Wu Tsai Neurosciences Institute
Showing 221-240 of 553 Results
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Shaul Hestrin, PhD
Professor of Comparative Medicine
Current Research and Scholarly InterestsThe main interest of my lab is to understand how the properties of neocortical neurons, the circuits they form and the inputs they receive give rise to neuronal activity and behavior. Our approach includes behavioral studies, two-photon calcium imaging, in vivo whole cell recording in behaving animals and optogenetic methods to activate or to silence the activity of cortical neurons.
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Karen G. Hirsch, MD
Associate Professor of Neurology (Adult Neurology)
Current Research and Scholarly InterestsDr. Karen G. Hirsch cares for critically ill patients with neurologic disorders in the intensive care unit. Dr. Hirsch's research focuses on using continuous and discrete multi-modal data to develop phenotypes and identify signatures of treatment responsiveness in patients with coma after cardiac arrest. She is the Co-PI of PRECICECAP (PRecision Care In Cardiac ArrEst - ICECAP, NINDS R01 NS119825-01) and works closely with collaborators in data science at Stanford and with industry partners to apply machine learning analyses to the complex multi-modal ICU data. Dr. Hirsch also studies neuro-imaging in post-cardiac arrest coma and traumatic brain injury.
Additional research interests include a broad array of topics and Dr. Hirsch greatly appreciates the importance of team science and collaboration. Along with colleagues in Biomedical Ethics, Dr. Hirsch studies brain death and organ donation with a focus on ethical challenges and prediction models. Along with colleagues in Cardiac Anesthesia and Cardiothoracic Surgery, Dr. Hirsch studies neurologic outcomes in patients on mechanical circulatory support including ECMO.
Dr. Hirsch is broadly interested in improving neurologic outcomes after acute brain injury and identifying early phenotypes to guide precision medicine in neurocritical care, especially in patients with post-cardiac arrest brain injury. -
Susan Holmes
Professor of Statistics
Current Research and Scholarly InterestsOur lab has been developing tools for the analyses of complex data structures, extending work on multivariate data to structured multitable table that include graphs, networks and trees as well as categorical and continuous measurements.
We created and support the Bioconductor package phyloseq for the analyses of microbial ecology data from the microbiome. We have specialized in developing interactive graphical visualization tools for doing reproducible research in biology. -
David S. Hong
Associate Professor of Psychiatry and Behavioral Sciences (Interdisciplinary Brain Science Research)
Current Research and Scholarly InterestsDr. Hong is a child and adolescent psychiatrist and clinician-scientist. His responsibilities span clinical care, teaching/mentorship, and research, with a unifying theme of advancing a developmental cognitive framework as applied to psychiatric conditions. Using this core premise, he work encompasses multiple domains: specialized clinical care, fellowship training, research mentorship, and elaborating the role of sex-specific determinants of development, one of the greatest contributors to individual developmental variation.
His lab investigates genetic and hormonal influences underlying sex differences in child psychiatric conditions. Sex has emerged as a critical variable driving differences in the phenomenology, course, and treatment of many mental health disorders. Unfortunately, an understanding of the biological mechanisms driving these effects are limited. By applying innovative neuroimaging and multiomic approaches, Dr. Hong seeks to provide a deeper understanding of the connection between sex-specific effects and complex psychiatric diseases. To do so, research in the Hong Lab focuses on the role of genes on the X and Y chromosomes, as well as circulating sex hormones on brain development, cognition, and behavior. The lab broadly aims to elucidate the changing nature of these mechanisms across various stages of development.
Another area of focus is the implementation of clinical informatics in child psychiatry and the development of digital mental health tools. As co-Director of the Mental Health Technology and Innovation Hub, Dr. Hong is helping to develop clinical and research infrastructure within the Department of Psychiatry and Behavioral Sciences to advance development of mobile mental health resources that will improve efficacy and access to mental health care. -
Guosong Hong
Assistant Professor of Materials Science and Engineering
BioGuosong Hong's research aims to bridge materials science and neuroscience, and blur the distinction between the living and non-living worlds by developing novel neuroengineering tools to interrogate and manipulate the brain. Specifically, the Hong lab is currently developing ultrasound, infrared, and radiofrequency-based in-vivo neural interfaces with minimal invasiveness, high spatiotemporal resolution, and cell-type specificity.
Dr. Guosong Hong received his PhD in chemistry from Stanford University in 2014, and then carried out postdoctoral studies with at Harvard University. Dr. Hong joined Stanford Materials Science and Engineering and Neurosciences Institute as an assistant professor in 2018. He is a recipient of the NIH Pathway to Independence (K99/R00) Award, the MIT Technology Review ‘35 Innovators Under 35’ Award, the Science PINS Prize for Neuromodulation, the NSF CAREER Award, the Walter J. Gores Award for Excellence in Teaching, and the Rita Allen Foundation Scholars Award. -
Yusuke Hori, MD
Clinical Instructor, Neurosurgery
BioDr. Hori received his MD from Sapporo Medical University, Japan, and during that time he served as a Medical Student Research Fellow in the Department of Pharmacology. He explored the functional role of the SIRT1 gene, a longevity-associated gene, and its association with various conditions such as muscular dystrophy. He also completed a Visiting Student Research Fellowship at the Health Sciences University of Hokkaido and participated in Human Genetics projects focusing on an association between the 27-bp deletion and 538G>A mutation in the ABCC11 Gene.
