Vice Provost and Dean of Research
Showing 521-540 of 2,473 Results
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David Donoho
Anne T. and Robert M. Bass Professor in the School of Humanities and Sciences
BioDavid Donoho is a mathematician who has made fundamental contributions to theoretical and computational statistics, as well as to signal processing and harmonic analysis. His algorithms have contributed significantly to our understanding of the maximum entropy principle, of the structure of robust procedures, and of sparse data description.
Research Statement:
My theoretical research interests have focused on the mathematics of statistical inference and on theoretical questions arising in applying harmonic analysis to various applied problems. My applied research interests have ranged from data visualization to various problems in scientific signal processing, image processing, and inverse problems. -
Les Dorfman, MD
Professor of Neurology and Neurological Sciences, Emeritus
Current Research and Scholarly InterestsClinical electrophysiology of the peripheral and central nervous systems, including nerve conduction velocity; electromyography (EMG); and visual, auditory and somatosensory evoked potentials. Multiple sclerosis (MS) diagnosis and treatment. Neurological education.
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Anthony G. Doufas, M.D., Ph.D.
Professor of Anesthesiology, Perioperative and Pain Medicine (MSD)
Current Research and Scholarly InterestsMy research focuses on the relationship between sleep abnormalities and pain behavior and opioid pharmacology in the postoperative, as well as chronic pain setting. More specifically, I am interested in delineating the effect of the different components of sleep-diosordered breathing, like nocturnal recurrent hypoxemia and sleep fragmentation on pain behavior in the acute and/or chronic care setting.
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Leora Dresselhaus-Marais
Assistant Professor of Materials Science and Engineering, of Photon Science and, by courtesy, of Mechanical Engineering
Current Research and Scholarly InterestsMy group develops new methods to update old processes in metals manufacturing
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Ron Dror
Cheriton Family Professor and Professor, by courtesy, of Structural Biology and of Molecular & Cellular Physiology
Current Research and Scholarly InterestsMy lab’s research focuses on computational biology, with an emphasis on 3D molecular structure. We combine two approaches: (1) Bottom-up: given the basic physics governing atomic interactions, use simulations to predict molecular behavior; (2) Top-down: given experimental data, use machine learning to predict molecular structures and properties. We collaborate closely with experimentalists and apply our methods to the discovery of safer, more effective drugs.
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David Drover
Professor of Anesthesiology, Perioperative and Pain Medicine (MSD), Emeritus
Current Research and Scholarly InterestsField of clinical pharmacology. This involves analysis of what the body does to a drug (pharmacokinetics) and how exactly a specific drug affects the body (pharmacodynamics). His research starts at the level of new drug development with detailed analysis of the pharmacokinetics and pharmacodynamics of a medication.
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Shaul Druckmann
Associate Professor of Neurobiology, of Psychiatry and Behavioral Sciences and, by courtesy, of Electrical Engineering
Current Research and Scholarly InterestsOur research goal is to understand how dynamics in neuronal circuits relate and constrain the representation of information and computations upon it. We adopt three synergistic strategies: First, we analyze neural circuit population recordings to better understand the relation between neural dynamics and behavior, Second, we theoretically explore the types of dynamics that could be associated with particular network computations. Third, we analyze the structural properties of neural circuits.
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Justin Du Bois
Henry Dreyfus Professor of Chemistry and Professor, by courtesy, of Chemical and Systems Biology
BioThe Du Bois lab is heavily invested in exploring voltage-gated ion channel function and physiology and the underlying role of specific channels in human pathologies, particularly nociception, epilepsy, and neurodevelopmental disorders. With expertise in chemical synthesis, we have access to a collection of exceptional natural products—tetrodotoxin, saxitoxin, gonyautoxin, batrachotoxin, veratridine, antillatoxin, to name a few—that act as selective modulators of sodium ion channels (NaVs). In addition, we have developed novel molecules as inhibitors and agonists of specific voltage-gated chloride (ClCs) and calcium (CaVs) channel isoforms. As a lab, we are uniquely positioned to advance high-precision chemical tools to interrogate underlying biochemical mechanisms of electrogenesis. Our work in this arena is guided by a number of questions related to the basic functioning of voltage-gated channels in neuronal cells and glia that include: 1) what is the rate at which channels are being made and degraded and is the rate of channel turnover context dependent (i.e., is protein turnover affected by increased neuronal activity, nerve cell damage, etc.); 2) to what extent is channel expression and cellular distribution affected by external factors (pH, inflammatory modulators, injury); 3) how do post-translational protein modifications influence channel function and how are such modifications altered in response to external factors; 4) how do neighboring glia influence channel expression and ion gating. Answers to these types of questions will provide a deeper understanding of the molecular mechanisms by which neuronal cells and tissue respond to external stimuli, stress, and injury. We benefit from the strong interest of others in our work and multiple collaborators at Stanford and at other institutions.
Ion channel function and physiology. We wish to understand the role of individual subtypes of voltage-gated sodium, chloride, and calcium channels in neuronal signaling and how structural changes (i.e., point mutations, post-translational modifications, partner proteins) alter channel function. Our interests include the design, development, and application of chemogenetic technologies for targeting individual channel subtypes and allosteric modulators of select channel isoforms. Our work aims to inform efforts in translational research, as voltage-gated ion channel dysregulation and malfunction underlie a wide range of human diseases and disorders.
