School of Medicine
Showing 1,601-1,700 of 13,032 Results
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Hsien-Hwa Alice Cha
Clinical Assistant Professor, Medicine
BioDr. Hsien-Hwa Alice Cha is a Clinical Assistant Professor of the Division of Hospital Medicine in the School of Medicine. A Bay Area native, she received her undergraduate degree from University of California, Berkeley with Honors in Molecular Cell Biology - Biochemistry. She completed her medical education at New York Medical College and her Internal Medicine Residency at Kaiser Permanente Santa Clara in 2016. She joined the Division of Hospital Medicine at Stanford Health-Care in Tri-Valley in 2016 as a hospitalist. She led the Tri-Valley Section as Section Chief from 2020-2023, during which she expanded the section’s clinical capabilities to include orthopedic pre-op care, and dedicated nocturnal care with nocturnists. Her interest in medical education led her to co-found Stanford Health-Care Tri-Valley’s Clinical Academy in 2019, a program designed for high school juniors and seniors interested in exploring medicine as a career. She was the recipient of the Department of Medicine’s Teaching Award for the Tri-Valley Division in 2022. Her other interests include clinical implications of metals, opioid stewardship, bioethics, undergraduate medical education, and physician leadership development.
Outside of work, she enjoys spending time with her two young children, cooking toddler meals, and watching crime dramas. -
Yashaar Chaichian, MD
Clinical Associate Professor, Medicine - Immunology & Rheumatology
Current Research and Scholarly InterestsSystemic lupus erythematosus
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Chayut Chaiperm
Affiliate, Orthopaedic Surgery
Visiting Scholar, Orthopaedic SurgeryBioDr. Chayut Chaiperm is an attending orthopaedic surgeon in the Division of Orthopaedics at Bhumibol Adulyadej Hospital in Bangkok, Thailand. He earned his MD from Chulalongkorn University (2015), completed orthopaedic residency training (2020), and pursued fellowship training in adult hip and knee reconstruction (2021). His clinical interests include adult hip and knee reconstruction, with a focus on robotic-assisted surgery and technology-enabled techniques to optimize patient outcomes.
Dr. Chaiperm is a member of the Royal College of Orthopaedic Surgeons of Thailand (RCOST) and the Thai Hip and Knee Society (THKS), and he recently became a member of the American Association of Hip and Knee Surgeons (AAHKS).
Education
Fellowship: Adult Hip & Knee reconstruction - Chulalongkorn University, Bangkok (2021)
Residency: Khon Kaen Hospital (2020)
Medical education (MD): Chulalongkorn University, Bangkok (2015)
Publications
-Tharakulphan S, Chaiperm C, Apivatgaroon A, Sangkomkamhang T. Analgesic efficacy of a single-dose, intraoperative, intra-articular morphine application in ACL reconstruction. Asia Pac J SportsMed Arthrosc RehabilTechnol. 2020;20:28-31
-Chaiperm C, Tanavalee C, Kampitak W, Amarase C, Ngarmukos S, Tanavalee A. Intraoperative Surgeon-Performed versus Conventional Anesthesiologist-Performed Continuous Adductor Canal Block in Total Knee Arthroplasty: A Randomized Controlled Trial. J Knee Surg. 2023 Apr 18. doi: 10.1055/a-2062-0264
-Chaiperm C, Waipanya P, Athikraimongkol B, Narinsorasak T. Acute Pseudoseptic Arthritis after Intra-Articular Sodium Hyaluronate Injection: A Case Report and Literature Review. JseaOrtho [Internet]. 2023 Apr.
