School of Medicine
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Kate Shaw, MD MS
Associate Professor of Obstetrics and Gynecology
Current Research and Scholarly InterestsMy research interests include expanding access to and and improving patient experience with contraception and abortion care both domestically and globally. I am also interested in medical education and resilience among physicians and trainees.
Clinical Associate Professor, Pediatrics
Current Research and Scholarly InterestsMy current interests include global mental health promotion in underserved pediatric populations, including refugee health in US-Mexico borders, minority mental health in the US, and parental mental health in low-middle-income countries. I am also interested in physician wellness and Diversity and Inclusion.
Postdoctoral Scholar, Neurology and Neurological Sciences
BioDr. Xiwei She is a postdoctoral scholar in the Department of Neurology. He received his B.S. degree in Computer Science from Shanghai Jiao Tong University in 2013, and his M.S. degree in Biomedical Engineering from Zhejiang University in 2016. Worked as a research assistant at the USC Neural Modeling and Interface Laboratory, he received his Ph.D. degree in Biomedical Engineering from the University of Southern California in 2022. After graduation, he joined Stanford University as a postdoctoral scholar at the Pediatric Neurostimulation Laboratory (Baumer Lab) and Wu Tsai Neuroscience Institute.
His research interests are largely directed toward identifying the causal relationship of neurons/brain regions and understanding how information is encoded in neural signals by employing machine learning models. Specifically, his postdoc research focuses on applying machine learning modeling techniques on EEG and TMS-EEG data to better understand the impact of interictal epileptiform discharges (IEDs) on brain activity in children with childhood epilepsy with centrotemporal spikes (CECTS).
Chambers-Okamura Endowed Professor of Pediatric Orthopaedics
BioKevin G. Shea, MD is an orthopaedic surgeon at Stanford University Medical Center and the Lucile Packard Children’s Hospital. Dr. Shea grew up in Montana and California, graduated from the UCLA School of Medicine, and completed his orthopaedic residency at the University of Utah School of Medicine. His advanced training includes pediatric orthopaedics at Rady Children’s Hospital in San Diego, AO Fellowship in Bern Switzerland with Drs. Ganz (Hip), Dr. Diego Fernandez (Trauma), and Dr. Hans Staubli (sports), and Ilizarov Training in Lecco, Italy. He was the AOSSM Traveling Sports Medicine Fellow in 2008, and practiced in Boise, ID prior to joining the Stanford Faculty. Dr. Shea is a founding member of the PRiSM Society (Pediatric Research in Sports Medicine), the ROCK (Research in OsteoChondritis of the Knee) Multi-center Study Group, and the SCORE prospective cohort registry for pediatric sports arthroscopy outcomes, complications. He is a member of the AAOS (American Academy of Orthopaedic Surgeons), POSNA (Pediatric Orthopaedic Society of North America) and the AOSSM (American Orthopedic Society for Sports Medicine). In addition, Dr. Shea has authored more than 240 scientific papers and book chapters.
Professor of Pathology and of Pediatrics
BioHiroyuki Shimada, MD, PhD, FRCPA (Hon), is Professor of Pathology and of Pediatrics at the Stanford University Medical Center. He was born in Tokyo, Japan, and completed MD (1973) and PhD (1982) at the Yokohama City University School of Medicine, Yokohama, Japan, and also completed his pathology training at the Children's Hospital (now the Nationwide Children’s Hospital) and the Ohio State University, Columbus, Ohio, USA (1988). Before moving to the Stanford University in 2019, he was Professor of Pathology (Clinical Scholar) at the University of Southern California Keck School of Medicine and working at the Children’s Hospital Los Angeles.
Dr. Shimada was Chair of the International Neuroblastoma Pathology Committee (1999-2017) and the founder of the International Neuroblastoma Pathology Classification (INPC). As Director of the COG (Children’s Oncology Group) Neuroblastoma Pathology Reference Laboratory (since 2001), he has been actively reviewing pathology samples of ~700 neuroblastoma cases per year from United States, Canada, Australia, and New Zealand. Pathology review results according to the INPC have been providing critical information for patient stratification and protocol assignment in the COG international neuroblastoma clinical trials.
Andrew Young Shin
Clinical Professor, Pediatrics - Cardiology
Current Research and Scholarly InterestsSURF PROGRAM
The SURF program is an innovative collaboration between LPCH, Stanford University Hospital and the Stanford School of Engineering. The program has focused on improving quality and safety of patient care, improving hospital operations and promoting clinical effectiveness utilizing contemporary technologies such as machine learning, mathematical optimization, simulation and a variety of statistical, probabilistic and computational tools. The program has 2 independent funding mechanism to primarily improve patient care/hospital operations and improve academics for faculty within the department of Pediatrics at LPCH.
The Clinical Effectiveness (CE) Program is a funded program that aims to understand and improve unnecessary variation in healthcare delivery in order to optimize quality of care and reduce wasteful expenditures. The CE program has developed innovative programs such as Target Based Care, an award-winning intervention to reduce variation in hospital length of stay and currently a multi-center trial involving more than 20 hospitals in North America. In 2016, the CE program included the first CE fellowship program in a pediatric training program with 3 cycles of graduates. The CE program is supported by LPCH and a philanthropic gift by Susan Choe and Thomas Tobiason.
Jade Shorter, MD, MSHP
Clinical Assistant Professor, Obstetrics & Gynecology
BioDr. Shorter specializes in complex family planning, early pregnancy management, and general gynecology. She is committed to improving the continuity of care for patients with early pregnancy complications and serves as the Director of the Early Pregnancy Assessment Program. Her clinical research interests include improving patients’ experience with abortion and early pregnancy care, addressing reproductive health disparities, and promoting health equity.
