Wu Tsai Neurosciences Institute


Showing 1-44 of 44 Results

  • Debra Safer

    Debra Safer

    Associate Professor of Psychiatry and Behavioral Sciences (General Psychiatry and Psychology-Adult)) at the Stanford University Medical Center

    Current Research and Scholarly InterestsPrimary research interests include the nature and treatment of eating disorders
    (particularly bulimia nervosa and binge eating disorder), the development and treatment of obesity, and the development and treatment of problematic eating patterns in patients following bariatric surgery.

  • Manish Saggar

    Manish Saggar

    Assistant Professor (Research) of Psychiatry and Behavioral Sciences (Interdisciplinary Brain Science Research)

    Current Research and Scholarly InterestsThe overarching goal of my research is to develop reliable computational methods that will allow for characterizing and modeling temporal dynamics of brain activity, without averaging data in either space or time. I firmly believe that the spatiotemporal richness in brain activity might hold the key to finding the person- and disorder-centric biomarkers. I am currently developing methods to model the temporal dynamics of brain activity in individuals with fragile X syndrome and healthy controls.

  • Alberto Salleo

    Alberto Salleo

    Professor of Materials Science and Engineering

    Current Research and Scholarly InterestsNovel materials and processing techniques for large-area and flexible electronic/photonic devices. Polymeric materials for electronics, bioelectronics, and biosensors. Electrochemical devices for neuromorphic computing. Defects and structure/property studies of polymeric semiconductors, nano-structured and amorphous materials in thin films. Advanced characterization techniques for soft matter.

  • Julia Salzman

    Julia Salzman

    Assistant Professor of Biochemistry and of Biomedical Data Science

    Current Research and Scholarly InterestsCircular RNA regulation and function; computational and experimental approaches

  • Peter L. Santa Maria, MD, PhD

    Peter L. Santa Maria, MD, PhD

    Assistant Professor of Otolaryngology - Head & Neck Surgery (OHNS) at the Stanford University Medical Center

    Current Research and Scholarly InterestsWe study chronic suppurative otitis media, a chronic biofilm infection of the middle ear predominantly involving pseudomonas and staph aureus. We are investigating mechanisms of sensory hearing loss, host microbe interactions and trialling novel therapeutics.

    Our work in tympanic membrane regeneration has entered clinical trials.

    Novel treatments for wound healing in intra oral wounds with potential applications to prevent post tonsillectomy wound healing and oral mucositis.

  • Robert Sapolsky

    Robert Sapolsky

    John A. and Cynthia Fry Gunn Professor and Professor of Neurology and of Neurosurgery

    Current Research and Scholarly InterestsNeuron death, stress, gene therapy

  • Ansuman Satpathy

    Ansuman Satpathy

    Assistant Professor of Pathology

    Current Research and Scholarly InterestsOur lab works at the interface of immunology, cancer biology, and genomics to study cellular and molecular mechanisms of the immune response to cancer. In particular, we are leveraging high-throughput genomic technologies to understand the dynamics of the tumor-specific T cell response to cancer antigens and immunotherapies (checkpoint blockade, CAR-T cells, and others). We are also interested in understanding the impact of immuno-editing on the heterogeneity and clonal evolution of cancer.

    We previously developed genome sequencing technologies that enable epigenetic studies in primary human immune cells from patients: 1) 3D enhancer-promoter interaction profiling (Nat Genet, 2017), 2) paired epigenome and T cell receptor (TCR) profiling in single cells (Nat Med, 2018), 3) paired epigenome and CRISPR profiling in single cells (Cell, 2019), and high-throughput single-cell ATAC-seq in droplets (Nature Biotech, 2019). We used these tools to study fundamental principles of the T cell response to cancer immunotherapy (PD-1 blockade) directly in cancer patient samples (Nature Biotech, 2019; Nat Med, 2019).