-Chaiperm C, Ittiravivongs A, Waipanya P, Athikraimongkol B, Narinsorasak T. Simultaneous Concurrent Bilateral Total Knee Replacement in a Patient With Bilateral Lipoma Arborescens With End-Stage Osteoarthritis. Arthroplast Today. 2024 Jun 5;27:101406. doi: 10.1016/j.artd.2024.101406. -
Antara Chakravarty
Postdoctoral Scholar, Microbiology and Immunology
BioAntara Chakravarty is a postdoctoral scholar in the laboratory of Dr. Priscilla Yang at Stanford Medicine, where she develops small-molecule-based targeted protein degradation strategies against viral proteins. Her work focuses on understanding how viral proteins interface with host cellular pathways, including mechanisms that influence antiviral signaling responses. She is also interested in virus-induced remodeling of host membrane lipids and studies these processes using the hepatitis C virus replicase complex as a model system.
Antara received her doctoral training in molecular virology in the laboratory of Dr. A. L. N. Rao at the University of California, Riverside, where she discovered key roles for viral capsid dynamics in the pathogenicity and infectivity of multipartite bromoviruses. Her emerging research interests focus on developing chemically controllable tools to investigate host immune signaling pathways. -
Lisa J. Chamberlain
Member, Maternal & Child Health Research Institute (MCHRI)
Current Research and Scholarly InterestsChild Health disparities - Projects focus on elucidating the non-clinical factors that impact access to appropriate care for children with chronic illness.
Health Policy - Projects explore the intersection of medicine as a profession and formation of child health policy. -
Monique Chambers, MD, MSL
Assistant Professor of Orthopedic Surgery
BioDr. Monique Chambers is a fellowship-trained orthopaedic surgeon at Stanford Health Care. She is also an assistant professor in the Department of Orthopaedic Surgery, Division of Foot and Ankle Surgery at Stanford University School of Medicine.
Dr. Chambers specializes in treating complex foot and ankle conditions, including those that affect dancers, post-traumatic injuries and complications, deformities, and degenerative joint diseases. She focuses on restoring function and preserving limbs whenever possible, utilizing minimally invasive techniques and limb salvage procedures. Dr. Chambers is committed to delivering compassionate, evidence-based care through multispecialty collaboration.
Dr. Chambers’ research involves innovations in surgery and medical education, health care outcomes, and complexities in medicine and law. Her work explores musculoskeletal conditions, as well as psychosocial and structural factors that influence quality and outcomes in residency training and surgical care. As director of research and pathway initiative outcomes at Nth Dimensions, a national nonprofit advancing access to surgical specialties, Dr. Chambers has mentored dozens of students and trainees.
Dr. Chambers has extensively published her findings in peer-reviewed journals, including Arthroplasty Today, Journal of the American Academy of Orthopaedic Surgeons, Journal of Surgical Education, and Journal of Racial and Ethnic Health Disparities. Her dedication to inclusive patient care and education has earned her national recognition, including the National Minority Quality Forum’s 40 Under 40 in Minority Health Award.
Dr. Chambers is a member of the American Academy of Orthopaedic Surgeons, the American Orthopaedic Foot and Ankle Society, and the National Medical Association. She is also a member of the Christian Medical and Dental Associations, the Ruth Jackson Orthopaedic Society, the Limb Lengthening and Reconstruction Society, and the J. Robert Gladden Orthopaedic Society. -
Charles Chan
Clinical Assistant Professor, Orthopaedic Surgery
Current Research and Scholarly InterestsDr. Chan's research interests include identifying risk factors for growth plate injuries during ACL reconstruction, developing new strategies to prevent pediatric sports injuries, and clinical outcomes of surgical reconstructions in the pediatric athlete.
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Emily Chan
Associate Professor of Pathology (Clinical Pathology)
BioDr. Chan is an Associate Professor of Pathology at Stanford University. She completed her MD, PhD at New York University and Anatomic Pathology residency with subspecialty Genitourinary Pathology training at University of California-San Francisco (UCSF). She is AP board-certified. Dr. Chan was a GU attending at UCSF for five years before joining Stanford to lead the Genitourinary Pathology Service and Fellowship. She has successfully mentored numerous trainees in projects, publications, and career planning. Dr. Chan has co-authored more than 70 peer-reviewed research publications and has a particular interest in integrating molecular testing in diagnostic pathology, as well as recognition of prostate cancer architectural patterns than can help with prognosis and treatment decision making.
