Wu Tsai Neurosciences Institute
Showing 371-380 of 556 Results
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Josef Parvizi, MD, PhD
Professor of Neurology (Adult Neurology) and, by courtesy, of Neurosurgery
BioDr. Parvizi completed his medical internship at Mayo Clinic, neurology training at Harvard, and subspecialty training in clinical neurophysiology and epilepsy at UCLA before joining the Department of Neurology and Neurological Sciences at Stanford in 2007. Dr. Parvizi directs the Stanford Program for Medication Resistant Epilepsies and specializes in surgical treatments of intractable focal epilepsies. Dr. Parvizi is the principal investigator in the Laboratory of Behavioral and Cognitive Neuroscience, where he leads a team of investigators to study the human brain. http://med.stanford.edu/parvizi-lab.html.
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Anca M. Pasca, MD
Assistant Professor of Pediatrics
Current Research and Scholarly InterestsThe research focus of the lab is to understand molecular mechanisms underlying neurodevelopmental disorders associated with premature birth, neonatal and fetal brain injury with the long-term goal of translating the lab’s findings into therapeutics. The research team employs a multidisciplinary approach involving genetics, molecular and developmental neurobiology, animal models and neural cells differentiated from patient-derived induced pluripotent stem (iPS) cells. In particular, the lab is using a powerful 3D human brain-region specific organoid system developed at Stanford (Nature Methods, 2015; Nature Protocols, 2018) to ask questions about brain injury during development.
https://www.neopascalab.org/ -
Sergiu P. Pasca
Kenneth T. Norris, Jr. Professor of Psychiatry and Behavioral Sciences and Bonnie Uytengsu and Family Director of the Stanford Brain Organogenesis Program
Current Research and Scholarly InterestsA critical challenge in understanding the intricate programs underlying development, assembly and dysfunction of the human brain is the lack of direct access to intact, functioning human brain tissue for detailed investigation by imaging, recording, and stimulation.
To address this, we are developing bottom-up approaches to generate and assemble, from multi-cellular components, human neural circuits in vitro and in vivo.
We introduced the use of instructive signals for deriving from human pluripotent stem cells self-organizing 3D cellular structures named brain region-specific spheroids/organoids. We demonstrated that these cultures, such as the ones resembling the cerebral cortex, can be reliably derived across many lines and experiments, contain synaptically connected neurons and non-reactive astrocytes, and can be used to gain mechanistic insights into genetic and environmental brain disorders. Moreover, when maintained as long-term cultures, they recapitulate an intrinsic program of maturation that progresses towards postnatal stages.
We also pioneered a modular system to integrate 3D brain region-specific organoids and study human neuronal migration and neural circuit formation in functional preparations that we named assembloids. We have actively applied these models in combination with studies in long-term ex vivo brain preparations to acquire a deeper understanding of human physiology, evolution and disease mechanisms.
We have carved a unique research program that combines rigorous in vivo and in vitro neuroscience, stem cell and molecular biology approaches to construct and deconstruct previously inaccessible stages of human brain development and function in health and disease.
We believe science is a community effort, and accordingly, we have been advancing the field by broadly and openly sharing our technologies with numerous laboratories around the world and organizing the primary research conference and the training courses in the area of cellular models of the human brain. -
Chirag Patel, MD, PhD
Member, Cardiovascular Institute
Current Research and Scholarly InterestsNeuro-oncology, Clinical Trials, Tumor Treating Fields (TTFields), Molecular/PET Imaging, Neuroimaging, Immunotherapy, Big Data Analysis
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Zara Patel, MD
Professor of Otolaryngology - Head & Neck Surgery (OHNS)
BioDr. Zara M. Patel is Director of Endoscopic Skull Base Surgery and a Professor of Otolaryngology and, by courtesy, of Neurosurgery at Stanford. She was born and raised in St. Louis, completed her MD at the Oregon Health and Sciences University in Portland, Oregon and completed her residency training in otolaryngology at Mount Sinai Medical Center in New York, NY. After pursuing fellowship training in rhinology and endoscopic skull base surgery at Stanford University, she was recruited to join the Emory University faculty in Atlanta in 2011. After four years, the rhinology division recruited her back to the West coast to rejoin the department here at Stanford University in 2015.
Dr. Patel is an expert in advanced endoscopic sinus and skull base surgery. She treats patients with a wide variety of rhinologic complaints, including chronic sinus infection or inflammation, sinus disease that has failed medical therapy, sinus disease that has failed prior surgical therapy, cerebrospinal fluid leaks, benign and and malignant sinus and skull base tumors, as well as olfactory disorders.
She has served as Chair of the Education Committee and Member of the Board of Directors for the American Rhinologic Society, is current Chair of the Rhinology and Allergy Education Committee for the American Academy of Otolaryngology - Head and Neck Surgery, and has developed a multitude of educational materials for both physicians and patients to help them better understand rhinologic disorders. She is passionate about educating patients to allow them to make the best decisions about their own care, leading to better outcomes.
Dr. Patel has published widely in topics such as avoiding complications in endoscopic sinus surgery, chronic rhinosinusitis in the immunosuppressed patient population, new devices and techniques for endoscopic skull base surgery, and olfactory dysfunction. She continues to perform research in these areas, and is currently collaborating with neuroscientists and engineers to develop technology that she hopes will eventually help cure patients with smell loss, and potentially even help those with neurodegenerative disorders, such as Alzheimer's and Parkinson's disease. -
John M. Pauly
Reid Weaver Dennis Professor
BioInterests include medical imaging generally, and magnetic resonance imaging (MRI) in particular. Current efforts are focused on medical applications of MRI where real-time interactive imaging is important. Two examples are cardiac imaging, and the interactive guidance of interventional procedures. Specific interests include rapid methods for the excitation and acquisition of the MR signal, and the reconstruction of images from the data acquired using these approaches.
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Kim Butts Pauly
Professor of Radiology (Radiological Sciences Lab) and, by courtesy, of Electrical Engineering and of Bioengineering
Current Research and Scholarly InterestsWe are investigating and developing, and applying focused ultrasound in neuromodulation, blood brain barrier opening, and ablation for both neuro and body applications.
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Roy Pea
Director, H-STAR, David Jacks Professor of Education and Professor, by courtesy, of Computer Science
Current Research and Scholarly Interestslearning sciences focus on advancing theories, research, tools and social practices of technology-enhanced learning of complex domains
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Jon-Paul Pepper, MD
Associate Professor of Otolaryngology - Head & Neck Surgery (OHNS)
Current Research and Scholarly InterestsFacial paralysis is a debilitating condition that affects thousands of people. Despite excellent surgical technique, we are currently limited by the regenerative capacity of the body. The mission of our research is to identify new treatments that improve current facial paralysis treatments. We do this by exploring the regenerative cues that the body uses to restore tissue after nerve injury, in particular through pathways of neurogenesis and nerve repair in small mammals.
