School of Medicine
Showing 301-400 of 415 Results
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Ansuman Satpathy
Assistant Professor of Pathology
Current Research and Scholarly InterestsOur lab works at the interface of immunology, cancer biology, and genomics to study cellular and molecular mechanisms of the immune response to cancer. In particular, we are leveraging high-throughput genomic technologies to understand the dynamics of the tumor-specific T cell response to cancer antigens and immunotherapies (checkpoint blockade, CAR-T cells, and others). We are also interested in understanding the impact of immuno-editing on the heterogeneity and clonal evolution of cancer.
We previously developed genome sequencing technologies that enable epigenetic studies in primary human immune cells from patients: 1) 3D enhancer-promoter interaction profiling (Nat Genet, 2017), 2) paired epigenome and T cell receptor (TCR) profiling in single cells (Nat Med, 2018), 3) paired epigenome and CRISPR profiling in single cells (Cell, 2019), and high-throughput single-cell ATAC-seq in droplets (Nature Biotech, 2019). We used these tools to study fundamental principles of the T cell response to cancer immunotherapy (PD-1 blockade) directly in cancer patient samples (Nature Biotech, 2019; Nat Med, 2019). -
Birgitt Schuele
Associate Professor (Research) of Pathology
BioBirgitt Schüle, MD, is an Associate Professor in the Department of Pathology, Stanford University School of Medicine. Her research focuses on medical genetics and stem cell modeling to unlock disease mechanisms and pathways leading to neurodegeneration in Parkinson’s disease and related disorders, and to develop new therapeutic strategies to advance precision medicine.
She received her medical training from the Georg-August University Göttingen and Medical University Lübeck, Germany (1993 - 2001) and completed doctoral degree in medicine (Dr. med.) in neurophysiology at the Georg-August University Göttingen (2001). During her neurology internship from 2001 to 2002 at Medical University of Lübeck with Prof. Christine Klein, Dr. Schüle studied genes for inherited forms of Parkinson’s disease and dystonia. From 2003 to 2005, she completed a postdoctoral fellowship in human genetics with Prof. Uta Francke at Stanford University School of Medicine. From 2005-2019, Dr. Schüle led key clinical research programs and biospecimen repositories for neurogenetics, translational stem cell and brain donation at the Parkinson’s Institute and Clinical Center.
Dr. Schuele is the associate core leader of the Neuropathology Core with the Stanford Alzheimer Research Center (ADRC) and core leader of the Analytics Core for the Pacific Udall Center. She supports the centers with genetic characterization, biobanking, and building a human induced pluripotent stem cell and post-mortem leptomeninges tissue bank shared with the data and tissue repositories at NIH. -
Robert W. Shafer
Professor (Research) of Medicine (Infectious Diseases) and, by courtesy, of Pathology
Current Research and Scholarly InterestsMy group’s research is on the mechanisms and consequences of virus evolution with a focus on HIV therapy and drug resistance. We maintain a public HIV drug resistance database (http://hivdb.stanford.edu) as a resource for HIV drug resistance surveillance, interpreting HIV drug resistance tests, and HIV drug development. Our paramount goal is to inform HIV treatment and prevention policies by identifying the main factors responsible for the emergence and spread of drug resistance.
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Hua Shan
Professor of Pathology
BioDr. Shan specializes in providing blood transfusion and apheresis treatment to patients with diverse medical problems. She has been practicing transfusion medicine for over twenty five years. Dr. Shan currently serves as the Medical Director of Transfusion Service at Stanford Medical Center. Dr. Shan has also been leading research and education programs in the fields of transfusion safety, optimizing clinical blood transfusion practice and blood availability.
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Jeanne Shen
Assistant Professor of Pathology
Current Research and Scholarly InterestsGastrointestinal and pancreatobiliary pathology, with major emphasis on GI and pancreatic neoplasia, inflammatory bowel disease, biodesign innovation, and the application of machine learning to digital pathology.
