School of Medicine
Showing 1-100 of 560 Results
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Gillian Abir
Clinical Professor, Anesthesiology, Perioperative and Pain Medicine
BioGillian Abir graduated from Glasgow University (UK) in 1998. After initially undertaking parts of surgical residency and emergency medicine residency, she completed her anesthesiology residency training in Glasgow and Sheffield (UK). Following this she undertook an obstetric anesthesiology fellowship-equivalent at Stanford University School of Medicine and is currently a Clinical Professor.
Gillian is the Associate Division Chief and Clinical Director for the Division of Obstetric Anesthesiology and the residency program coordinator for obstetric anesthesiology.
Gillian has published several manuscripts and book chapters, and is the lead anesthesiologist in the multidisciplinary obstetric simulation team. She is a member of the obstetric disaster preparedness committee and labor and delivery patient safety committee, amongst several other committees. She is the co-chair of the simulation committee and a member of the patient safety and international outreach committees in the Society of Obstetric Anesthesia and Perinatology.
Gillian has an interest in global health and is a member of the Board of Directors of Kybele Inc. (www.kybeleworldwide.org) for which she regularly volunteers to teach obstetric anesthesiology in other countries. -
Emma Adair
Clinical Research Manager, Anesthesia
Current Role at StanfordEmma manages the Neurology & Neurosurgery Clinical Trials Team consisting of 17 Clinical Research Coordinators conducting 70+ clinical trials in areas including: Device Neurosurgery, Functional Neurosurgery, Headache, Epilepsy, Neuroimmunology, Alzheimers/Memory Disorders, Parkinson's, Radiology, and Bio Banks.
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Rita Agarwal
Clinical Professor, Anesthesiology, Perioperative and Pain Medicine
Current Research and Scholarly InterestsPart of the Society for Pediatric Anesthesia Information Network (SPAIN) Steering Committee, looking at shirt and long tern outcomes of various pain management techniques in children.
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Anuj Aggarwal
Clinical Assistant Professor, Anesthesiology, Perioperative and Pain Medicine
BioAnuj Aggarwal, M.D., is both a practicing anesthesiologist and pain specialist. Originally from Southern California, Dr. Aggarwal completed his undergraduate studies in biology with honors at the University of Southern California, Los Angeles, CA. He earned his medical degree from University of California, San Francisco School of Medicine with distinction, completing the Health Professions Education (HPE) Pathway advanced program. He completed his internship at Santa Barbara Cottage Hospital in Santa Barbara, CA. He then completed his Anesthesiology residency and Pain Medicine fellowship at Stanford Hospital, joining the faculty in 2018.
In addition to his research and clinical areas of interest of perioperative pain and orofacial pain, he is the associate program director for the pain management fellowship, course director of pharmacology for the medical school, and E4C (Educator for Care) faculty member, and directs medical student and resident clerkships in pain management. Dr. Aggarwal has served as the pain theme lead in the pre-clerkship curriculum and has lectured in the pharmacological treatment of disease and practice of medicine courses for the medical students and pre-clerkship course for the physician assistant students. -
Nima Aghaeepour
Associate Professor (Research) of Anesthesiology, Perioperative and Pain Medicine (Adult MSD), of Pediatrics (Neonatology) and, by courtesy, of Biomedical Data Science
BioThank you for your interest. Please use the links on the bottom right side of this page to learn more about our laboratory's work.
