Vice Provost and Dean of Research
Showing 501-550 of 1,154 Results
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Daniel Jarosz
Senior Associate Dean, Basic Science, Professor of Chemical and Systems Biology and of Developmental Biology
Current Research and Scholarly InterestsMy laboratory studies conformational switches in evolution, disease, and development. We focus on how molecular chaperones, proteins that help other biomolecules to fold, affect the phenotypic output of genetic variation. To do so we combine classical biochemistry and genetics with systems-level approaches. Ultimately we seek to understand how homeostatic mechanisms influence the acquisition of biological novelty and identify means of manipulating them for therapeutic and biosynthetic benefit.
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R Brooke Jeffrey
Professor of Radiology (Body Imaging), Emeritus
Current Research and Scholarly InterestsPancreatic MDCT
Thyroid ultrasound/biopsy
Virtual Colonoscopy
Imaging of appendicitis
Hepatic MDCT
Capsule ultrasound (wireless) of GI tract -
Stefanie S. Jeffrey, MD
John and Marva Warnock Professor, Emerita
Current Research and Scholarly InterestsDr. Jeffrey led the multidisciplinary team from the Schools of Medicine, Engineering, and Genome Technology Center that invented the MagSweeper, an automated device that immunomagnetically captures live circulating tumor cells (CTCs) from cancer patient blood for single cell analysis or culture. Her lab also works on microfluidic technologies for tumor cell capture, characterization, and growth - with the goal of defining individual patient response to newer biologically-based cancer therapies.
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Livnat Jerby
Assistant Professor of Genetics
Current Research and Scholarly InterestsCombining and advancing functional genomics, cell engineering, synthetic biology, AI, and basic immunology to uncover, decode, rewire, and develop mechanisms to selectively eliminate and reprogram disease-driving cells as a foundation for disease treatment and prevention.
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Michael Christopher Jewett
Professor of Bioengineering and, by courtesy, of Chemical Engineering
BioMichael Jewett is a Professor of Bioengineering at Stanford University. He received his B.S. from UCLA and PhD from Stanford University, both in Chemical Engineering. He completed postdoctoral studies at the Center for Microbial Biotechnology in Denmark and the Harvard Medical School. Jewett was also a guest professor at the Swiss Federal Institute of Technology (ETH Zurich). His research group focuses on advancing synthetic biology research to support planet and societal health, with applications in medicine, manufacturing, sustainability, and education.
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Hanlee P. Ji
Professor of Medicine (Oncology) and, by courtesy of Electrical Engineering
Current Research and Scholarly InterestsCancer genomics and genetics, translational applications of next generation sequencing technologies, development of molecular signatures as prognostic and predictive biomarkers in oncology, primary genomic and proteomic technology development, cancer rearrangements, genome sequencing, big data analysis
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Shamit Kachru
Professor of Physics and Director, Stanford Institute for Theoretical Physics, Emeritus
Current Research and Scholarly InterestsMy current research is focused in three directions:
— Mathematical aspects of string theory (with a focus on BPS state counts, black holes, and moonshine)
— Quantum field theory approaches to condensed matter physics (with a focus on physics of non-Fermi liquids)
— Theoretical biology, with a focus on evolution and ecology -
Joseph Kahn
Harald Trap Friis Professor
BioJoseph M. Kahn is a Professor of Electrical Engineering at Stanford University. His research addresses communication and imaging through optical fibers, including modulation, detection, signal processing and spatial multiplexing. He received A.B. and Ph.D. degrees in Physics from U.C. Berkeley in 1981 and 1986. From 1987-1990, he was at AT&T Bell Laboratories, Crawford Hill Laboratory, in Holmdel, NJ. He was on the Electrical Engineering faculty at U.C. Berkeley from 1990-2003. In 2000, he co-founded StrataLight Communications, which was acquired by Opnext, Inc. in 2009. He received the National Science Foundation Presidential Young Investigator Award in 1991 and is a Life Fellow of the IEEE.
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A Dale Kaiser
Member, Bio-X
Current Research and Scholarly InterestsHow are genes regulated to construct a developmental program? How do signals received from other cells change the program and coordinate it for multicellular development? The approach taken by our laboratory group to answer these questions utilizes biochemistry and genetics; genetics to isolate mutants that have particular defects in development and biochemistry to determine the molecular basis of the defects. We study swarming in Myxococcus xanthus that builds fruiting bodies.
