Wu Tsai Neurosciences Institute
Showing 421-430 of 597 Results
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Matthew Porteus
Sutardja Chuk Professor of Definitive and Curative Medicine
BioDr. Porteus was raised in California and was a local graduate of Gunn High School before completing A.B. degree in “History and Science” at Harvard University where he graduated Magna Cum Laude and wrote an thesis entitled “Safe or Dangerous Chimeras: The recombinant DNA controversy as a conflict between differing socially constructed interpretations of recombinant DNA technology.” He then returned to the area and completed his combined MD, PhD at Stanford Medical School with his PhD focused on understanding the molecular basis of mammalian forebrain development with his PhD thesis entitled “Isolation and Characterization of TES-1/DLX-2: A Novel Homeobox Gene Expressed During Mammalian Forebrain Development.” After completion of his dual degree program, he was an intern and resident in Pediatrics at Boston Children’s Hospital and then completed his Pediatric Hematology/Oncology fellowship in the combined Boston Chidlren’s Hospital/Dana Farber Cancer Institute program. For his fellowship and post-doctoral research he worked with Dr. David Baltimore at MIT and CalTech where he began his studies in developing homologous recombination as a strategy to correct disease causing mutations in stem cells as definitive and curative therapy for children with genetic diseases of the blood, particularly sickle cell disease. Following his training with Dr. Baltimore, he took an independent faculty position at UT Southwestern in the Departments of Pediatrics and Biochemistry before again returning to Stanford in 2010 as an Associate Professor. During this time his work has been the first to demonstrate that gene correction could be achieved in human cells at frequencies that were high enough to potentially cure patients and is considered one of the pioneers and founders of the field of genome editing—a field that now encompasses thousands of labs and several new companies throughout the world. His research program continues to focus on developing genome editing by homologous recombination as curative therapy for children with genetic diseases but also has interests in the clonal dynamics of heterogeneous populations and the use of genome editing to better understand diseases that affect children including infant leukemias and genetic diseases that affect the muscle. Clinically, Dr. Porteus attends at the Lucille Packard Children’s Hospital where he takes care of pediatric patients undergoing hematopoietic stem cell transplantation.
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Kathleen Poston, MD, MS
Edward F. and Irene Thiele Pimley Professor of Neurology and the Neurological Sciences and Professor, by courtesy, of Neurosurgery
Current Research and Scholarly InterestsMy research addresses one of the most devastating and poorly treated symptoms that can develop in people with Parkinson's disease - Dementia. We use biological markers, multi-modal neuroimaging and genetics to understand the different underlying causes of dementia and to understand why dementia develops more quickly in some patients, but not others.
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Manu Prakash
Associate Professor of Bioengineering, Senior Fellow at the Woods Institute for the Environment and Associate Professor, by courtesy, of Oceans and of Biology
BioWe use interdisciplinary approaches including theory and experiments to understand how computation is embodied in biological matter. Examples include cognition in single cell protists and morphological computing in animals with no neurons and origins of complex behavior in multi-cellular systems. Broadly, we invent new tools for studying non-model organisms with significant focus on life in the ocean - addressing fundamental questions such as how do cells sense pressure or gravity? Finally, we are dedicated towards inventing and distributing “frugal science” tools to democratize access to science (previous inventions used worldwide: Foldscope, Abuzz), diagnostics of deadly diseases like malaria and convening global citizen science communities to tackle planetary scale environmental challenges such as mosquito surveillance or plankton surveillance by citizen sailors mapping the ocean in the age of Anthropocene.
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James Priest
Adjunct Clinical Assistant Professor, Pediatrics - Cardiology
Current Research and Scholarly InterestsThe Priest lab seeks a better understanding of the genetics and pathogenesis of congenital heart disease using translational genomics, big-data, and vertebrate models of cardiac development.
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David Prince
Edward F. and Irene Thiele Pimley Professor of Neurology and the Neurological Sciences, Emeritus
Current Research and Scholarly InterestsExperiments examine
1)intrinsic properties of neuronal membranes; actions of neurotransmitters that regulate neocortical and thalamic excitability
2) chronic epileptogenesis following cortical injury; changes in intracortical connectivity and receptors;
3) effects of early injury and activity on cortical development/maldevelopment Electrophysiological, anatomical and pharmacological techniques employed.