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Jeremy Chan
Clinical Assistant Professor, Orthopaedic Surgery
BioDr. Chan is a board certified Clinical Assistant Professor within the Department of Orthopaedic Surgery at Stanford University. He specializes in the surgical treatment of orthopedic conditions in the foot and ankle including ankle arthroscopy, ankle fusions, total ankle replacement, deformity reconstruction, ligament and tendon repair as well as fractures involving the foot and ankle. Having treated athletes from recreational to professional levels, Dr. Chan has a particular interest in acute foot and ankle injuries including treatment of Achilles ruptures, ankle syndesmosis and lateral ankle ligament injuries, ankle fractures and Lisfranc injuries. Dr. Chan also has expertise in early weightbearing and accelerated rehabilitation approaches to ankle fractures and Achilles tendon surgery. He has been a foot and ankle consultant for the San Francisco 49ers. As a faculty member, Dr. Chan serves as a team physician for Stanford Athletics and is an associate program director for the Stanford orthopedic residency program. He has been recognized for his dedication to resident education with the Saul Halpern Orthopedic Educator of the Year Award. He is currently helping to develop a coaching curriculum for orthopedic surgery residents, and is an orthopedic resident mentor. In addition, Dr. Chan serves as a file reviewer for MD Admissions at the Stanford School of Medicine and is a member of the faculty senate. He is an active committee member for the Postgraduate Education and Public Education Committees of the American Orthopaedic Foot and Ankle Society.
Dr. Chan has authored or co-authored over 20 peer-reviewed scientific articles, reviews and chapters while also serving as a journal reviewer for both Foot and Ankle International (FAI) as well as the Journal of the American Academy of Orthopaedic Surgeons (JAAOS). For his research in flatfoot reconstruction, he was awarded the Leonard J. Goldner Award from the American Orthopaedic Foot and Ankle Society. He is a fellow of the American Academy of Orthopaedic Surgeons (AAOS) and member of the American Orthopaedic Foot and Ankle Society (AOFAS).
He graduated magna cum laude with honors during his undergraduate studies at the University of Washington. He went on to medical school at Cornell University graduating with honors in research. During his time in medical school, he was awarded the Sidney and Viola Borkon Memorial Prize as the top student in his class and was inducted into the Alpha Omega Alpha (AOA) Honor Medical Society. He then completed his orthopedic surgery residency at Stanford and was chosen as the American Orthopaedic Association Evarts Resident Leader representative during his time in residency. Dr. Chan completed his subspecialty orthopedic foot and ankle fellowship training at Cedars-Sinai Medical Center. He has been trained and mentored by several former and future presidents of the American Orthopedic Foot and Ankle Society including Drs. David Thordarson, Scott Ellis and Glenn Pfeffer. -
John K. Chan
Adjunct Clinical Associate Professor, Obstetrics & Gynecology - Gynecologic Oncology
BioAs a board-certified gynecologic oncologist caring for cancer patients undergoing surgery, chemotherapy, and biologic treatment over the last 20 years, I have a deep understanding of the pathophysiology of ovarian, uterine, cervical, and vulvovaginal cancers. I trained at MD Anderson Cancer Center under the Felix Rutledge oncology fellowship and at University of California, Los Angeles and Irvine for Medical School and Gynecologic Oncology fellowship.
My translational science research on cancer immunotherapy was supported under a National Institute of Health Career Development Award. With respect to population science, I studied ovarian cancer prevention and outcomes under a National Cancer Institute grant. As a clinical researcher, I served as the principal investigator for numerous phase II and III clinical trials and received multiple grants and awards, including those from the National Cancer Institute, the Ovarian Cancer Research Foundation, Gynecologic Cancer Foundation, and the Gynecologic Oncology Group / NRG.