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Anusha Kalbasi, MD
Associate Professor of Radiation Oncology (Radiation Therapy)
BioDr. Kalbasi is a physician-scientist at the Stanford Cancer Institute. In the clinic, Dr. Kalbasi is a radiation oncologist specializing in the treatment of patients with sarcoma and other solid tumors, with expertise in early phase clinical trials related to immunotherapy, cellular therapy, and radiation therapy.
The Kalbasi laboratory studies cancer immunology, with a focus on understanding—and re-engineering—the molecular conversations that immune cells have with one another and with cancer cells, especially through cytokines. By mapping how these signals are sent, received, and interpreted within immune cells and cancer cells, the lab aims to design next-generation immunotherapies that deliver the right messages at the right time—making cancer-fighting cells more potent, more persistent, and more precise. -
Julia Kaltschmidt
Professor of Neurosurgery
Current Research and Scholarly InterestsThe lab’s primary research interest is to understand how specific neuronal circuits are established. We use mouse genetics, combinatorial immunochemical labeling and high-resolution laser scanning microscopy to identify, manipulate, and quantitatively analyze synaptic contacts within the complex neuronal milieu of the spinal cord and the enteric nervous system.
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Aya Kamaya, MD
Professor of Radiology (Body Imaging)
On Partial Leave from 03/02/2026 To 04/17/2026Current Research and Scholarly InterestsHepatobiliary imaging
Hepatocellular carcinoma
Urologic imaging
Gynecologic imaging
Thyroid imaging
Novel ultrasound technologies
Perfusion CT imaging of abdominal tumors -
Matthew Kanan
Professor of Chemistry and Senior Fellow at the Precourt Institute for Energy
BioMatt Kanan is a Professor of Chemistry and Director of the TomKat Center for Sustainable Energy at Stanford. Matt’s research group addresses challenges in energy conversion, sustainable resource utilization, and carbon dioxide removal. Their work has led to several inventions in these areas, including process technology that utilizes CO2 to streamline chemical production, metal-free CO2 hydrogenation catalysts that improve the efficiency of sustainable fuel synthesis, membrane-free electrochemical systems to generate acid and base from water, and thermochemical methods to activate silicate rocks for CO2 removal. Matt is the co-founder and Chief Scientific Advisor for ReSource Chemical Corp., an Oakland-based start-up commercializing a process created in his group to produce performance-advantaged plastics from CO2 and inedible biomass. At the TomKat Center, Matt directs programs that help Stanford students and researchers develop and commercialize innovations that impact energy and sustainability. Prior to joining the Stanford faculty in 2009, Matt did his Ph.D. studies in organic chemistry at Harvard and postdoctoral research at MIT in inorganic chemistry. He earned his B.A. in chemistry from Rice University in 2000.
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Peter Kao
Associate Professor of Medicine (Pulmonary and Critical Care Medicine)
Current Research and Scholarly InterestsOur research program has several active projects:
1.) Pulmonary Vascular Disease Simvastatin reversed experimental pulmonary hypertension, and is safe for treatment of patients. Blinded clinical trials of efficacy are in progress.
2.) Lung inflammation and regeneration (stem cells)
3.) Lung surfactant rheology and oxidative stress
4.) Gene regulation by RNA binding proteins, NF45 and NF90 through transcriptional and posttranscriptional mechanisms -
Zerina Kapetanovic
Assistant Professor of Electrical Engineering and, by courtesy, of Computer Science and of Geophysics
BioZerina Kapetanovic is an Assistant Professor in the Department of Electrical Engineering at Stanford University working in the area of low-power wireless communication, sensing, and Internet of Things (IoT) systems. Prior to starting at Stanford, Kapetanovic was a postdoctoral researcher at Microsoft Research in the Networking Research Group and Research for Industry Group.
Kapetanovic's research has been recognized by the Yang Research Award, the Distinguished Dissertation Award from the University of Washington. She also received the Microsoft Research Distinguished Dissertation Grant and was selected to attend the 2020 UC Berkeley Rising Stars in EECS Workshop. Kapetanovic completed her PhD in Electrical Engineering from the University of Washington in 2022. -
Spyros Karadimas, MD, PhD
Assistant Professor of Neurosurgery
BioDr. Spyridon Karadimas is a board-certified, fellowship-trained cerebrovascular neurosurgeon and physician-scientist with Stanford Health Care. He is also an assistant professor in the Department of Neurosurgery at Stanford University School of Medicine.
