School of Humanities and Sciences
Showing 701-800 of 2,065 Results
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Keith Hodgson
David Mulvane Ehrsam and Edward Curtis Franklin Professor of Chemistry and Professor of Photon Science at SLAC
BioCombining inorganic, biophysical and structural chemistry, Professor Keith Hodgson investigates how structure at molecular and macromolecular levels relates to function. Studies in the Hodgson lab have pioneered the use of synchrotron x-radiation to probe the electronic and structural environment of biomolecules. Recent efforts focus on the applications of x-ray diffraction, scattering and absorption spectroscopy to examine metalloproteins that are important in Earth’s biosphere, such as those that convert nitrogen to ammonia or methane to methanol.
Keith O. Hodgson was born in Virginia in 1947. He studied chemistry at the University of Virginia (B.S. 1969) and University of California, Berkeley (Ph.D. 1972), with a postdoctoral year at the ETH in Zurich. He joined the Stanford Chemistry Department faculty in 1973, starting up a program of fundamental research into the use of x-rays to study chemical and biological structure that made use of the unique capabilities of the Stanford Synchrotron Radiation Lightsource (SSRL). His lab carried out pioneering x-ray absorption and x-ray crystallographic studies of proteins, laying the foundation for a new field now in broad use worldwide. In the early eighties, he began development of one of the world's first synchrotron-based structural molecular biology research and user programs, centered at SSRL. He served as SSRL Director from 1998 to 2005, and SLAC National Accelerator Laboratory (SLAC) Deputy Director (2005-2007) and Associate Laboratory Director for Photon Science (2007-2011).
Today the Hodgson research group investigates how molecular structure at different organizational levels relates to biological and chemical function, using a variety of x-ray absorption, diffraction and scattering techniques. Typical of these molecular structural studies are investigations of metal ions as active sites of biomolecules. His research group develops and utilizes techniques such as x-ray absorption and emission spectroscopy (XAS and XES) to study the electronic and metrical details of a given metal ion in the biomolecule under a variety of natural conditions.
A major area of focus over many years, the active site of the enzyme nitrogenase is responsible for conversion of atmospheric di-nitrogen to ammonia. Using XAS studies at the S, Fe and Mo edge, the Hodgson group has worked to understand the electronic structure as a function of redox in this cluster. They have developed new methods to study long distances in the cluster within and outside the protein. Studies are ongoing to learn how this cluster functions during catalysis and interacts with substrates and inhibitors. Other components of the protein are also under active study.
Additional projects include the study of iron in dioxygen activation and oxidation within the binuclear iron-containing enzyme methane monooxygenase and in cytochrome oxidase. Lab members are also investigating the role of copper in electron transport and in dioxygen activation. Other studies include the electronic structure of iron-sulfur clusters in models and enzymes.
The research group is also focusing on using the next generation of x-ray light sources, the free electron laser. Such a light source, called the LCLS, is also located at SLAC. They are also developing new approaches using x-ray free electron laser radiation to image noncrystalline biomolecules and study chemical reactivity on ultrafast time scales. -
Leo Hollberg
Professor (Research) of Physics and of Geophysics
BioHow can we make optimal use of quantum systems (atoms, lasers, and electronics) to test fundamental physics principles, enable precision measurements of space-time and when feasible, develop useful devices, sensors, and instruments?
Professor Hollberg’s research objectives include high precision tests of fundamental physics as well as applications of laser physics and technology. This experimental program in laser/atomic physics focuses on high-resolution spectroscopy of laser-cooled and -trapped atoms, non-linear optical coherence effects in atoms, optical frequency combs, optical/microwave atomic clocks, and high sensitivity trace gas detection. Frequently this involves the study of laser noise and methods to circumvent measurement limitations, up to, and beyond, quantum limited optical detection. Technologies and tools utilized include frequency-stabilized lasers and chip-scale atomic devices. Based in the Hansen Experimental Physics Laboratory (HEPL), this research program has strong, synergistic, collaborative connections to the Stanford Center on Position Navigation and Time (SCPNT). Research directions are inspired by experience that deeper understanding of fundamental science is critical and vital in addressing real-world problems, for example in the environment, energy, and navigation. Amazing new technologies and devices enable experiments that test fundamental principles with high precision and sometimes lead to the development of better instruments and sensors. Ultrasensitive optical detection of atoms, monitoring of trace gases, isotopes, and chemicals can impact many fields. Results from well-designed experiments teach us about the “realities” of nature, guide and inform, occasionally produce new discoveries, frequently surprise, and almost always generate new questions and perspectives. -
Susan Holmes
Professor of Statistics
Current Research and Scholarly InterestsOur lab has been developing tools for the analyses of complex data structures, extending work on multivariate data to structured multitable table that include graphs, networks and trees as well as categorical and continuous measurements.
We created and support the Bioconductor package phyloseq for the analyses of microbial ecology data from the microbiome. We have specialized in developing interactive graphical visualization tools for doing reproducible research in biology. -
Andrew Mosser Hong
Masters Student in Management Science and Engineering, admitted Autumn 2022
Peer Advisor, Statistics
Stanford Student Employee, Statistics
Student Assistant, StatisticsCurrent Role at StanfordMasters student in Management Science & Engineering. Undergraduate student in Data Science. Peer Advisor in Data Science. Resident Assistant.
