School of Medicine
Showing 951-1,000 of 1,063 Results
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Jennifer Tremmel
Susan P. and Riley P. Bechtel Medical Director and Associate Professor of Medicine (Cardiovascular Medicine)
Current Research and Scholarly InterestsDr. Tremmel studies sex differences in cardiovascular disease. Current research projects include evaluating sex differences in coronary pathophysiology, young patients presenting with myocardial infarction, the impact of stress on anginal symptoms, chronic total coronary occlusions, and vascular access site complications.
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Jennifer Tsai
Adjunct Clinical Instructor, Pediatrics - Hematology & Oncology
BioJennifer is a researcher in clinical development of novel therapeutics for hematologic diseases. She has a special interest in bone marrow failure and rare pediatric disorders.
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Philip S. Tsao, PhD
Professor (Research) of Medicine (Cardiovascular Medicine)
Current Research and Scholarly InterestsOur primary interests are in the molecular underpinnings of vascular disease as well as assessing disease risk. In addition to targeted investigation of specific signaling molecules, we utilize global genomic analysis to identify gene expression networks and regulatory units. We are particularly interested in the role of microRNAs in gene expression pathways associated with disease.
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Themistoklis Tsarouchas
Postdoctoral Scholar, Psychiatry
BioThemis completed his PhD at the Centre for Discovery Brain Sciences of the University of Edinburgh in Scotland under Prof Catherina Becker, with focus on the contribution of the innate immune system during regeneration of the zebrafish spinal cord. As a postdoctoral researcher with Prof Anna Williams at the Centre for Regenerative Medicine in Edinburgh he worked on the molecular mechanisms that regulate the differentiation and functional maturation of human oligodendrocytes. Over the last few years, he worked on several projects focused on the identification of genes that regulate the axonal regeneration of spinal cord after injury and the differentiation of human oligodendrocyte progenitor cells into myelin producing oligodendrocytes. As a member in the Gibson lab, Themis aims to identify molecular regulators of the circadian clock and how tuning the circadian system affects the maturation and function of oligodendrocytes in health and disease.
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Jason Tucciarone, MD, PhD
Assistant Professor of Psychiatry and Behavioral Sciences (General Psychiatry and Psychology)
BioJason Tucciarone MD, PhD is an Assistant Professor with Stanford School of Medicine’s Department of Psychiatry and Behavioral Sciences. As a neuroscientist, he leads a lab interested in biological mechanisms of mental illness and investigating new therapies for mood disorders and addiction. In particular, he is defining new cell types and evolutionary conserved circuits in emotional processing centers of the brain, with the hope of finding new entry points for novel therapeutics. Working with Dr Robert Malenka, he is using optogenetic, chemogenetic, neuroimaging and behavioral approaches in mouse models of addiction to uncover vulnerable brain circuitry in opioid use disorder. Alongside Dr Alan Schatzberg, he is investigating the efficacy of buprenorphine augmentation to IV ketamine infusion at reducing suicidality in treatment resistant depression.
Clinically, he works collaboratively in the department’s Neuropsychiatry clinic and his clinical focus includes treating patients with diverse and complex presentations at the interface of psychiatry and neurology with particular interest in functional neurological disorders. He sees a small cohort of psychotherapy patients in Individual Psychotherapy Clinic. He also works weekend shifts on Stanford’s inpatient psychiatry units.
Prior to training in psychiatry at Stanford’s research residency track Jason received his bachelor’s degree in biology and philosophy from Union College. He spent three years as a Post-Baccalaureate IRTA fellow at the National Institute of Neurological Disorders and Stroke investigating and developing MRI reportable contrast agents to map neuronal connectivity. Following this he entered the Medical Scientist Training Program (MD/PhD) at the State University of NY Stony Brook University. There he completed a doctoral dissertation in neuroscience under the mentorship Dr. Josh Huang at Cold Spring Harbor Laboratory. His thesis work employed mouse genetic dissections of excitatory and inhibitory cortical circuits with a focus on the circuitry of chandelier inhibitory interneurons in prefrontal cortex.