Dr. Karadimas offers advanced, personalized treatment for complex vascular disorders of the brain, neck, and spine in both adults and children. His expertise spans brain aneurysms, arteriovenous malformations, cavernous malformations, arteriovenous fistulas, Moyamoya disease, stroke, and carotid artery disease. Dr. Karadimas is a rare combination of surgeon, scientist, and innovator dedicated to advancing patient care and shaping the future of cerebrovascular neurosurgery.
Dr. Karadimas directs a basic and translational research program focused on the neural circuits of motor control and stroke recovery. His laboratory integrates systems neuroscience, in vivo imaging, electrophysiology, and brain-computer interface development to uncover the principles of neuroplasticity, or how the brain adapts to change. This knowledge allows him to create new ways to help people move again after a brain injury.
Dr. Karadimas has published his research as first author in peer-reviewed journals such as Nature, Nature Neuroscience and Science Translational Medicine. His work has received editorial highlight at Nature Reviews Neuroscience. He has presented to his peers at international, national, and regional meetings, including those of the American Academy of Neurological Surgery, American Association of Neurological Surgeons (AANS), European Association of Neurosurgical Societies, and World Federation of Skull Base Societies.
Dr. Karadimas is a fellow of the Royal College of Surgeons of Canada and American Association of Neurological Surgeons as well as member of the Congress of Neurological Surgeons, and the North American Skull Base Society. -
Cansu Karakas
Assistant Professor of Pathology (Clinical Pathology)
BioDr. Cansu Karakas is an Assistant Professor, with subspecialty expertise in Breast Pathology. Her academic career spans notable institutions such as MD Anderson Cancer Center and (2010–2017) and NYU (2017-2018). She is passionate about research with a focus on HER2-driven breast cancers, artificial intelligence (AI) applications in breast cancer and identifying resistance mechanisms to guide novel, personalized therapeutic strategies in breast cancer.
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Ioannis Karakikes
Associate Professor (Research) of Cardiothoracic Surgery
Current Research and Scholarly InterestsThe Karakikes Lab aims to uncover fundamental new insights into the molecular mechanisms and functional consequences of pathogenic mutations associated with familial cardiovascular diseases.
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Hemamala Karunadasa
J.G. Jackson and C.J. Wood Professor of Chemistry and Senior Fellow at the Precourt Institute for Energy and Professor, by courtesy, of Materials Science and Engineering
BioProfessor Hema Karunadasa works with colleagues in materials science, earth science, and applied physics to drive the discovery of new materials with applications in clean energy. Using the tools of synthetic chemistry, her group designs materials that couple the structural tunability of organic molecules with the diverse electronic and optical properties of extended inorganic solids. This research targets materials such as sorbents for capturing environmental pollutants, phosphors for solid-state lighting, and absorbers for solar cells.
Hemamala Karunadasa studied chemistry and materials science at Princeton University (A.B. with high honors 2003; Certificate in Materials Science and Engineering 2003), where her undergraduate thesis project with Professor Robert J. Cava examined geometric magnetic frustration in metal oxides. She moved from solid-state chemistry to solution-state chemistry for her doctoral studies in inorganic chemistry at the University of California, Berkeley (Ph.D. 2009) with Professor Jeffrey R. Long. Her thesis focused on heavy atom building units for magnetic molecules and molecular catalysts for generating hydrogen from water. She continued to study molecular electrocatalysts for water splitting during postdoctoral research with Berkeley Professors Christopher J. Chang and Jeffrey R. Long at the Lawrence Berkeley National Lab. She further explored molecular catalysts for hydrocarbon oxidation as a postdoc at the California Institute of Technology with Professor Harry B. Gray. She joined the Stanford Chemistry Department faculty in September 2012. Her research explores solution-state routes to new solid-state materials.
Professor Karunadasa’s lab at Stanford takes a molecular approach to extended solids. Lab members gain expertise in solution- and solid-state synthetic techniques and structure determination through powder- and single-crystal x-ray diffraction. Lab tools also include a host of spectroscopic and electrochemical probes, imaging methods, and film deposition techniques. Group members further characterize their materials under extreme environments and in operating devices to tune new materials for diverse applications in renewable energy.
