Showing 841-860 of 929 Results
Capucine van Rechem
Assistant Professor of Pathology (Pathology Research)
Current Research and Scholarly InterestsMy long-term interest lies in understanding the impact chromatin modifiers have on disease development and progression so that more optimal therapeutic opportunities can be achieved. My laboratory explores the direct molecular impact of chromatin-modifying enzymes during cell cycle progression, and characterizes the unappreciated and unconventional roles that these chromatin factors have on cytoplasmic function such as protein synthesis.
Benjamin Van Roy
Professor of Electrical Engineering, of Management Science and Engineering
BioBenjamin Van Roy is a Professor at Stanford University, where he has served on the faculty since 1998. His research focuses on understanding how an agent interacting with a poorly understood environment can learn over time to make effective decisions. He is interested in the design of efficient reinforcement learning algorithms, understanding what is possible or impossible in this domain, and applying the technology toward the benefit of society. Beyond academia, he leads a DeepMind Research team in Mountain View, and has also led research programs at Unica (acquired by IBM), Enuvis (acquired by SiRF), and Morgan Stanley.
He is a Fellow of INFORMS and IEEE and has served on the editorial boards of Machine Learning, Mathematics of Operations Research, for which he co-edits the Learning Theory Area, Operations Research, for which he edited the Financial Engineering Area, and the INFORMS Journal on Optimization.
He received the SB in Computer Science and Engineering and the SM and PhD in Electrical Engineering and Computer Science, all from MIT. He has been a recipient of the MIT George C. Newton Undergraduate Laboratory Project Award, the MIT Morris J. Levin Memorial Master's Thesis Award, the MIT George M. Sprowls Doctoral Dissertation Award, the National Science Foundation CAREER Award, the Stanford Tau Beta Pi Award for Excellence in Undergraduate Teaching, and the Management Science and Engineering Department's Graduate Teaching Award. He has held visiting positions as the Wolfgang and Helga Gaul Visiting Professor at the University of Karlsruhe, the Chin Sophonpanich Foundation Professor and the InTouch Professor at Chulalongkorn University, a Visiting Professor at the National University of Singapore, and a Visiting Professor at the Chinese University of Hong Kong, Shenzhen.
Shreyas Vasanawala, MD/PhD
Professor of Radiology (Pediatric Radiology)
Current Research and Scholarly InterestsOur group is focused on developing new fast and quantitative MRI techniques.
Assistant Professor of Neurosurgery and, by courtesy, of Orthopaedic Surgery at the Stanford University Medical Center
Current Research and Scholarly InterestsThe focus of my laboratory is to utilize precision medicine techniques to improve the diagnosis and treatment of neurologic conditions. From traumatic brain injury to spinal scoliosis, the ability to capture detailed data regarding clinical symptoms and treatment outcomes has empowered us to do better for patients. Utilize data to do better for patients, that’s what we do.
Stanford Neurosurgical Ai and Machine Learning Lab
Assistant Professor of Comparative Medicine at the Stanford University Medical Center
BioDr. José G. Vilches-Moure, DVM, PhD, Assistant Professor, received his DVM degree from Purdue University in Indiana in 2007. He completed his residency training in Anatomic Pathology (with emphasis in pathology of laboratory animal species) and his PhD in Comparative Pathology at the University of California-Davis. He joined Stanford in 2015, and is the Director of the Animal Histology Services (AHS). Dr. Vilches-Moure is a diplomate of the American College of Veterinary Pathologists, and his collaborative research interests include cardiac development and pathology, developmental pathology, and refinement of animal models in which to study early cancer detection techniques. His teaching interests include comparative anatomy/histology, general pathology, comparative pathology, and pathology of laboratory animal species.
Professor of Developmental Biology and of Genetics
Current Research and Scholarly InterestsMechanisms underlying homologous chromosome pairing, DNA recombination and chromosome remodeling during meiosis, using the nematode Caenorhabditis elegans as an experimental system. High-resolution 3-D imaging of dynamic reorganization of chromosome architecture. Role of protease inhibitors in regulating sperm activation.
Hannes Vogel MD
Professor of Pathology and of Pediatrics (Pediatric Genetics) and, by courtesy, of Neurosurgery and of Comparative Medicine at the Stanford University Medical Center
Current Research and Scholarly InterestsMy research interests include nerve and muscle pathology, mitochondrial diseases, pediatric neurooncology, and transgenic mouse pathology.
