Bio-X
Showing 451-500 of 1,076 Results
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Gianluca Iaccarino
Professor of Mechanical Engineering
Current Research and Scholarly InterestsComputing and data for energy, health and engineering
Challenges in energy sciences, green technology, transportation, and in general, engineering design and prototyping are routinely tackled using numerical simulations and physical testing. Computations barely feasible two decades ago on the largest available supercomputers, have now become routine using turnkey commercial software running on a laptop. Demands on the analysis of new engineering systems are becoming more complex and multidisciplinary in nature, but exascale-ready computers are on the horizon. What will be the next frontier? Can we channel this enormous power into an increased ability to simulate and, ultimately, to predict, design and control? In my opinion two roadblocks loom ahead: the development of credible models for increasingly complex multi-disciplinary engineering applications and the design of algorithms and computational strategies to cope with real-world uncertainty.
My research objective is to pursue concerted innovations in physical modeling, numerical analysis, data fusion, probabilistic methods, optimization and scientific computing to fundamentally change our present approach to engineering simulations relevant to broad areas of fluid mechanics, transport phenomena and energy systems. The key realization is that computational engineering has largely ignored natural variability, lack of knowledge and randomness, targeting an idealized deterministic world. Embracing stochastic scientific computing and data/algorithms fusion will enable us to minimize the impact of uncertainties by designing control and optimization strategies that are robust and adaptive. This goal can only be accomplished by developing innovative computational algorithms and new, physics-based models that explicitly represent the effect of limited knowledge on the quantity of interest.
Multidisciplinary Teaching
I consider the classical boundaries between disciplines outdated and counterproductive in seeking innovative solutions to real-world problems. The design of wind turbines, biomedical devices, jet engines, electronic units, and almost every other engineering system requires the analysis of their flow, thermal, and structural characteristics to ensure optimal performance and safety. The continuing growth of computer power and the emergence of general-purpose engineering software has fostered the use of computational analysis as a complement to experimental testing in multiphysics settings. Virtual prototyping is a staple of modern engineering practice! I have designed a new undergraduate course as an introduction to Computational Engineering, covering theory and practice across multidisciplanary applications. The emphasis is on geometry modeling, mesh generation, solution strategy and post-processing for diverse applications. Using classical flow/thermal/structural problems, the course develops the essential concepts of Verification and Validation for engineering simulations, providing the basis for assessing the accuracy of the results. -
Andrei Iagaru
Professor of Radiology (Nuclear Medicine)
Current Research and Scholarly InterestsCurrent research projects include:
1) PET/MRI and PET/CT for Early Cancer Detection
2) Targeted Radionuclide Therapy
3) Clinical Translation of Novel PET Radiopharmaceuticals; -
John P.A. Ioannidis
Professor of Medicine (Stanford Prevention Research), of Epidemiology and Population Health and, by courtesy, of Biomedical Data Science
Current Research and Scholarly InterestsMeta-research
Evidence-based medicine
Clinical and molecular epidemiology
Human genome epidemiology
Research design
Reporting of research
Empirical evaluation of bias in research
Randomized trials
Statistical methods and modeling
Meta-analysis and large-scale evidence
Prognosis, predictive, personalized, precision medicine and health
Sociology of science -
Haruka Itakura, MD, PhD
Assistant Professor of Medicine (Oncology)
BioDr. Haruka Itakura is an Assistant Professor of Medicine (Oncology) in the Stanford University School of Medicine, a data scientist, and a practicing breast medical oncologist at the Stanford Women’s Cancer Center. She is board-certified in Oncology, Clinical Informatics, Hematology, and Internal Medicine. Her research mission is to drive medical advances at the intersection of cancer and data science, applying state-of-the-art machine learning/artificial intelligence techniques to extract clinically actionable knowledge from heterogeneous multi-scale cancer data to improve patient outcomes. Her ongoing research to develop robust methodologies and apply cutting-edge techniques to analyze complex cancer big data was catapulted by an NIH K01 Career Development Award in Biomedical Big Data Science after obtaining a PhD in Biomedical Informatics at Stanford University. Her cancer research focuses on extracting radiomic (pixel-level quantitative imaging) features of tumors from medical imaging studies and applying machine learning frameworks, including radiogenomic approaches, for the integrative analysis of heterogeneous, multi-omic (e.g., radiomic, genomic, transcriptomic) data to accelerate discoveries in cancer diagnostics and therapeutics. Her current projects include prediction modeling of survival, treatment response, recurrence, and CNS metastasis in different cancer subtypes; detection of occult invasive breast cancer; and identification of novel therapeutic targets. Her ultimate goal is to be able to translate her research findings back to the clinical setting for the benefit of patients with difficult-to-treat cancers.