Please visit the lab website for more details and recent news. -
Maya M. Kasowski
Assistant Professor of Pathology, of Medicine (Pulmonary, Allergy and Critical Care Medicine) and, by courtesy, of Genetics
BioI am a clinical pathologist and assistant professor in the Departments of Medicine, Pathology, and Genetics (by courtesy) at Stanford. I completed my MD-PhD training at Yale University and my residency training and a post-doctoral fellowship in the Department of Genetics at Stanford University. My experiences as a clinical pathologist and genome scientist have made me passionate about applying cutting-edge technologies to primary patient specimens in order to characterize disease pathologies at the molecular level. The core focus of my lab is to study the mechanisms by which genetic variants influence the risk of disease through effects on intermediate molecular phenotypes.
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Riitta Katila
W.M. Keck Professor and Professor of Management Science and Engineering
Current Research and Scholarly InterestsThe question that drives Prof. Katila's research is how technology-based firms with significant resources can stay innovative. Her work lies at the intersection of the fields of technology, innovation, and strategy and focuses on strategies that enable organizations to discover, develop and commercialize technologies. She combines theory with longitudinal large-sample data (e.g., robotics, biomedical, platform and multi-industry datasets), background fieldwork, and state-of-the-art quantitative methods. The ultimate objective is to understand what makes technology-based firms successful.
To answer this question, Prof. Katila conducts two interrelated streams of research. She studies (1) strategies that help firms leverage their existing resources (leverage stream), and (2) strategies through which firms can acquire new resources (acquisition stream) to create innovation. Her early contributions were firm centric while recent contributions focus on innovation in the context of competitive interaction and ecosystems.
Professor Katila's work has appeared in the Academy of Management Journal, Administrative Science Quarterly, Organization Science, Strategic Entrepreneurship Journal, Strategy Science, Strategic Management Journal, Research Policy and other outlets. In her work, supported by the National Science Foundation, Katila examines how firms create new products successfully. Focusing on the robotics and medical device industries, she investigates how different search approaches, such as the exploitation of existing knowledge and the exploration for new knowledge, influence the kinds of new products that technology-intensive firms introduce. -
Laurence Katznelson, MD
Professor of Neurosurgery, Emeritus
Current Research and Scholarly InterestsDr. Katznelson is an internationally known neuroendocrinologist and clinical researcher, with research expertise in the diagnosis and management of hypopituitarism, the effects of hormones on neurocognitive function, and the development of therapeutics for acromegaly and Cushings syndrome, and neuroendocrine tumors. Dr. Katznelson is the medical director of the multidisciplinary Stanford Pituitary Center, a program geared for patient management, clinical research and patient education
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Mark A. Kay, M.D., Ph.D.
Dennis Farrey Family Professor of Pediatrics, and Professor of Genetics
Current Research and Scholarly InterestsMark A. Kay, M.D., Ph.D. Director of the Program in Human Gene Therapy and Professor in the Departments of Pediatrics and Genetics. Respected worldwide for his work in gene therapy for hemophilia, Dr. Kay and his laboratory focus on establishing the scientific principles and developing the technologies needed for achieving persistent and therapeutic levels of gene expression in vivo. The major disease models are hemophilia, hepatitis C, and hepatitis B viral infections.
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Electron Kebebew, MD, FACS
Harry A. Oberhelman, Jr. and Mark L. Welton Professor
Current Research and Scholarly InterestsDr. Kebebew’s translational and clinical investigations have three main scientific goals: 1) to develop effective therapies for fatal, rare and neglected endocrine cancers, 2) to identify new methods, strategies and technologies for improving the diagnosis and treatment of endocrine neoplasms and the prognostication of endocrine cancers, and 3) to develop methods for precision treatment of endocrine tumors.
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Corey Keller, MD, PhD
Associate Professor of Psychiatry and Behavioral Sciences (Public Mental Health and Population Sciences)
Current Research and Scholarly InterestsThe goal of my lab is to understand the fundamental principles of human brain plasticity and build trans-diagnostic real-time monitoring platforms for personalized neurotherapeutics.
