Institute for Stem Cell Biology and Regenerative Medicine
Showing 51-100 of 107 Results
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Michelle Monje
Associate Professor of Neurology and, by courtesy, of Neurosurgery, of Pediatrics, of Pathology and of Psychiatry and Behavioral Sciences
Current Research and Scholarly InterestsThe Monje Lab studies the molecular and cellular mechanisms of postnatal neurodevelopment. This includes microenvironmental influences on neural precursor cell fate choice in normal neurodevelopment and in disease states.
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Hiromitsu (Hiro) Nakauchi
Professor of Genetics (Stem Cell)
Current Research and Scholarly InterestsTranslation of discoveries in basic research into practical medical applications
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Gernot Neumayer
Postdoctoral Research Fellow, Stem Cell Biology and Regenerative Medicine
Current Research and Scholarly InterestsMy MSc project, carried out at the University of Salzburg in cooperation with the biotechnology company ProComCure, investigated the molecular interface between human cells and the bacterium Staphylococcus aureus. S. aureus exhibits a dramatic increase in resistance to antibiotics, thereby causing enormous challenges for health care. Using proteomics platforms, I identified numerous novel host-pathogen interactions. These findings are being developed further by ProComCure in order to design innovative therapies for S. aureus infections.
My dissertation project, carried out at the University of Calgary, defined the functions of the human protein TPX2. TPX2 has been discovered over 17 years ago for its unique property to mediate cell division. However, when not involved in cell division TPX2 resides in the cell nucleus where its role had remained unknown. Building on my background in proteomics, I discovered a novel TPX2-containing protein complex that resides in the nucleus. Analysis of this complex unraveled a completely unexpected role for TPX2 in cellular reactions triggered by insults to DNA. To avoid cancers, cells respond to damaged DNA by either attempting its repair or, if this is not possible, by committing 'suicide'. My findings established that TPX2 impacts the molecular mechanisms that underlie these responses to DNA damage. More specifically, I found that TPX2 accumulates at DNA lesions and that the cellular levels of TPX2 negatively correlate with the ‘strength’ of the DNA damage response. Thus, TPX2 affects cellular proliferation, DNA repair, and survival upon genomic insult. This was the first function discovered for TPX2 in the cell nucleus. Since abnormally high levels of TPX2 are often found in human cancers, my discovery sheds light on the mechanistic implication of this protein in carcinogenesis. Furthermore, TPX2 is also a promising therapeutic target and my findings may advance novel cancer therapies. We propose that future treatments may attempt to reduce TPX2 levels in order to increase the strength of the DNA damage response. Subsequently, chemo- and radiotherapy doses may be lowered but still stay effective.
In 2014, I joined the Wernig laboratory at Stanford University. Here, I capitalize on my expertise in mechanisms of DNA damage response to develop a pioneering technique capable of repairing pathogenic mutations in the genetic material of patients suffering from Epidermolysis Bullosa (a devastating and often lethal disease that causes chronic erosion of the skin). This novel technique, called CRISPR, introduces experimentally controlled and transient damage to the mutated DNA of patient cells and exploits naturally occurring DNA repair mechanisms to transform the disease-causing mutation to a normal state. I will combine development of CRISPR with Dr. Wernig’s expertise in regenerative medicine to generate patient derived stem cells with repaired (i.e. normal) genes. Subsequently, these stem cells will be employed to regenerate the skin of Epidermolysis Bullosa patients. -
Aaron Newman
Assistant Professor of Biomedical Data Science
Current Research and Scholarly InterestsOur group focuses on building novel data science tools to better understand the cellular and molecular composition of normal and neoplastic tissues. We are using these tools, together with high throughput sequencing, single cell genomics, and experimental techniques, to study the diversity and clinical significance of (i) cancer cell subtypes involved in tumor initiation, maintenance, and metastasis, and (ii) stromal cell subsets in the tumor microenvironment.
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Roeland Nusse
Virginia and Daniel K. Ludwig Professor in Cancer Research and the Reed-Hodgson Professor in Human Biology
Current Research and Scholarly InterestsOur laboratory studies Wnt signaling in development and disease. We found recently that Wnt proteins are unusual growth factors, because they are lipid-modified. We discovered that Wnt proteins promote the proliferation of stem cells of various origins. Current work is directed at understanding the function of the lipid on the Wnt, using Wnt proteins as factors the expand stem cells and on understanding Wnt signaling during repair and regeneration after tissue injury.
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Theo Palmer
Professor of Neurosurgery
Current Research and Scholarly InterestsMembers of the Palmer Lab study the biology of neural stem cells in brain development and in the adult. Our primary goal is to understand how genes and environment synergize in influencing stem cell behavior during development and how mild genetic or environmental risk factors for disease may synergize in their detrimental effects on brain development or in the risk of neuronal loss in age-related degenerative disease.