  • Silvio Savarese

    Silvio Savarese

    Associate Professor of Computer Science

    BioSilvio Savarese is an Associate Professor of Computer Science at Stanford University and the inaugural Mindtree Faculty Scholar. He earned his Ph.D. in Electrical Engineering from the California Institute of Technology in 2005 and was a Beckman Institute Fellow at the University of Illinois at Urbana-Champaign from 2005–2008. He joined Stanford in 2013 after being Assistant and then Associate Professor of Electrical and Computer Engineering at the University of Michigan, Ann Arbor, from 2008 to 2013. From 2016 to 2018, he served as a director of the SAIL-Toyota Center for AI Research at Stanford. He co-founded a stealth start up in 2017 where he served as a Chief Scientist from 2018 to 2020.

    Dr Savarese addresses theoretical foundations and practical applications of computational vision and robotic perception. His research focuses on developing algorithms for enabling autonomous and embodied systems to understand and interact with the environment. Contributions include: i) investigation of methods for interpreting complex situations and behaviors from sensory streams; ii) development of computational models for capturing social norms and common sense rules allowing agents to effectively predict and respond to the environment; iii) exploration of machine vision methodologies for enabling automatic performance analysis and sustainability assessment in construction engineering.

    Dr Savarese has published more than 200 scientific articles in top-tier journals and conferences, including IJCV, IEEE-PAMI, CVPR, ICCV, NIPS, ECCV, ICRA, IROS, and RSS. He was program chair of the Conference on Computer Vision and Pattern Recognition (CVPR) in 2020, general chair of the 4th International Conference on 3D Vision (3DV) in 2016, area chair of CVPR 2010, ICCV 2011, CVPR 2013, ECCV 2014, CVPR 2015, ICCV 2015, ECCV 2016, ICCV 2017, and an Associate editor of IEEE Transactions on Pattern Analysis and Machine Intelligence (PAMI), from 2016-2019.

    Dr. Savarese has been recipient of several awards including a Best Paper Award at the IEEE International Conference on Robotics and Automation (ICRA) in 2019, a Best Paper Award at the Conference on Computer Vision and Pattern Recognition (CVPR) in 2018, a Best Student Paper Award at CVPR 2016, the James R. Croes Medal in 2013, a TRW Automotive Endowed Research Award in 2012, an NSF Career Award in 2011 and Google Research Award in 2020 and 2010. In 2002 he was awarded the Walker von Brimer Award for outstanding research initiative. He has been a keynote speaker at various academic conferences and his work has been featured in a variety of media outlets, magazines and domestic and international newspapers including The New York Times, CBS, PBS, Financial Times, Quartz, ABC, BBC, Corriere Della Sera and La Repubblica.

  • Alan F. Schatzberg

    Alan F. Schatzberg

    Kenneth T. Norris, Jr. Professor of Psychiatry and Behavioral Sciences

    Current Research and Scholarly InterestsBiological bases of depressive disorders;, glucocorticoid/dopamine interactions in delusional depression;, pharmacologic treatment of depressive disorders.

  • Mark J. Schnitzer

    Mark J. Schnitzer

    Professor of Biology and of Applied Physics

    Current Research and Scholarly InterestsThe goal of our research is to advance experimental paradigms for understanding normal cognitive and disease processes at the level of neural circuits, with emphasis on learning and memory processes. To advance these paradigms, we invent optical brain imaging techniques, several of which have been widely adopted. Our neuroscience studies combine these imaging innovations with behavioral, electrophysiological, optogenetic and computational methods, enabling a holistic approach to brain science.

  • Birgitt Schuele

    Birgitt Schuele

    Associate Professor (Research) of Pathology

    BioBirgitt Schüle, MD, is an Associate Professor in the Department of Pathology, Stanford University School of Medicine. Her research focuses on medical genetics and stem cell modeling to unlock disease mechanisms and pathways leading to neurodegeneration in Parkinson’s disease and related disorders, and to develop new therapeutic strategies to advance precision medicine.
    She received her medical training from the Georg-August University Göttingen and Medical University Lübeck, Germany (1993 - 2001) and completed doctoral degree in medicine (Dr. med.) in neurophysiology at the Georg-August University Göttingen (2001). During her neurology internship from 2001 to 2002 at Medical University of Lübeck with Prof. Christine Klein, Dr. Schüle studied genes for inherited forms of Parkinson’s disease and dystonia. From 2003 to 2005, she completed a postdoctoral fellowship in human genetics with Prof. Uta Francke at Stanford University School of Medicine. From 2005-2019, Dr. Schüle led key clinical research programs and biospecimen repositories for neurogenetics, translational stem cell and brain donation at the Parkinson’s Institute and Clinical Center.