We use an array of neuroscience methods to better understand the basic principles of how to create change in brain circuits. We use this knowledge to develop more effective treatment strategies for depression and other psychiatric disorders. -
Kevin Kelley
Assistant Professor of Psychiatry and Behavioral Sciences (General Psychiatry and Psychology)
BioAs a neuroscientist and psychiatrist, I am motivated by how little we understand about the pathophysiology of psychiatric disorders and hope that further knowledge will help to alleviate the ongoing distress of many of our patients. My research program leverages computational genomics, human brain cellular models, and molecular neuroscience techniques to understand the cellular and molecular mechanisms of human brain development and how dysfunction in these processes lead to psychiatric disorders.
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Monroe Kennedy III
Assistant Professor of Mechanical Engineering and, by courtesy, of Computer Science
Current Research and Scholarly InterestsMy research focus is to develop technology that improves everyday life by anticipating and acting on the needs of human counterparts. My research can be divided into the following sub-categories: robotic assistants, connected devices and intelligent wearables. My Assistive Robotics and Manipulation lab focuses heavily on both the analytical and experimental components of assistive technology design.
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Thomas Kenny
Senior Associate Dean for Education and Student Affairs and Richard W. Weiland Professor in the School of Engineering
BioKenny's group is researching fundamental issues and applications of micromechanical structures. These devices are usually fabricated from silicon wafers using integrated circuit fabrication tools. Using these techniques, the group builds sensitive accelerometers, infrared detectors, and force-sensing cantilevers. This research has many applications, including integrated packaging, inertial navigation, fundamental force measurements, experiments on bio-molecules, device cooling, bio-analytical instruments, and small robots. Because this research field is multidisciplinary in nature, work in this group is characterized by strong collaborations with other departments, as well as with local industry.
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Oussama Khatib
Weichai Professor and Professor, by courtesy, of Electrical Engineering
BioRobotics research on novel control architectures, algorithms, sensing, and human-friendly designs for advanced capabilities in complex environments. With a focus on enabling robots to interact cooperatively and safely with humans and the physical world, these studies bring understanding of human movements for therapy, athletic training, and performance enhancement. Our work on understanding human cognitive task representation and physical skills is enabling transfer for increased robot autonomy. With these core capabilities, we are exploring applications in healthcare and wellness, industry and service, farms and smart cities, and dangerous and unreachable settings -- deep in oceans, mines, and space.
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Paul A. Khavari, MD, PhD
Carl J. Herzog Professor of Dermatology in the School of Medicine
Current Research and Scholarly InterestsWe work in epithelial tissue as a model system to study stem cell biology, cancer and new molecular therapeutics. Epithelia cover external and internal body surfaces and undergo constant self-renewal while responding to diverse environmental stimuli. Epithelial homeostasis precisely balances stem cell-sustained proliferation and differentiation-associated cell death, a balance which is lost in many human diseases, including cancer, 90% of which arise in epithelial tissues.
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Chaitan Khosla
Wells H. Rauser and Harold M. Petiprin Professor and Professor of Chemistry and, by courtesy, of Biochemistry
Current Research and Scholarly InterestsResearch in this laboratory focuses on problems where deep insights into enzymology and metabolism can be harnessed to improve human health.
For the past two decades, we have studied and engineered enzymatic assembly lines called polyketide synthases that catalyze the biosynthesis of structurally complex and medicinally fascinating antibiotics in bacteria. An example of such an assembly line is found in the erythromycin biosynthetic pathway. Our current focus is on understanding the structure and mechanism of this polyketide synthase. At the same time, we are developing methods to decode the vast and growing number of orphan polyketide assembly lines in the sequence databases.
For more than a decade, we have also investigated the pathogenesis of celiac disease, an autoimmune disorder of the small intestine, with the goal of discovering therapies and related management tools for this widespread but overlooked disease. Ongoing efforts focus on understanding the pivotal role of transglutaminase 2 in triggering the inflammatory response to dietary gluten in the celiac intestine. -
Butrus Khuri-Yakub
Professor (Research) of Electrical Engineering, Emeritus
BioButrus (Pierre) T. Khuri-Yakub is a Professor of Electrical Engineering at Stanford University. He received the BS degree from the American University of Beirut, the MS degree from Dartmouth College, and the Ph.D. degree from Stanford University, all in electrical engineering. His current research interests include medical ultrasound imaging and therapy, ultrasound neuro-stimulation, chemical/biological sensors, gas flow and energy flow sensing, micromachined ultrasonic transducers, and ultrasonic fluid ejectors. He has authored over 600 publications and has been principal inventor or co-inventor of 107 US and international issued patents. He was awarded the Medal of the City of Bordeaux in 1983 for his contributions to Nondestructive Evaluation, the Distinguished Advisor Award of the School of Engineering at Stanford University in 1987, the Distinguished Lecturer Award of the IEEE UFFC society in 1999, a Stanford University Outstanding Inventor Award in 2004, Distinguished Alumnus Award of the School of Engineering of the American University of Beirut in 2005, Stanford Biodesign Certificate of Appreciation for commitment to educate, mentor and inspire Biodesgin Fellows, 2011, and 2011 recipient of IEEE Rayleigh award.