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Peter K. Jackson
Professor of Microbiology and Immunology (Baxter Labs) and of Pathology
Current Research and Scholarly InterestsCell cycle and cyclin control of DNA replication .
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Charlotte D. Jacobs M.D.
Drs. Ben and A. Jess Shenson Professor in the School of Medicine, Emerita
Current Research and Scholarly InterestsClinical Interests: general oncology, sarcomas. Research Interests: clinical trials in solid tumors.
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Christine Jacobs-Wagner
Dennis Cunningham Professor, Professor of Biology and of Microbiology and Immunology
BioChristine Jacobs-Wagner is a Dennis Cunningham Professor in the Department of Biology and the ChEM-H Institute at Stanford University. She is interested in understanding the fundamental mechanisms and principles by which cells, and, in particular, bacterial cells, are able to multiple. She received her PhD in Biochemistry in 1996 from the University of Liège, Belgium where she unraveled a molecular mechanism by which some bacterial pathogens sense and respond to antibiotics attack to achieve resistance. For this work, she received multiple awards including the 1997 GE & Science Prize for Young Life Scientists. During her postdoctoral work at Stanford Medical School, she demonstrated that bacteria can localize regulatory proteins to specific intracellular regions to control signal transduction and the cell cycle, uncovering a new, unsuspected level of bacterial regulation.
She started her own lab at Yale University in 2001. Over the years, her group made major contributions in the emerging field of bacterial cell biology and provided key molecular insights into the temporal and spatial mechanisms involved in cell morphogenesis, cell polarization, chromosome segregation and cell cycle control. For her distinguished work, she received the Pew Scholars award from the Pew Charitable Trust, the Woman in Cell Biology Junior award from the American Society of Cell Biology and the Eli Lilly award from the American Society of Microbiology. She held the Maxine F. Singer and William H. Fleming professor chairs at Yale. She was elected to the Connecticut academy of Science, the American Academy of Microbiology and the National Academy of Sciences. She has been an investigator of the Howard Hughes Medical Institute since 2008.
Her lab moved to Stanford in 2019. Current research examines the general principles and spatiotemporal mechanisms by which bacterial cells replicate, using Caulobacter crescentus and Escherichia coli as models. Recently, the Jacobs-Wagner lab expanded their interests to the Lyme disease agent Borrelia burgdorferi, revealing unsuspected ways by which this pathogen grows and causes disease -
Prasanna Jagannathan
Associate Professor of Medicine (Infectious Diseases) and of Microbiology and Immunology
Current Research and Scholarly InterestsWe study innate immunity and immune regulation of Plasmodium Falciparum malaria in children and pregnant women. Our work focuses on understanding how malaria shapes the immune state in individuals following repeated exposure. We are also testing novel interventions to enhance protective immunity against malaria in children via large, randomized controlled trials. Our work in malaria has been based in Eastern Uganda, where malaria transmission is among the highest in the world.
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Siddhartha Jaiswal
Associate Professor of Pathology
Current Research and Scholarly InterestsWe identified a common disorder of aging called clonal hematopoiesis of indeterminate potential (CHIP). CHIP occurs due to certain somatic mutations in blood stem cells and represents a precursor state for blood cancer, but is also associated with increased risk of cardiovascular disease and death. We hope to understand more about the biology and clinical implications of CHIP using human and model system studies.
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Doug James
Professor of Computer Science and, by courtesy, of Music
Current Research and Scholarly InterestsComputer graphics & animation, physics-based sound synthesis, computational physics, haptics, reduced-order modeling
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Michelle L. James
Assistant Professor of Radiology (Molecular Imaging Program at Stanford) and of Neurology and Neurological Sciences (Neurology Research)
Current Research and Scholarly InterestsThe primary aim of my lab is to improve the diagnosis and treatment of brain diseases by developing translational molecular imaging agents for visualizing neuroimmune interactions underlying conditions such as Alzheimer’s disease, multiple sclerosis, and stroke.
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Ted Jardetzky
Professor of Structural Biology
Current Research and Scholarly InterestsThe Jardetzky laboratory is studying the structures and mechanisms of macromolecular complexes important in viral pathogenesis, allergic hypersensitivities and the regulation of cellular growth and differentiation, with an interest in uncovering novel conceptual approaches to intervening in disease processes. Ongoing research projects include studies of paramyxovirus and herpesvirus entry mechanisms, IgE-receptor structure and function and TGF-beta ligand signaling pathways.
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Daniel Jarosz
Associate Professor of Chemical and Systems Biology and of Developmental Biology
Current Research and Scholarly InterestsMy laboratory studies conformational switches in evolution, disease, and development. We focus on how molecular chaperones, proteins that help other biomolecules to fold, affect the phenotypic output of genetic variation. To do so we combine classical biochemistry and genetics with systems-level approaches. Ultimately we seek to understand how homeostatic mechanisms influence the acquisition of biological novelty and identify means of manipulating them for therapeutic and biosynthetic benefit.