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Kang Shen
Professor of Biology and of Pathology
Current Research and Scholarly InterestsThe connectivity of a neuron (its unique constellation of synaptic inputs and outputs) is essential for its function. Neuronal connections are made with exquisite accuracy between specific types of neurons. How each neuron finds its synaptic partners has been a central question in developmental neurobiology. We utilize the relatively simple nervous system of nematode C. elegans, to search for molecules that can specify synaptic connections and understand the molecular mechanisms of synaptic as
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Run Zhang Shi
Clinical Associate Professor, Pathology
Current Research and Scholarly InterestsClinical chemistry and therapeutic drug monitoring;
adult and pediatric clinical endocrine testing;
screening, detection and follow up of multiple myeloma;
tumor markers;
clinical utility of tandem mass spectrometry and high resolution mass spectrometry. -
Hiroyuki Shimada
Professor of Pathology and of Pediatrics
BioHiroyuki Shimada, MD, PhD, FRCPA (Hon), is Professor of Pathology and of Pediatrics at the Stanford University Medical Center. He was born in Tokyo, Japan, and completed MD (1973) and PhD (1982) at the Yokohama City University School of Medicine, Yokohama, Japan, and also completed his pathology training at the Children's Hospital (now the Nationwide Children’s Hospital) and the Ohio State University, Columbus, Ohio, USA (1988). Before moving to the Stanford University in 2019, he was Professor of Pathology (Clinical Scholar) at the University of Southern California Keck School of Medicine and working at the Children’s Hospital Los Angeles.
Dr. Shimada was Chair of the International Neuroblastoma Pathology Committee (1999-2017) and the founder of the International Neuroblastoma Pathology Classification (INPC). As Director of the COG (Children’s Oncology Group) Neuroblastoma Pathology Reference Laboratory (since 2001), he has been actively reviewing pathology samples of ~700 neuroblastoma cases per year from United States, Canada, Australia, and New Zealand. Pathology review results according to the INPC have been providing critical information for patient stratification and protocol assignment in the COG international neuroblastoma clinical trials. -
Richard Sibley
Professor of Pathology, Emeritus
Current Research and Scholarly InterestsImmunologic mechanism of rejection in humans and animal, models of organ transplantation; histological definition of clinical pathology studies of various renal disorders.
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Arend Sidow
Professor of Pathology and of Genetics
Current Research and Scholarly InterestsWe have a highly collaborative research program in the evolutionary genomics of cancer. We apply well-established principles of phylogenetics to cancer evolution on the basis of whole genome sequencing and functional genomics data of multiple tumor samples from the same patient. Introductions to our work and the concepts we apply are best found in the Newburger et al paper in Genome Research and the Sidow and Spies review in TIGS.
More information can be found here: http://www.sidowlab.org -
Oscar Silva
Clinical Assistant Professor, Pathology
BioOscar is an academic hematopathologist who completed anatomic and clinical pathology residency and hematopathology fellowship at Stanford in 2020. Prior to Stanford, he received his MD and PhD from UCLA. His interests include immunology, the pathogenesis and diagnosis of lymphomas, and global health.
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Raymond A. Sobel, M.D.
Professor of Pathology
Current Research and Scholarly InterestsWe study cellular and molecular mechanisms of immune-mediated injury in CNS tissues that are affected in multiple sclerosis (MS). We study: 1) tissues of mice with EAE using histology and immunohistochemistry, 2) cross-recognition of neurons by antibodies against myelin proteolipid protein epitopes, and a distinct oligodendrogliopathy induced in mice by the non-protein amino acid azetidine (Aze), (which is found in the human diet); Aze-induced abnormalities mimic those in MS patient CNS tissues
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Melissa Steele-Ogus
Postdoctoral Scholar, Pathology
BioMelissa Steele-Ogus grew up in Berkeley, California. She received a BS in Environmental Sciences and BA in Molecular Biology from the University of California, Berkeley, in 2012. She earned a PhD in Biology from the University of Washington in 2021, studying the actin cytoskeleton of Giardia lamblia. In her free time, she enjoys dancing, baking, and birdwatching. She may be secretly some sort of weird bug, but probably isn't.
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Henning Stehr
Clinical Assistant Professor, Pathology
Current Research and Scholarly InterestsBioinformatics & Clinical Cancer Genomics
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David Steiner
Adjunct Clinical Assistant Professor, Pathology
Current Research and Scholarly InterestsMechanistic and translational studies to better understand the functional and clinical implications of somatic mutations in aging and cancer.
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Carlos Jose Suarez
Clinical Associate Professor, Pathology
BioDr. Suarez is a board-certified pathologist specializing in anatomic, clinical and molecular genetic pathology. He received his M.D. degree with the highest honors (summa cum laude) from the University of the Valley (Universidad del Valle), Cali, Colombia. After medical school, he was a research fellow at a WHO-collaborating center investigating pattern of nosocomial antibiotic resistance, and later joined the University of California at San Diego (UCSD) as postdoctoral research fellow in cancer and lung immunology laboratories. He completed an anatomic and clinical pathology residency at the University of Washington, Seattle, and a Molecular Genetic Pathology fellowship at Stanford University. Dr. Suarez is currently co-Director of the Genetic and Genomic Testing Optimization Service and Associate Director of the Molecular Pathology Laboratory at the Stanford University Medical Center.