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Mathew Kiang
Assistant Professor of Epidemiology and Population Health (Epidemiology)
BioI am an assistant professor in the Department of Epidemiology and Population Health. My research lies at the intersection of computational epidemiology and social epidemiology. Methodologically, my work revolves around combining disparate data sources in epidemiologically meaningful ways. For example, I work with individual-level, non-health data (e.g., GPS, accelerometer, and other sensor data from smartphones), traditional health data (e.g., survey, health systems, or death certificate data), and third-party data (e.g., cellphone providers or ad-tech data). To do this, I use a variety of methods such as joint Bayesian spatial models, traditional epidemiologic models, dynamical models, microsimulation, and demographic analysis. Substantively, my work focuses on socioeconomic and racial/ethnic inequities, substance use, and child health. For example, recently, my work has examined inequities in COVID-19 vaccine distribution, cause-specific excess mortality, and drug poisonings. Other work has examined the impact of changing vaccination rates on the reemergence of infectious diseases and the prevalence of parental death among children.
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Juyong Brian Kim
Assistant Professor of Medicine (Cardiovascular Medicine)
Current Research and Scholarly InterestsThe lifetime risk of developing cardiovascular disease (CVD) is determined by the genetic makeup and exposure to modifiable risk factors. The Cardiovascular Link to Environmental ActioN (CLEAN) Lab is interested in understanding how various environmental pollutants (eg. tobacco, e-cigarettes, air pollution and wildfire) interact with genes to affect the transcriptome, epigenome, and eventually disease phenotype of CVD. The current focus is to investigate how different toxic exposures can adversely remodel the vascular wall leading to increased cardiac events. We intersect human genomic discoveries with animal models of disease, in-vitro and in-vivo systems of exposure, single-cell sequencing technologies to solve these questions. Additionally, we collaborate with various members of the Stanford community to develop biomarkers that will aid with detection and prognosis of CVD. We are passionate about the need to reduce the environmental effects on health through strong advocacy and outreach.
(http://kimlab.stanford.edu) -
Peter S. Kim
Virginia and D. K. Ludwig Professor of Biochemistry
Current Research and Scholarly InterestsOur research focuses on developing new strategies for vaccine creation. We also aim to generate vaccines targeting infectious agents that have eluded efforts to date. We integrate experimental approaches with protein language models to guide artificial evolution and enable efficient antibody and protein engineering. Our interdisciplinary approach aims to address critical global health challenges.
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Seung K. Kim M.D., Ph.D.
KM Mulberry Professor, Professor of Developmental Biology, of Medicine (Endocrinology) and, by courtesy, of Pediatrics (Endocrinology)
On Partial Leave from 09/16/2025 To 03/31/2026Current Research and Scholarly InterestsWe study the development of pancreatic islet cells using molecular, embryologic and genetic methods in several model systems, including mice, pigs, human pancreas, embryonic stem cells, and Drosophila. Our work suggests that critical factors required for islet development are also needed to maintain essential functions of the mature islet. These approaches have informed efforts to generate replacement islets from renewable sources for diabetes.
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Sun Kim, M.D. M.S.
Associate Professor of Medicine (Endocrinology)
Current Research and Scholarly InterestsWe are interested in studying the pathophysiological processes that contribute to glucose intolerance and type 2 diabetes mellitus. My current research focuses on characterizing pancreatic beta-cell function in populations with significant insulin resistance and vulnerability to developing diabetes: individuals with schizophrenia, morbid obesity, and history of gestational diabetes.