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R Brooke Jeffrey
Professor of Radiology (Body Imaging), Emeritus
Current Research and Scholarly InterestsPancreatic MDCT
Thyroid ultrasound/biopsy
Virtual Colonoscopy
Imaging of appendicitis
Hepatic MDCT
Capsule ultrasound (wireless) of GI tract -
Stefanie S. Jeffrey, MD
John and Marva Warnock Professor, Emerita
Current Research and Scholarly InterestsDr. Jeffrey led the multidisciplinary team from the Schools of Medicine, Engineering, and Genome Technology Center that invented the MagSweeper, an automated device that immunomagnetically captures live circulating tumor cells (CTCs) from cancer patient blood for single cell analysis or culture. Her lab also works on microfluidic technologies for tumor cell capture, characterization, and growth - with the goal of defining individual patient response to newer biologically-based cancer therapies.
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Livnat Jerby
Assistant Professor of Genetics
Current Research and Scholarly InterestsImmune responses are highly orchestrated processes that span various interconnected regulatory modalities within and across cells. My lab develops high-throughput, quantitative, engineering-based, approaches to dissect multicellular immune dynamics at unprecedented scale, resolution, and depth, and identify new immunomodulating interventions at an accelerated pace.
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Michael Christopher Jewett
Professor of Bioengineering
BioMichael Jewett is a Professor of Bioengineering at Stanford University. He received his B.S. from UCLA and PhD from Stanford University, both in Chemical Engineering. He completed postdoctoral studies at the Center for Microbial Biotechnology in Denmark and the Harvard Medical School. Jewett was also a guest professor at the Swiss Federal Institute of Technology (ETH Zurich). His research group focuses on advancing synthetic biology research to support planet and societal health, with applications in medicine, manufacturing, sustainability, and education.
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Hanlee P. Ji
Professor of Medicine (Oncology) and, by courtesy of Electrical Engineering
Current Research and Scholarly InterestsCancer genomics and genetics, translational applications of next generation sequencing technologies, development of molecular signatures as prognostic and predictive biomarkers in oncology, primary genomic and proteomic technology development, cancer rearrangements, genome sequencing, big data analysis
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Shamit Kachru
Professor of Physics and Director, Stanford Institute for Theoretical Physics, Emeritus
Current Research and Scholarly InterestsMy current research is focused in three directions:
— Mathematical aspects of string theory (with a focus on BPS state counts, black holes, and moonshine)
— Quantum field theory approaches to condensed matter physics (with a focus on physics of non-Fermi liquids)
— Theoretical biology, with a focus on evolution and ecology -
Joseph Kahn
Professor of Electrical Engineering
BioJoseph M. Kahn is a Professor of Electrical Engineering at Stanford University. His research addresses communication and imaging through optical fibers, including modulation, detection, signal processing and spatial multiplexing. He received A.B. and Ph.D. degrees in Physics from U.C. Berkeley in 1981 and 1986. From 1987-1990, he was at AT&T Bell Laboratories, Crawford Hill Laboratory, in Holmdel, NJ. He was on the Electrical Engineering faculty at U.C. Berkeley from 1990-2003. In 2000, he co-founded StrataLight Communications, which was acquired by Opnext, Inc. in 2009. He received the National Science Foundation Presidential Young Investigator Award in 1991 and is a Fellow of the IEEE.
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A Dale Kaiser
Member, Bio-X
Current Research and Scholarly InterestsHow are genes regulated to construct a developmental program? How do signals received from other cells change the program and coordinate it for multicellular development? The approach taken by our laboratory group to answer these questions utilizes biochemistry and genetics; genetics to isolate mutants that have particular defects in development and biochemistry to determine the molecular basis of the defects. We study swarming in Myxococcus xanthus that builds fruiting bodies.
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Anusha Kalbasi, MD
Associate Professor of Radiation Oncology (Radiation Therapy)
BioDr. Kalbasi is a board-certified radiation oncologist and physician-scientist at the Stanford Cancer Institute. He is also an associate professor of radiation oncology at Stanford Medicine and a project member of the Parker Institute for Cancer Immunotherapy.
In the clinic, Dr. Kalbasi specializes in the diagnosis and treatment of solid tumors, especially sarcoma and melanoma, with a focus on bringing new treatments to patients. This focus includes using advanced techniques in radiation oncology and cancer immunotherapy.
Dr. Kalbasi's NIH-funded laboratory studies the cancer-immune interface in various therapeutic contexts, including T cell therapy, cytokine therapy and innate immune agonism. The lab has described tumor cell-, T cell- and myeloid cell-intrinsic mechanisms of resistance to therapy and approaches to overcome therapy resistance. Dr. Kalbasi is also an experienced leader of clinical trials related to immunotherapy, T cell therapy and radiation therapy.