  • Daniel Schwartz

    Daniel Schwartz

    Dean of the Graduate School of Education and the Nomellini-Olivier Professor of Educational Technology

    Current Research and Scholarly InterestsInstructional methods, transfer of learning and assessment, mathematical development, teachable agents, cognition, and cognitive neuroscience.

  • Matthew P. Scott

    Matthew P. Scott

    Professor of Developmental Biology, Emeritus

    Current Research and Scholarly InterestsOur research has been focused on the genetic regulation of animal development and its relation to birth defects, cancer, and neurodegeneration. We studied mechanisms and functions of Hedgehog (Hh) signaling, which controls cell fates and growth, in the context of normal development and brain cancer. We studied a neurodegenerative disease, Niemann-Pick C syndrome, that affects intracellular organelle movements and sterol homeostasis. Due to Dr. Scott's new job, the lab is no longer active.

  • Vittorio Sebastiano

    Vittorio Sebastiano

    Assistant Professor (Research) of Obstetrics and Gynecology (Reproductive and Stem Cell Biology)
    On Leave from 10/01/2020 To 11/30/2020

    Current Research and Scholarly InterestsThe thread of Ariadne that connects germ cells, preimplatation development and pluripotent stem cells is the focus of my research, with a specific interest in human development. My long-term goals are: 1. Understanding the biology of germ cells and and their ability to sustain early preimplantation development; 2. Understanding the mechanisms that regulate very early cell fate decisions in human embryos; 3. Understanding the biology of derivation and maintenance of Pluripotent Stem Cells

  • Nigam H. Shah, MBBS, PhD

    Nigam H. Shah, MBBS, PhD

    Associate Professor of Medicine (Biomedical Informatics) and of Biomedical Data Science

    Current Research and Scholarly InterestsMy research group studies ontology-based approaches to annotate, index, integrate and analyze unstructured information available in biomedicine for the purpose of enabling data-driven analytics in medicine and health care.

  • Nirao Shah

    Nirao Shah

    Professor of Psychiatry and Behavioral Sciences (Major Laboratories and Clinical Translational Neurosciences Incubator) and of Neurobiology

    Current Research and Scholarly InterestsWe study how our brains generate social interactions that differ between the sexes. Such gender differences in behavior are regulated by sex hormones, experience, and social cues. Accordingly, we are characterizing how these internal and external factors control gene expression and neuronal physiology in the two sexes to generate behavior. We are also interested in understanding how such sex differences in the healthy brain translate to sex differences in many neuro-psychiatric illnesses.

  • Mehrdad Shamloo

    Mehrdad Shamloo

    Professor (Research) of Neurosurgery and, by courtesy, of Neurology

    Current Research and Scholarly InterestsThe ultimate goal of the Shamloo laboratory is to rapidly advance our understanding of brain function at the molecular, cellular, circuit and behavioral levels, and to elucidate the pathological process underlying malfunction of the nervous system following injury and neurologic disorders such as stroke, Alzheimer's disease, Parkinson’s disease, and autism. We have been focusing on the noradrenergic system and approaches leading to restoration of brain adrenergic signaling in these disorders.

  • Carla Shatz

    Carla Shatz

    Sapp Family Provostial Professor, The Catherine Holman Johnson Director of Stanford Bio-X and Professor of Biology and of Neurobiology

    Current Research and Scholarly InterestsThe goal of research in the Shatz Laboratory is to discover how brain circuits are tuned up by experience during critical periods of development both before and after birth by elucidating cellular and molecular mechanisms that transform early fetal and neonatal brain circuits into mature connections. To discover mechanistic underpinnings of circuit tuning, the lab has conducted functional screens for genes regulated by neural activity and studied their function for vision, learning and memory.