Linda M. Dairiki Shortliffe
Stanley McCormick Memorial Professor in the School of Medicine, Emerita
Current Research and Scholarly InterestsThe timing for intervention in obstruction in the infant and child is poorly understood.Our group has been interested in trying to define the risks that may be involved in obstructive and infectious uropathies and discovering early signs of damage to the urinary tract and kidney. We have explored ways of imaging the urinary tract using nonionizing radiation (US, MRI). We have studied the relationships of sex steroid hormones, pregnancy, reflux, urinary tract infection and urinary tract function.
Ann Shue, MD
Clinical Assistant Professor, Ophthalmology
Bio**Dr. Shue is taking new patients for glaucoma, cataracts, and adult strabismus.**
Ann Shue, MD, is a Clinical Assistant Professor of Ophthalmology at Stanford University School of Medicine, where she specializes in glaucoma, pediatric ophthalmology, and adult strabismus, a unique combination of subspecializations practiced by few surgeons worldwide. She is a board-certified ophthalmologist who completed fellowships in glaucoma at Yale University and pediatric ophthalmology and adult strabismus at Duke University. She practices at the Stanford Byers Eye Institute and the Lucile Packard Children's Hospital.
Dr. Shue loves seeing patients of all ages with eye problems big or small, including glaucoma due to any reason, glaucoma suspicion, family history of glaucoma, cataracts, strabismus (eye misalignment) or double vision from any cause, including after eye surgeries. She completed her ophthalmology residency at the University of Pittsburgh and an internal medicine internship at UCSF Fresno. She holds a medical degree from University of California, Irvine and an undergraduate degree in biology from Yale University.
Dr. Shue is a member of the American Glaucoma Society, the American Association for Pediatric Ophthalmology and Strabismus, and the UK Paediatric Glaucoma Society. She is active in presenting at regional and national conferences. She is the author of several journal articles and recently wrote two textbook chapters on pediatric glaucoma and pediatric glaucoma surgery.
Eric Sibley, M.D., Ph.D.
Professor of Pediatrics (Gastroenterology)
Current Research and Scholarly InterestsMolecular Regulation of Intestinal Development and Maturation. We study transcriptional mechanisms regulating the spatial and temporal restriction of intestine-specific gene expression during gut development. Our approach is to characterize the function of gene-specific DNA cis elements and interacting nuclear proteins in cell culture and in transgenic animals. The goal is to relate the gene-specific control mechanisms to the broader pathways specifying acquisition of gut phenotypes.
Douglas Sidell, MD
Associate Professor of Otolaryngology - Head & Neck Surgery (OHNS) and, by courtesy, of Pediatrics
Current Research and Scholarly InterestsDr. Sidell's clinical interests include the management of children with voice and swallowing disorders, and congenital or acquired airway abnormalities. Examples of ongoing or upcoming prospective trials include an investigation into the utility of acid suppression in children with laryngomalacia, the management of vocal cord paralysis following cardiac surgery, and the management of type 1 laryngeal clefts in children.
Professor of Pathology and of Genetics
Current Research and Scholarly InterestsWe have a highly collaborative research program in the evolutionary genomics of cancer. We apply well-established principles of phylogenetics to cancer evolution on the basis of whole genome sequencing and functional genomics data of multiple tumor samples from the same patient. Introductions to our work and the concepts we apply are best found in the Newburger et al paper in Genome Research and the Sidow and Spies review in TIGS.
More information can be found here: http://www.sidowlab.org
Dawn H. Siegel, MD
Clinical Professor, Dermatology
Clinical Professor (By courtesy), Pediatrics
Current Research and Scholarly InterestsI'm dedicated to connecting patients with clinical research trials and contributing to research on specific skin conditions particularly hemangiomas, birthmarks, and PHACE syndrome. My research also aims to develop solutions to health disparities through improved access to pediatric dermatologists and treatments.
Clinical Assistant Professor, Pathology
BioOscar is an academic hematopathologist who completed anatomic and clinical pathology residency and hematopathology fellowship at Stanford in 2020. Prior to Stanford, he received his MD and PhD from UCLA. His interests include immunology, the pathogenesis and diagnosis of lymphomas, and global health.
Norman H. Silverman
Honorary Faculty Emeritus, Pediatrics
Current Research and Scholarly InterestsMy research interests center around cardiac ultrasound. I am currently working on several areas in the development of human cardiac ultrasound.
These are fetal cardiac ultrasound. intraoperative and transesophageal ultrasound imaging in children, imaging potiential for ultrasound two and three dimensional modalities in children with congenital heart disease
Julia Fridman Simard
Associate Professor of Epidemiology and Population Health, of Medicine (Immunology & Rheumatology) and, by courtesy, of Obstetrics and Gynecology (Maternal Fetal Medicine)
BioJulia Fridman Simard, ScD, is an Associate Professor of Epidemiology & Population Health, and, by courtesy, of Medicine in Immunology and Rheumatology and Obstetrics and Gynecology in Maternal Fetal Medicine at Stanford University School of Medicine.
Dr. Simard earned her Masters and Doctorate of Science in Epidemiology degrees at the Harvard School of Public Health. During that time she trained with investigators at the Section of Clinical Sciences, Division of Rheumatology, Immunology, and Allergy at Brigham and Women’s Hospital and the Cardiovascular Epidemiology Research Unit at Beth Israel Deaconess Medical Center. In 2008, Dr. Simard relocated to Sweden to begin a Postdoctoral Fellowship in Clinical Epidemiology at the Karolinska Institutet in Stockholm. She became an Assistant Professor in their Clinical Epidemiology Unit in 2011, and was later honored with a Karolinska Institutet Teaching Award. Leveraging the population-based registers of Sweden, Dr. Simard initiated a national register linkage study to examine the utility of registers in Systemic Lupus Erythematosus (SLE) research and develop an extensive data repository for future epidemiologic investigations.
