School of Medicine
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Trung Hoang Minh Pham
Assistant Professor of Pediatrics (Infectious Diseases)
Current Research and Scholarly InterestsUncovering mechanisms of tissue immunity and immunophysiology during persistent infection
The immune system safeguards the health of complex organisms by rapidly eliminating invading pathogens, curbing infection-induced tissue disruptions, and maintaining tissue homeostasis. Many bacterial pathogens evade host antimicrobial mechanisms and persist in infected tissues at low levels for long periods of time even in the presence of innate and adaptive immune resistance. During persistent infection, the immune system simultaneously orchestrates antimicrobial responses to contain the pathogen, repairs damaged tissue, regulates nutrient resources, and maintains other tissue physiologic functions to ensure host survival. Failure of any of these tasks leads to uncontrolled infection, devastating disease, and even death. The goals of our research are to understand:
1)What are the innate and adaptive immune cellular mechanisms that contain pathogens during persistent infection?
2)How are tissue physiological functions, such as tissue repair and nutrient regulation, maintained during persistent infection?
3)How do pathogens survive innate and adaptive antimicrobial mechanisms in infected tissues?
4)How does persistent infection impact host immunity to secondary infections of a similar or different pathogen?
Through investigating these fundamental questions, we may be able to decode the underlying cellular and molecular mechanisms that can be harnessed to eradicate infections and help restore health after an infectious insult. We employ animal infection models and bring together immunology, tissue biology, microbiology, and genetics to uncover the mechanisms of tissue immunity and immunophysiology during persistent infection from the molecular to organismal level.
Current areas of research:
•Development, maintenance, and plasticity of macrophage functional diversity in infected tissue
•Tissue repair and nutrient regulation during persistent infection
•Cellular dynamics and bacterial persistence in lymphoid organs
We are looking for highly motivated team members who are passionate about making impactful scientific discoveries to join our group at all levels. For opportunities and positions available for pre-doctoral students and postdoctoral fellows, please contact tpham8@stanford.edu! -
Harold Westley Phillips
Assistant Professor of Neurosurgery (Pediatric Neurosurgery)
BioH. Westley Phillips, MD is an Assistant Professor of Neurosurgery at Stanford University where he is a neurosurgeon-scientist specializing in pediatric neurosurgery with a special interest in epilepsy. Dr. Phillips received his undergraduate degree at Yale University where he was a member of the Varsity Football Team and received a Fulbright Scholarship. He completed an MD at the Perelman School of Medicine at the University of Pennsylvania, graduating with a certificate of distinction in the Clinical Neuroscience Training Program. He completed neurosurgical residency at UCLA where he received 2 years of NIH funding to investigate the genetic underpinnings of epilepsy. He received fellowship training in pediatric epilepsy surgery and genetics research at Boston Children’s Hospital as well as pediatric neurosurgery at the University of Pittsburgh Medical Center, Children’s Hospital of Pittsburgh before his arrival at Stanford. At Stanford, Dr. Phillips leads a molecular genetics laboratory and has a particular interest in defining and further understanding somatic mosaicism and its role in epileptogenesis. He has published manuscripts in leading academic journals including Nature: Genetics, JAMA Neurology, Journal of Neuroscience, Scientific Reports, Epilepsia and Neurology. He is dedicated to improving the treatment and outcomes for children with drug resistant epilepsy through innovative research and cutting-edge surgical techniques.
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Jennifer M. Phillips, PhD
Clinical Professor, Psychiatry and Behavioral Sciences - Child & Adolescent Psychiatry and Child Development
Current Research and Scholarly InterestsAutism spectrum disorders, young child assessment, developmental disabilities
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Ruoxi Pi
Postdoctoral Scholar, Infectious Diseases
BioI received my BS in Biological Sciences in Zhejiang University in China, where I conducted research in polyphasic taxonomy in anaerobic bacteria. I received my PhD in Yale University, where I studied the early events of retrovirus infection in animal models. Now in the Blish lab, I am investigating NK cell responses during HIV-1 infection and trying to manipulate the NK cells to target latently infected cells.
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Andrew Picel
Clinical Associate Professor, Radiology
Current Research and Scholarly InterestsProstate artery embolization (PAE) for the treatment of lower urinary tract symptoms (LUTS) from benign prostatic hyperplasia (BPH).
Prophylactic balloon occlusion catheters and uterine artery embolization to reduce blood loss in patients with invasive placenta.
Geniculate artery embolization for relief of osteoarthritis related knee pain. -
Jennifer Pien MD
Clinical Associate Professor, Psychiatry and Behavioral Sciences
BioJennifer H. Pien is a Clinical Associate Professor and Stanford Medical Humanities & Arts faculty through the Department of Psychiatry at Stanford University. She is the Director of The Pegasus Physician Writers, Founder of The Pegasus Review, and is on the faculty editorial team for the Oxford Review of Books x Stanford collaboration. She also serves on the Advisory Board for The Bellevue Literary Press and the Stanford School of Medicine Medical Humanities Fellowship. In addition to her work in Medical Humanities, her interests include advocacy for adults with developmental disabilities where she cofounded Puente Clinic through the San Mateo County Medical System, an innovative dev. disabilities subspecialty clinic. She serves on the Regional Advisory Committee to the California State Council on Developmental Disabilities. Currently, her clinical focus is on physician well-being through the WellConnect team.
