School of Medicine
Showing 1-100 of 108 Results
-
Axel Brunger
Professor of Molecular and Cellular Physiology, of Neurology, of Photon Science and, by courtesy, of Structural Biology
Current Research and Scholarly InterestsOne of Axel Brunger's major goals is to decipher the molecular mechanisms of synaptic neurotransmitter release by conducting imaging and single-molecule/particle reconstitution experiments, combined with near-atomic resolution structural studies of the synaptic vesicle fusion machinery.
-
Steven Chu
William R. Kenan Jr. Professor and Professor of Molecular and Cellular Physiology
Current Research and Scholarly InterestsSynthesis, functionalization and applications of nanoparticle bioprobes for molecular cellular in vivo imaging in biology and biomedicine. Linear and nonlinear difference frequency mixing ultrasound imaging. Lithium metal-sulfur batteries, new approaches to electrochemical splitting of water. CO2 reduction, lithium extraction from salt water
-
Ron Dror
Associate Professor of Computer Science and, by courtesy, of Molecular and Cellular Physiology and of Structural Biology
BioRon Dror is an Associate Professor of Computer Science and, by courtesy, Molecular and Cellular Physiology and Structural Biology at Stanford University, where he is also affiliated with the Institute for Computational and Mathematical Engineering, the Stanford Artificial Intelligence Lab, Bio-X, ChEM-H, and the Biophysics and Biomedical Informatics Programs. Dr. Dror's research at Stanford addresses a broad set of computational biology problems related to the spatial organization and dynamics of biomolecules and cells.
Before joining Stanford in March 2014, Dr. Dror served as second-in-command of D. E. Shaw Research, a hundred-person company, having joined in 2002 as its first hire. At DESRES, he focused on high-performance computing and biomolecular simulation—in particular, developing technology that accelerates molecular dynamics simulations by orders of magnitude, and applying these simulations to the study of protein function, protein folding, and protein-drug interactions (part of a project highlighted by Science as one of the top 10 scientific breakthroughs of 2010).
Dr. Dror earned a PhD in Electrical Engineering and Computer Science at MIT, an MPhil in Biological Sciences as a Churchill Scholar at the University of Cambridge, and both a BA in Mathematics and a BS in Electrical and Computer Engineering at Rice University, summa cum laude. As a student, he worked in genomics, vision, image analysis, and neuroscience. He has been awarded a Fulbright Scholarship and fellowships from the National Science Foundation, the Department of Defense, and the Whitaker Foundation, as well as a Gordon Bell Prize and several Best Paper awards. -
Liang Feng
Assistant Professor of Molecular and Cellular Physiology
Current Research and Scholarly InterestsWe are interested in the structure, dynamics and function of eukaryotic transport proteins mediating ions and major nutrients crossing the membrane, the kinetics and regulation of transport processes, the catalytic mechanism of membrane embedded enzymes and the development of small molecule modulators based on the structure and function of membrane proteins.
-
Chris Garcia
Younger Family Professor and Professor of Structural Biology
Current Research and Scholarly InterestsStructural and functional studies of transmembrane receptor interactions with their ligands in systems relevant to human health and disease - primarily in immunity, infection, and neurobiology. We study these problems using protein engineering, structural, biochemical, and combinatorial biology approaches.
-
Miriam B. Goodman
Professor of Molecular and Cellular Physiology
Current Research and Scholarly InterestsWe study the molecular events that give rise to the sensation of touch and temperature in C. elegans. To do this, we use a combination of quantitative behavioral analysis, genetics, in vivo electrophysiology, and heterologous expression of ion channels. We also collaborate with Pruitt's group in Mechanical Engineering to develop and fabricate novel devices for the study of sensory transduction.
-
John Huguenard
Professor of Neurology, of Neurosurgery and, by courtesy, of Molecular and Cellular Physiology
Current Research and Scholarly InterestsWe are interested in the neuronal mechanisms that underlie synchronous oscillatory activity in the thalamus, cortex and the massively interconnected thalamocortical system. Such oscillations are related to cognitive processes, normal sleep activities and certain forms of epilepsy. Our approach is an analysis of the discrete components (cells, synapses, microcircuits) that make up thalamic and cortical circuits, and reconstitution of components into in silico computational networks.
-
Brian Kobilka
Helene Irwin Fagan Chair in Cardiology
Current Research and Scholarly InterestsStructure, function and physiology of adrenergic receptors.
-
Richard Lewis
Professor of Molecular and Cellular Physiology
Current Research and Scholarly InterestsWe study molecular mechanisms of calcium signaling with a focus on store-operated CRAC channels and their essential roles in T cell development and function. Currently we aim to define the molecular mechanism for CRAC channel activation and the means by which calcium signal dynamics mediate specific activation of transcription factors and T-cell genes during development.