Prior to his arrival at Stanford Health Care, Dr. Kalbasi was assistant professor of radiation oncology in the David Geffen School of Medicine at UCLA and chief of sarcoma radiotherapy at the UCLA Jonsson Comprehensive Cancer Center. During his tenure, he was named a NextGen Star by the American Association of Cancer Research in recognition for excellence in cancer research.
Dr. Kalbasi’s work has been published in leading journals including Nature, Science Translational Medicine, JAMA Oncology, Lancet Oncology, Nature Cancer and Cancer Discovery. He has served as a peer reviewer for multiple prestigious journals, including the Proceedings of the National Academy of Sciences, Cell and the Journal of Clinical Investigation. He has also presented research to his peers at the American Association for Cancer Research and the American Institute of Chemical Engineers. -
Julia Kaltschmidt
Associate Professor of Neurosurgery
Current Research and Scholarly InterestsThe lab’s primary research interest is to understand how specific neuronal circuits are established. We use mouse genetics, combinatorial immunochemical labeling and high-resolution laser scanning microscopy to identify, manipulate, and quantitatively analyze synaptic contacts within the complex neuronal milieu of the spinal cord and the enteric nervous system.
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Aya Kamaya, MD
Professor of Radiology (Body Imaging)
On Leave from 02/18/2025 To 04/25/2025Current Research and Scholarly InterestsHepatobiliary imaging
Hepatocellular carcinoma
Urologic imaging
Gynecologic imaging
Thyroid imaging
Novel ultrasound technologies
Perfusion CT imaging of abdominal tumors -
Matthew Kanan
Professor of Chemistry
BioAssociate Professor of Chemistry Matthew Kanan develops new catalysts and chemical reactions for applications in renewable energy conversion and CO2 utilization. His group at Stanford University has recently developed a novel method to create plastic from carbon dioxide and inedible plant material rather than petroleum products, and pioneered the study of “defect-rich” heterogeneous electro-catalysts for converting carbon dioxide and carbon monoxide to liquid fuel.
Matthew Kanan completed undergraduate study in chemistry at Rice University (B.A. 2000 Summa Cum Laude, Phi Beta Kappa). During doctoral research in organic chemistry at Harvard University (Ph.D. 2005), he developed a novel method for using DNA to discover new chemical reactions. He then moved into inorganic chemistry for his postdoctoral studies as a National Institutes of Health Postdoctoral Research Fellow at the Massachusetts Institute of Technology, where he discovered a water oxidation catalyst that operates in neutral water. He joined the Stanford Chemistry Department faculty in 2009 to continue research into energy-related catalysis and reactions. His research and teaching have already been recognized in selection as one of Chemistry & Engineering News’ first annual Talented 12, the Camille Dreyfus Teacher-Scholar Award, Eli Lilly New Faculty Award, and recognition as a Camille and Henry Dreyfus Environmental Mentor, among other honors.
The Kanan Lab addresses fundamental challenges in catalysis and synthesis with an emphasis on enabling new technologies for scalable CO2 utilization. The interdisciplinary effort spans organic synthesis, materials chemistry and electrochemistry.
One of the greatest challenges of the 21st century is to transition to an energy economy with ultra-low greenhouse gas emissions without compromising quality of life for a growing population. The Kanan Lab aims to help enable this transition by developing catalysts and chemical reactions that recycle CO2 into fuels and commodity chemicals using renewable energy sources. To be implemented on a substantial scale, these methods must ultimately be competitive with fossil fuels and petrochemicals. With this requirement in mind, the group focuses on the fundamental chemical challenge of making carbon–carbon (C–C) bonds because multi-carbon compounds have higher energy density, greater value, and more diverse applications that one-carbon compounds. Both electrochemical and chemical methods are being pursued. For electrochemical conversion, the group studies how defects known as grain boundaries can be exploited to improve CO2/CO electro-reduction catalysis. Recent work has unveiled quantitative correlations between grain boundaries and catalytic activity, establishing a new design principle for electrocatalysis, and developed grain boundary-rich copper catalysts with unparalleled activity for converting carbon monoxide to liquid fuel. For chemical CO2 conversion, the group is developing C–H carboxylation and CO2 hydrogenation reactions that are promoted by simple carbonate salts. These reactions provide a way to make C–C bonds between un-activated substrates and CO2 without resorting to energy-intensive and hazardous reagents. Among numerous applications, carbonate-promoted carboxylation enables the synthesis of a monomer used to make polyester plastic from CO2 and a feedstock derived from agricultural waste.