While maintaining a close collaboration with the Karolinska Institutet, she joined Stanford’s Epidemiology faculty in 2013. Dr. Simard studies outcomes such as malignancy, stroke, infection, and mortality, in patients with systemic autoimmune rheumatic diseases with a focus on systemic lupus erythematosus. Recently her primary research focus has shifted to the intersection between reproductive epidemiology and rheumatic disease fueled by a K01 career development award from the NIH (NIAMS) to study maternal and fetal outcomes in systemic lupus pregnancy. This led to collaborations with colleagues at Stanford, throughout the US, and abroad, and a series of projects focused on the diagnosis of preeclampsia and associated risks in pregnant women with systemic lupus. Dr. Simard was awarded a Peter Joseph Pappas Research Grant from the Preeclampsia Foundation for her lab's work examining preeclampsia risk in high-risk populations, and a McCormick Faculty Award from Stanford Medicine to take important steps towards disentangling preeclampsia from lupus nephritis. Dr. Simard is leading an international study of hydroxychloroquine in lupus pregnancy leveraging mixed methods in partnership with qualitative researchers, patients, clinicians, and epidemiologists in Sweden, Canada, and in the United States.
In addition to these issues of misclassification in reproductive rheumatology questions, Dr. Simard's lab is also interested in how misclassification, missed opportunities, and misdiagnosis contribute to disparities in complex conditions such as systemic lupus. In addition to methodologic issues around misclassification and bias and the largely clinical epidemiology focus of her work, Dr. Simard's work examines social determinants of health and health disparities. Dr. Simard was recently awarded an R01 from NIH (NIAID) to study the role of cognitive and unconscious bias in clinical decision making for female-predominant diseases including lupus.
Professor of Anesthesiology, Perioperative and Pain Medicine (Pediatric)
Current Research and Scholarly InterestsThe primary goal of my research is to promote the health and well being of children and adolescents with chronic pain and their families. In line with this goal, research projects focus on biological, neurological, cognitive, affective, and social risk and resiliency factors of the pain experience. Projects include brain imaging, longitudinal clinical cohort, and treatment interventions studies.
Some current research orojects include:
Learning and Memory in Pediatric Chronic Pain
Funding: NIH/NICHD R01
Description: Investigating the mechanisms underlying fear learning, extinction and disruption of fear reconsolidation in adolescents with chronic pain and health controls using behavioral and neuroimaging measures. Multi-site study with Boston Children's Hospital (Collaborator: David Borsook, MD).
Children Pain Behaviors in Context: A functional-cognitive perspective
Leading Site: University of Ghent (Collaborator: Liesbet Goubert, PhD)
Description: Identifying key antecedents and consequences that give rise to and maintain children's pain-related behaviors and investigate impact these antecedents on children's behavior and functioning through daily surveys and activity monitoring.
Manpreet K. Singh, MD MS
Associate Professor of Psychiatry and Behavioral Sciences (Child and Adolescent Psychiatry and Child Development)
Current Research and Scholarly InterestsDr. Singh conducts research in the phenomenology, neurobiology, pharmacology, and genetic aspects of depression and bipolar disorder in children. These studies include brain imaging (MRI, MRS, fMRI), medication, and psychotherapy trials. She is particularly interested in risk factors for the development of major mood disorders and associated morbidities, and early intervention strategies to delay the onset and progression of symptoms.
Stanford Medicine Professor of Infectious Disease and Professor of Medicine (Infectious Diseases & Geographic Medicine) and of Microbiology and Immunology
Current Research and Scholarly InterestsOur lab elucidates the molecular basis of pathogenesis of the protozoan parasite Entamoeba histolytica. We use genetic and genomic approaches to identify novel virulence determinants and to characterize the global epidemiology of the parasite.
Stephanie Melissa Smith
Instructor, Pediatrics - Hematology & Oncology
Current Research and Scholarly InterestsI am involved with clinical research related to cancer survivorship, with a particular focus on late effects of childhood cancer treatments and community partnerships to improve health equity for adolescent/young adult cancer survivors in under-resourced settings.
Michael Snyder, Ph.D.
Stanford W. Ascherman Professor of Genetics
Current Research and Scholarly InterestsOur laboratory use different omics approaches to study a) regulatory networks, b) intra- and inter-species variation which differs primarily at the level of regulatory information c) human health and disease. For the later we have established integrated Personal Omics Profiling (iPOP), an analysis that combines longitudinal analyses of genomic, transcriptomic, proteomic, metabolomic, DNA methylation, microbiome and autoantibody profiles to monitor healthy and disease states
Hyongsok Tom Soh
Professor of Radiology (Early Detection), of Electrical Engineering, of Bioengineering and, by courtesy, of Chemical Engineering
BioDr. Soh received his B.S. with a double major in Mechanical Engineering and Materials Science with Distinction from Cornell University and his Ph.D. in Electrical Engineering from Stanford University. From 1999 to 2003, Dr. Soh served as the technical manager of MEMS Device Research Group at Bell Laboratories and Agere Systems. He was a faculty member at UCSB before joining Stanford in 2015. His current research interests are in analytical biotechnology, especially in high-throughput screening, directed evolution, and integrated biosensors.