-
Kif Liakath-Ali
Postdoctoral Research Fellow, Molecular and Cellular Physiology
BioDr Liakath-Ali holds a PhD degree in molecular genetics from the University of Cambridge, UK. He carried out his doctoral and a brief post-doctoral research under the supervision of Professor Fiona Watt at Cambridge and King’s College London. While in Watt lab, he conducted a first, large-scale tissue-specific phenotype screen on hundreds of knockout mice and discovered many novel genes that are essential for mammalian skin function. He further elucidated the mechanistic roles of sphingolipid and a ribosome-rescue pathway in epidermal stem cell function. He has published many papers in the area of skin biology and won several awards, including, most recently a long-term fellowship from the European Molecular Biology Organization (EMBO).
Dr Liakath-Ali obtained his bachelor and master degree in Zoology from Jamal Mohamed College (Bharathidasan University), Trichy, India. He further specialized in human genetics and obtained an MPhil from the University of Madras, India. He went on to work at various capacities at Centre for DNA Fingerprinting and Diagnostics, Hyderabad, India, Institute of Human Genetics, University of Göttingen, Germany and the Wellcome Sanger Institute, Cambridge, UK. Dr Liakath-Ali also holds a degree equivalent (Associateship of King’s College (AKC) in Philosophy, Ethics and Theology.
It is perhaps these combinations of diverse backgrounds and training that led Dr Liakath-Ali to develop an interest in fundamental questions in neuroscience. He is currently an EMBO Research Fellow, working under the supervision of Professor Thomas Südhof at Stanford on genetic mechanisms involved in synapse formation and function. He is also an avid communicator of science, STEM ambassador and open science advocate. -
Daniel V. Madison
Associate Professor of Molecular and Cellular Physiology
Current Research and Scholarly InterestsOur laboratory is interested in the function and plasticity CNS synapses, including studies of the detailed structure and protein content of synapses in different plastic states. We also have a strong interest in the pathophysiology of Azheimer’s disease as related to endocannabinoids. We use primarily electrophysiogy and high-resolution array tomographic imaging to dissect the function of synapses undergoing changes due either to external stimuli, disease states or internal modulation.
-
Merritt Maduke
Associate Professor of Molecular and Cellular Physiology
Current Research and Scholarly InterestsMolecular mechanisms of chloride channels & transporters studied by integration of structural and electrophysiological methods.
-
Lucy Erin O'Brien
Assistant Professor of Molecular and Cellular Physiology
Current Research and Scholarly InterestsMany adult organs tune their functional capacity to variable levels of physiologic demand. Adaptive organ resizing breaks the allometry of the body plan that was established during development, suggesting that it occurs through different mechanisms. Emerging evidence points to stem cells as key players in these mechanisms. We use the Drosophila midgut, a stem-cell based organ analogous to the vertebrate small intestine, as a simple model to uncover the rules that govern adaptive remodeling.
-
Richard J. Reimer, MD
Associate Professor of Neurology and, by courtesy, of Molecular and Cellular Physiology at the Palo Alto Veterans Administration Health Care System
Current Research and Scholarly InterestsReimer Lab interests
A primary interest of our lab is to understand how nerve cells make and recycle neurotransmitters, the small molecules that they use to communicate with each other. In better defining these processes we hope to achieve our long-term goal of identifying novel sites for treatment of diseases such as epilepsy and Parkinson Disease. In our studies on neurotransmitter metabolism we have focused our efforts on transporters, a functional class of proteins that move neurotransmitters and other small molecules across membranes in cells. Transporters have many characteristics that make them excellent pharmacological targets, and not surprisingly some of the most effective treatments for neuropsychiatric disorders are directed at transporters. We are specifically focusing on two groups of transporters vesicular neurotransmitter transporters that package neurotransmitters into vesicles for release, and glutamine transporters that shuttle glutamine, a precursor for two major neurotransmitters glutamate and GABA, to neurons from glia, the supporting cells that surround them. We are pursuing these goals through molecular and biochemical studies, and, in collaboration with the Huguenard and Prince labs, through physiological and biosensor based imaging studies to better understand how pharmacological targeting of these molecules will influence neurological disorders.