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Kanwaljeet S. Anand
Professor of Pediatrics (Pediatric Critical Care) and of Anesthesiology, Perioperative and Pain Medicine
Current Research and Scholarly InterestsDr. Anand is a translational clinical researcher who pioneered research on the endocrine-metabolic stress responses of infants undergoing surgery and developed the first-ever scientific rationale for pain perception in early life. This provided a framework for newer methods of pain assessment, numerous clinical trials of analgesia/anesthesia in newborns, infants and older children. His research focus over the past 30+ years has contributed fundamental knowledge about pediatric pain/stress, long-term effects of pain in early life, management of pain, mechanisms for opioid tolerance and withdrawal. Current projects in his laboratory are focused on developing biomarkers for repetitive pain/stress in critically ill children and the mechanisms underlying sedative/anesthetic neurotoxicity in the immature brain. He designed and directed many randomized clinical trials (RCT), including the largest-ever pediatric analgesia trial studying morphine therapy in ventilated preterm neonates. He has extensive experience in clinical and translational research from participating in collaborative networks funded by NIMH, NINDS, or NICHD, a track-record of excellent collaboration across multiple disciplines, while achieving success with large research teams like the Collaborative Pediatric Critical Care Research Network (CPCCRN). He played a leadership roles in CANDLE (Condition Affecting Neuro-Development & Learning in Early infancy) and other activities of the Urban Child Institute and UT Neuroscience Institute. More recently, he led the NeoOpioid Consortium funded by the European Commission, which collected data from 243 NICUs in 18 European countries.
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Thomas Anthony Anderson
Clinical Professor, Anesthesiology, Perioperative and Pain Medicine
Current Research and Scholarly InterestsMy lab's research focuses on two areas:
1. Focused ultrasound for peripheral nervous system modulation- We are interested in the potential of focused ultrasound to modulate peripheral nerves and improve both acute and chronic pain.
2. Pediatric perioperative outcomes- Our goals are to understand A) how various perioperative pain management strategies affect outcomes in children who undergo surgery and B) whether disparities in the perioperative pain management of children occur. -
Kazuo Ando
Clinical Assistant Professor, Anesthesiology, Perioperative and Pain Medicine
BioBorn and raised in Japan, Dr. Ando received an MD-PhD degree from the Aichi Medical University. After anesthesia training, Dr. Ando came to Stanford to pursue clinical and basic research experience. During his postdoctoral fellowship in Dr. Gaudilliere's laboratory, Dr. Ando worked on publication of “A next-generation single-cell technology (mass cytometry) to study the feto-maternal immune system,” a project designed to evaluate the immune response associated with preterm birth. In addition, Dr. Ando performs research in Obstetric Anesthesia, such as respiratory monitoring after cesarean sections and labor satisfaction, to obtain clinical research experience and to understand the key differences in medicine between the United States and Japan.
After his postdoctoral fellowship, Dr. Ando has maintained his status as a researcher in Dr. Gaudilliere's laboratory, continuing work relating to pregnancy and preterm birth.
Dr. Ando divides his efforts between laboratory research and the clinic. -
Timothy Angelotti MD, PhD
Associate Professor of Anesthesiology, Perioperative and Pain Medicine (Adult MSD)
Current Research and Scholarly InterestsMy research efforts are focused on investigating the pharmacological and physiological interface of the autonomic nervous system with effector organs. Utilizing molecular, cellular, and electrophysiological techniques, we are examining alpha2 adrenergic receptor function in cultured sympathetic neurons. Future research aims will be directed toward understanding neurotransmitter release in general.
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Martin S. Angst
Professor of Anesthesiology, Perioperative and Pain Medicine
Current Research and Scholarly InterestsOur laboratory's current transformative research efforts focus on studying immune health in the context of surgery and anesthesia.
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Michelle (Duperrault) Arteaga, MS, MHA
Global Health Program Administrator, Anesthesiology, Perioperative and Pain Medicine
BioProgram manager experienced working with academic medical centers in US and sub-Saharan Africa. Global education, legal background, and travel to 30+ countries. Highly skilled in curriculum development, partnership building, and strategic planning. Passionate about interdisciplinary learning and research in strengthening health systems.