After graduating from medical school, Dr. Hori completed a neurosurgery residency at National Hospital Organization Okayama Medical Center in Japan. Subsequently, he completed a Stereotactic and Functional Neurosurgery Fellowship and then a Neurosurgical Oncology and Radiosurgery Fellowship at The Cleveland Clinic. He also completed an International Neurosurgery Fellowship at Boston Children's Hospital, Harvard Medical School. In 2022, he moved to Stanford University as a postdoctoral fellow, and under the supervision of Dr. Anca Pasca, he participated in brain organoid research focusing on hypoxic brain injuries.
Since July 2023, Dr. Hori has been working as a Clinical Instructor (Neurosurgical Oncology and Radiosurgery) in the Department of Neurosurgery at Stanford under the supervision of Dr. Steven D. Chang. His clinical interests include malignant brain and spine tumors in both adult and pediatric patients. His clinical research focuses on the application of minimally invasive treatments such as laser interstitial thermal therapy, focused ultrasound, and radiosurgery to treat various neurosurgical conditions. His current lab research aims to develop an organoid model for radiation-induced brain injuries and a high-throughput screening platform to identify novel therapeutic compounds, for which he received a Clinician Educator Grant from Stanford University Maternal and Child Health Research Institute. Outside of medicine, he enjoys playing music including guitar and drums. -
Mark Horowitz
Fortinet Founders Chair of the Department of Electrical Engineering , Yahoo! Founders Professor in the School of Engineering and Professor of Computer Science
BioProfessor Horowitz initially focused on designing high-performance digital systems by combining work in computer-aided design tools, circuit design, and system architecture. During this time, he built a number of early RISC microprocessors, and contributed to the design of early distributed shared memory multiprocessors. In 1990, Dr. Horowitz took leave from Stanford to help start Rambus Inc., a company designing high-bandwidth memory interface technology. After returning in 1991, his research group pioneered many innovations in high-speed link design, and many of today’s high speed link designs are designed by his former students or colleagues from Rambus.
In the 2000s he started a long collaboration with Prof. Levoy on computational photography, which included work that led to the Lytro camera, whose photographs could be refocused after they were captured.. Dr. Horowitz's current research interests are quite broad and span using EE and CS analysis methods to problems in neuro and molecular biology to creating new agile design methodologies for analog and digital VLSI circuits. He remains interested in learning new things, and building interdisciplinary teams. -
Hadi Hosseini
Associate Professor (Research) of Psychiatry and Behavioral Sciences (Interdisciplinary Brain Science Research)
Current Research and Scholarly InterestsOur lab’s research portfolio crosses multiple disciplines including computational neuropsychiatry, cognitive neuroscience, multimodal neuroimaging and neurocognitive rehabilitation. Our computational neuropsychiatry research mainly involves investigating alterations in the organization of connectome in various neurodevelopmental and neurocognitive disorders using state of the art neuroimaging techniques (fMRI, sMRI, DWI, functional NIRS) combined with novel computational methods (graph theoretical and multivariate pattern analyses).
The ultimate goal of our research is to translate the findings from computational neuropsychiatry research toward developing personalized interventions. We have been developing personalized interventions that integrate computerized cognitive rehabilitation, real-time functional brain imaging and neurofeedback, as well as virtual reality (VR) tailored toward targeted rehabilitation of the affected brain networks in patients with neurocognitive disorders. -
Roger Howe
William E. Ayer Professor of Electrical Engineering, Emeritus
BioDesign and fabrication of sensors and actuators using micro and nanotechnologies, with applications to information processing and energy conversion.
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Yang Hu, MD, PhD
Professor of Ophthalmology
Current Research and Scholarly InterestsThe ultimate goal of the laboratory is to develop efficient therapeutic strategies to achieve CNS neural repair, through promoting neuroprotection, axon regeneration and functional recovery.
More specifically, we study retinal ganglion cell (RGC) and optic nerve in various optic neuropathies including traumatic, glaucomatous and inflammatory optic nerve injuries to fully understand the molecular mechanisms of CNS neurodegeneration and axon regeneration failure. -
Ting-Ting Huang
Associate Professor (Research) of Neurology (Adult Neurology)
Current Research and Scholarly InterestsWe study the role of oxygen free radicals in oxidative tissue damage and degeneration. Our research tools include transgenic and knockout mice and tissue culture cells for in vitro gene expression.