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Katrin J Svensson
Assistant Professor of Pathology
Current Research and Scholarly InterestsMolecular metabolism
Protein biochemistry
Cell biology and function
Animal physiology -
Brent Tan
Clinical Associate Professor, Pathology
Current Research and Scholarly InterestsMy research interest is in the use of molecular, flow cytometric, and cytogenetic methods to understand and characterize hematopoietic neoplasms. In addition, I have medical oversight of clinical laboratory informatics.
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Megan Troxell
Professor of Pathology
Current Research and Scholarly InterestsBreast pathology, renal pathology with tumors, transplant; immunohistochemistry
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Albert Tsai, M.D., Ph.D.
Assistant Professor of Pathology
BioDr. Tsai received his undergraduate training at the University of California, Los Angeles (B.S., Biochemistry, summa cum laude), followed by combined medical and graduate training at the University of Southern California (M.D., Ph.D., Biochemistry). He completed anatomic and clinical pathology (AP/CP) residency and hematopathology fellowship at Stanford University, receiving board certification in AP/CP and hematopathology. As an instructor, he performed clinical diagnostic duties on the hematopathology service while doing postdoctoral training in the laboratory of Dr. Sean Bendall, with funding from the Damon Runyon Cancer Research Foundation.
As a physician and hematopathologist, he seeks to mechanistically dissect myelodysplastic syndromes (MDS) using highly-multiplexed immunophenotyping — mass cytometry / cytometry by time-of-flight (CyTOF) and multiplexed ion beam imaging (MIBI). MDS is an especially complex and heterogeneous disease of abnormal blood cell development with increasing prevalence and few treatments. By combining practical experience clinically diagnosing MDS, next generation single cell proteomic approaches, fundamental discoveries in the biology of MDS, and knowledge of clinical laboratory testing, we hope to develop new clinical diagnostics for personalizing MDS therapies and therapeutic monitoring.
His clinical diagnostic duties are on the hematopathology service, primarily in the diagnosis of MDS, leukemias, lymphomas, and other hematopoietic diseases from blood, bone marrow, and tissue samples. -
Mindy Tsai
Sr Res Scientist-Basic Ls, Pathology Sponsored Projects
BioMindy Tsai is Sr. Research Scientist in the Department of Pathology. She received the D.M.Sc. (Doctor of Medical Sciences) in Oral Biology from Harvard School of Dental Medicine and completed her postdoctoral training at Harvard Medical School. Dr. Tsai’s research focuses on studies that are designed to understand the regulation of mast cell and basophil development and to elucidate the roles of these cells in health and disease. Dr. Tsai’s research approaches include in vitro analyses of mast cells and basophils in human and mice, as well as using mouse models of disease to investigate the effector and immunoregulatory functions of these cells in vivo.
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Matt van de Rijn
Sabine Kohler, MD, Professor of Pathology
Current Research and Scholarly InterestsOur research focuses on molecular analysis of human soft tissue tumors (sarcomas) with an emphasis on leiomyosarcoma and desmoid tumors. In addition we study the role of macrophages in range of malignant tumors.
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Capucine van Rechem
Assistant Professor of Pathology (Pathology Research)
Current Research and Scholarly InterestsMy long-term interest lies in understanding the impact chromatin modifiers have on disease development and progression so that more optimal therapeutic opportunities can be achieved. My laboratory explores the direct molecular impact of chromatin-modifying enzymes during cell cycle progression, and characterizes the unappreciated and unconventional roles that these chromatin factors have on cytoplasmic function such as protein synthesis.
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Mrigender Singh Virk
Clinical Assistant Professor, Pathology
BioDr. Mrigender Virk completed his residency in Anatomic & Clinical Pathology at Georgetown University before joining Stanford for his Transfusion Medicine Fellowship. After completion of the fellowship, Dr. Virk joined the Department of Pathology as a Clinical Assistant Professor for Transfusion Medicine.
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Hannes Vogel MD
Professor of Pathology and of Pediatrics (Pediatric Genetics) and, by courtesy, of Neurosurgery and of Comparative Medicine
Current Research and Scholarly InterestsMy research interests include nerve and muscle pathology, mitochondrial diseases, pediatric neurooncology, and transgenic mouse pathology.
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Chengkun Wang
Postdoctoral Scholar, Pathology
BioChengkun Wang got his PhD from Zhejiang University in 2018.