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Matthew Porteus
Professor of Pediatrics (Stem Cell Transplantation)
Current Research and Scholarly InterestsGenome Editing and Population Dynamics for Gene Therapy and Cancer Research
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Zhen Qi
Postdoctoral Research Fellow, Stem Cell Biology and Regenerative Medicine
Current Research and Scholarly InterestsThe majority of cancer deaths are actually due to spread of the disease to other organs. My research focuses on understanding the mechanisms of cancer metastasis.
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Maria Grazia Roncarolo
George D. Smith Professor in Stem Cell and Regenerative Medicine and Professor of Medicine (Blood and Marrow Transplantation)
Current Research and Scholarly InterestsResearch Interests
Immunetolerance: Mechanisms underlying T-cell tolerance, induction of T-cell anergy and regulatory T cells; Immunomodulation: mAbs, proteins and low molecular weight compounds which can modulate T-cell activation; Primary immunodeficiencies: Characterization of molecular and immunological defects; Gene therapy: Gene transduction of hematopoietic cells for gene therapy in primary immunodeficiencies and metabolic diseases; Hematopoiesis: Mechanisms underlying growth and differentiation of hematopoietic stem cells; Transplantation: Immune reconstitution and T-cell tolerance after allogenic stem cell transplantation; Cytokines/Cytokine receptors: Role in regulation of immune and inflammatory responses
Clinical Interests
Primary Immunodeficiencies
Monogenic Autoimmune Disorders
Allogenic Bone Marrow Transplantation
Gene Therapy Clinical Trials
Cell Therapy Clinical Trials
Clinical Trials in Autoimmune Diseases and Organ Transplantation
Clinical Trials in Hemoglobinopathies -
Vittorio Sebastiano
Assistant Professor (Research) of Obstetrics and Gynecology (Reproductive and Stem Cell Biology)
Current Research and Scholarly InterestsThe thread of Ariadne that connects germ cells, preimplatation development and pluripotent stem cells is the focus of my research, with a specific interest in human development. My long-term goals are: 1. Understanding the biology of germ cells and and their ability to sustain early preimplantation development; 2. Understanding the mechanisms that regulate very early cell fate decisions in human embryos; 3. Understanding the biology of derivation and maintenance of Pluripotent Stem Cells
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Judith Shizuru
Professor of Medicine (Blood and Marrow Transplantation) and of Pediatrics (Stem Cell Transplantation)
Current Research and Scholarly InterestsTransplantation of defined populations of allogeneic hematopoietic cells. Specifically, the way in which hematopoietic cell grafts alter antigen specific immune responses to allo-, auto- and viral antigens. The cellular and molecular basis of resistance to engraftment of allogeneic hematopoietic stem cells.
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Michal Tal
Instructor, Institute for Stem Cell Biology and Regenerative Medicine
Current Research and Scholarly InterestsInvestigating how the CD47-SIRPa axis modulates multiple facets of immunity
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Ayelet Voskoboynik
Sr Res Scientist-Basic Life, Stem Cell Bio Regenerative Med Institute
Current Role at StanfordAdvising and Mentoring
Benyamin, Rosental
benyamin@stanford.edu
(1) 831-224-2187 Postdoctoral Fellow, Weissman Lab.
Mark Alec Kowarsky
markak@stanford.edu
Doctoral program physics, Quake Lab.
Pre Major Advisees
Ratteray, Alida Nicole
aratt@stanford.edu
1 (603) 921-7328Undergrad, ENGR-BS, Junior
Philp, Charlotte Victoria
cphilp@stanford.edu
1 (650) 391-3140Undergrad, BIOE-BS, Junior
Stevens, Lydia Rose
lydiars@stanford.edu
(805) 440-9115Undergrad, UNDCL-B, Sophomore
Lim, Joseph Patrick
jlim19@stanford.edu
(501) 305-1504Undergrad, UNDCL-B, Sophomore
Kumarasinghe, Raveen Lashlen
rkumaras@stanford.edu
(510) 766-5999Undergrad, UNDCL-B, Sophomore -
Irving Weissman
Director, Stanford Institute for Stem Cell Biology and Regenerative Medicine, Virginia & D.K. Ludwig Professor for Clinical Investigation in Cancer Research, Professor of Developmental Biology and, by courtesy, of Biology
Current Research and Scholarly InterestsStem cell and cancer stem cell biology; development of T and B lymphocytes; cell-surface receptors for oncornaviruses in leukemia. Hematopoietic stem cells; Lymphocyte homing, lymphoma invasiveness and metastasis.
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Marius Wernig
Professor of Pathology and, by courtesy, of Chemical and Systems Biology
Current Research and Scholarly InterestsEpigenetic Reprogramming, Direct conversion of fibroblasts into neurons, Pluripotent Stem Cells, Neural Differentiation: implications in development and regenerative medicine