  • Kang Shen

    Kang Shen

    Professor of Biology and of Pathology

    Current Research and Scholarly InterestsThe connectivity of a neuron (its unique constellation of synaptic inputs and outputs) is essential for its function. Neuronal connections are made with exquisite accuracy between specific types of neurons. How each neuron finds its synaptic partners has been a central question in developmental neurobiology. We utilize the relatively simple nervous system of nematode C. elegans, to search for molecules that can specify synaptic connections and understand the molecular mechanisms of synaptic as

  • Krishna Shenoy

    Krishna Shenoy

    Hong Seh and Vivian W. M. Lim Professor in the School of Engineering and Professor, by courtesy, of Neurobiology and of Bioengineering

    Current Research and Scholarly InterestsWe conduct neuroscience, neuroengineering and translational research to better understand how the brain controls movement, and to design medical systems to assist people with paralysis. These medical systems are referred to as brain-machine interfaces (BMIs), brain-computer interfaces (BCIs) and intra-cortical neural prostheses. We conduct this research as part of our Neural Prosthetic Systems Lab (NPSL) and our Neural Prosthetics Translational Lab (NPTL).

  • Laura Simons

    Laura Simons

    Associate Professor of Anesthesiology, Perioperative and Pain Medicine (Pediatric) at the Stanford University Medical Center

    Current Research and Scholarly InterestsThe primary goal of my research is to promote the health and well being of children and adolescents with chronic pain and their families. In line with this goal, research projects focus on biological, neurological, cognitive, affective, and social risk and resiliency factors of the pain experience. Projects include brain imaging, longitudinal clinical cohort, and treatment interventions studies.

    Some current research orojects include:

    Learning and Memory in Pediatric Chronic Pain
    Funding: NIH/NICHD R01
    Description: Investigating the mechanisms underlying fear learning, extinction and disruption of fear reconsolidation in adolescents with chronic pain and health controls using behavioral and neuroimaging measures. Multi-site study with Boston Children's Hospital (Collaborator: David Borsook, MD).

    Children Pain Behaviors in Context: A functional-cognitive perspective
    Leading Site: University of Ghent (Collaborator: Liesbet Goubert, PhD)
    Description: Identifying key antecedents and consequences that give rise to and maintain children's pain-related behaviors and investigate impact these antecedents on children's behavior and functioning through daily surveys and activity monitoring.

  • Manpreet K. Singh, MD MS

    Manpreet K. Singh, MD MS

    Associate Professor of Psychiatry and Behavioral Sciences (Child and Adolescent Psychiatry and Child Development) at the Lucile Salter Packard Children's Hospital

    Current Research and Scholarly InterestsAs part of the Pediatric Mood Disorders Program, Dr. Singh conducts research in the phenomenology, neurobiology, pharmacology, and genetic aspects of depression and bipolar disorder in children. These studies include brain imaging (MRI, MRS, fMRI), medication, and psychotherapy trials. She is particularly interested in risk factors for the development of major mood disorders and associated morbidities, and early intervention strategies to delay the onset and progression of symptoms.

  • Georgios Skiniotis

    Georgios Skiniotis

    Professor of Molecular and Cellular Physiology, of Structural Biology and of Photon Science

    BioThe Skiniotis laboratory seeks to resolve structural and mechanistic questions underlying biological processes that are central to cellular physiology. Our investigations employ primarily cryo-electron microscopy (cryoEM) and 3D reconstruction techniques complemented by biochemistry, biophysics and simulation methods to obtain a dynamic view into the macromolecular complexes carrying out these processes. The main theme in the lab is the structural biology of cell surface receptors that mediate intracellular signaling and communication. Our current main focus is the exploration of the mechanisms responsible for transmembrane signal instigation in cytokine receptors and G protein coupled receptor (GPCR) complexes.

  • Stephen J Smith

    Stephen J Smith

    Professor of Molecular and Cellular Physiology, Emeritus

    Current Research and Scholarly InterestsResearch in the Smith Laboratory addresses basic mechanisms and and disorders of brain function. Present efforts are focused on the development and application of new proteomic imaging methods to explore the circuit and molecular architectures of memory storage and retrieval in cerebral cortex.

