School of Medicine
Showing 9,601-9,610 of 12,956 Results
-
Maria Grazia Roncarolo
George D. Smith Professor of Stem Cell and Regenerative Medicine and Professor of Medicine (Blood and Marrow Transplantation and Cellular Therapy)
Current Research and Scholarly InterestsResearch Interests
Immunetolerance: Mechanisms underlying T-cell tolerance, induction of T-cell anergy and regulatory T cells; Immunomodulation: mAbs, proteins and low molecular weight compounds which can modulate T-cell activation; Primary immunodeficiencies: Characterization of molecular and immunological defects; Gene therapy: Gene transduction of hematopoietic cells for gene therapy in primary immunodeficiencies and metabolic diseases; Hematopoiesis: Mechanisms underlying growth and differentiation of hematopoietic stem cells; Transplantation: Immune reconstitution and T-cell tolerance after allogenic stem cell transplantation; Cytokines/Cytokine receptors: Role in regulation of immune and inflammatory responses
Clinical Interests
Primary Immunodeficiencies
Monogenic Autoimmune Disorders
Allogenic Bone Marrow Transplantation
Gene Therapy Clinical Trials
Cell Therapy Clinical Trials
Clinical Trials in Autoimmune Diseases and Organ Transplantation
Clinical Trials in Hemoglobinopathies -
Morteza Roodgar DVM, PhD
Veterinarian Research Scientist, Genetics
BioDr. Morteza Roodgar is a veterinarian scientist with a research focus on Primate induced Pluripotent Stem Cells (iPSCs) and long-read genomics tools.
Dr. Roodgar's research focus is on primate stem cell biology, immunology, and comparative genomics of nonhuman primate models for human diseases. The long-term goal of Dr. Roodgar's research is to Replace, Reduce and Refine (aka 3 R’s) the use of animals in biomedical research leveraging primate induced pluripotent stem cells (iPSCs) and long-read genomic tools to speed up preclinical testing.
Previous research includes immunology and genomic susceptibility to infectious diseases (e.g., tuberculosis, TB) in nonhuman primate models, Preventive Veterinary Medicine and emerging zoonotic diseases (e.g., COVID-19 and Monkeypox).