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Naola Austin
Clinical Associate Professor, Anesthesiology, Perioperative and Pain Medicine
BioNaola S. Austin M.D., is a Clinical Associate Professor in the Department of Anesthesiology, Perioperative and Pain Medicine at Stanford University and the Veterans Affairs Palo Alto Health Care System. She co-directs the Anesthesia Crisis Resource Management (ACRM) course and teaches a number of simulation courses as faculty with the Center for Immersive and Simulation-based Learning, OB SIM Team, InterCEPT Team, and VA Palo Alto. As a point-of-care ultrasound (POCUS) faculty, she teaches neuraxial, transthoracic, lung, gastric, FAST, and other ultrasound techniques. She is also a member of the Stanford Anesthesia Cognitive Aid Program (SACAP), a collaborative group who designs and updates the Stanford Emergency Manual.
She is originally from New Mexico and received her medical degree at Weill Cornell Medical College in New York, NY. After completing residency training in Anesthesiology at the University of Washington, she went on to dual fellowship training in Obstetric Anesthesia and Healthcare Simulation.
In addition to her work as a Co-Primary Investigator with the Safety Learning Lab, she has published basic science articles on synapse biology, clinical reviews on cervical spine injury in trauma and burns, and Simulation and Communication in Obstetric care. She has received multiple honors including U.S.-E.U. Exchange Scholar Rogers’ Colloquium Speaker, Resident of the Year, Foundation for Anesthesia Education & Research Scholar, and Alpha Omega Alpha Honor Society.
Naola is an avid gardener, leisure cyclist, and very amateur rock climber. -
Meredith Barad, MD
Clinical Associate Professor, Anesthesiology, Perioperative and Pain Medicine
Clinical Associate Professor, Neurology & Neurological SciencesCurrent Research and Scholarly InterestsMy current research interests involve novel treatment paradigms for challenging pain problems such as orofacial pain, trigeminal neuralgia and low pressure headaches. I am also interested in migraine and trigeminal autonomic cephalgias and their intersection with chronic pain.
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Juliana Barr
Professor of Anesthesiology, Perioperative and Pain Medicine, Emerita
Current Research and Scholarly Interests1) ICU Outcomes Research; 2) Clinical pharmacology of sedative-hypnotic agents in ICU patients.
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Jennifer Basarab-Tung
Adjunct Clinical Assistant Professor, Anesthesiology, Perioperative and Pain Medicine
BioI enjoy providing anesthesia for a wide variety of patients, procedures, and conditions. My practice sites include the Stanford Main Operating Room, Ambulatory Surgical Center, Labor and Delivery, Outpatient Surgical Center in Redwood City, Cancer Center South Bay in Los Gatos, and Reproductive Endocrinology/Infertility in Sunnyvale. Some of my clinical areas of focus include thoracic surgery and obstetrics. I am also involved in resident education and help manage the resident lecture curriculum.
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Brian T. Bateman
Anesthesiology, Perioperative and Pain Medicine Professor and Professor, by courtesy, of Epidemiology and Population Health
BioBrian T. Bateman, MD, MSc is the Stanford Medicine Professor of Anesthesiology, Perioperative and Pain Medicine and Chair of the Department of Anesthesiology, Perioperative, and Pain Medicine.
Before coming to Stanford, Dr. Bateman served as the Vice Chair for Faculty Development and Chief of the Division of Obstetric Anesthesia in the Department of Anesthesiology, Perioperative and Pain Medicine at the Brigham and Women’s Hospital/Harvard Medical School and as Co-Director of the Harvard Program on Perinatal and Pediatric Pharmacoepidemiology in the Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women’s Hospital.
Dr. Bateman’s scholarship focuses on the study of medication safety in pregnancy and on predictors and management of maternal morbidity. To address questions in these areas, Dr. Bateman and collaborators at Harvard helped pioneer the use of advanced epidemiological techniques applied to large, routinely collected healthcare utilization data. This research has been funded by multiple R01 grants from the NIH and by grants from the FDA and has been published in leading clinical journals including JAMA, NEJM, BMJ, Lancet, Annals of Internal Medicine, JAMA Pediatrics, JAMA Psychiatry, and Obstetrics and Gynecology. Dr. Bateman’s bibliography contains over 200 publications. This research is frequently cited in clinical reviews and guidelines and has prompted both the FDA and EMA to make labelling changes to medications regarding use in pregnancy. Dr. Bateman is also a founding member of the International Pregnancy Safety Study Consortium (InPress) which is a collaborative effort between investigators from the US and each of the five Nordic countries to pool data for studies evaluating the safety of medications.