In addition to CO2 chemistry, the Kanan group is pursuing new strategies to control selectivity in molecular catalysis for fine chemical synthesis. Of particular interest in the use of electrostatic interactions to discriminate between competing reaction pathways based on their charge distributions. This effort uses ion pairing or interfaces to control the local electrostatic environment in which a reaction takes place. The group has recently shown that local electric fields can control regioselectivity in isomerization reactions catalyzed by gold complexes. -
Peter Kao
Associate Professor of Medicine (Pulmonary and Critical Care Medicine)
Current Research and Scholarly InterestsOur research program has several active projects:
1.) Pulmonary Vascular Disease Simvastatin reversed experimental pulmonary hypertension, and is safe for treatment of patients. Blinded clinical trials of efficacy are in progress.
2.) Lung inflammation and regeneration (stem cells)
3.) Lung surfactant rheology and oxidative stress
4.) Gene regulation by RNA binding proteins, NF45 and NF90 through transcriptional and posttranscriptional mechanisms -
Ioannis Karakikes
Associate Professor (Research) of Cardiothoracic Surgery
Current Research and Scholarly InterestsThe Karakikes Lab aims to uncover fundamental new insights into the molecular mechanisms and functional consequences of pathogenic mutations associated with familial cardiovascular diseases.
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Hemamala Karunadasa
J.G. Jackson and C.J. Wood Professor of Chemistry
BioProfessor Hema Karunadasa works with colleagues in materials science, earth science, and applied physics to drive the discovery of new materials with applications in clean energy. Using the tools of synthetic chemistry, her group designs materials that couple the structural tunability of organic molecules with the diverse electronic and optical properties of extended inorganic solids. This research targets materials such as sorbents for capturing environmental pollutants, phosphors for solid-state lighting, and absorbers for solar cells.
Hemamala Karunadasa studied chemistry and materials science at Princeton University (A.B. with high honors 2003; Certificate in Materials Science and Engineering 2003), where her undergraduate thesis project with Professor Robert J. Cava examined geometric magnetic frustration in metal oxides. She moved from solid-state chemistry to solution-state chemistry for her doctoral studies in inorganic chemistry at the University of California, Berkeley (Ph.D. 2009) with Professor Jeffrey R. Long. Her thesis focused on heavy atom building units for magnetic molecules and molecular catalysts for generating hydrogen from water. She continued to study molecular electrocatalysts for water splitting during postdoctoral research with Berkeley Professors Christopher J. Chang and Jeffrey R. Long at the Lawrence Berkeley National Lab. She further explored molecular catalysts for hydrocarbon oxidation as a postdoc at the California Institute of Technology with Professor Harry B. Gray. She joined the Stanford Chemistry Department faculty in September 2012. Her research explores solution-state routes to new solid-state materials.
Professor Karunadasa’s lab at Stanford takes a molecular approach to extended solids. Lab members gain expertise in solution- and solid-state synthetic techniques and structure determination through powder- and single-crystal x-ray diffraction. Lab tools also include a host of spectroscopic and electrochemical probes, imaging methods, and film deposition techniques. Group members further characterize their materials under extreme environments and in operating devices to tune new materials for diverse applications in renewable energy.
Please visit the lab website for more details and recent news. -
Maya M. Kasowski
Assistant Professor of Pathology, of Medicine (Pulmonary, Allergy and Critical Care Medicine) and, by courtesy, of Genetics
BioI am a clinical pathologist and assistant professor in the Departments of Medicine, Pathology, and Genetics (by courtesy) at Stanford. I completed my MD-PhD training at Yale University and my residency training and a post-doctoral fellowship in the Department of Genetics at Stanford University. My experiences as a clinical pathologist and genome scientist have made me passionate about applying cutting-edge technologies to primary patient specimens in order to characterize disease pathologies at the molecular level. The core focus of my lab is to study the mechanisms by which genetic variants influence the risk of disease through effects on intermediate molecular phenotypes.
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Riitta Katila
W.M. Keck Professor and Professor of Management Science and Engineering
Current Research and Scholarly InterestsThe question that drives Prof. Katila's research is how technology-based firms with significant resources can stay innovative. Her work lies at the intersection of the fields of technology, innovation, and strategy and focuses on strategies that enable organizations to discover, develop and commercialize technologies. She combines theory with longitudinal large-sample data (e.g., robotics, biomedical, platform and multi-industry datasets), background fieldwork, and state-of-the-art quantitative methods. The ultimate objective is to understand what makes technology-based firms successful.
To answer this question, Prof. Katila conducts two interrelated streams of research. She studies (1) strategies that help firms leverage their existing resources (leverage stream), and (2) strategies through which firms can acquire new resources (acquisition stream) to create innovation. Her early contributions were firm centric while recent contributions focus on innovation in the context of competitive interaction and ecosystems.