A second interest of our lab is to define mechanism underlying the pathology of lysosomal storage disorders. Lysosomes are membrane bound acidic intracellular organelles filled with hydrolytic enzymes that normally function as recycling centers within cells by breaking down damaged cellular macromolecules. Several degenerative diseases designated as lysosomal storage disorders (LSDs) are associated with the accumulation of material within lysosomes. Tay-Sachs disease, Neimann-Pick disease and Gaucher disease are some of the more common LSDs. For reasons that remain incompletely understood, these diseases often affect the nervous system out of proportion to other organs. As a model for LSDs we are studying the lysosomal free sialic acid storage disorders. These diseases are the result of a defect in transport of sialic acid across lysosomal membranes and are associated with mutations in the gene encoding the sialic acid transporter sialin. We are using molecular, genetic and biochemical approaches to better define the normal function of sialin and to determine how loss of sialin function leads to neurodevelopmental defects and neurodegeneration associated with the lysosomal free sialic acid storage disorders. -
Junming Ren
Postdoctoral Research Fellow, Molecular and Cellular Physiology
Current Research and Scholarly InterestsImmune Engineering, Synthetic Medicine, Synthetic Immunology
-
Ehsan Rezaei
Postdoctoral Research Fellow, Molecular and Cellular Physiology
Current Research and Scholarly InterestsExperimental and computational studies of force transmission responsible for touch sensation on C. elegans nematode outer shell wall.
-
Anthony Ricci
Edward C. and Amy H. Sewall Professor in the School of Medicine and Professor, by courtesy, of Molecular and Cellular Physiology
Current Research and Scholarly InterestsThe auditory sensory cell, the hair cell, detects mechanical stimulation at the atomic level and conveys information regarding frequency and intensity to the brain with high fidelity. Our interests are in identifying specializations associated with mechanotransduction and synaptic transmission leading to the amazing sensitivities of the auditory system. We are also interested in the developmental process, particularly in how development gives insight into repair and regenerative mechanisms.
-
Gregory Scherrer
Assistant Professor of Anesthesiology, Perioperative and Pain Medicine, of Neurosurgery and, by courtesy, of Molecular and Cellular Physiology
Current Research and Scholarly InterestsOur laboratory investigates the neural mechanisms that underlie the sensory and affective dimensions of pain experience. We also study how opioids interfere with these mechanisms to provide pain relief, but also deleterious effects such as tolerance, addiction and respiratory depression. Our goal is to better understand the neural basis of pain experience and opioid effects to discover novel treatments that block pain more efficiently and safely than current opioid drugs.
-
Georgios Skiniotis
Professor of Molecular and Cellular Physiology, of Structural Biology and of Photon Science
BioThe Skiniotis laboratory seeks to resolve structural and mechanistic questions underlying biological processes that are central to cellular physiology. Our investigations employ primarily cryo-electron microscopy (cryoEM) and 3D reconstruction techniques complemented by biochemistry, biophysics and simulation methods to obtain a dynamic view into the macromolecular complexes carrying out these processes. The main theme in the lab is the structural biology of cell surface receptors that mediate intracellular signaling and communication. Our current main focus is the exploration of the mechanisms responsible for transmembrane signal instigation in cytokine receptors and G protein coupled receptor (GPCR) complexes.
-
Stephen J Smith
Professor of Molecular and Cellular Physiology, Emeritus
Current Research and Scholarly InterestsResearch in the Smith Laboratory addresses basic mechanisms and and disorders of brain function. Present efforts are focused on the development and application of new proteomic imaging methods to explore the circuit and molecular architectures of memory storage and retrieval in cerebral cortex.
-
Thomas Sudhof
Avram Goldstein Professor in the School of Medicine and Professor, by courtesy, of Neurology and of Psychiatry and Behavioral Sciences
Current Research and Scholarly InterestsInformation transfer at synapses mediates information processing in brain, and is impaired in many brain diseases. Thomas Südhof is interested in how synapses are formed, how presynaptic terminals release neurotransmitters at synapses, and how synapses become dysfunctional in diseases such as autism or Alzheimer's disease. To address these questions, Südhof's laboratory employs approaches ranging from biophysical studies to the electrophysiological and behavioral analyses of mutant mice.
-
Richard Tsien
George D. Smith Professor, Emeritus
Current Research and Scholarly InterestsWe study synaptic communication between brain cells with the goal of understanding neuronal computations and memory mechanisms. Main areas of focus include: presynaptic calcium channels, mechanisms of vesicular fusion and recycling. Modulation of synaptic strength through changes in postsynaptic receptors and dendritic morphology. Signaling that links synaptic activity to nuclear transcription and local protein translation. Techniques include imaging, electrophysiology, molecular biology.
-
William Weis
William M. Hume Professor in the School of Medicine, Professor of Structural Biology, of Molecular and Cellular Physiology and of Photon Science
Current Research and Scholarly InterestsOur laboratory studies molecular interactions that underlie the establishment and maintenance of cell and tissue structure. Our specific areas of interest are the architecture and dynamics of intercellular adhesion junctions, the molecular basis of cell polarity, and the Wnt signaling pathway. We also have a long-standing interest in carbohydrate-based cellular recognition and adhesion.