Dr. Bateman currently serves as Chairperson of FDA’s Anesthetic and Analgesic Drug Products Advisory Committee after having previously served a 4-year term (2015-2019) as a voting member of this Committee. He was a technical advisor for the recent revision of the Joint Commission’s pain management standards. He has served on expert panels and workshops sponsored by the National Academy of Medicine, the FDA, the NIH, the CDC, and the Department of Health and Human Services, and on multiple grant review committees for the NIH and other funders. He is an Editor for the journal, Anesthesiology, and the textbook, Chestnut’s Obstetric Anesthesia: Principles and Practice.
Dr. Bateman’s work has been recognized by a number of awards including his selection in 2017 by the Society for Obstetric Anesthesia and Perinatology as the Gerard Ostheimer lecturer and in 2018 by the American Society of Anesthesiologists as the James E. Cottrell Presidential Scholar Awardee, which is given to one clinical-scientist each year within 10 years of initial faculty appointment for accomplishment in research.
Faculty development and mentorship has been a central focus of Dr. Bateman’s career. He has mentored numerous trainees who have gone on to outstanding academic careers. As Division Chief and Vice Chair for Faculty Development at the Brigham, he worked particularly hard to advance the careers of women and underrepresented minorities in the Department and to create an environment where everyone is welcomed and has an opportunity to advance.
Dr. Bateman is a Phi Beta Kappa graduate Yale College and received his MD from Columbia University College of Physicians & Surgeons, where he was a member of Alpha Omega Alpha and was awarded the Janeway Prize for the highest achievements and abilities in the graduating class. He completed an internship in internal medicine at Brigham and Women’s Hospital and residency and chief residency in anesthesiology at the Massachusetts General Hospital. He completed a Masters in Epidemiology at the Harvard School of Public Health. -
Toni Benevento
Web Designer, Anesthesia
Current Role at StanfordWed Designer for the Department of Anesthesia.
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Ardin S. Berger, D.O. (they/them)
Clinical Assistant Professor, Anesthesiology, Perioperative and Pain Medicine
BioDr. Berger is a pediatric pain physician who is ABA boarded in pain medicine, anesthesiology, and pediatric anesthesiology.
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Edward Bertaccini
Professor of Anesthesiology, Perioperative and Pain Medicine
Current Research and Scholarly Interestsmolecular modeling of anesthetic-protein interactions, molecular modeling of the ligand-gated ion channels
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Rashmi Parekh Bhandari
Clinical Associate Professor, Anesthesiology, Perioperative and Pain Medicine
Current Research and Scholarly InterestsClinical interventions, treatments, and outcomes in pediatric pain management
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Vimala Bharadwaj
Postdoctoral Scholar, Anesthesiology, Perioperative and Pain Medicine
BioDr. Bharadwaj grew up in India and came to the United States for her graduate studies. She completed her Ph.D. in Biomedical Engineering at Arizona State University. Her doctoral work focused on preclinical studies investigating nanoparticle delivery across the blood-brain barrier after traumatic brain injury. In 2018, she joined Drs. Porreca and Anderson laboratories at the University of Arizona for postdoctoral training. Her postdoctoral work focused on identifying the critical role of dorsal pons neurons in the migraine pain pathway. Currently, she continues her migraine research in Dr. Yeomans’s lab at Stanford Medicine. Dr. Bharadwaj is also currently involved in post-traumatic headache research in Dr. David Clark's laboratory at the Veterans Affairs (Palo Alto). Recently, she was awarded the prestigious International Headache Society Fellowship for investigating mechanisms for migraine pain generation. Over the years, she has held several leadership positions including serving as the communications director for Stanford Postdoctoral Association, as a diversity, equity, and inclusion Ally for the American Headache Society, and as an assistant editorial team member for the Headache journal.