Professor Katila's work has appeared in the Academy of Management Journal, Administrative Science Quarterly, Organization Science, Strategic Entrepreneurship Journal, Strategy Science, Strategic Management Journal, Research Policy and other outlets. In her work, supported by the National Science Foundation, Katila examines how firms create new products successfully. Focusing on the robotics and medical device industries, she investigates how different search approaches, such as the exploitation of existing knowledge and the exploration for new knowledge, influence the kinds of new products that technology-intensive firms introduce. -
Laurence Katznelson, MD
Professor of Neurosurgery, Emeritus
Current Research and Scholarly InterestsDr. Katznelson is an internationally known neuroendocrinologist and clinical researcher, with research expertise in the diagnosis and management of hypopituitarism, the effects of hormones on neurocognitive function, and the development of therapeutics for acromegaly and Cushings syndrome, and neuroendocrine tumors. Dr. Katznelson is the medical director of the multidisciplinary Stanford Pituitary Center, a program geared for patient management, clinical research and patient education
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Mark A. Kay, M.D., Ph.D.
Dennis Farrey Family Professor of Pediatrics, and Professor of Genetics
Current Research and Scholarly InterestsMark A. Kay, M.D., Ph.D. Director of the Program in Human Gene Therapy and Professor in the Departments of Pediatrics and Genetics. Respected worldwide for his work in gene therapy for hemophilia, Dr. Kay and his laboratory focus on establishing the scientific principles and developing the technologies needed for achieving persistent and therapeutic levels of gene expression in vivo. The major disease models are hemophilia, hepatitis C, and hepatitis B viral infections.
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Electron Kebebew, MD, FACS
Harry A. Oberhelman, Jr. and Mark L. Welton Professor
Current Research and Scholarly InterestsDr. Kebebew’s translational and clinical investigations have three main scientific goals: 1) to develop effective therapies for fatal, rare and neglected endocrine cancers, 2) to identify new methods, strategies and technologies for improving the diagnosis and treatment of endocrine neoplasms and the prognostication of endocrine cancers, and 3) to develop methods for precision treatment of endocrine tumors.
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Corey Keller, MD, PhD
Assistant Professor of Psychiatry and Behavioral Sciences (Public Mental Health and Population Sciences)
Current Research and Scholarly InterestsThe goal of my lab is to understand the fundamental principles of human brain plasticity and build trans-diagnostic real-time monitoring platforms for personalized neurotherapeutics.
We use an array of neuroscience methods to better understand the basic principles of how to create change in brain circuits. We use this knowledge to develop more effective treatment strategies for depression and other psychiatric disorders. -
Monroe Kennedy III
Assistant Professor of Mechanical Engineering
Current Research and Scholarly InterestsMy research focus is to develop technology that improves everyday life by anticipating and acting on the needs of human counterparts. My research can be divided into the following sub-categories: robotic assistants, connected devices and intelligent wearables. My Assistive Robotics and Manipulation lab focuses heavily on both the analytical and experimental components of assistive technology design.
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Thomas Kenny
Senior Associate Dean for Education and Student Affairs and Richard W. Weiland Professor in the School of Engineering
BioKenny's group is researching fundamental issues and applications of micromechanical structures. These devices are usually fabricated from silicon wafers using integrated circuit fabrication tools. Using these techniques, the group builds sensitive accelerometers, infrared detectors, and force-sensing cantilevers. This research has many applications, including integrated packaging, inertial navigation, fundamental force measurements, experiments on bio-molecules, device cooling, bio-analytical instruments, and small robots. Because this research field is multidisciplinary in nature, work in this group is characterized by strong collaborations with other departments, as well as with local industry.
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Oussama Khatib
Weichai Professor and Professor, by courtesy, of Electrical Engineering
BioRobotics research on novel control architectures, algorithms, sensing, and human-friendly designs for advanced capabilities in complex environments. With a focus on enabling robots to interact cooperatively and safely with humans and the physical world, these studies bring understanding of human movements for therapy, athletic training, and performance enhancement. Our work on understanding human cognitive task representation and physical skills is enabling transfer for increased robot autonomy. With these core capabilities, we are exploring applications in healthcare and wellness, industry and service, farms and smart cities, and dangerous and unreachable settings -- deep in oceans, mines, and space.
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Paul A. Khavari, MD, PhD
Carl J. Herzog Professor of Dermatology in the School of Medicine
Current Research and Scholarly InterestsWe work in epithelial tissue as a model system to study stem cell biology, cancer and new molecular therapeutics. Epithelia cover external and internal body surfaces and undergo constant self-renewal while responding to diverse environmental stimuli. Epithelial homeostasis precisely balances stem cell-sustained proliferation and differentiation-associated cell death, a balance which is lost in many human diseases, including cancer, 90% of which arise in epithelial tissues.
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Chaitan Khosla
Wells H. Rauser and Harold M. Petiprin Professor and Professor of Chemistry and, by courtesy, of Biochemistry
Current Research and Scholarly InterestsResearch in this laboratory focuses on problems where deep insights into enzymology and metabolism can be harnessed to improve human health.