4. prophylaxis of postraumatic epilepsy
5. Neocortical interneuronal function/modulation -
Patrick Lee Purdon
Professor of Anesthesiology, Perioperative and Pain Medicine (Department Research) and, by courtesy, of Bioengineering
BioMy research integrates neuroimaging, biomedical signal processing, and the systems neuroscience of general anesthesia and sedation.
My group conducts human studies of anesthesia-induced unconsciousness, using a variety of techniques including multimodal neuroimaging, high-density EEG, and invasive neurophysiological recordings used to diagnose medically refractory epilepsy. We also develop novel methods in neuroimaging and biomedical signal processing to support these studies, as well as methods for monitoring level of consciousness under general anesthesia using EEG. -
Lei (Stanley) Qi
Associate Professor of Bioengineering
BioDr. Lei (Stanley) Qi is an Associate Professor of Bioengineering, an Institute Scholar at Sarafan ChEM-H, and a Chan Zuckerberg Biohub Investigator. He earned B.S. in Physics and Mathematics from Tsinghua University and Ph.D. in Bioengineering from UC Berkeley. Before joining the Stanford faculty in 2014, Dr. Qi was a Systems Biology Faculty Fellow at UCSF.
Dr. Qi is a pioneer in CRISPR technology development, particularly in the areas of epigenetic regulation and chromatin DNA imaging. He invented the first nuclease-deactivated Cas9 (dCas9) system for targeted gene regulation in living cells. His lab has since expanded the CRISPR-dCas toolbox, including new tools and variants like hyperCas12a and the compact CasMINI. These new technologies have enabled CRISPRi and CRISPRa for targeted gene repression and activation in various cells and organisms, large-scale genetic perturbation screens, and precision epigenetic editing in primary cells. His lab also developed technologies for dynamic chromatin DNA imaging in live cells (LiveFISH), 3D genome structure manipulation (CRISPR-GO), and multiplexed transcriptome engineering (MEGA).
Dr. Qi has used these new technologies to make key discoveries in epigenetics, such as the synergistic functions of enhancer elements in cancer gene regulation, metabolic pathways in T cell dysfunction, and novel antivirals against RNA viruses. Dr. Qi’s current research explores synthetic biology, epigenetics, immune cell engineering, and innovative targets for gene therapy in immunology and neurobiology. -
Xiang Qian
Stanford Medicine Endowed Director
Clinical Professor, Anesthesiology, Perioperative and Pain Medicine
Clinical Professor (By courtesy), NeurosurgeryCurrent Research and Scholarly InterestsClinical Interests
-Pain Medicine:
Facial pain
Migraine and headache
Trigeminal Neuralgia and Glossopharyngeal neuralgia
Cancer Pain
Spine Disease
Neuropathic pain
Interventional Surgery
CT guided Procedure
Opioid Management
-Facial Nerve neuralgia and neuropathy
Hemifacial Spasm
CT guided awake RFA of facial nerve
Research Interests:
-Medical device development
-AI based headache diagnosis and management
-CT guided intervention
-Intra-nasal endoscopy guided procedure
-Optogenetics
-Mechanisms of neuropathic pain
-Ion channel and diseases
-Neurotoxicity of anesthetics -
Jian Qin
Associate Professor of Chemical Engineering
BioJian Qin is an Associate Professor in the Department of Chemical Engineering at the Stanford University. His research focuses on development of microscopic understanding of structural and physical properties of soft matters by using a combination of analytical theory, scaling argument, numerical computation, and molecular simulation. He worked as a postdoctoral scholar with Juan de Pablo in the Institute for Molecular Engineering at the University of Chicago and with Scott Milner in the Department of Chemical Engineering at the Pennsylvania State University. He received his Ph.D. in the Department of Chemical Engineering and Materials Science at the University of Minnesota under the supervision of David Morse and Frank Bates. His research covers self-assembly of multi-component polymeric systems, molecular origin of entanglement and polymer melt rheology, coacervation of polyelectrolytes, Coulomb interactions in dielectrically heterogeneous electrolytes, and surface charge polarizations in particulate aggregates in the absence or presence of flow.