In addition to his research and clinical work, Jason is passionate about teaching, mentorship, and resident clinical supervision. He joined a working group early in his clinical residency to restructure trainee’s neuroscience education. He teaches introductory lectures in the neuroscience of addiction, PTSD, psychosis, and mood disorders. He also leads resident group supervision in their introductory psychodynamic psychotherapy clinical experience. He supervises medical students, residents, and clinical fellows in Neuropsychiatry clinic. Finally, committed to the Stanford clinical community, he leads a support group for Internal Medicine interns and residents. -
Mirko Uljarevic
Clinical Associate Professor, Psychiatry and Behavioral Sciences
BioI am a medically trained researcher focused academic with a background in developmental psychopathology, psychometrics and big data science. My research takes a life-span perspective and is driven by the urgent need to improve outcomes for people with autism and other neuropsychiatric (NPD) disorders and neurodevelopmental conditions (NDD). My primary research interest has focused on combining cutting-edge psychometric procedures and a big data approach to better understand structure of clinical phenotypes across autism and other NPD and NDD and on using this knowledge to improve existing and develop new clinical assessments that are more effective for screening and diagnosis, tracking the natural and treatment-related symptom progression and for use in genetic and neurobiological studies. In addition to my focus on the development of outcome measures, I have collaborated with leading psychopathology researchers and groups in the United States, Europe and Australia on numerous projects spanning a range of topics including genetics, treatment and employment, with a particular focus on understanding risk and resilience factors underpinning poor mental health outcomes in adolescents and adults. Most recently, through several competitively funded projects, I have led the statistical analyses to uncover the latent structure of social and communication and restricted and repetitive behaviors (RRB) clinical phenotypes across NPD and NDD. These findings have enabled us to (i) start capturing and characterizing a highly variable social functioning phenotype across a range of disorders and understanding mechanisms underpinning this variability, (ii) combine phenotypic and genetic units of analyses to advance our understanding of the genetic architecture of RRB, and (iii) focus on identification and characterization of subgroups of individuals that share distinct symptom profiles and demonstrate clinical utility and neurobiological validity. Importantly, this work has provided key information for developing a programmatic line of research aimed at developing novel, comprehensive assessment protocols that combine parent and clinician reports, objective functioning indicators and incorporate state-of-the-art psychometric, mobile and connected technologies and procedures.
I am a co-director of the recently established Program for Psychometrics and Measurement-Based Care (https://med.stanford.edu/sppmc.html) that aims to bring together world-leading expertise in clinical science, psychometrics, and big data analytics to bridge the gap between the science of measurement development and clinical practice and bring improvements to both clinical care and research. -
Alexander Eckehart Urban
Associate Professor of Psychiatry and Behavioral Sciences (Major Laboratories and Clinical Translational Neurosciences Incubator) and of Genetics
Current Research and Scholarly InterestsComplex behavioral and neuropsychiatric phenotypes often have a strong genetic component. This genetic component is often extremely complex and difficult to dissect. The current revolution in genome technology means that we can avail ourselves to tools that make it possible for the first time to begin understanding the complex genetic and epigenetic interactions at the basis of the human mind.
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PJ Utz
Professor of Medicine (Immunology and Rheumatology)
Current Research and Scholarly InterestsThe long-term research goal of the Utz laboratory is to understand autoimmunity, autoantibodies, and how tolerance is broken and can be reestablished.
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Tulio Valdez, MD, MSc
Professor of Otolaryngology - Head & Neck Surgery (OHNS) and, by courtesy, of Pediatrics
BioDr. Tulio A Valdez is a surgeon scientist born and raised in Colombia with a subspecialty interest in Pediatric Otolaryngology. He attended medical school at Universidad Javeriana in Bogota Colombia before undertaking his residency in Otolaryngology, Head and Neck Surgery in Boston. He completed his Pediatric Otolaryngology Fellowship at Texas Children’s Hospital (2007), Houston and obtained his Master’s in Clinical and Translational Research at the University of Connecticut.
Clinically, Dr. Valdez has an interest in pediatric sleep apnea. He has a special interest in the management of sinus disease in cystic fibrosis. Dr. Valdez has co-authored one textbook and numerous book chapters and scientific manuscripts. Dr. Valdez continues his clinical research in these areas, particularly with a focus on aerodigestive disorders.
Scientifically, Dr. Valdez has developed various imaging methods to diagnose otitis media and cholesteatoma a middle ear condition that can lead to hearing loss. He was part of the Laser Biomedical Research Center at the Massachusetts Institute of Technology. His research includes novel imaging modalities to better diagnose ear infections one of the most common pediatric problems. His research has now expanded to include better intraoperative imaging modalities in pediatric patients to improve surgical outcomes without the need for radiation exposure.