Associate Professor of Genetics and, by courtesy, of Ophthalmology
Current Research and Scholarly InterestsThe Vollrath lab works to uncover molecular mechanisms relevant to the health and pathology of the outer retina. We study the retinal pigment epithelium (RPE), a cell monolayer adjacent to photoreceptors that performs a variety of tasks crucial for retinal homeostasis. Specific areas of interest include the circadian regulation of RPE phagocytosis of photoreceptor outer segment tips, and how RPE metabolic dysfunction contributes to retinal degenerative diseases.
Jensen Huang Professor of Global Leadership and Professor, by courtesy, of Applied Physics
Current Research and Scholarly Interestsphotonics, quantum technologies, quantum optics, inverse design
Lucie Stern Professor in the Social Sciences
Current Research and Scholarly InterestsCognitive neuroscience of memory and cognitive/executive control in young and older adults. Research interests include encoding and retrieval mechanisms; interactions between declarative, nondeclarative, and working memory; forms of cognitive control; neurocognitive aging; functional organization of prefrontal cortex, parietal cortex, and the medial temporal lobe; assessed by functional MRI, scalp and intracranial EEG, and transcranial magnetic stimulation.
Professor of Photon Science and of Structural Biology
Current Research and Scholarly InterestsUbiquitin signaling: structure, function, and therapeutics
Ubiquitin is a small protein modifier that is ubiquitously produced in the cells and takes part in the regulation of a wide range of cellular activities such as gene transcription and protein turnover. The key to the diversity of the ubiquitin roles in cells is that it is capable of interacting with other cellular proteins either as a single molecule or as different types of chains. Ubiquitin chains are produced through polymerization of ubiquitin molecules via any of their seven internal lysine residues or the N-terminal methionine residue. Covalent interaction of ubiquitin with other proteins is known as ubiquitination which is carried out through an enzymatic cascade composed of the ubiquitin-activating (E1), ubiquitin-conjugating (E2), and ubiquitin ligase (E3) enzymes. The ubiquitin signals are decoded by the ubiquitin-binding domains (UBDs). These domains often specifically recognize and non-covalently bind to the different ubiquitin species, resulting in distinct signaling outcomes.
We apply a combination of the structural (including protein crystallography, small angle x-ray scattering, cryo-electron microscopy (Cryo-EM) etc.), biocomputational and biochemical techniques to study the ubiquitylation and deubiquitination processes, and recognition of the ubiquitin chains by the proteins harboring ubiquitin-binding domains. Current research interests including SARS-COV2 proteases and their interactions with polyubiquitin chains and ubiquitin pathways in host cell responses, with an ultimate goal of providing strategies for effective therapeutics with reduced levels of side effects.
Protein self-assembly processes and applications.
The Surface layers (S-layers) are crystalline protein coats surrounding microbial cells. S-layer proteins (SLPs) regulate their extracellular, self-assembly by crystallizing when exposed to an environmental trigger. We have demonstrated that the Caulobacter crescentus SLP readily crystallizes into sheets both in vivo and in vitro via a calcium-triggered multistep assembly pathway. Observing crystallization using a time course of Cryo-EM imaging has revealed a crystalline intermediate wherein N-terminal nucleation domains exhibit motional dynamics with respect to rigid lattice-forming crystallization domains. Rate enhancement of protein crystallization by a discrete nucleation domain may enable engineering of kinetically controllable self-assembling 2D macromolecular nanomaterials. In particular, this is inspiring designing robust novel platform for nano-scale protein scaffolds for structure-based drug design and nano-bioreactor design for the carbon-cycling enzyme pathway enzymes. Current research focuses on development of nano-scaffolds for high throughput in vitro assays and structure determination of small and flexible proteins and their interaction partners using Cryo-EM, and applying them to cancer and anti-viral therapeutics.
Multiscale imaging and technology developments.
Multimodal, multiscale imaging modalities will be developed and integrated to understand how molecular level events of key enzymes and protein network are connected to cellular and multi-cellular functions through intra-cellular organization and interactions of the key machineries in the cell. Larger scale organization of these proteins will be studied by solution X-ray scattering and Cryo-EM. Their spatio-temporal arrangements in the cell organelles, membranes, and cytosol will be further studied by X-ray fluorescence imaging and correlated with cryoEM and super-resolution optical microscopy. We apply these multiscale integrative imaging approaches to biomedical, and environmental and bioenergy research questions with Stanford, DOE national labs, and other domestic and international collaborators.