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Andrew D. Huberman
Associate Professor of Neurobiology and, by courtesy, of Psychiatry and Behavioral Sciences
Current Research and Scholarly InterestsIn 2017, we developed a virtual reality platform to investigate the neural and autonomic mechanisms contributing to fear and anxiety. That involved capturing 360-degree videos of various fear-provoking situations in real life for in-lab VR movies, such as heights and claustrophobia, as well as unusual scenarios like swimming in open water with great white sharks. The primary objective of our VR platform is to develop new tools to help people better manage stress, anxiety and phobias in real-time, as an augment to in-clinic therapies.
In May 2018, we reported the discovery of two novel mammalian brain circuits as a Research Article published in Nature. One circuit promotes fear and anxiety-induced paralysis, while the other fosters confrontational reactions to threats. This led to ongoing research into the involvement of these brain regions in anxiety-related disorders such as phobias and generalized anxiety in humans.
In 2020, we embarked on a collaborative effort with Dr. David Spiegel's laboratory in the Stanford Department of Psychiatry and Behavioral Sciences, aimed to explore how specific respiration patterns synergize with the visual system to influence autonomic arousal and stress, and other brain states, including sleep.
In 2023, the first results of that collaboration were published as a randomized controlled trial in Cell Reports Medicine, demonstrating that specific brief patterns of deliberate respiration are particularly effective in alleviating stress and enhancing mood, and improving sleep.
In a 2021, our collaboration with Dr. Edward Chang, professor and chair of the Department of Neurological Surgery at the University of California, San Francisco (UCSF), was published in Current Biology, revealing that specific patterns of insular cortex neural activity may be linked to, and potentially predict, anxiety responses. -
John Huguenard
Professor of Neurology (Neurology Research Faculty), of Neurosurgery (Adult Neurosurgery) and, by courtesy, of Molecular and Cellular Physiology
Current Research and Scholarly InterestsWe are interested in the neuronal mechanisms that underlie synchronous oscillatory activity in the thalamus, cortex and the massively interconnected thalamocortical system. Such oscillations are related to cognitive processes, normal sleep activities and certain forms of epilepsy. Our approach is an analysis of the discrete components (cells, synapses, microcircuits) that make up thalamic and cortical circuits, and reconstitution of components into in silico computational networks.
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Keith Humphreys
Esther Ting Memorial Professor
On Partial Leave from 05/06/2024 To 06/05/2024Current Research and Scholarly InterestsDr. Humphreys researches individual and societal level interventions for addictive and psychiatric disorders. He focuses particularly on evaluating the outcomes of professionally-administered treatments and peer-operated self-help groups (e.g., Alcoholics Anonymous), and, analyzing the impact of public policies touching addiction, mental health, public health, and public safety.
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Ruth Huttenhain
Assistant Professor of Molecular and Cellular Physiology
Current Research and Scholarly InterestsMy group deciphers how G protein-coupled receptors decode extracellular cues into dynamic and context-specific cellular signaling networks to elicit diverse physiologic responses. We exploit quantitative proteomics to capture the spatiotemporal organization of signaling networks combined with functional genomics to study their impact on physiology.
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Robert K. Jackler, MD
Edward C. and Amy H. Sewall Professor, Emeritus
Current Research and Scholarly InterestsSince the early 2000s, study of tobacco industry marketing has become my primary field of research. Motivated by the lack of a comprehensive and well-organized compendium of tobacco advertisements, and the relative paucity of scholarly research analyzing the marketing practices of the industry, I chose to focus my research on advertising. The overarching purpose of my research has been to reveal the behavior of the tobacco industry in recruiting and retaining its consumers with the goal of infor
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Matthew O. Jackson
Eberle Professor of Economics and Senior Fellow at the Stanford Institute for Economic Policy Research
On Leave from 10/01/2023 To 06/30/2024Biohttp://www.stanford.edu/~jacksonm/bio.html
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Siddhartha Jaiswal
Assistant Professor of Pathology
Current Research and Scholarly InterestsWe identified a common disorder of aging called clonal hematopoiesis of indeterminate potential (CHIP). CHIP occurs due to certain somatic mutations in blood stem cells and represents a precursor state for blood cancer, but is also associated with increased risk of cardiovascular disease and death. We hope to understand more about the biology and clinical implications of CHIP using human and model system studies.
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Daniel Jarosz
Associate Professor of Chemical and Systems Biology and of Developmental Biology
Current Research and Scholarly InterestsMy laboratory studies conformational switches in evolution, disease, and development. We focus on how molecular chaperones, proteins that help other biomolecules to fold, affect the phenotypic output of genetic variation. To do so we combine classical biochemistry and genetics with systems-level approaches. Ultimately we seek to understand how homeostatic mechanisms influence the acquisition of biological novelty and identify means of manipulating them for therapeutic and biosynthetic benefit.
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Julia Kaltschmidt
Associate Professor of Neurosurgery
Current Research and Scholarly InterestsThe lab’s primary research interest is to understand how specific neuronal circuits are established. We use mouse genetics, combinatorial immunochemical labeling and high-resolution laser scanning microscopy to identify, manipulate, and quantitatively analyze synaptic contacts within the complex neuronal milieu of the spinal cord and the enteric nervous system.