Dr. Valdez believes in multi-disciplinary collaborations to tackle medical problems and has co-invented various medical devices and surgical simulation models. -
Matt van de Rijn
Sabine Kohler, MD, Professor of Pathology
On Leave from 05/01/2024 To 06/30/2024Current Research and Scholarly InterestsOur research focuses on molecular analysis of human soft tissue tumors (sarcomas) with an emphasis on leiomyosarcoma and desmoid tumors. In addition we study the role of macrophages in range of malignant tumors.
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Keith Van Haren, MD
Assistant Professor of Neurology (Pediatric Neurology) and of Pediatrics
Current Research and Scholarly InterestsOur research team is working to develop new treatments for children at risk of neurodegenerative diseases. We are primarily focused on multiple sclerosis and X-linked adrenoleukodystrophy, two conditions that involve inflammatory and metabolic disruption of the myelin that insulates brain cells. A key area of interest for us is how nutrient deficiencies during childhood may contribute to the disease processes and whether nutritional interventions could play a role in prevention.
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Capucine Van Rechem
Assistant Professor of Pathology (Pathology Research)
Current Research and Scholarly InterestsMy long-term interest lies in understanding the impact chromatin modifiers have on disease development and progression so that more optimal therapeutic opportunities can be achieved. My laboratory explores the direct molecular impact of chromatin-modifying enzymes during cell cycle progression, and characterizes the unappreciated and unconventional roles that these chromatin factors have on cytoplasmic function such as protein synthesis.
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Shreyas Vasanawala, MD/PhD
William R. Brody Professor of Pediatric Radiology and Child Health
Current Research and Scholarly InterestsOur group is focused on developing new fast and quantitative MRI techniques.
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Anne Villeneuve
Berthold and Belle N. Guggenhime Professor and Professor of Developmental Biology and of Genetics
Current Research and Scholarly InterestsMechanisms underlying homologous chromosome pairing, DNA recombination and chromosome remodeling during meiosis, using the nematode Caenorhabditis elegans as an experimental system. High-resolution 3-D imaging of dynamic reorganization of chromosome architecture. Role of protease inhibitors in regulating sperm activation.
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Allison Vreeland
Clinical Instructor, Psychiatry and Behavioral Sciences - Child & Adolescent Psychiatry and Child Development
BioDr. Allison Vreeland (she/her) is a licensed clinical psychologist specializing in working with children, teens, and families. Dr. Vreeland received her PhD in Clinical Psychological Science with a minor in Quantitative Studies at Vanderbilt University. She completed her predoctoral clinical internship in Child Psychology at UCSF with specialty training through the Child Trauma Research Program. She completed a research and clinical fellowship in the Immune Behavioral Health Clinic at Stanford University, where she focused her research efforts on examining neurological markers of patients diagnosed with pediatric acute neuropsychiatric syndrome (PANS). Clinically, Dr. Vreeland’s program of clinical care is focused on the delivery of evidence-based clinical interventions for individuals with anxiety, OCD, PANS/PANDAS, mood disorders, and behavioral challenges.
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David Vu
Clinical Associate Professor, Pediatrics - Infectious Diseases
BioDr. Vu is a pediatric infectious diseases specialist who is researching human responses to dengue virus and malaria infections. He performed his undergraduate studies at the University of California, San Diego, and obtained his medical doctorate at the University of Pennsylvania School of Medicine. He trained in general pediatrics at UCSF Benioff Children's Hospital Oakland, and in pediatric infectious diseases at Emory University School of Medicine. His present studies on pediatric dengue and malaria co-infection are supported by an NIAID Career Development Award (K23 AI127909) and a Instructor K Award Support Program Award from the Maternal & Child Health Research Institute and Department of Pediatrics.
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Soichi Wakatsuki
Professor of Photon Science and of Structural Biology
Current Research and Scholarly InterestsUbiquitin signaling: structure, function, and therapeutics
Ubiquitin is a small protein modifier that is ubiquitously produced in the cells and takes part in the regulation of a wide range of cellular activities such as gene transcription and protein turnover. The key to the diversity of the ubiquitin roles in cells is that it is capable of interacting with other cellular proteins either as a single molecule or as different types of chains. Ubiquitin chains are produced through polymerization of ubiquitin molecules via any of their seven internal lysine residues or the N-terminal methionine residue. Covalent interaction of ubiquitin with other proteins is known as ubiquitination which is carried out through an enzymatic cascade composed of the ubiquitin-activating (E1), ubiquitin-conjugating (E2), and ubiquitin ligase (E3) enzymes. The ubiquitin signals are decoded by the ubiquitin-binding domains (UBDs). These domains often specifically recognize and non-covalently bind to the different ubiquitin species, resulting in distinct signaling outcomes.
