School of Medicine
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Joanna Wysocka
Lorry Lokey Professor and Professor of Developmental Biology
Current Research and Scholarly InterestsThe precise and robust regulation of gene expression is a cornerstone for complex biological life. Research in our laboratory is focused on understanding how regulatory information encoded by the genome is integrated with the transcriptional machinery and chromatin context to allow for emergence of form and function during human embryogenesis and evolution, and how perturbations in this process lead to disease.
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Tony Wyss-Coray, PhD
D. H. Chen Professor II
Current Research and Scholarly InterestsUse of genetic and molecular tools to dissect immune and inflammatory pathways in Alzheimer's and neurodegeneration.
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Jinxi Xiang
Postdoctoral Scholar, Radiation Physics
Current Research and Scholarly InterestsI develop machine leanring methods to autonomate the digital pathology.
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Haopeng Xiao
Assistant Professor of Biochemistry
BioUnderstanding mechanisms of metabolic regulation in physiology and disease forms the basis for developing therapies to treat diseases in which metabolism is perturbed. We devise novel mass spectrometry (MS)-based proteomics technologies, combined with data science, to systematically discover mechanisms of metabolic regulation over protein function. Our strategies established the first tissue-specific landscape of protein cysteine redox regulation during aging, elucidating mechanisms of redox signaling in physiology that remained elusive for decades. We also leverage the genetic diversity of outbred populations to systematically annotate protein function and protein-metabolite co-regulation. The aim of our research program is to develop next-generation MS-based strategies to understand mechanisms of metabolic regulation in aging, metabolic disease, and cancer, and to use this knowledge as a basis to develop translational therapeutics.