James R. Doty Professor of Neurosurgery and Neurosciences
BioIvan Soltesz received his doctorate in Budapest and conducted postdoctoral research at universities at Oxford, London, Stanford and Dallas. He established his laboratory at the University of California, Irvine, in 1995. He became full Professor in 2003, and served as department Chair from 2006 to July 2015. He returned to Stanford in 2015 as the James R. Doty Professor of Neurosurgery and Neurosciences at Stanford University School of Medicine. His major research interest is focused on neuronal microcircuits, network oscillations, cannabinoid signaling and the mechanistic bases of circuit dysfunction in epilepsy.
His laboratory employs a combination of closely integrated experimental and theoretical techniques, including closed-loop in vivo optogenetics, paired patch clamp recordings, in vivo electrophysiological recordings from identified interneurons in awake mice, 2-photon imaging, machine learning-aided 3D video analysis of behavior, video-EEG recordings, behavioral approaches, and large-scale computational modeling methods using supercomputers. He is the author of a book on GABAergic microcircuits (Diversity in the Neuronal Machine, Oxford University Press), and editor of a book on Computational Neuroscience in Epilepsy (Academic Press/Elsevier). He co-founded the first Gordon Research Conference on the Mechanisms of neuronal synchronization and epilepsy, and taught for five years in the Ion Channels Course at Cold Springs Harbor. He has over 30 years of research experience, with over 20 years as a faculty involved in the training of graduate students (total of 16, 6 of them MD/PhDs) and postdoctoral fellows (20), many of whom received fellowship awards, K99 grants, joined prestigious residency programs and became independent faculty.
Justin L. Sonnenburg
Professor of Microbiology and Immunology
Current Research and Scholarly InterestsThe goals of the Sonnenburg Lab research program are to (i) elucidate the basic mechanisms that underlie dynamics within the gut microbiota and (ii) devise and implement strategies to prevent and treat disease in humans via the gut microbiota. We investigate the principles that govern gut microbial community function and interaction with the host using a broad range of experimental approaches including studies of microbiomes in diverse human cohorts.
Sean Paul Spencer, MD,PhD
Instructor, Medicine - Gastroenterology & Hepatology
BioSean Spencer, MD,PhD is a Gastroenterologist and Physician Scientist at Stanford University working with Justin Sonennburg,PhD to uncover the role of dietary intake on the gut microbiome and mucosal immune system. Sean obtained his medical degree University of Pennsylvania, earning his PhD studying nutritional immunology with Yasmine Belkaid,PhD at the National Institutes of Health (NIH), after which he moved to Boston for residency training at Massachusetts General Hospital and completed his Gastroenterology training at Stanford University. Sean’s career goal is to study mechanisms by which dietary intake influences our microbiome and immune system to better understand and treat gastrointestinal disease.
Associate Professor of Medicine (Pulmonary and Critical Care Medicine)
Current Research and Scholarly InterestsPulmonary Arterial Hypertension
Pulmonary Vascular Remodeling
Modulation of BMPR, ENG, ACVRL1 (ALK1), SMAD signaling
Structural and molecular programs governing right ventricular adaptation and failure
Hereditary Hemorrhagic Telangiectasia
Pulmonary Arteriovenous malformations
Computational Drug Prediction and Repurposing
Deep Tissue Confocal Imaging
Professor of Radiology (Radiological Sciences Lab) and, by courtesy, of Electrical Engineering
Current Research and Scholarly InterestsMy research interests are in the field of medical imaging, particularly magnetic resonance imaging and in vivo spectroscopy. Current projects include MRI and MRS at high magnetic fields and metabolic imaging using hyperpolarized 13C-labeled MRS.
Alfred M. Spormann
Professor of Civil and Environmental Engineering and of Chemical Engineering, Emeritus
Current Research and Scholarly InterestsMetabolism of anaerobic microbes in diseases, bioenergy, and bioremediation
Douglass M. and Nola Leishman Professor of Cardiovascular Disease, Emeritus
Current Research and Scholarly InterestsThe general research interest of this laboratory is the molecular basis of cell motility, with a current emphasis on power output by the human heart. We have three specific research interests, the molecular basis of energy transduction that leads to ATP-driven myosin movement on actin, the biochemical basis of the regulation of actin and myosin interaction and their assembly states, and the roles these proteins play in vivo, in cell movement, changes in cell shape and muscle contraction.
Endowed Professor of Pediatric Cancer
Current Research and Scholarly InterestsMy research focuses primarily on the management of children, adolescents, and young adults with soft tissue sarcomas. I also have an interest in developmental therapeutics and late effects of cancer therapy,
Gayathri Srinivasan OD, MS
Clinical Associate Professor, Ophthalmology
BioDr. Srinivasan is a Clinical Associate Professor in the Department of Ophthalmology at Stanford University. Her clinical focus is in the management of concussion-related vision disorders. Dr. Srinivasan's research interests are amblyopia, strabismus, and concussion-related vision disorders. She serves as an investigator for ongoing clinical studies in the Vision Development and Oculomotor lab headed by Dr. Tawna Roberts.
Professor of Medicine (Stanford Center for Research in Disease Prevention)
Current Research and Scholarly InterestsAs Director of the SPRC Program on Prevention Outcomes and Practices, my work focuses on cardiovascular disease treatment and prevention, the adoption of new technology and practices, and patterns of physician practice, particularly medication prescribing. Specific interests include measuring and improving the quality of outpatient care, disparities in health care by race, gender, age and socioeconomic status, and interventions to improve prevention outcomes.
Marcia L. Stefanick, Ph.D.
