience in managing and coordinating collaborative teams comprised of scientists and research technicians working to advance scientific knowledge. Technical experience in precision medicine diagnostics, cancer biology, neurobiology and epigenetics as well as in various molecular, biochemical and cell biology techniques.
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Matthew P. Scott
Professor of Developmental Biology, Emeritus
Current Research and Scholarly InterestsOur research has been focused on the genetic regulation of animal development and its relation to birth defects, cancer, and neurodegeneration. We studied mechanisms and functions of Hedgehog (Hh) signaling, which controls cell fates and growth, in the context of normal development and brain cancer. We studied a neurodegenerative disease, Niemann-Pick C syndrome, that affects intracellular organelle movements and sterol homeostasis. Due to Dr. Scott's new job, the lab is no longer active.
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Lucy Shapiro
Virginia and D. K. Ludwig Professor, Emerita
Current Research and Scholarly InterestsA basic question in developmental biology involves the mechanisms used to generate the three-dimensional organization of a cell from a one-dimensional genetic code. Our goal is to define these mechanisms using both molecular genetics and biochemistry.
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William Talbot
Mary and Dr. Salim Shelby Professor
Current Research and Scholarly InterestsWe use genetic and cellular approaches to investigate the molecular basis of glial development and myelination in the zebrafish.
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Anne Villeneuve
Berthold and Belle N. Guggenhime Professor and Professor of Developmental Biology and of Genetics
Current Research and Scholarly InterestsMechanisms underlying homologous chromosome pairing, DNA recombination and chromosome remodeling during meiosis, using the nematode Caenorhabditis elegans as an experimental system. High-resolution 3-D imaging of dynamic reorganization of chromosome architecture. Role of protease inhibitors in regulating sperm activation.
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Bo Wang
Assistant Professor of Bioengineering and, by courtesy, Developmental Biology
Current Research and Scholarly InterestsResearch interests:
(1) Systems biology of whole-body regeneration
(2) Cell type evolution through the lens of single-cell multiomic sequencing analysis
(3) Quantitative biology of brain regeneration
(4) Regeneration of animal-algal photosymbiotic systems -
Irving Weissman
Virginia & D.K. Ludwig Professor of Clinical Investigation in Cancer Research, Professor of Pathology, and of Developmental Biology
Current Research and Scholarly InterestsStem cell and cancer stem cell biology; development of T and B lymphocytes; cell-surface receptors for oncornaviruses in leukemia. Hematopoietic stem cells; Lymphocyte homing, lymphoma invasiveness and metastasis; order of events from hematopoietic stem cells [HSC] to AML leukemia stem cells and blood diseases, and parallels in other tissues; discovery of tumor and pathogenic cell 'don't eat me' and 'eat me' signals, and translation into therapeutics.
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Joanna Wysocka
Lorry Lokey Professor and Professor of Developmental Biology
Current Research and Scholarly InterestsThe precise and robust regulation of gene expression is a cornerstone for complex biological life. Research in our laboratory is focused on understanding how regulatory information encoded by the genome is integrated with the transcriptional machinery and chromatin context to allow for emergence of form and function during human embryogenesis and evolution, and how perturbations in this process lead to disease.