Over the years, my research studies have published nearly 200 peer-reviewed journals in the New England Journal of Medicine, Journal of the American Medical Association, Lancet Oncology, Journal of Clinical Oncology and Clinical Cancer Research and numerous textbook chapters. Clinically, I have been elected as the Best doctor in America and Best Doctors as recognized by the U.S. News and World Report. -
Kevin Chuen Wing Chan
Associate Professor of Ophthalmology (Research/Clinical Trials)
Current Research and Scholarly Interests(1) MR ocular imaging and neuroimaging of degeneration, development, protection, plasticity, and regeneration in humans and experimental animal models.
(2) Structural, metabolic, physiological, and functional relationships between eye, brain, and behavior in health and disease. -
Pak H. Chan
The James R. Doty Professor in Neurosurgery and Neurosciences, Emeritus
Current Research and Scholarly InterestsNeuronal death and regeneration after strokeand neural injury
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Steven Chan, MD MBA
Clinical Associate Professor (Affiliated), Psych/Public Mental Health & Population Sciences
Staff, Psychiatry and Behavioral SciencesBioDr. Steven Chan is a Faculty Co-Director at Stanford Frontier Technology Lab, a member of Stanford Psychiatry’s TechHub Leadership Committee, faculty with the Stanford Addiction Medicine Fellowship, and a clinical educator caring for patients with substance use disorders (SUD) and addictions.
Dr. Chan is a clinical informaticist, addiction medicine physician, and psychiatrist. He is a clinical associate professor affiliated with the Stanford University School of Medicine, and Immediate Past Chair of the Committee on Innovation at the American Psychiatric Association. Dr. Chan is a sought-after national speaker whose ideas, thoughts, and research have been featured at Google headquarters, JAMA, Telemedicine and e-Health, JMIR (Journal of Medical Internet Research), Wired, PBS, and NPR Ideastream. He serves as Chief Technology Officer and co-founder of AsyncHealth — a University of California-backed digital mental health startup supported by Berkeley SkyDeck PAD-13 and the National Science Foundation's Innovation Corps (NSF i-Corps) — and writes at both @stevenchanMD and @mpowerhacks. -
Rachel Ellen Chan Seay
Clinical Associate Professor, Obstetrics & Gynecology - General
BioMy clinical focus is the care of people across the age spectrum from adolescence to menopause. I attend to both Obstetric and benign Gynecologic needs in both ambulatory and hospital settings. I strive to provide a holistic approach to consultations for full-scope benign Gyn medical and surgical problems. In my practice of clinical medicine, I strongly value the role of education across all levels, including medical staff, students, resident physicians, patients and their families. I emphasize effective communication, professionalism, and inclusive patient-centered care.
I am actively involved in national and international programs that focus on teaching medical students, residents and faculty. Since completing my residency training, I have worked regularly in international low-resource settings. I have served as Visiting Clinical Faculty in Thomonde, Haiti; at Hospital Nacional Juan Jose Ortega in Coatepeque, Guatemala; and at Orotta School of Medicine in Asmara, Eritrea. I have completed emergency OBGYN field assignments as a clinical consultant for Médecins Sans Frontières/Doctors Without Borders (MSF) in Sierra Leone and South Sudan. I worked as a consultant for an academic partnership with the University of Colorado School of Public Health to train local traditional birth attendants, and developed a long-term partnership to augment the local OBGYN residency program in Coatepeque in the southwest Trifinio region of Guatemala. I was the 2015 Research Fellow in the History of American Ob/Gyn at the American College of Obstetricians and Gynecologists in Washington DC, where my research focused on the evolution of the management of postpartum hemorrhage in the US from 1903-1940. Since 2023, I have served as Adjunct Faculty at the University of Global Health Equity in Butaro, Rwanda.
My ongoing scholarly activities focus on designing global health curricula for medical trainees from high-resources settings, and supporting medical education in low-resource settings. -
Mishu Chandra
Clinical Assistant Professor, Adult Neurology
BioDr. Chandra is clinical assistant professor in the divisions of Comprehensive Neurology and Epilepsy in the Department of Neurology and Neurological Sciences at Stanford University School of Medicine. She is board-certified in Neurology, Clinical Neurophysiology, and Epilepsy.