Professor (Research) of Medicine (Stanford Prevention Research Center), of Obstetrics and Gynecology and, by courtesy, of Epidemiology and Population Health
Current Research and Scholarly InterestsMarcia L. Stefanick, Ph.D is a Professor of Medicine Professor of Obstetrics and Gynecology, and by courtesy, Professor of Epidemiology and Population Health at Stanford University School of Medicine. Dr. Stefanick’s research focuses on chronic disease prevention (particularly, heart disease, breast cancer, osteoporosis, and dementia) in both women and men. She is currently the Principal Investigator the Women’s Health Initiative (WHI) Extension Study, having been the PI of the Stanford Clinical Center of the landmark WHI Clinical Trials and Observational Study since 1994 and Chair of the WHI Steering and Executive Committees from 1998-2011, as well as PI of the WHI Strong and Healthy (WHISH) Trial which is testing the hypothesis that a DHHS-based physical activity intervention, being delivered to a multi-ethnic cohort of about 24,000 WHI participants across the U.S., aged 68-99 when the trial started in 2015, will reduce major cardiovascular events over 8 years, compared to an equal number of “usual activity” controls. Dr. Stefanick is also PI of the Osteoporotic Study of Men (MrOS) which is continuing to conduct clinical assessments of bone and body composition in survivors of an original cohort of nearly 6000 men aged 65 and over in 2001. As founding Director of the Stanford Women’s Health and Sex Differences in Medicine (WHSDM, “wisdom”) Center, she plays a major role in promoting research and teaching on Sex and Gender in Human Physiology and Disease, Women’s Health and Queer Health and Medicine. Dr. Stefanick also plays major leadership roles at the Stanford School of Medicine, including as co-leader of the Population Sciences Program of the Stanford Cancer Institute, Stanford’s NCI-funded comprehensive cancer center.
Dr. Stefanick obtained her B.A. in biology from the University of Pennsylvania, Philadelphia, PA (1974), then pursued her interest in hormone and sex difference research at the Oregon Regional Primate Research Center, after which she obtained her PhD in Physiology at Stanford University, focusing on reproductive physiology and neuroendocrinology, with exercise physiology as a secondary focus. Her commitment to human research led to a post-doctoral fellowship in Cardiovascular Disease Prevention at the Stanford Prevention Research Center, which has been her academic home for nearly 40 years.
Clinical Associate Professor, Pediatrics - Critical Care
Current Research and Scholarly InterestsMy research interests focus on using dissemination and implementation science tools to study and enhance care provided to patients in the pediatric ICU. I have a background in human factors research and in implementation science and am also interested in clinical effectiveness and outcomes in the PICU.
Instructor, Pediatrics - Pulmonary Medicine
BioDr. Steffes, a Wisconsin native, completed medical school and pediatric residency at the Medical College of Wisconsin. She then moved to the Bay Area and completed her clinical fellowship in pediatric pulmonary medicine at Stanford University in 2020. Additionally, Dr. Steffes received further post-doctoral training in the laboratories of Dr. Maya Kumar and Dr. David Cornfield, studying the cellular and molecular mechanism driving pulmonary vascular disease. In addition to her role as an Instructor in Pediatrics in the division of Pulmonary Medicine, Dr. Steffes is also completing an advanced clinical fellowship in Pulmonary Hypertension at Lucile Packard Children’s Hospital Stanford. Her clinical work consists of caring for patients with pediatric pulmonary and pulmonary vascular diseases such as pulmonary hypertension, bronchopulmonary dysplasia, interstitial lung disease, respiratory failure, chronic cough and asthma. Her research is focused on the vascular changes seen in pulmonary hypertension, more specifically understanding the cellular characteristics of occlusive neointimal lesions, the abnormal cells that block pulmonary blood flow in pulmonary hypertension. In her most recent work, Dr. Steffes identified a subset of healthy vascular smooth muscle cells that are the cell of origin for the pathologic neointimal cells and a specific signaling pathway, that when blocked, inhibits the formation of neointimal lesions.
Dr. Steffes is currently employing advanced single cell sequencing technologies to further understand neointimal cells with the ultimate goal identifying new therapies for pulmonary hypertension, a fatal disease with no known cure.
Lawrence Steinman, MD
George A. Zimmermann Professor and Professor of Pediatrics
Current Research and Scholarly InterestsOur laboratory is dedicated to understanding the pathogenesis of autoimmune diseases, particularly multiple sclerosis. We have developed several new therapies for autoimmunity, including some in Phase 2 clinical trials, as well as one approved drug, natalizumab. We have developed microarray technology for detecting autoantibodies to myelin proteins and lipids. We employ a diverse range of molecular and celluar approaches to trying to understand multiple sclerosis.
Dieter Schwarz Foundation Endowed Professor and Professor of Genetics
Current Research and Scholarly InterestsWe apply diverse genomic approaches to understand how genetic variation affects health and disease by: 1) functional and mechanistic analyses of gene regulation, 2) studies of meiotic recombination and inheritance, 3) analyses of genetic and environmental interactions, and 4) characterization of diseases in human cells and model organisms. We integrate wet lab and computational genomic, transcriptomic, proteomic and metabolic approaches, and develop technologies to enable personalized medicine.
David A. Stevens
Professor of Medicine, Emeritus
Current Research and Scholarly InterestsImmunology and chemotherapy of human fungal diseases, particularly coccidioidomycosis (Valley Fever) in California and aspergillosis, and the parasitic disease, trypanosomiasis.
Professor of Pediatrics (Genetics)
Current Research and Scholarly InterestsMy research focuses on disorders of the RAS/MAPK pathway (eg. NF1, Noonan, CFC, and Costello syndrome). I am working on understanding the impact of RAS signaling on the musculoskeletal system. I use genomic approaches to identify somatic events and modifiers in the RASopathies. I am also involved in identifying outcome measures for use in clinical trials for the associated orthopedic manifestations. Other areas of research involve vascular anomalies, Prader-Willi syndrome, and hypophosphatasia.
David K. Stevenson, M.D.