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Andrew James Howard
Ph.D. Student in Applied Physics, admitted Autumn 2019
BioAndrew J. Howard received his B.S. in Optics from the University of Rochester in 2019. During his time at Rochester, he served as a Research Assistant in the ultrafast group at the Laboratory for Laser Energetics. He was awarded the Charles L. Newton Prize for his work. In late 2019, Howard enrolled in the Applied Physics Ph.D. program at Stanford University and was named the Albion Walter Hewlett Fellow. Here he studies experimental strong-field physics and ultrafast laser-driven molecular dynamics. He currently specializes in 3D fragment-momentum imaging, in which the three-dimensional momentum of molecular fragments produced during the interaction between a laser and a molecule yields valuable information about femtosecond molecular processes and light-matter interactions.
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Wray Huestis
Professor of Chemistry, Emerita
BioProfessor Wray Huestis’ research concerns the molecular mechanisms whereby cells control their shape, motility, deformability and the structural integrity of their membranes. Metabolic control of interprotein and protein-lipid interactions is studied by a variety of biochemical, spectroscopic and radiochemical techniques, including fluorescence and EPR spectrometry, autoradiography and electron microscopy. The role of lipid metabolism and transport in regulating the fluid dynamics of cell suspensions (red blood cells, platelets, lymphocytes) is examined using circulating cells and cells grown in culture. Cell-cell and cell-liposome interactions are studied using model membrane systems with widely differing physical properties. Complexes of liposomes and encapsulated viruses are used as selective vectors to deliver water-soluble compounds across the membranes of intact cells. The particular projects described in the listed publications have as a common goal an understanding of the molecular workings of the cell membrane.
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Pamela Hung
Adm Assoc 3, Biology
Current Role at StanfordAdministrative Associate at Biology Department
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Khoi Huynh
Fac Spclst 2, Physics
Current Role at StanfordManager of Physics Store & Copy Center
Webmaster of Physics Department website
Physics Department health & safety coordinator
Physics Department space inventory coordinator
Photography & design for Physics Department website and correspondence -
Jamie Imam
Advanced Lecturer
BioDr. Jamie Imam received her bachelor's degree in Biological Sciences and Psychology from Carnegie Mellon University and her Ph.D. in Genetics from the Stanford School of Medicine. In addition to teaching, Jamie is the Director of the Honors Program in Biology and a Lecturer Consultant with the Center for Teaching and Learning. When she is not teaching or doing science outreach, she enjoys reading, baking and spending time outdoors with her family.
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Kent Irwin
Director, Hansen Experimental Physics Laboratory (HEPL), Professor of Physics, of Particle Physics and Astrophysics and of Photon Science
BioIrwin Group web page:
https://irwinlab.stanford.edu/ -
Christine Jacobs-Wagner
Dennis Cunningham Professor, Professor of Biology and of Microbiology and Immunology
BioChristine Jacobs-Wagner is a Dennis Cunningham Professor in the Department of Biology and the ChEM-H Institute at Stanford University. She is interested in understanding the fundamental mechanisms and principles by which cells, and, in particular, bacterial cells, are able to multiple. She received her PhD in Biochemistry in 1996 from the University of Liège, Belgium where she unraveled a molecular mechanism by which some bacterial pathogens sense and respond to antibiotics attack to achieve resistance. For this work, she received multiple awards including the 1997 GE & Science Prize for Young Life Scientists. During her postdoctoral work at Stanford Medical School, she demonstrated that bacteria can localize regulatory proteins to specific intracellular regions to control signal transduction and the cell cycle, uncovering a new, unsuspected level of bacterial regulation.
She started her own lab at Yale University in 2001. Over the years, her group made major contributions in the emerging field of bacterial cell biology and provided key molecular insights into the temporal and spatial mechanisms involved in cell morphogenesis, cell polarization, chromosome segregation and cell cycle control. For her distinguished work, she received the Pew Scholars award from the Pew Charitable Trust, the Woman in Cell Biology Junior award from the American Society of Cell Biology and the Eli Lilly award from the American Society of Microbiology. She held the Maxine F. Singer and William H. Fleming professor chairs at Yale. She was elected to the Connecticut academy of Science, the American Academy of Microbiology and the National Academy of Sciences. She has been an investigator of the Howard Hughes Medical Institute since 2008.
Her lab moved to Stanford in 2019. Current research examines the general principles and spatiotemporal mechanisms by which bacterial cells replicate, using Caulobacter crescentus and Escherichia coli as models. Recently, the Jacobs-Wagner lab expanded their interests to the Lyme disease agent Borrelia burgdorferi, revealing unsuspected ways by which this pathogen grows and causes disease -
Aditi Jha
Postdoctoral Scholar, Statistics
BioI am a computational neuroscientist, working at the intersection of machine learning and systems neuroscience.
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Iain Johnstone
Marjorie Mhoon Fair Professor of Quantitative Science and Professor of Statistics and of Biomedical Data Sciences
Current Research and Scholarly InterestsEmpirical bias/shrinkage estimation; non-parametric, smoothing; statistical inverse problems.
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Shaili Johri
Postdoctoral Scholar, Hopkins Marine Station
BioI am a geneticist who works in the field of marine science and conservation. My work is aimed at reducing knowledge gaps in conservation science through scientific research, community partnerships and knowledge exchange across disciplines. Genomics research by our group aims to inform conservation policy and assist in reducing illegal wildlife trade.
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Patricia Jones
The Dr. Nancy Chang Professor, Emerita
Current Research and Scholarly InterestsDr. Jones' research focused on genetic, molecular, and cellular mechanisms that regulate immune responses. She hHer most recent work was centered on the regulation of innate immune responses that are triggered by conserved microbial components. As these responses can be harmful they are highly regulated in their occurrence, magnitude, and duration. Her lab discovered a novel mechanism that negatively regulates innate responses, mediated by the phosphatase calcineurin.