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Emma Elizabeth Biggs
Postdoctoral Scholar, Anesthesiology, Perioperative and Pain Medicine
Current Research and Scholarly InterestsMy main research interests are in the field of chronic pain and learning. I am interested in understanding how processes related to learning can contribute to the development, spreading, and treatment of chronic pain. I am especially interested in understanding how fear and pain interact across complex brain networks.
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Adjoa Boateng
Clinical Assistant Professor, Anesthesiology, Perioperative and Pain Medicine
BioAdjoa Boateng is a physician, writer, mother and humanitarian. She completed her undergraduate degree and anesthesiology training at Yale, then undertaking a critical care fellowship at Stanford. Prior to her role as an anesthesiologist and critical care physician, Adjoa completed work in several facets of addiction medicine performing clinical research at the Mount Sinai Hospital in New York City, undertaking projects focusing on Hepatitis C in injection drug users, during her MPH degree she analyzed programs in Philadelphia which trained heroin users to inject Naloxone to mitigate overdose, and in medical school was selected among many to complete a prestigious training course at the renowned Betty Ford Center in Rancho Mirage, California, always seeking to assist the forgotten; those at the margins of society. Adjoa marries this to her current areas of interest, which include the intersection of medicine, the arts and the disadvantaged. She currently is investigating racial and ethnic disparities in critical care medicine.
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Anna Maria Bombardieri
Clinical Assistant Professor, Anesthesiology, Perioperative and Pain Medicine
Masters Student in Epidemiology and Clinical Research, admitted Autumn 2022Current Research and Scholarly InterestsMy overall research goal is to advance clinical practice by providing anesthesiologists with data to most effectively maintain cerebral blood flow in the perioperative period.
I am interested in the effect of the autonomic nervous system on cerebral blood flow regulation.
I intend to combine regional anesthetic techniques and noninvasive bedside cerebral blood flow monitoring to understand the effect of the sympathetic system on cerebral blood flow.
A secondary goal is to apply this new knowledge to investigate whether cervical sympathetic blocks improve long term neurological outcomes. -
John Brock-Utne
Professor (Clinical) of Anesthesia, Emeritus
Current Research and Scholarly InterestsA large variety of clinical research including new non-invasive warming technology, temperature measurement during anesthesia, new non-pulsetile oximetry, monitoring of systemic ischemia, new technology to be used in anesthesia, airway management, and operating room waste
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Jay B. Brodsky
Professor (Clinical) of Anesthesiology, Perioperative and Pain Medicine, Emeritus
Current Research and Scholarly InterestsClinical aspects of anesthesia for non-cardiac thoracic surgery including lung separation techniques, management of one-lung ventilation and post-thoracotomy analgesia.
Anesthesia for the morbidly obese patient' bariatric surgery -
Jessica Brodt
Clinical Associate Professor, Anesthesiology, Perioperative and Pain Medicine
Current Research and Scholarly InterestsClinical Education
Regional Anesthesia for Cardiothoracic Enhanced Recovery (RACER)
Anesthesia for transcatheter and electrophyiology procedures -
Dr. Alyssa Burgart (she/her)
Clinical Associate Professor, Anesthesiology, Perioperative and Pain Medicine
Clinical Associate Professor (By courtesy), PediatricsBioDr. Alyssa Burgart is a board certified pediatric anesthesiologist and bioethicist.
Dr. Burgart specializes in pediatric anesthesia and pediatric abdominal transplant anesthesia. She has special interest in transplantation, PANS/PANDAS, spinal muscular atrophy, and trauma. Dr. Burgart is committed to finding the most successful way for each child to interact with the anesthesia team, in order to create an overall positive experience. She champions a program specifically supporting children with unique needs, such as those with sensory integration differences.
Dr. Burgart has a joint appointment in the Stanford Center for Biomedical Ethics, serves as the Co-Chair of the LPCH Ethics Committee and as a member of the SHC Ethics Committee. She provides ethics consultation services for people of all ages. Her ethics interests include pediatric ethics, organ transplantation, communication skills, disability rights, women's healthcare access, adolescent decision-making, ethics education, and excellence in ethics consultation.