Professor of BiologyOn Leave from 05/01/2020 To 08/31/2020
Current Research and Scholarly InterestsOur current focus is on maize anther development to understand how cell fate is specified. We discovered that hypoxia triggers specification of the archesporial (pre-meiotic) cells, and that these cells secrete a small protein MAC1 that patterns the adjacent soma to differentiate as endothecial and secondary parietal cell types. We also discovered a novel class of small RNA: 21-nt and 24-nt phasiRNAs that are exceptionally abundant in anthers and exhibit strict spatiotemporal dynamics.
Professor (Research) of Mechanical Engineering, Emeritus
BioKenneth J. Waldron is Professor of Mechanical and Mechatronic Engineering at UTS. He is also Professor Emeritus from the Design Group in the Department of Mechanical Engineering of Stanford University. He holds bachelors and masters degrees from the University of Sydney, and PhD from Stanford. He works in machine design, and design methodology with a particular focus on robotic and mechatronic systems.
Associate Professor of Pediatrics (Systems Medicine), of Biomedical Data Science and, by courtesy, of Psychiatry and Behavioral Sciences
Current Research and Scholarly InterestsSystems biology for design of clinical solutions that detect and treat disease
Professor of Statistics
BioGuenther Walther studied mathematics, economics, and computer science at the University of Karlsruhe in Germany and received his Ph.D. in Statistics from UC Berkeley in 1994.
His research has focused on statistical methodology for detection problems, shape-restricted inference, and mixture analysis, and on statistical problems in astrophysics and in flow cytometry.
He received a Terman fellowship, a NSF CAREER award, and the Distinguished Teaching Award of the Dean of Humanities and Sciences at Stanford. He has served on the editorial boards of the Journal of Computational and Graphical Statistics, the Journal of the Royal Statistical Society, the Annals of Statistics, the Annals of Applied Statistics, and Statistical Science. He was program co-chair of the 2006 Annual Meeting of the Institute of Mathematical Statistics and served on the executive committee of IMS from 1998 to 2012.
Brian A. Wandell
Isaac and Madeline Stein Family Professor and Professor, by courtesy, of Electrical Engineering, of Ophthalmology and at the Graduate School of Education
Current Research and Scholarly InterestsModels and measures of the human visual system. The brain pathways essential for reading development. Diffusion tensor imaging, functional magnetic resonance imaging and computational modeling of visual perception and brain processes.
Professor of Chemical and Systems Biology and, by courtesy, of Chemistry
Current Research and Scholarly InterestsWe employ an interdisciplinary approach to studies of biological systems, combining synthetic chemistry with biochemistry, cell biology, and structural biology. We invent tools for biology and we are motivated by approaches that enable new experiments with unprecedented control. These new techniques may also provide a window into mechanisms involved in maintaining cellular homeostasis. Protein quality control is a particular interest at present.
Assistant Professor of Radiology and, by courtesy, of Electrical Engineering
BioMy group develops technologies for advanced x-ray and CT imaging, including novel system design, model-based image reconstruction, spectral imaging, and radiation transport methods. I am also the Director of the Zeego Lab and the Tabletop X-Ray Lab.
I completed my PhD in Electrical Engineering at Stanford under the supervision of Dr. Norbert Pelc, developing strategies for maximizing the information content of dual energy CT and photon counting detectors. I then pursued a postdoc at Johns Hopkins with Dr. Jeff Siewerdsen in Biomedical Engineering, developing reconstruction and registration methods for x-ray based image-guided surgery. Prior to returning to Stanford in 2018, I was a Senior Scientist at Varian Medical Systems, developing x-ray/CT methods for image-guided radiation therapy.
Assistant Professor of Bioengineering
BioWe are a discovery-driven research group working at the interface between developmental biology, bioengineering, and statistical physics. We combine quantitative organism-wide fluorescence imaging ("deep imaging"), functional genomics ("deep sequencing"), and physical modeling to understand the fundamental rules that control collective cell behaviors to optimize tissue regeneration, adaptation, and evolution. We also seek for opportunities for applying these rules to improve multicellular engineering systems.
Kevin Wang, MD, PhD
Assistant Professor of Dermatology
Current Research and Scholarly InterestsThe Wang lab takes an interdisciplinary approach to studying fundamental mechanisms controlling gene expression in mammalian cells, and how epigenetic mechanisms such as DNA methylation, chromatin modifications, and RNA influence chromatin dynamics to affect gene regulation.