  • Christina Smolke

    Christina Smolke

    Adjunct Professor

    BioProfessor Smolke's research program focuses on developing modular genetic platforms for programming information processing and control functions in living systems, resulting in transformative technologies for engineering, manipulating, and probing biological systems. She has pioneered the design and application of a broad class of RNA molecules, called RNA devices, that process and transmit user-specified input signals to targeted protein outputs, thereby linking molecular computation to gene expression. This technology has been extended to efficiently construct multi-input devices exhibiting various higher-order information processing functions, demonstrating combinatorial assembly of many information processing, transduction, and control devices from a smaller number of components. Her laboratory is applying these technologies to addressing key challenges in cellular therapeutics, targeted molecular therapies, and green biosynthesis strategies.

  • Matthew Smuck, MD

    Matthew Smuck, MD

    Associate Professor of Orthopaedic Surgery at the Stanford University Medical Center

    Current Research and Scholarly InterestsI direct the Wearable Health Lab at Stanford, investigating medical applications of mobile technology to improve musculoskeletal and neurologic disease detection, treatment and prevention.

  • Michael Snyder

    Michael Snyder

    Stanford W. Ascherman, MD, FACS, Professor in Genetics

    Current Research and Scholarly InterestsOur laboratory use different omics approaches to study a) regulatory networks, b) intra- and inter-species variation which differs primarily at the level of regulatory information c) human health and disease. For the later we have established integrated Personal Omics Profiling (iPOP), an analysis that combines longitudinal analyses of genomic, transcriptomic, proteomic, metabolomic, DNA methylation, microbiome and autoantibody profiles to monitor healthy and disease states

  • Raymond A. Sobel, M.D.

    Raymond A. Sobel, M.D.

    Professor of Pathology

    Current Research and Scholarly InterestsWe study cellular and molecular mechanisms of immune-mediated injury in CNS tissues that are affected in multiple sclerosis (MS). We study: 1) tissues of mice with EAE using histology and immunohistochemistry, 2) cross-recognition of neurons by antibodies against myelin proteolipid protein epitopes, and a distinct oligodendrogliopathy induced in mice by the non-protein amino acid azetidine (Aze), (which is found in the human diet); Aze-induced abnormalities mimic those in MS patient CNS tissues

  • Hyongsok Tom  Soh

    Hyongsok Tom Soh

    Professor of Radiology (Early Detection), of Electrical Engineering and, by courtesy, of Chemical Engineering and of Bioengineering

    BioDr. Soh received his B.S. with a double major in Mechanical Engineering and Materials Science with Distinction from Cornell University and his Ph.D. in Electrical Engineering from Stanford University. From 1999 to 2003, Dr. Soh served as the technical manager of MEMS Device Research Group at Bell Laboratories and Agere Systems. He was a faculty member at UCSB before joining Stanford in 2015. His current research interests are in analytical biotechnology, especially in high-throughput screening, directed evolution, and integrated biosensors.

  • Olav Solgaard

    Olav Solgaard

    Professor of Electrical Engineering

    BioThe Solgaard group focus on design and fabrication of nano-photonics and micro-optical systems. We combine photonic crystals, optical meta-materials, silicon photonics, and MEMS, to create efficient and reliable systems for communication, sensing, imaging, and optical manipulation.

  • Ivan Soltesz

    Ivan Soltesz

    James R. Doty Professor of Neurosurgery and Neurosciences

    BioIvan Soltesz received his doctorate in Budapest and conducted postdoctoral research at universities at Oxford, London, Stanford and Dallas. He established his laboratory at the University of California, Irvine, in 1995. He became full Professor in 2003, and served as department Chair from 2006 to July 2015. He returned to Stanford in 2015 as the James R. Doty Professor of Neurosurgery and Neurosciences at Stanford University School of Medicine. His major research interest is focused on neuronal microcircuits, network oscillations, cannabinoid signaling and the mechanistic bases of circuit dysfunction in epilepsy.
    His laboratory employs a combination of closely integrated experimental and theoretical techniques, including closed-loop in vivo optogenetics, paired patch clamp recordings, in vivo electrophysiological recordings from identified interneurons in awake mice, 2-photon imaging, machine learning-aided 3D video analysis of behavior, video-EEG recordings, behavioral approaches, and large-scale computational modeling methods using supercomputers. He is the author of a book on GABAergic microcircuits (Diversity in the Neuronal Machine, Oxford University Press), and editor of a book on Computational Neuroscience in Epilepsy (Academic Press/Elsevier). He co-founded the first Gordon Research Conference on the Mechanisms of neuronal synchronization and epilepsy, and taught for five years in the Ion Channels Course at Cold Springs Harbor. He has over 30 years of research experience, with over 20 years as a faculty involved in the training of graduate students (total of 16, 6 of them MD/PhDs) and postdoctoral fellows (20), many of whom received fellowship awards, K99 grants, joined prestigious residency programs and became independent faculty.