For the past two decades, we have studied and engineered enzymatic assembly lines called polyketide synthases that catalyze the biosynthesis of structurally complex and medicinally fascinating antibiotics in bacteria. An example of such an assembly line is found in the erythromycin biosynthetic pathway. Our current focus is on understanding the structure and mechanism of this polyketide synthase. At the same time, we are developing methods to decode the vast and growing number of orphan polyketide assembly lines in the sequence databases.
For more than a decade, we have also investigated the pathogenesis of celiac disease, an autoimmune disorder of the small intestine, with the goal of discovering therapies and related management tools for this widespread but overlooked disease. Ongoing efforts focus on understanding the pivotal role of transglutaminase 2 in triggering the inflammatory response to dietary gluten in the celiac intestine. -
Butrus Khuri-Yakub
Professor (Research) of Electrical Engineering, Emeritus
BioButrus (Pierre) T. Khuri-Yakub is a Professor of Electrical Engineering at Stanford University. He received the BS degree from the American University of Beirut, the MS degree from Dartmouth College, and the Ph.D. degree from Stanford University, all in electrical engineering. His current research interests include medical ultrasound imaging and therapy, ultrasound neuro-stimulation, chemical/biological sensors, gas flow and energy flow sensing, micromachined ultrasonic transducers, and ultrasonic fluid ejectors. He has authored over 600 publications and has been principal inventor or co-inventor of 107 US and international issued patents. He was awarded the Medal of the City of Bordeaux in 1983 for his contributions to Nondestructive Evaluation, the Distinguished Advisor Award of the School of Engineering at Stanford University in 1987, the Distinguished Lecturer Award of the IEEE UFFC society in 1999, a Stanford University Outstanding Inventor Award in 2004, Distinguished Alumnus Award of the School of Engineering of the American University of Beirut in 2005, Stanford Biodesign Certificate of Appreciation for commitment to educate, mentor and inspire Biodesgin Fellows, 2011, and 2011 recipient of IEEE Rayleigh award.
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Mathew Kiang
Assistant Professor of Epidemiology and Population Health (Epidemiology)
BioI am an assistant professor in the Department of Epidemiology and Population Health. My research lies at the intersection of computational epidemiology and social epidemiology. Methodologically, my work revolves around combining disparate data sources in epidemiologically meaningful ways. For example, I work with individual-level, non-health data (e.g., GPS, accelerometer, and other sensor data from smartphones), traditional health data (e.g., survey, health systems, or death certificate data), and third-party data (e.g., cellphone providers or ad-tech data). To do this, I use a variety of methods such as joint Bayesian spatial models, traditional epidemiologic models, dynamical models, microsimulation, and demographic analysis. Substantively, my work focuses on socioeconomic and racial/ethnic inequities. For example, recently, my work has examined inequities in COVID-19 vaccine distribution, cause-specific excess mortality, and drug poisonings. I have an NIDA-funded R00 examining equitable ways to improve treatment for opioid use disorder across structurally disadvantaged groups and am Co-I on a NIDA-funded R21 examining ways to use novel data sources (such as social media) to predict surges in opioid-related mortality.
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Juyong Brian Kim
Assistant Professor of Medicine (Cardiovascular Medicine)
Current Research and Scholarly InterestsThe lifetime risk of developing cardiovascular disease (CVD) is determined by the genetic makeup and exposure to modifiable risk factors. The Cardiovascular Link to Environmental ActioN (CLEAN) Lab is interested in understanding how various environmental pollutants (eg. tobacco, e-cigarettes, air pollution and wildfire) interact with genes to affect the transcriptome, epigenome, and eventually disease phenotype of CVD. The current focus is to investigate how different toxic exposures can adversely remodel the vascular wall leading to increased cardiac events. We intersect human genomic discoveries with animal models of disease, in-vitro and in-vivo systems of exposure, single-cell sequencing technologies to solve these questions. Additionally, we collaborate with various members of the Stanford community to develop biomarkers that will aid with detection and prognosis of CVD. We are passionate about the need to reduce the environmental effects on health through strong advocacy and outreach.
(http://kimlab.stanford.edu) -
Peter S. Kim
Virginia and D. K. Ludwig Professor of Biochemistry
Current Research and Scholarly InterestsOur research focuses on developing new strategies for vaccine creation. We also aim to generate vaccines targeting infectious agents that have eluded efforts to date. We integrate experimental approaches with protein language models to guide artificial evolution and enable efficient antibody and protein engineering. Our interdisciplinary approach aims to address critical global health challenges.
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Seung K. Kim M.D., Ph.D.