Dr. Burgart is active on Twitter, where she comments on Anesthesiology and Bioethics issues. @BurgartBioethix -
Alex Butwick
Professor of Anesthesiology, Perioperative and Pain Medicine (OB)
Current Research and Scholarly InterestsI perform outcomes-based research in obstetrics investigating strategies to better prevent and treat patients with postpartum hemorrhage, a leading cause of maternal morbidity and mortality. I also have research interests in the use of point-of-care devices for investigating key changes in the maternal hematologic and hemostatic profiles that occur during the peripartum and postpartum periods.
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Daenis Camire
Clinical Instructor, Anesthesiology, Perioperative and Pain Medicine
BioOriginally from Thunder Bay, Ontario, Canada, Dr. Camiré completed his BSc in Nursing at Lakehead University. Dr. Camiré gained valuable experience working as a Registered Nurse on a Mobile Suboxone Treatment Team. In this capacity, he collaborated with rural and remote First Nations communities in Northern Ontario to treat opiate addiction states using a holistic approach. He obtained his Medical Degree from the Northern Ontario School of Medicine in Canada. He completed his Anesthesiology Residency training and a MSc in Healthcare Quality at Queen's University in Kingston, Ontario. Throughout his Nursing and Medical career, Dr. Camiré served as a Reservist in the Canadian Armed Forces as a Medical Assistant. He pursued his passion in caring for critically-ill patients as a Critical Care Clinical Associate for Lakeridge Health Hospital in Oshawa, Ontario.
Dr. Camiré's professional interests include Head and Neck Anesthesia/Advanced Airway Management, Perioperative Medicine, Critical Care, Transport Medicine, Perioperative Pain Management, Medical Education, the Use of Technology/AI in Healthcare and Quality Improvement.
During his free time, Dr. Camiré enjoys hiking, camping, fishing, travelling and spending time with his wife and family. -
Ian Carroll, MD, MS
Associate Professor of Anesthesiology, Perioperative and Pain Medicine (Adult Pain)
Current Research and Scholarly InterestsWe are committed to promoting an understanding of cerebrospinal fluid (CSF) leaks, and ensuring that all patients who are suffering from cerebrospinal fluid leaks receive appropriate diagnosis and treatment of this devastating, chronic, and fixable condition. We believe this can be best accomplished in a multidisciplinary setting involving expertise in radiology, neurology, and interventional pain medicine.
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Thomas Caruso
Clinical Professor, Anesthesiology, Perioperative and Pain Medicine
Ph.D. Student in Education, admitted Autumn 2019Current Research and Scholarly InterestsMy research pursuits are focused on system based improvement projects. At Lucile Packard Children's Hospital Stanford, I use system based approaches to improve the quality of care patients receive in the perioperative area and in the ICUs, with a focus on safe transitions of care. Through the Department of Graduate Medical Education at Stanford School of Medicine, I advise residency and fellowship programs on evidence based methods to improve their programs, with a focus on mentorship.
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Brendan Carvalho
Professor of Anesthesiology, Perioperative and Pain Medicine (Adult MSD)
Current Research and Scholarly InterestsMy main research interest is in clinical and translational research related to cesarean delivery and labor analgesia as well as maternal-fetal pharmacokinetics and pharmacodynamics drug modeling.
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Austen Brooks Casey
Postdoctoral Scholar, Anesthesiology, Perioperative and Pain Medicine
BioAusten Brooks Casey, PhD, is a postdoctoral scholar in the Department of Anesthesiology, Perioperative and Pain Medicine (advisor: Boris Dov Heifets, MD, PhD). He originates from western North Carolina, and has had a long-standing interest in drug discovery for major depression and schizophrenia, which was invigorated by initial coursework in organic chemistry and biochemistry. Austen trained at Northeastern University (advisor: Raymond G. Booth, PhD) where he studied the medicinal chemistry and pharmacology of novel ligands targeting serotonergic G protein-coupled receptors. Currently, he is investigating neural circuits activated by psychedelic drugs, with the long-term goal of using modern techniques in neuroscience to complement drug design efforts toward the development of novel antidepressant and antipsychotic medications.