  • David Spiegel

    David Spiegel

    Jack, Samuel and Lulu Willson Professor in Medicine
    On Partial Leave from 01/01/2020 To 12/10/2021

    Current Research and Scholarly InterestsDr. Spiegel's research program involves mind/body interactions, including cancer progression, the response to traumatic stress, and the effect of hypnosis on the perception of pain and anxiety.

  • Daniel Spielman

    Daniel Spielman

    Professor of Radiology (Radiological Sciences Lab) and, by courtesy, of Electrical Engineering

    Current Research and Scholarly InterestsMy research interests are in the field of medical imaging, particularly magnetic resonance imaging and in vivo spectroscopy. Current projects include MRI and MRS at high magnetic fields and metabolic imaging using hyperpolarized 13C-labeled MRS.

  • Creed Stary

    Creed Stary

    Associate Professor of Anesthesiology, Perioperative and Pain Medicine (Adult MSD) and, by courtesy, of Ophthalmology at the Stanford University Medical Center

    Current Research and Scholarly InterestsMechanisms promoting neuronal survival following cerebral ischemia-reperfusion injury; utilizing microRNA's to target multiple pathways to promote mitochondrial homeostasis and cell survival; anesthetic neurotoxicity; astrocyte-neuronal interaction

  • Marcia L. Stefanick, Ph.D.

    Marcia L. Stefanick, Ph.D.

    Professor (Research) of Medicine (Stanford Prevention Research Center), of Obstetrics and Gynecology and, by courtesy, of Epidemiology and Population Health

    Current Research and Scholarly InterestsMarcia Stefanick, Ph.D a Professor of Medicine at the Stanford Prevention Research Center, (SPRC) and Professor of Obstetrics and Gynecology, Stanford University School of Medicine.
    Dr. Stefanick's research focuses on chronic disease prevention (particularly, heart disease, breast cancer, osteoporosis, and dementia) in both women and men. Her work on the effects of menopausal hormones on cardiovascular and other health outcomes in mostly healthy postmenopausal women (in the Women's Health Initiative, WHI), in women with established heart disease, (the Heart and Estrogen-progesterone Replacement Study, HERS), and in peri-menopausal and early post-menopausal women (the Postmenopausal Estrogen and Progesterone Interventions, PEPI) trials has been widely disseminated both nationally and internationally. She was also the principal investigator of two large diet trials focusing on the role of a low-fat eating pattern (including increased vegetables & fruits) on preventing breast cancer (WHI) and recurrence (Women's Healthy Eating and Living, WHEL, trial) and she conducted several medium-sized diet, exercise, and weight control trials focused on heart disease risk and body composition that have influenced national guidelines. [She is currently writing a proposal for a large national trial of physical activity in older women with cardiovascular outcomes, not just risk factors.] Her current passion is the study of Sex (and Gender) Differences in Human Physiology and Disease, the title of a course she teaches in Stanford's Human Biology program, in addition to a course entitled: Current Topics and Controversies in Women's Health. Dr. Stefanick also plays major leadership roles in Stanford's Cardiovascular Institutes Women's Heart Health Program and Stanford Cancer Institutes Cancer Prevention and Control Program.
    Dr. Stefanick obtained her B.A. in biology from the University of Pennsylvania, Philadelphia, PA (1974), then pursued her interest in hormone and sex difference research at the Oregon Regional Primate Research Center, after which she obtained her PhD in Physiology at Stanford University, focusing on reproductive physiology and neuroendocrinology with exercise physiology as a secondary focus. Her commitment to human research directed her to a post-doctoral fellowship in Cardiovascular Disease Prevention at SPRC, which has been her academic home for nearly 30 years.

