School of Medicine
Showing 301-320 of 12,928 Results
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Derek F. Amanatullah, M.D., Ph.D.
Associate Professor of Orthopaedic Surgery
BioDr. Amanatullah specializes in hip and knee replacements for individuals with osteoarthritis, rheumatoid arthritis, infectious arthritis and avascular necrosis. He also performs revision surgeries of knee and hip implants with problems.
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Melanie Ambler
MD Student with Scholarly Concentration in Biomedical Ethics & Medical Humanities, expected graduation Spring 2026
BioMelanie Ambler is an aspiring physician-artist-scientist, interested in the integration of the arts into the medical field. She is a classically-trained cellist and founded two live virtual concert series for patients and care providers in both the United States and France. In 2019, she received a Fulbright Fellowship for study and research in the city of Caen, France. She pursued a master's in Neuroscience at the Université de Caen-Normandie, and performed a research study with the Neuroimaging Lab of Human Memory regarding the ability of patients with clinical amnesia to recognize new melodies or paintings. She is currently a musician on call for the nonprofit Project: Music Heals Us and plays weekly one-on-one virtual concerts for critically ill patients.
Melanie hopes to continuing bridging the arts and medicine during her time at Stanford Medicine by researching promising interventions and then putting them into practice as a care provider. -
Michelle Ameri, BA, RVT
Adm Svcs Admstr 2, Pediatrics - Cardiology
Current Role at StanfordBASE Operations Manager
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Manuel R. Amieva
Professor of Pediatrics (Infectious Diseases) and of Microbiology and Immunology
Current Research and Scholarly InterestsMy laboratory studies how bacteria colonize our bodies for long periods of time, and how interactions between bacteria and the epithelial surfaces of the gastrointestinal tract and skin may lead to disease. Epithelial surfaces are the first barrier against infection, but they also where our bodies meet and co-evolve with the microbial world.. Several of our studies have focused on the epithelial junctions as a target for bacterial pathogens. The host epithelium uses its epithelial junctions to form a tight but dynamic barrier with an external surface that is inhospitable to microbial attachment, secretes anti-microbial compounds, and has a rapid rate of self-renewal. The balance in the microbe-epithelial relationship results in silent commensalism or symbiosis; an imbalance results in diseases ranging from acute bacterial invasive disease to chronic ulcers or carcinoma.
Our laboratory has developed novel microscopy applications such as quantitative 3D confocal microscopy, electron microscopy, time-lapse imaging, microinjection and micromanipulation to visualize the interaction of pathogens with epithelial cells in culture and in animal and human tissues. Many of out studies focus on the gastric pathogen Helicobacter pylori, but we have also expanded our investigations to include the intestinal pathogens Listeria monocytogenes and Salmonella enterica, and the skin pathogen and colonizer Staphylococcus aureus. I believe that elucidating how microbes communicate with and alter our epithelial cells at a molecular level will be important for finding novel therapeutic targets to control mucosal colonization and prevent invasive disease.
Using this perspective, we have uncovered several novel concepts of how bacteria colonize and breach our epithelial surfaces. For example, we discovered that Helicobacter pylori target the intercellular junctions, and in particular that the virulence factor CagA affects junction assembly and cell polarity. This confers H. pylori the ability to extract nutrients and grow directly on the epithelial surface. We also found that these properties of CagA have consequences for cellular transformation of the epithelium. For instance, we showed that H. pylori affect the activity and state of epithelial stem cells in the stomach by colonizing the epithelial surface deep in the gastric glands. This gland-associated population is essential for pathological inflammation and hyperplasia in animal models, and confers significant colonization advantages to the bacteria. Our Listeria research uncovered a new mechanism and site where bacteria can breach the gastrointestinal epithelial barrier to invade. We found that Listeria find their receptor for invasion at sites of epithelial senescence, where the epithelial junctions undergo dynamic turnover. To study Salmonella and H. pylori we have developed a human organoid model to study their interactions with human gut epithelium in vitro. To study Staphylococcus aureus pathogenesis, we have developed methods to visualize infection at the scale of a single bacterial microcolony using an organoid culture system of human keratinocytes and fibroblasts that grow into a 3D skin-equivalent. We recently identified several proteins at the eptithelial junctions as host factors involved in the pathogenesis of one of Staphylococcus aureus major toxins. -
Maryam Amirahmadi
Postdoctoral Scholar, Cardiovascular Medicine
BioDr. Maryam Amirahmadi is a microsurgery expert and postdoctoral research fellow at Stanford Cardiovascular Institute. She obtained her Doctor of Medicine (MD) degree from Hamadan University of Medical Sciences. After more than a year of experience as a Family and Emergency Physician, she spent around 4 years at the Department of Cardiovascular Surgery of Shiraz University of Medical Sciences where she served as a pediatric and adult Cardiac Intensive Care physician and received training in cardiovascular surgery at Namazi and Faghihi hospitals. She then spent a year in the Department of Vascular Surgery at the University of Miami, Miller School of Medicine, serving as a postdoctoral researcher and performing microsurgery on animals, with her research focused on therapeutic strategies to improve neovascularization after limb ischemia. Dr. Amirahmadi joined Stanford Cardiovascular Institute in 2022 where she is now a postdoctoral research fellow under the supervision of Prof. Philip S. Tsao, a renowned cardiovascular scientist. Her research interests and practical expertise include Microsurgery, and the effect of e-cigarette vaping on factors of inflammatory or immune pathways that can subsequently be related to the molecular mechanisms involved in angiogenesis and arteriogenesis in the murine model of hindlimb ischemia, as well as the mechanisms of e-cigarette and nicotine’s effects in augmenting Abdominal Aortic Aneurysm (AAA) in rodent models of aortic aneurysm, including porcine pancreatic elastase-induced AAA. Dr. Maryam Amirahmadi and her colleagues are currently investigating the transgenerational effects of vaping/nicotine on abdominal aortic aneurysm (AAA) risk.