A Bay Area native, Dr. Chandra completed her undergraduate education at the University of California, Berkeley. She earned her medical degree from Rush University Medical College and completed her neurology residency at the University of Texas Southwestern Medical Center (UTSW), where she served as the Academic Chief Resident. She pursued her passion for medical education by founding the Clinician Educator Track for the residency program, and continued to serve as Course Director during her fellowship training in both Clinical Neurophysiology and Epilepsy at UTSW. Dr. Chandra later served as an Associate Program Director for the Neurology residency program. Her clinical and research interests include psychiatric disorders in refractory epilepsy, perioperative management of refractory epilepsy requiring surgical intervention, women’s health in neurology, as well as medical education in clinical neurophysiology. -
Venita Chandra
Clinical Professor, Surgery - Vascular Surgery
Clinical Professor (By courtesy), NeurosurgeryBioDr. Chandra is a board certified vascular surgeon who specializes in cutting edge approaches to aortic aneurysmal disease, peripheral vascular disease and limb salvage.
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Anusha Chandrakanthan
Clinical Assistant Professor, Psychiatry and Behavioral Sciences
BioDr. Anusha Chandrakanthan is a clinical instructor in psychiatry. She is a family practice physician who is board certified in Addiction Medicine. Previously, she was the medical director for a company that provided substance use treatment using telemedicine. Presently, she works with the Valley Homeless Healthcare Program at Santa Clara Valley Medical Center providing services to a marginalized population. She also continues to teach at the Stanford Addiction Medicine fellowship.
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Andrew Y. Chang, MD, MS(Epi)
Member (Postdoc), Cardiovascular Institute
Current Research and Scholarly InterestsMy research interests center around the epidemiology, environmental determinants, and health services dimensions of heart disease, with an emphasis on vulnerable populations, both international and domestic. Current projects include the development of novel care quality metrics for use in rheumatic heart disease in East Africa, testing of low sodium salt substitutes in South Asia, and describing the cardiovascular impacts of cyclical climate change-associated major environmental events.
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Anne Lynn S. Chang, MD
Professor of Dermatology
Current Research and Scholarly InterestsMy two main research interests are:
1) To better understand and treat patients with aggressive basal and squamous cell carcinomas
2) To better understand the genetic and epigenetic mechanisms of healthy human skin aging and to translate these insights into better care of skin diseases enriched in older patients, particularly skin cancer and rosacea -
Crystal Chang, D.D.S.
Clinical Assistant Professor, Surgery - Plastic & Reconstructive Surgery
BioDr. Crystal Chang is a Hospital Dentist and Clinical Assistant Professor in Dental Medicine & Surgery. She focuses on maintaining oral health through the management of infection, trauma and secondary comorbidities to the dentition and its supporting structures. She performs medically necessary dental surgery in the context of cardiac disease, orthopedic surgery, cancer therapy and organ transplants. Dr. Chang is also a Diplomate of the American Board of Dental Sleep Medicine and provides oral appliance therapy for obstructive sleep apnea.
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Edwin Chang
Director, Small Animal Imaging Facility at Porter Drive, Rad/Molecular Imaging Program at Stanford
Current Role at StanfordDirector, SCI3@Porter or the Canary Core Preclinical Imaging Facility at Stanford
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Felix Chang, MD
Clinical Assistant Professor, Adult Neurology
BioDr. Felix Chang's clinical practice mainly involves intraoperative neurophysiologic monitoring (IONM) and the treatment of neurological disorders with botulinum toxin. He earned his medical degree at the University of Texas Southwestern Medical Center. He completed his neurology residency at the Harvard Neurology Program at the Beth Israel Deaconess Medical Center in Boston. He then went on to complete a fellowship in clinical neurophysiology with a focus in intraoperative neurophysiologic monitoring at Stanford.