Natural products synthesis. We are interested in developing efficient and flexible synthetic routes to natural products that serve as ‘lead’ compounds for advancing high precision pharmacological tools. Most of the targets we are interested in obtaining are not available in sufficient quantities from natural sources, thus necessitating de novo preparation. To streamline the assembly process of these complex molecules, we are challenged to develop, in parallel, new tactics and chemical methods that facilitate C–C, C–N, and C–O bond formation.
Toxin ‘sponge’ proteins. A longstanding collaboration with the Minor lab at UCSF has focused on understanding how certain organisms that ingest dietary toxins such as saxitoxin, tetrodotoxin, and batrachotoxin survive their poisonous effects. This work has resulted in the elucidation of the structures of novel paralytic shellfish-binding proteins (so-called saxiphilins) and the toxin ‘binding code’. Studies are ongoing to integrate saxiphilins into a diagnostic device for measuring toxin concentrations in shellfish and to advance an engineered toxin-binding protein as a countermeasure for paralytic shellfish poisoning. -
Alfredo Dubra, PhD
Professor of Ophthalmology
Current Research and Scholarly InterestsOur lab seeks to help the early diagnosing and monitoring progression of ocular, vascular, neurodegenerative and systemic diseases through novel non-invasive optical ophthalmic imaging. We pursue this goal through a multidisciplinary approach that integrates optics, computer science, vision science, electrical engineering and other engineering disciplines.
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John Duchi
Associate Professor of Statistics, of Electrical Engineering and, by courtesy, of Computer Science
Current Research and Scholarly InterestsMy work spans statistical learning, optimization, information theory, and computation, with a few driving goals: 1. To discover statistical learning procedures that optimally trade between real-world resources while maintaining statistical efficiency. 2. To build efficient large-scale optimization methods that move beyond bespoke solutions to methods that robustly work. 3. To develop tools to assess and guarantee the validity of---and confidence we should have in---machine-learned systems.
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Mark Duggan
Wayne and Jodi Cooperman Professor and Senior Fellow at the Stanford Institute for Economic Policy Research
BioMark Duggan is a Professor of Economics at Stanford University and a Research Associate at the National Bureau of Economic Research. He received his B.S. and M.S. degrees in Electrical Engineering at M.I.T. in 1992 and 1994, respectively, and his Ph.D. in Economics from Harvard University in 1999. He currently is a Co-Editor at the American Economic Journal: Economic Policy and was previously a Co-Editor at the Journal of Public Economics. Before arriving to Stanford in the summer of 2014, Duggan served on the faculty at the University of Pennsylvania's Wharton School (2011-14), the University of Maryland's Economics Department (2003-11), and the University of Chicago's Economics Department (1999-2003).
Professor Duggan's research focuses primarily on the effect of government expenditure programs such as Social Security, Medicare, and Medicaid on the behavior of individuals and firms. Some of his more recent research is exploring the effect of federal disability programs on the labor market and of changes to the Medicare and Medicaid programs on the cost and quality of health care. He is also estimating the effect of patent reforms in India on the price and utilization of pharmaceutical treatments. His research has been published in leading academic journals including the American Economic Review, the Journal of Political Economy, and the Quarterly Journal of Economics and has been featured in outlets such as The Economist, the New York Times, and the Wall Street Journal.
Professor Duggan was the 2010 recipient of the ASHEcon Medal, which is awarded every two years by the American Society of Health Economists to the economist aged 40 and under in the U.S. who has made the most significant contributions to the field of health economics. Along with his co-author Fiona Scott Morton, he received the National Institute for Health Care Management's 2011 Health Care Research Award for their work on Medicare Part D. He was a Fellow of the Alfred P. Sloan Foundation from 2004 to 2006 and a Visiting Fellow at the Brookings Institution from 2006 to 2007. His research has been funded by the National Science Foundation, the National Institutes of Health, the Social Security Administration, and the Robert Wood Johnson Foundation. Duggan served from 2009 to 2010 as the Senior Economist for Health Care Policy at the White House Council of Economic Advisers and has also been an Expert Witness for the U.S. Department of Justice. -
Rob Dunbar
W.M. Keck Professor in the School of Earth Sciences, Professor of Oceans, Senior Fellow at the Woods Institute for the Environment and Professor, by courtesy, of Earth System Science
Current Research and Scholarly InterestsOcean processes, biogeochemistry, climatology/paleoclimatology, isotopic chemistry, ocean policy
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Laramie Duncan
Assistant Professor of Psychiatry and Behavioral Sciences (Major Laboratories and Clinical Translational Neurosciences Incubator)
Current Research and Scholarly InterestsOur work is at the intersection of statistical genetics, psychiatry, and neuroscience. We use massive datasets and primarily computational approaches to identify mechanisms contributing to mental health problems like schizophrenia and depression. The overall goal of the lab is to discover fundamental information about psychiatric disorders, and ultimately to build more effective approaches to classification, prevention, and treatment.