  • Gary K. Steinberg, MD, PhD

    Gary K. Steinberg, MD, PhD

    Bernard and Ronni Lacroute-William Randolph Hearst Professor in Neurosurgery and Neurosciences and Professor, by courtesy, of Neurology

    Current Research and Scholarly InterestsOur laboratory investigates the pathophysiology and treatment of cerebral ischemia, and methods to restore neurologic function after stroke. Treatment strategies include brain hypothermia, stem cell transplantation and optogenetic stimulation. Our clinical research develops innovative surgical, endovascular and radiosurgical approaches for treating difficult intracranial aneurysms, complex vascular malformations and occlusive disease, including Moyamoya disease, as well as stem cell transplant.

  • Lawrence Steinman, MD

    Lawrence Steinman, MD

    George A. Zimmermann Professor and Professor of Pediatrics

    Current Research and Scholarly InterestsOur laboratory is dedicated to understanding the pathogenesis of autoimmune diseases, particularly multiple sclerosis. We have developed several new therapies for autoimmunity, including some in Phase 2 clinical trials, as well as one approved drug, natalizumab. We have developed microarray technology for detecting autoantibodies to myelin proteins and lipids. We employ a diverse range of molecular and celluar approaches to trying to understand multiple sclerosis.

  • Lars Steinmetz

    Lars Steinmetz

    Professor of Genetics

    Current Research and Scholarly InterestsWe apply diverse genomic approaches to understand how genetic variation affects health and disease by: 1) functional and mechanistic analyses of gene regulation, 2) studies of meiotic recombination and inheritance, 3) analyses of genetic and environmental interactions, and 4) characterization of diseases in human cells and model organisms. We integrate wet lab and computational genomic, transcriptomic, proteomic and metabolic approaches, and develop technologies to enable personalized medicine.

  • Aaron F. Straight

    Aaron F. Straight

    Professor of Biochemistry and, by courtesy, of Chemical and Systems Biology

    Current Research and Scholarly InterestsWe study the biology of chromosomes. Our research is focused on understanding how chromosomal domains are specialized for unique functions in chromosome segregation, cell division and cell differentiation. We are particularly interested in the genetic and epigenetic processes that govern vertebrate centromere function, in the organization of the genome in the eukaryotic nucleus and in the roles of RNAs in the regulation of chromosome structure.

  • Thomas Sudhof

    Thomas Sudhof

    Avram Goldstein Professor in the School of Medicine and Professor, by courtesy, of Neurology and of Psychiatry and Behavioral Sciences

    Current Research and Scholarly InterestsInformation transfer at synapses mediates information processing in brain, and is impaired in many brain diseases. Thomas Südhof is interested in how synapses are formed, how presynaptic terminals release neurotransmitters at synapses, and how synapses become dysfunctional in diseases such as autism or Alzheimer's disease. To address these questions, Südhof's laboratory employs approaches ranging from biophysical studies to the electrophysiological and behavioral analyses of mutant mice.

  • Edith Vioni Sullivan

    Edith Vioni Sullivan

    Professor of Psychiatry and Behavioral Sciences (Major Laboratories and Clinical Translational Neurosciences Incubator)
    On Leave from 10/01/2020 To 12/31/2020

    Current Research and Scholarly InterestsApplication of neuroimaging modalities and component process analysis of cognitive, sensory, and motor functions to identify brain structural and functional mechanisms disrupted in diseases affecting the brain: alcoholism, HIV infection, dementia, and normal aging from adolescence to senescence.

  • Yang Sun, MD, PhD

    Yang Sun, MD, PhD

    Associate Professor of Ophthalmology at the Stanford University Medical Center

    Current Research and Scholarly InterestsWe are interested in the role of inositol phosphatases in eye development and disease, using both animal models and human disease tissue. We are a translational laboratory seeking to understand the basic function of proteins as well as developing therapeutic strategies for clinical trials.

  • Katrin J Svensson

    Katrin J Svensson

    Assistant Professor of Pathology

    Current Research and Scholarly InterestsMolecular metabolism