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Yong Yean Kim
Assistant Professor of Pediatrics ( Hematology & Oncology)
BioOur lab is interested in translational science to bring new therapies to clinical trials. In particular, we are interested in pediatric sarcomas which have not had advancement in clinical treatment for decades. Current projects in the lab focus on understanding of the biology of fusion transcription factor PAX3::FOXO1 which is the driver mutation in fusion positive rhabdomyosarcoma. PAX3::FOXO1 is a powerful oncogenic transcription factor which rewires the transcriptional organization to lock the cancer cell in the proliferative state. Since transcription factors including PAX3::FOXO1 are difficult to target using small molecules, we aim to understand how PAX3::FOXO1 is regulated and targeting the regulators of PAX3::FOXO1. By understanding and targeting the regulation of PAX3::FOXO1, we hope to bring new therapies for fusion positive rhabdomyosarcoma. Additionally, these regulatory mechanisms may also be active in other transcription driven cancers such as the EWSR1::FLI1 driven Ewings Sarcoma.
Our lab is also interested in exploring the epigenetic landscape of pediatric solid tumors and trying to understand how dysregulation in the epigenome drives oncogenesis. We utilize various CRISPR mediated genetic techniques to interrogate the regulators of epigenome focusing on the histone lysine demethylases (KDMs). KDMs are an understudied group of epigenetic regulators which can be targeted for therapeutic effect. We explore the role of KDMs in pediatric solid tumors and hope to identify potential targets for drug development. -
David Kingsley
Rudy J. and Daphne Donohue Munzer Professor in the School of Medicine
Current Research and Scholarly InterestsWe use mice, stickleback fish, and humans to study the molecular basis of evolution and common diseases. By combining genetics and genomics, we have identified key DNA changes that control bone formation, limb patterning, hair color, brain evolution, and susceptibility to arthritis, schizophrenia, and bipolar disorder. We find that the same genetic mechanisms are often used repeatedly in nature, providing new insights into the origin of key traits in many different species, including ourselves.
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Amanda Kirane, MD, PhD, FACS, FSSO
Associate Professor of Surgery (General Surgery)
BioDr. Kirane is a fellowship-trained, board-certified specialist in complex general surgical oncology. She is an Assistant Professor in the Department of Surgery, Section of Surgical Oncology, at Stanford University School of Medicine. Dr. Kirane serves as Director of Cutaneous Surgical Oncology at the Stanford Cancer Center and her clinical practice focuses on the diagnosis and treatment of melanoma and other skin cancers. She partners closely with patients and families to provide the most effective treatment approach possible. For each patient, she tailors an evidence-based, personalized care plan that is innovative, comprehensive, and compassionate.
Dr. Kirane is Principal Investigator of multiple studies in melanoma and mechanisms of resistance to immunotherapy, with focus on myeloid biology. Her current interests include immune response and novel therapies in melanoma, predictive modeling of patient responses using organoid technology, and translational biomarker development. She has led research into immune therapy for earlier stage melanoma using regionally directed therapy to augment immune response in melanoma and trials in surgical care in melanoma.
The National Institutes of Health, American Society of Clinical Oncology, the Melanoma Research Alliance, and others have funded her research. She has co-authored articles on her discoveries in the Journal of Clinical Investigation, Nature Communications, Nature Genetics, Cancer Research, Journal of Surgical Oncology, Annals of Surgery, Annals of Surgical Oncology, and elsewhere. Topics include intratumoral therapy, biomarker development, macrophage biology in melanoma and immunotheraputic resistance, and patient-derived organoid modeling. Dr. Kirane has presented updates on the management of melanoma and other cancers to her peers at meetings of the American College of Surgeons, Society of Surgical Oncology, and Society for Immunotherapy in Cancer.
Dr. Kirane has earned awards for her achievements in clinical care, research, and scholarship. The Society for Immunotherapy of Cancer, Society of Surgical Oncology, Memorial Sloan Kettering Cancer Center, and other prestigious organizations have honored her work. She is a fellow of the American College of Surgeons (FACS) and Society of Surgical Oncology (FSSO). She is a member of the Society for Immunotherapy of Cancer, American Association of Cancer Research, Society for Melanoma Research, Connective Tissue Oncology Society, Association of Academic Surgeons, and Association of Women Surgeons.