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Howard Y. Chang, MD, PhD
Virginia and D. K. Ludwig Professor of Cancer Research, Professor of Genetics and, by courtesy, of Pathology
Current Research and Scholarly InterestsOur research is focused on how the activities of hundreds or even thousands of genes (gene parties) are coordinated to achieve biological meaning. We have pioneered methods to predict, dissect, and control large-scale gene regulatory programs; these methods have provided insights into human development, cancer, and aging.
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James Chang, MD
Johnson and Johnson Professor of Surgery
Current Research and Scholarly InterestsMy role in research is to apply novel advances in tissue engineering and microsurgery to the clinical problems of hand trauma, peripheral nerve injuries, and congenital hand problems. I am interested in developing new tissues and techniques that will allow optimal reconstruction of form and function to those patients requiring reconstructive surgery.
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Joy Chang
Clinical Assistant Professor, Surgery - Plastic & Reconstructive Surgery
BioDr. Joy Chang earned her Bachelor of Science degree in Chemical and Biomolecular Engineering from Johns Hopkins University, then completed a research fellowship at the National Institutes of Health. She then pursued her dental education at the University of California, San Francisco and completed her orthodontic residency and Master’s degree at the University of Connecticut. Dr. Chang has since been practicing orthodontics in the Bay Area.
Dr. Chang has received the Harry Sicher Award from the American Association of Orthodontists (AAO), as well as awards from the American Association of Orthodontists Foundation (AAOF) and the Northeastern Society of Orthodontists (NESO) for her research and publications on the acceleration of orthodontic tooth movement. She is a Diplomate of the American Board of Orthodontics as well as an active member of the Angle Society.
Clinically, Dr. Chang focuses on the comprehensive management of patients with complex craniofacial deformities or multidisciplinary healthcare needs. She takes a comprehensive approach to treatment, emphasizing function, health, and long-term well-being. -
Julia J. Chang, MD
Clinical Assistant Professor, Medicine - Endocrinology, Gerontology, & Metabolism
BioDr. Chang is a board-certified endocrinologist. She is a Clinical Assistant Professor in Stanford Medicine’s Division of Endocrinology and, by courtesy, the Department of Neurosurgery. She specializes in pituitary disorders, including prolactinomas, Cushing disease, acromegaly, non-functional pituitary masses and cysts, and hypopituitarism, as well as transgender health and gender-affirming hormone care.
For each patient, she develops a comprehensive, compassionate care plan personalized to individual needs. Her goal is always the best possible health and quality of life for every patient in her care.
Dr. Chang actively leads several pituitary and transgender care research, quality improvement, and education initiatives. She teaches Stanford trainees and serves as the associate program director for the Stanford Endocrinology Fellowship. She has published widely and presented her research at international conferences and is a member of the Endocrine Society, Pituitary Society, and the World Professional Association of Transgender Health. She is a native English speaker, and she also understands Korean.
In-person and telehealth appointments with Dr. Chang are available at Stanford Endocrinology Clinic at Hoover Pavilion, Pituitary Center at Stanford Neurosciences Health Center, and the Stanford Brain Tumor Center at Stanford Cancer Center. She is also a part of the LGBTQ+ Health Program. -
Kay W. Chang, MD
Professor of Otolaryngology - Head & Neck Surgery (OHNS) and, by courtesy, of Pediatrics
Current Research and Scholarly Interestshttp://med.stanford.edu/ohns/research/labs_chang.html
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Michael Chang, MD
Assistant Professor of Otolaryngology - Head & Neck surgery (OHNS)
BioDr. Michael Chang is an Assistant Professor in the Department of Otolaryngology – Head & Neck Surgery at Stanford University School of Medicine. He graduated magna cum laude with honors in Neuroscience from Brown University and earned his medical degree from Yale University. He completed both his residency in Otolaryngology and his fellowship in Neuro-rhinology – Advanced Sinus & Skull Base Surgery at Stanford, where he was subsequently recruited to join the faculty.