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Danton Char
Associate Professor of Anesthesiology, Perioperative and Pain Medicine (Pediatric)
Current Research and Scholarly InterestsDr. Char's research is focused on identifying and addressing ethical concerns associated with the implementation of next generation technologies like whole genome sequencing and its attendant technologies like machine learning to bedside clinical care.
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QiLiang “Q” Chen
Fellow in Anesthesiology, Perioperative and Pain Medicine
Affiliate, Dean's Office Operations - Dean OtherBioQiLiang “Q” Chen, MD, PhD, is a Pain Medicine Fellow and a postdoctoral researcher at Stanford University. He is also part of the Stanford Fellowship in Anesthesia Research (FARM) program. His research focuses on delineating the basic mechanism of chronic pain and characterizing the physiological changes in the descending pain-modulating circuits after head injury and other forms of trauma, a topic especially relevant to chronic posttraumatic pain sufferers. Clinically, his interests include integrating advanced image guidance in pain procedures and exploring novel pharmacological and minimally invasive interventions for complex headaches and craniofacial pain conditions.
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Lawrence Chu, MD, MS
Professor of Anesthesiology, Perioperative and Pain Medicine
Current Research and Scholarly InterestsI have two lines of research, one involving educational informatics and use of technology in postgraduate medical education and another involving NIH-funded work in patient-oriented clinical research regarding opioid use and physiologic responses associated with acute and chronic exposure in humans.
For a full description of my educational informatics work, please see my website aim.stanford.edu.
My clinical research focuses on the study opiate-induced hyperalgesia in patients suffering from chronic pain.
I am currently conducting an NIH-funded five year double-blinded randomized controlled clinical study (NIGMS award 1K23GM071400-01) that prospectively examines the following hypotheses: 1) pain patients on chronic opioid therapy develop dose-dependent tolerance and/or hyperalgesia to these medications over time, 2) opiate-induced tolerance and hyperalgesia develop differently with respect to various types of pain, 3) opioid-induced hyperalgesia occurs independently of withdrawal phenomena, and 4) opiate-induced tolerance and hyperalgesia develop differently based on gender and/or ethnicity.
The study is the first quantitative and prospective examination of tolerance and hyperalgesia in pain patients and may have important implications for the rational use of opioids in the treatment of chronic pain. -
David Clark
Professor of Anesthesiology, Perioperative and Pain Medicine
BioMy career is dedicated to improving the safety, effectiveness and availability of pain relief. Both the needs and opportunities in these areas are limitless. I have had the good fortune of working as a clinician, teacher and scientist at Stanford University and the Palo Alto VA hospital for more than two decades.
Much of my time is spent on laboratory, translational and clinical research. In the laboratory, we are pursuing several projects related to the questions of why pain sometimes becomes chronic after injuries and why opioids lose their effectiveness over time. Alterations in endogenous pain control mechanisms and the involvement of the adaptive system of immunity are central to these investigations. We would like to find ways to maximize functional recovery after surgery and other forms of trauma while minimizing the risks of analgesic use. This work involves local, national and international collaborations. Clinical trials work involves establishing the efficacy of novel forms of analgesic therapy as well as the comparative effectiveness of long-established approaches to controlling common forms of pain such as low back pain. This spectrum of pain-related pursuits continues to evolve with the rapid expansion of the field. -
Sheila E. Cohen
Professor (Clinical) of Anesthesia, Emerita
Current Research and Scholarly InterestsOur obstetric anesthesia group is interested in a variety of topics including the efficacy and mechanism of action of spinal and epidural opioids for production of analgesia during labor, and the functionality of epidural analgesia for labor pain relief.