She volunteers her time and expertise on behalf of the Melanoma Research Foundation, members of her community in need, STEM programs for girls, and other initiatives. She also is fellowship trained in Physician Wellness and Wellbeing and teaches somatic technique, mindfulness-based stress reduction, meditation, and breathwork. -
Varvara A. Kirchner
Associate Professor of Surgery (Abdominal Transplantation) and, by courtesy, of Pediatrics
BioDr. Kirchner completed her medical school, surgical residency and multi-organ transplant fellowship in adult and pediatric liver, pancreas, kidney transplantation and total pancreatectomy with islet auto-transplantation at the University of Minnesota. She underwent further training in living donor liver transplantation and hepatobiliary surgery at the Asan Medical Center, Seoul, South Korea. Her clinical practice involves living and deceased donor liver and kidney transplantation in adult and pediatric patients as well as total pancreatectomy with islet auto-transplantation for patients with chronic and acute recurrent pancreatitis. She currently serves as Surgical Director of the Islet Cell Auto-Transplant at Stanford Children’s and Associate Director of the Living Donor Liver Transplant Program at the Division of Abdominal Transplantation. Dr. Kirchner’s research focuses on the biology of aging, cellular and solid organ transplantation. Her specific interests are in auto-islet transplantation, iPSC-derived hepatocyte therapies and liver regeneration. Dr. Kirchner's research on the impact of donor age on generation of iPSC-derived hepatocyte-like cells is supported by the NIA K08 Faculty Development Award. She is an active member of the American Society of Transplant Surgeons and the International Liver Transplantation Society.
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Karla Kirkegaard
Violetta L. Horton Professor and Professor of Microbiology and Immunology
Current Research and Scholarly InterestsThe biochemistry of RNA-dependent RNA polymerase function, the cell biology of the membrane rearrangements induced by positive-strand RNA virus infection of human cells, and the genetics of RNA viruses, which, with their high error rates, live at the brink of error catastrophe, are investigated in the Kirkegaard laboratory.
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Peter K. Kitanidis
Professor of Civil and Environmental Engineering
BioKitanidis develops methods for the solution of interpolation and inverse problems utilizing observations and mathematical models of flow and transport. He studies dilution and mixing of soluble substances in heterogeneous geologic formations, issues of scale in mass transport in heterogeneous porous media, and techniques to speed up the decay of pollutants in situ. He also develops methods for hydrologic forecasting and the optimization of sampling and control strategies.
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Jonathan D Klein
Marron and Mary Elizabeth Kendrick Professor of Pediatrics
Current Research and Scholarly InterestsMy studies address:
1. Confidentiality and Access to Care studies of confidential time during well-visits and policy analyses addressing quality of care and health systems capacity for adolescents and young adults in the US and globally; and,
2, Tobacco, nicotine, and second-hand smoke studies of primary care counseling to reduce nicotine addiction in adolescents and programs to engage medical specialty groups in secondhand smoke clinical and policy interventions. -
Matthias Kling
Director, PULSE Institute, Professor of Photon Science and, by courtesy, of Applied Physics
Current Research and Scholarly InterestsKling's research focuses on ultrafast electronics and nanophotonics employing ultrashort flashes of light from table-top and free-electron laser sources.
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Joshua W. Knowles
Associate Professor of Medicine (Cardiovascular Medicine)
Current Research and Scholarly InterestsGenetic basis of coronary disease
Genetic basis of insulin resistance
Familial Hypercholesterolemia (FH) -
Juliet Klasing Knowles
Assistant Professor of Neurology and Neurological Sciences (Pediatric Neurology) and of Pediatrics
Current Research and Scholarly InterestsThe Knowles lab studies how white matter structure changes in different forms of epilepsy, and how aberrant white matter structure, in turn, shapes neuronal network function. In mouse models, we use a variety of innovative tools including neurophysiology, quantitative EEG, behavior, histological measures of white matter structure and MR imaging. We also conduct clinical research to study white matter abnormalities in children with epilepsy.
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Susan Knox
Associate Professor of Radiation Oncology, Emerita
Current Research and Scholarly InterestsOur interests include 1) study of the effect of radiation on regulatory cell subpopulations and co-stimulatory molecules, 2) use of radiation as an immune modulator for optimization of transplant regimens, 3) the role of radiation in tumor vaccine strategies, 4) study of new radiosensitizers and radioprotectors, and 5) discovery of new targeted therapies for the treatment of solid tumors.