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Teresa Wang
Klaus Bensch Professor in Experimental Pathology, Emerita
Current Research and Scholarly InterestsThe main focus of our research is to understand how cells maintain genome integrity by checkpoint mechanisms during chromosome replication.
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Roger Warnke
Ronald F. Dorfman, M.B.B.ch., FRCPath, Professor in Hematopathology, Emeritus
Current Research and Scholarly InterestsAs an Emeritus Professor, I no longer have a research laboratory and devote my 10% voluntary effort to lymphoma diagnosis and teaching. I do devote a small amount of effort to lymphoma research in collaboration with Yaso Natkunam and others in the Department of Pathology.
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Lianna Wat
Postdoctoral Scholar, Pathology
BioLianna obtained her Ph.D. in Cell and Developmental Biology in Dr. Elizabeth Rideout’s lab at the University of British Columbia in 2021 where she studied the sex-specific regulation of fat metabolism using Drosophila as a model system. Lianna is bringing her expertise on sex differences and fat metabolism to the Svensson lab where she is interested in understanding in discovering secreted metabolic effectors that regulate male-female differences in energy metabolism and the development of metabolic disease
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Alexis Thomas Weiner
Postdoctoral Scholar, Pathology
Current Research and Scholarly InterestsThe planar cell polarity (PCP) signaling pathway polarizes animal cells along an axis parallel to the tissue plane, and in so doing generates long-range organization that can span entire tissues. Although its core proteins and much about their interactions are known, how PCP signaling occurs at a mechanistic level remains fundamentally mysterious. In my current project I will employ novel genetic methods to dissect the logic underlying how cellular asymmetry arises at a molecular level.
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Irving Weissman
Director, Stanford Institute for Stem Cell Biology and Regenerative Medicine, Virginia & D.K. Ludwig Professor of Clinical Investigation in Cancer Research, Professor of Developmental Biology and, by courtesy, of Biology
Current Research and Scholarly InterestsStem cell and cancer stem cell biology; development of T and B lymphocytes; cell-surface receptors for oncornaviruses in leukemia. Hematopoietic stem cells; Lymphocyte homing, lymphoma invasiveness and metastasis; order of events from hematopoietic stem cells [HSC] to AML leukemia stem cells and blood diseases, and parallels in other tissues; discovery of tumor and pathogenic cell 'don't eat me' and 'eat me' signals, and translation into therapeutics.
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Gerlinde Wernig
Assistant Professor of Pathology
Current Research and Scholarly InterestsFibrotic diseases kill more people than cancer in this country and worldwide. We believe that scar-forming cells called fibroblasts are at the core of the fibrotic response in parenchymal organ fibrosis in the lung, liver, skin, bone marrow and tumor stroma. At the cellular level we think of fibrosis as a step wise process which implicates inflammation and fibrosis. We seek to identify new effective immune therapy targets to treat fibrotic diseases.
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Marius Wernig
Professor of Pathology and, by courtesy, of Chemical and Systems Biology
Current Research and Scholarly InterestsEpigenetic Reprogramming, Direct conversion of fibroblasts into neurons, Pluripotent Stem Cells, Neural Differentiation: implications in development and regenerative medicine
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Robert West
Professor of Pathology
Current Research and Scholarly InterestsRob West, MD, PhD, is a Professor of Pathology at Stanford University Medical Center. He is a clinician scientist with experience in translational genomics research to identify new prognostic and therapeutic markers in cancer. His research focus is on the progression of neoplasia to carcinoma. His lab has developed spatially oriented in situ methods to study archival specimens. He also serves as a surgical pathologist specializing in breast pathology.
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Monte Winslow
Associate Professor of Genetics and of Pathology
Current Research and Scholarly InterestsOur laboratory uses genome-wide methods to uncover alterations that drive cancer progression and metastasis in genetically-engineered mouse models of human cancers. We combine cell-culture based mechanistic studies with our ability to alter pathways of interest during tumor progression in vivo to better understand each step of metastatic spread and to uncover the therapeutic vulnerabilities of advanced cancer cells.
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Lu Yang
Affiliate, Dean's Office Operations - Dean Other
Resident in PathologyBioPhysician-scientist with broad interests in genetics/genomics, cell biology, developmental biology, cancer, clinical pathology, bioinformatics, and computer vision.
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Ellen Yeh
Associate Professor of Pathology and of Microbiology and Immunology
Current Research and Scholarly InterestsThe chemistry and biology of the unusual plastid organelle, the apicoplast, in malaria parasites