KM Mulberry Professor, Professor of Developmental Biology, of Medicine (Endocrinology) and, by courtesy, of Pediatrics (Endocrinology)
Current Research and Scholarly InterestsWe study the development of pancreatic islet cells using molecular, embryologic and genetic methods in several model systems, including mice, pigs, human pancreas, embryonic stem cells, and Drosophila. Our work suggests that critical factors required for islet development are also needed to maintain essential functions of the mature islet. These approaches have informed efforts to generate replacement islets from renewable sources for diabetes.
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David Kingsley
Rudy J. and Daphne Donohue Munzer Professor in the School of Medicine
Current Research and Scholarly InterestsWe use mice, stickleback fish, and humans to study the molecular basis of evolution and common diseases. By combining genetics and genomics, we have identified key DNA changes that control bone formation, limb patterning, hair color, brain evolution, and susceptibility to arthritis, schizophrenia, and bipolar disorder. We find that the same genetic mechanisms are often used repeatedly in nature, providing new insights into the origin of key traits in many different species, including ourselves.
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Amanda Kirane, MD, PhD, FACS, FSSO
Assistant Professor of Surgery (General Surgery)
BioDr. Kirane is a fellowship-trained, board-certified specialist in complex general surgical oncology. She is an Assistant Professor in the Department of Surgery, Section of Surgical Oncology, at Stanford University School of Medicine. Dr. Kirane serves as Director of Cutaneous Surgical Oncology at the Stanford Cancer Center and her clinical practice focuses on the diagnosis and treatment of melanoma and other skin cancers. She partners closely with patients and families to provide the most effective treatment approach possible. For each patient, she tailors an evidence-based, personalized care plan that is innovative, comprehensive, and compassionate.
Dr. Kirane is Principal Investigator of multiple studies in melanoma and mechanisms of resistance to immunotherapy, with focus on myeloid biology. Her current interests include immune response and novel therapies in melanoma, predictive modeling of patient responses using organoid technology, and translational biomarker development. She has led research into immune therapy for earlier stage melanoma using regionally directed therapy to augment immune response in melanoma and trials in surgical care in melanoma.
The National Institutes of Health, American Society of Clinical Oncology, the Melanoma Research Alliance, and others have funded her research. She has co-authored articles on her discoveries in the Journal of Clinical Investigation, Nature Communications, Nature Genetics, Cancer Research, Journal of Surgical Oncology, Annals of Surgery, Annals of Surgical Oncology, and elsewhere. Topics include intratumoral therapy, biomarker development, macrophage biology in melanoma and immunotheraputic resistance, and patient-derived organoid modeling. Dr. Kirane has presented updates on the management of melanoma and other cancers to her peers at meetings of the American College of Surgeons, Society of Surgical Oncology, and Society for Immunotherapy in Cancer.
Dr. Kirane has earned awards for her achievements in clinical care, research, and scholarship. The Society for Immunotherapy of Cancer, Society of Surgical Oncology, Memorial Sloan Kettering Cancer Center, and other prestigious organizations have honored her work. She is a fellow of the American College of Surgeons (FACS) and Society of Surgical Oncology (FSSO). She is a member of the Society for Immunotherapy of Cancer, American Association of Cancer Research, Society for Melanoma Research, Connective Tissue Oncology Society, Association of Academic Surgeons, and Association of Women Surgeons.
She volunteers her time and expertise on behalf of the Melanoma Research Foundation, members of her community in need, STEM programs for girls, and other initiatives. She also is fellowship trained in Physician Wellness and Wellbeing and teaches somatic technique, mindfulness-based stress reduction, meditation, and breathwork. -
Varvara A. Kirchner
Associate Professor of Surgery (Abdominal Transplantation) and, by courtesy, of Pediatrics
BioDr. Kirchner completed her medical school, surgical residency and multi-organ transplant fellowship in adult and pediatric liver, pancreas, kidney transplantation and total pancreatectomy with islet auto-transplantation at the University of Minnesota. She underwent further training in living donor liver transplantation and hepatobiliary surgery at the Asan Medical Center, Seoul, South Korea. Her clinical practice involves living and deceased donor liver and kidney transplantation in adult and pediatric patients as well as total pancreatectomy with islet auto-transplantation for patients with chronic and acute recurrent pancreatitis. She currently serves as Surgical Director of the Islet Cell Auto-Transplant at Stanford Children’s and Associate Director of the Living Donor Liver Transplant Program at the Division of Abdominal Transplantation. Dr. Kirchner’s research focuses on the biology of aging, cellular and solid organ transplantation. Her specific interests are in auto-islet transplantation, iPSC-derived hepatocyte therapies and liver regeneration. Dr. Kirchner's research on the impact of donor age on generation of iPSC-derived hepatocyte-like cells is supported by the NIA K08 Faculty Development Award. She is an active member of the American Society of Transplant Surgeons and the International Liver Transplantation Society.