Dr. Chang specializes in the treatment of nasal, sinus, and skull base disorders. He also leads a research lab focused on the application of artificial intelligence in surgery. His additional research interests include novel endoscopic imaging technologies, sinonasal cancer, and outcomes of surgical treatments for sinus and skull base disease. His work has received numerous research awards and has been published in high-impact journals. He regularly teaches on advancements in rhinology at national and international conferences.
Dr. Chang serves as Associate Program Director for Stanford’s Rhinology Fellowship, helping to train future rhinologic surgeons. He is a member of the American Academy of Otolaryngology–Head and Neck Surgery, the North American Skull Base Society, and the American Rhinologic Society. He currently serves on the American Rhinology Society's Information Technology Committee. -
Robert Chang, MD
Professor of Ophthalmology
Current Research and Scholarly InterestsI'm interested in developing a best in class glaucoma registry, utilizing modern algorithm techniques on imaging, text, and biologic data for precision health predictive analytics in glaucoma diagnosis and treatment, validating new medical devices and technologies, especially portable ones, and working on implementation science
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Spencer Chang
Clinical Assistant Professor, Medicine - Primary Care and Population Health
BioDr. Spencer Chang is a board-certified Internal Medicine physician who practices at the Stanford Internal Medicine Clinic in Palo Alto. Dr. Chang earned his MD at Duke University School of Medicine where he was part of the Primary Care Leadership Track. He completed his Internal Medicine Residency training at UCLA in the Primary Care Program. Dr. Chang has interests in medical education, improving access to primary care, community health, and Asian Pacific Islander health disparities. He believes in a holistic approach to patient care, addressing the physical, mental, and emotional well-being of his patients and partnering with them to achieve their health goals.
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Stephanie Tzu-Ying Chang
Assistant Professor of Radiology
BioDr. Stephanie Chang is an Assistant Professor in Radiology at Stanford University School of Medicine, Section Chief in Abdominal Imaging, and Interim Director of Diagnostic Radiology in the Department of Radiology at VA Palo Alto.
Dr. Chang’s research program aims to utilize state-of-the-art diagnostic technology to non-invasively detect abdominal diseases that predispose or lead to cancer since the most beneficial and cost-effective cancer imaging occurs in the screening/early detection phase.
Currently, metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH) are leading worldwide causes of end-stage liver disease and liver cancer (hepatocellular carcinoma, HCC). To determine the optimal multimodality screening and diagnostic pathway, Dr. Chang leads prospective research studies at VA Palo Alto comparing blood-based and imaging-based diagnostic tests – the Fibrosis-4 (FIB-4) Index, the Enhanced Liver Fibrosis (ELF) test, vibration controlled transient elastography (VCTE), ultrasound point shear wave elastography (US pSWE), and magnetic resonance imaging (MRI) elastography – among high-risk veterans with obesity and/or type 2 diabetes to compare relative performance and costs/benefits.
To improve detection of hepatocellular carcinoma (HCC) among patients with end-stage liver disease (cirrhosis), Dr. Chang also serves as a member of the VA National Radiology Working Group and radiology local site investigator at VA Palo Alto for a multicenter VA research study CSP #2023 PREventing liver cancer Mortality through Imaging with Ultrasound vs. MRI (PREMIUM STUDY) comparing US and MRI to determine optimal screening strategies for hepatocellular carcinoma.
While MRI has the overall highest sensitivity and specificity for many diseases and contains additional biological/prognostic information not obtainable via other imaging methods, the utility of MRI as a powerful non-invasive screening tool has been hampered by its limitations in access, time, and cost. Dr. Chang is interested in significantly shortening MRI exam times to accelerate MRI throughput, decrease patient discomfort, and reduce costs. To accomplish this goal, Dr. Chang is interested in improving pulse sequences to shorten MRI acquisition times while maintaining or increasing diagnostic quality. In addition, Dr. Chang is interested in novel MRI techniques to improve disease detection and staging.