Harold K. Faber Professor of Pediatrics, Senior Associate Dean, Maternal and Child Health and Professor, by courtesy, of Obstetrics and Gynecology
Current Research and Scholarly InterestsOur research is focused on the study of the ontogeny and control of heme catabolism and bilirubin production in the developing neonate. A better understanding of the role of increased bilirubin production in neonatal jaundice and the prevention of hemolytic jaundice has remained an overall objective of our program. We are also study the causes of preterm birth and ways to prevent it.
Aaron F. Straight
Pfeiffer and Herold Families Professor, Professor of Biochemistry and, by courtesy, of Chemical and Systems Biology
Current Research and Scholarly InterestsWe study the biology of chromosomes. Our research is focused on understanding how chromosomal domains are specialized for unique functions in chromosome segregation, cell division and cell differentiation. We are particularly interested in the genetic and epigenetic processes that govern vertebrate centromere function, in the organization of the genome in the eukaryotic nucleus and in the roles of RNAs in the regulation of chromosome structure.
Clinical Professor, Medicine - Gastroenterology & Hepatology
BioDr. Sarah Streett is a Clinical Professor of Medicine, the Director of Inflammatory Bowel Disease Education at Stanford, and she is passionate about taking care of people with IBD. She is a national expert in treating complex IBD and initiated a multi-disciplinary approach to care with colorectal surgery, pediatrics, and nutrition. In 2018 she received the Champion of Hope Award from the Crohn’s and Colitis Foundation and serves on their National Scientific Advisory Committee. Her interests focus on fertility and pregnancy in people with IBD, developing precision approaches to IBD therapy, and the role that the microbiome and diet play in its pathogenesis. She is a primary investigator of the Stanford IBD Registry and has research projects focused on optimizing clinical outcomes in IBD, the role of the microbiota and diet in IBD and pregnancy, and applying new technologies to individualizing therapy for IBD. She is also the primary investigator on multiple industry-sponsored IBD trials.
Teaching is a top priority for Dr. Streett who feels that mentoring fellows in the development of their careers is a privilege. She has held many national leadership roles in the American Gastroenterological Association, where she has been Chair of the Practice Management and Economics Committee, and currently serves on the Government Affairs Committee. She also an appointed member of the Gastrointestinal Drug Advisory Committee at the FDA. She has represented the interests of gastroenterologists and their patients on Capitol Hill numerous times. Dr. Streett believes strongly in a collaborative approach to give patients personalized care based on the latest therapies for the treatment of IBD and is committed to mentoring the next generation of experts in the field.
Professor of Emergency Medicine
Current Research and Scholarly InterestsDr. Strehlow's research is focused on global health and global emergency care. Working with in-country partners, he aims to identify the epidemiology of emergencies in developing countries and leverage the growth of emergency care systems in innovative ways to improve the overall health of the population. Specific examples include improving patient flow between the community and different level facilities and using emergency call center infrastructure to combat gender based violence.
Adjunct Clinical Assistant Professor, Medicine - Infectious Diseases
BioAshley Styczynski, MD, MPH, is an Adjunct Clinical Assistant Professor in the Division of Infectious Diseases & Geographic Medicine and Global Health Faculty Fellow, and a Medical Officer in the International Infection and Control Program at the Centers for Disease Control and Prevention (CDC). Dr. Styczynski's research interests are in infectious disease epidemiology, global health, emerging infections, and antimicrobial resistance. She holds an MPH from Johns Hopkins Bloomberg School of Public Health and an MD from University of Illinois at Chicago. Prior to coming to Stanford for her infectious disease fellowship, she spent two years as an Epidemic Intelligence Service (EIS) Officer at the CDC. During her time as an EIS officer, Dr. Styczynski conducted outbreak investigations on Zika virus, vaccinia virus, and rabies. She is currently conducting research on antimicrobial resistance and interventions to reduce nosocomial infections within low-resource healthcare facilities.
Clinical Professor, Pediatrics - Critical Care
Current Research and Scholarly InterestsMy clinical pharmacology research is focused on investigating the impact of dynamic organ function on drug disposition and designing dosing strategies based on mathematical models that account for these changes in order to optimize safe medication administration in critically ill children.
Research through the REVIVE Initiative for Resuscitation Excellence investigates the quality of resuscitation during cardiopulmonary arrest. Areas of focus include early identification during the no-flow state prior to CPR initiation and quality of CPR simulation education.
Leslee L.Subak, MD
Katharine Dexter McCormick and Stanley McCormick Memorial Professor and Professor, by courtesy, of Urology
Current Research and Scholarly InterestsMy research focuses on the association of weight and urinary incontinence (UI) in women and clinical trials to test strategies to improve outcomes in women’s genitourinary health. We have shown the independent association of weight and UI and the efficacy of weight loss to treat women with UI. I also conduct studies of epidemiology, economics and cost-effectiveness, and novel interventions for UI, sexual dysfunction, vaginal atrophy, pelvic organ prolapse and menopause symptoms.
Avram Goldstein Professor in the School of Medicine, Professor of Neurosurgery and, by courtesy, of Neurology and of Psychiatry and Behavioral Sciences
Current Research and Scholarly InterestsInformation transfer at synapses mediates information processing in brain, and is impaired in many brain diseases. Thomas Südhof is interested in how synapses are formed, how presynaptic terminals release neurotransmitters at synapses, and how synapses become dysfunctional in diseases such as autism or Alzheimer's disease. To address these questions, Südhof's laboratory employs approaches ranging from biophysical studies to the electrophysiological and behavioral analyses of mutant mice.
