School of Medicine
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Tho Duc Pham
Clinical Associate Professor, Pathology
Current Research and Scholarly InterestsMy areas of interest involve exploring antibody function as it relates to transfusion medicine, blood safety, and emerging infectious diseases. This ranges from natural immune responses to the ABO blood group, antibody profiling anti-SARS-CoV-2 antibodies, and studying HEV seroprevalence in the local community. I am also interested in exploring statistical approaches to improve blood product availability and overall health care efficiency in a tertiary care system.
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Trung Hoang Minh Pham
Assistant Professor of Pediatrics (Infectious Diseases)
Current Research and Scholarly InterestsUncovering mechanisms of tissue immunity and immunophysiology during persistent infection
The immune system safeguards the health of complex organisms by rapidly eliminating invading pathogens, curbing infection-induced tissue disruptions, and maintaining tissue homeostasis. Many bacterial pathogens evade host antimicrobial mechanisms and persist in infected tissues at low levels for long periods of time even in the presence of innate and adaptive immune resistance. During persistent infection, the immune system simultaneously orchestrates antimicrobial responses to contain the pathogen, repairs damaged tissue, regulates nutrient resources, and maintains other tissue physiologic functions to ensure host survival. Failure of any of these tasks leads to uncontrolled infection, devastating disease, and even death. The goals of our research are to understand:
1)What are the innate and adaptive immune cellular mechanisms that contain pathogens during persistent infection?
2)How are tissue physiological functions, such as tissue repair and nutrient regulation, maintained during persistent infection?
3)How do pathogens survive innate and adaptive antimicrobial mechanisms in infected tissues?
4)How does persistent infection impact host immunity to secondary infections of a similar or different pathogen?
Through investigating these fundamental questions, we may be able to decode the underlying cellular and molecular mechanisms that can be harnessed to eradicate infections and help restore health after an infectious insult. We employ animal infection models and bring together immunology, tissue biology, microbiology, and genetics to uncover the mechanisms of tissue immunity and immunophysiology during persistent infection from the molecular to organismal level.
Current areas of research:
•Development, maintenance, and plasticity of macrophage functional diversity in infected tissue
•Tissue repair and nutrient regulation during persistent infection
•Cellular dynamics and bacterial persistence in lymphoid organs
We are looking for highly motivated team members who are passionate about making impactful scientific discoveries to join our group at all levels. For opportunities and positions available for pre-doctoral students and postdoctoral fellows, please contact tpham8@stanford.edu! -
Harold Westley Phillips
Assistant Professor of Neurosurgery (Pediatric Neurosurgery)
BioH. Westley Phillips, MD is an Assistant Professor of Neurosurgery at Stanford University where he is a neurosurgeon-scientist specializing in pediatric neurosurgery with a special interest in epilepsy. Dr. Phillips received his undergraduate degree at Yale University where he was a member of the Varsity Football Team and received a Fulbright Scholarship. He completed an MD at the Perelman School of Medicine at the University of Pennsylvania, graduating with a certificate of distinction in the Clinical Neuroscience Training Program. He completed neurosurgical residency at UCLA where he received 2 years of NIH funding to investigate the genetic underpinnings of epilepsy. He received fellowship training in pediatric epilepsy surgery and genetics research at Boston Children’s Hospital as well as pediatric neurosurgery at the University of Pittsburgh Medical Center, Children’s Hospital of Pittsburgh before his arrival at Stanford. At Stanford, Dr. Phillips leads a molecular genetics laboratory and has a particular interest in defining and further understanding somatic mosaicism and its role in epileptogenesis. He has published manuscripts in leading academic journals including Nature: Genetics, JAMA Neurology, Journal of Neuroscience, Scientific Reports, Epilepsia and Neurology. He is dedicated to improving the treatment and outcomes for children with drug resistant epilepsy through innovative research and cutting-edge surgical techniques.