Associate Professor of Anesthesiology, Perioperative and Pain Medicine
BioDr. Pervez Sultan is an Associate Professor of Obstetric Anesthesiology at Stanford University School of Medicine and an Honorary Professor at University College London. His research interests include defining, characterizing and measuring postpartum recovery.
Dr. Sultan is an NIH funded researcher with an active R01 grant from the NHLBI to develop and validate a new PROMIS-based measure to assess postpartum sleep (2023-28). He is also a co-investigator on a Maternal Centers of Excellence U54 award from the NICHD entitled: Stanford PRIHSM: PReventing Inequities in Hemorrhage-related Severe Maternal Morbidity (2023-2020).
Dr. Sultan is an elected member of the Association of University Anesthesiologists, serves on the Society for Obstetric Anesthesia and Perinatology (SOAP) Board as the Director from Academic Practice, and on the Annual Meeting and Live Events Committee. He also serves on the American Society of Anesthesiologists' Subcommittee for Obstetric Anesthesia and the International Anesthesia Research Society.
He is a former Arline and Pete Harman Endowed Faculty Scholar of the Stanford Maternal and Child Health Research Institute at Stanford University and a previous recipient of the UK National Institute of Academic Anesthesia Research Award.
Researchgate profile: https://www.researchgate.net/profile/Pervez_Sultan2
Google Scholar profile: https://scholar.google.com/citations?user=Z2ftv_IAAAAJ&hl=en
Associate Professor of LinguisticsOn Leave from 10/01/2023 To 06/30/2024
BioI am an Associate Professor in the Department of Linguistics at Stanford University. I conduct research examining the representations and mechanisms listeners use to understand spoken language, and how linguistic and social factors affect speech perception and word recognition. My current research centers around two main themes: (1) Investigating the effects social information cued by different voices have on memory, and the way social biases result in misremembering, and (2) Using foundational psycholinguistic methodologies to understand how speakers and speaker groups who are new to a community (e.g., the case of Syrian refugees in Germany) accommodate to cultural norms within their native languages.
Vivien Kon-Ea Sun
Clinical Assistant Professor, Pediatrics
BioVivien Sun is a pediatric hospitalist and Clinical Assistant Professor within Stanford’s Division of Pediatric Hospital Medicine. She practices at Stanford Healthcare-Valleycare and California Pacific Medical Center. Vivien’s interests include medical education, professional development, advocacy, and caring for the underserved.
Yang Sun, MD, PhD
Professor of Ophthalmology
Current Research and Scholarly InterestsWe are interested in the role of inositol phosphatases in eye development and disease, using both animal models and human disease tissue. We are a translational laboratory seeking to understand the basic function of proteins as well as developing therapeutic strategies for clinical trials.
Professor of Urology, Emeritus
Current Research and Scholarly InterestsWe focus on understanding the molecular mechanism of transcription factors that govern the transformation of normal cells to a neoplastic state. We are especially interested in nuclear hormone action and its interactions with other signaling pathways in tumor development and progression.
Professor of Pediatrics at the Lucile Salter Packard Children's Hospital, Emeritus
Current Research and Scholarly InterestsMy primary interests are in the area of neonatal nutrition and developmental gastroenterology. The use of parenteral nutrition in very low birth weight infants, and the introduction of early enteral feeding to stimulate gastrointestinal maturation are my specific areas of investigative endeavors.
Katrin J Svensson
Assistant Professor of Pathology
Current Research and Scholarly InterestsMolecular metabolism
Cell biology and function
James H. Clark Professor in the School of Engineering and Professor of Chemical Engineering and of Bioengineering
Current Research and Scholarly InterestsProgram Overview
The world we enjoy, including the oxygen we breathe, has been beneficially created by biological systems. Consequently, we believe that innovative biotechnologies can also serve to help correct a natural world that non-natural technologies have pushed out of balance. We must work together to provide a sustainable world system capable of equitably improving the lives of over 10 billion people.
Toward that objective, our program focuses on human health as well as planet health. To address particularly difficult challenges, we seek to synergistically combine: 1) the design and evolution of complex protein-based nanoparticles and enzymatic systems with 2) innovative, uniquely capable cell-free production technologies.
To advance human health we focus on: a) achieving the 120 year-old dream of producing “magic bullets”; smart nanoparticles that deliver therapeutics or genetic therapies only to specific cells in our bodies; b) precisely designing and efficiently producing vaccines that mimic viruses to stimulate safe and protective immune responses; and c) providing a rapid point-of-care liquid biopsy that will count and harvest circulating tumor cells.
To address planet health we are pursuing biotechnologies to: a) inexpensively use atmospheric CO2 to produce commodity biochemicals as the basis for a new carbon negative chemical industry, and b) mitigate the intermittency challenges of photovoltaic and wind produced electricity by producing hydrogen either from biomass sugars or directly from sunlight.
More than 25 years ago, Professor Swartz began his pioneering work to develop cell-free biotechnologies. The new ability to precisely focus biological systems toward efficiently addressing new, “non-natural” objectives has proven tremendously useful as we seek to address the crucial and very difficult challenges listed above. Another critical feature of the program is the courage (or naivete) to approach important objectives that require the development and integration of several necessary-but- not-sufficient technology advances.
Ali Bin Syed
Clinical Assistant Professor, Radiology - Pediatric Radiology
BioDr. Syed is a member of the divisions of Pediatric Radiology and Body MRI and serves as the Director of MRI for Stanford Medicine Children's Health. His clinical interests include MR imaging of pediatric and adult hepatobiliary disorders, inflammatory bowel disease, gynecologic pathology, and congenital heart disease. He is also an active researcher, collaborating with fellow engineers and scientists at Stanford to translate technical innovations in MRI into improved patient care. His recent work focuses on translation of machine learning techniques for rapid, robust MRI in children and adults.
Karl G. Sylvester
Professor of Surgery (Pediatric Surgery)
Current Research and Scholarly InterestsScholarly interests include investigation of molecular markers of human disease that provide diagnostic function, serve as targets for possible therapeutic manipulation, or provide insight into mechanisms of human disease. Specific diseases of interest include common conditions of pregnancy, gut microbial ecology and Necrotizing Enterocolitis (NEC).
Daniel Sze, MD, PhD
Professor of Radiology (Interventional Radiology)
Current Research and Scholarly InterestsTransarterial administration of chemotherapeutics, radioactive microspheres, and biologics for the treatment of unresectable tumors; management of portal hypertension and complications of cirrhosis (TIPS); treatment of complications of organ transplantation; Venous and pulmonary arterial thrombolysis and reconstruction; Stent and Stent-graft treatment of peripheral vascular diseases, aneurysms, aortic dissections
Jean Y. Tang MD PhD
Professor of Dermatology
Current Research and Scholarly InterestsMy research focuses on 2 main areas:
1. Skin cancer:
- New therapeutics to treat and prevent non-melanoma skin cancer, especially by targeting the Hedgehog signaling pathway for BCC tumors
- Genomic analysis of drug-resistant cancers
- Identifying risk factors for skin cancer in the Women's Health Initiative
2. Epidermolysis Bullosa: gene therapy and protein therapy to replace defective/absent Collagen 7 in children and adults with Recessive Dystrophic EB
Professor of Neurosurgery
BioDr. Peter Tass investigates and develops neuromodulation techniques for understanding and treating neurologic conditions such as Parkinson’s disease, epilepsy, dysfunction following stroke and tinnitus. He creates invasive and non-invasive therapeutic procedures by means of comprehensive computational neuroscience studies and advanced data analysis techniques. The computational neuroscience studies guide experiments that use clinical electrophysiology measures, such as high density EEG recordings and MRI imaging, and various outcome measures. He has pioneered a neuromodulation approach based on thorough computational modelling that employs dynamic self-organization, plasticity and other neuromodulation principles to produce sustained effects after stimulation. To investigate stimulation effects and disease-related brain activity, he focuses on the development of stimulation methods that cause a sustained neural desynchronization by an unlearning of abnormal synaptic interactions. He also performs and contributes to pre-clinical and clinical research in related areas.
Joyce Teng, MD, PhD
Professor of Dermatology and, by courtesy, of Pediatrics
BioJoyce Teng, MD, PhD is a professor in dermatology at Stanford University. She is affiliated with multiple hospitals in the area, including Lucile Salter Packard Children's Hospital (LPCH) at Stanford and Stanford Hospital and Clinics (SHC). She received her medical degree from Vanderbilt University School of Medicine and has been in practice for more than 12 years. She is one of the 6 pediatric dermatologists practicing at LPCH and one of 72 at SHC who specialize in Dermatology. She sees patients with rare genetic disorders, birthmarks, vascular anomalies and a variety of inflammatory skin diseases. She is also an experienced pediatric dermatological surgeon. Her research interests are drug discovery and novel therapy for skin disorders.
Associate Professor of Radiology (Pediatric Radiology)
Current Research and Scholarly InterestsInterventional Radiologists can access almost any part of the human body without the need for conventional open surgical techniques. As such, they are poised to change the way patients can be treated, given they can locally deliver drug, gene, cell and cell-free therapies directly to affected organs using image-guided endovascular, percutaneous, endoluminal, and even using device implantation approaches
Associate Professor of Neurosurgery
Current Research and Scholarly InterestsThe long-term goal of my research is the repair of damaged corticospinal circuitry. Therapeutic regeneration strategies will be informed by an understanding both of corticospinal motor neuron (CSMN) development and of events occurring in CSMN in the setting of spinal cord injury. MicroRNAs are small, non-coding RNAs that regulate the expression of “suites” of genes. The work in my lab seeks to identify microRNA controls over CSMN development and over the CSMN response to spinal cord injury.
Hawa Racine Thiam
Assistant Professor of Bioengineering and of Microbiology and Immunology
Current Research and Scholarly InterestsCellular Biophysical Mechanisms of Innate Immune Cells Functions
Clinical Professor, Psychiatry and Behavioral Sciences - Child & Adolescent Psychiatry and Child Development
Current Research and Scholarly InterestsPediatric Acute-Onset Neuropsychiatric Disorder
Reena Thomas, MD PhD
Clinical Associate Professor, Neurology & Neurological Sciences
Clinical Associate Professor (By courtesy), Neurosurgery
Current Research and Scholarly Interests-Neuro Oncology Immunotherapy
Professor of Biomedical Data Science and of Statistics
Current Research and Scholarly InterestsMy research is in applied statistics and biostatistics. I specialize in computer-intensive methods for regression and classification, bootstrap, cross-validation and statistical inference, and signal and image analysis for medical diagnosis.
Professor of Pediatrics (Cardiology)
Current Research and Scholarly InterestsAssessment of vascular health in children by non-invasive modalities
Exercise interventions in children with congenital and acquired heart disease
Use of telehealth to deliver interventions to children with congenital and acquired heart disease
Quality Improvement in Pediatric Echocardiography
Echocardiography and outcomes in congenital heart disease
Professor of Genetics, of Biology and, by courtesy, of Chemistry
Current Research and Scholarly InterestsWe develop chemogenetic and optogenetic technologies for probing and manipulating protein networks, cellular RNA, and the function of mitochondria and the mammalian brain. Our technologies draw from protein engineering, directed evolution, chemical biology, organic synthesis, high-resolution microscopy, genetics, and computational design.