We apply a combination of the structural (including protein crystallography, small angle x-ray scattering, cryo-electron microscopy (Cryo-EM) etc.), biocomputational and biochemical techniques to study the ubiquitylation and deubiquitination processes, and recognition of the ubiquitin chains by the proteins harboring ubiquitin-binding domains. Current research interests including SARS-COV2 proteases and their interactions with polyubiquitin chains and ubiquitin pathways in host cell responses, with an ultimate goal of providing strategies for effective therapeutics with reduced levels of side effects.
Protein self-assembly processes and applications.
The Surface layers (S-layers) are crystalline protein coats surrounding microbial cells. S-layer proteins (SLPs) regulate their extracellular, self-assembly by crystallizing when exposed to an environmental trigger. We have demonstrated that the Caulobacter crescentus SLP readily crystallizes into sheets both in vivo and in vitro via a calcium-triggered multistep assembly pathway. Observing crystallization using a time course of Cryo-EM imaging has revealed a crystalline intermediate wherein N-terminal nucleation domains exhibit motional dynamics with respect to rigid lattice-forming crystallization domains. Rate enhancement of protein crystallization by a discrete nucleation domain may enable engineering of kinetically controllable self-assembling 2D macromolecular nanomaterials. In particular, this is inspiring designing robust novel platform for nano-scale protein scaffolds for structure-based drug design and nano-bioreactor design for the carbon-cycling enzyme pathway enzymes. Current research focuses on development of nano-scaffolds for high throughput in vitro assays and structure determination of small and flexible proteins and their interaction partners using Cryo-EM, and applying them to cancer and anti-viral therapeutics.
Multiscale imaging and technology developments.
Multimodal, multiscale imaging modalities will be developed and integrated to understand how molecular level events of key enzymes and protein network are connected to cellular and multi-cellular functions through intra-cellular organization and interactions of the key machineries in the cell. Larger scale organization of these proteins will be studied by solution X-ray scattering and Cryo-EM. Their spatio-temporal arrangements in the cell organelles, membranes, and cytosol will be further studied by X-ray fluorescence imaging and correlated with cryoEM and super-resolution optical microscopy. We apply these multiscale integrative imaging approaches to biomedical, and environmental and bioenergy research questions with Stanford, DOE national labs, and other domestic and international collaborators. -
Rebecca D. Walker
Clinical Associate Professor, Emergency Medicine
Current Research and Scholarly InterestsInterests include international development in emergency care, healthcare disparities, wilderness medicine, human rights, administration
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Dennis Wall
Professor of Pediatrics (Clinical Informatics), of Biomedical Data Science and, by courtesy, of Psychiatry and Behavioral Sciences
Current Research and Scholarly InterestsSystems biology for design of clinical solutions that detect and treat disease
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James Wall
Associate Professor of Surgery (Pediatric Surgery) and, by courtesy, of Bioengineering
On Partial Leave from 07/01/2023 To 06/30/2024Current Research and Scholarly InterestsHealth Technology Innovation
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Brian A. Wandell
Isaac and Madeline Stein Family Professor and Professor, by courtesy, of Electrical Engineering, of Ophthalmology and of Education
Current Research and Scholarly InterestsModels and measures of the human visual system. The brain pathways essential for reading development. Diffusion tensor imaging, functional magnetic resonance imaging and computational modeling of visual perception and brain processes. Image systems simulations of optics and sensors and image processing. Data and computation management for reproducible research.
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Bing Wang
Postdoctoral Scholar, Stem Cell Transplantation
BioMy academic training and research experience have equipped me with multidisciplinary skills and knowledge of molecular biology and immunology.
I led two projects when I was an undergraduate, in which I got primary academic learning. My team member and I investigated the bacteria content in drinking water from two types of machines that are commonly used in colleges under the guidance of our experimental microbiology teacher Zhihong Zhong. Secondly, we produced a hybridoma cell line secreting monoclonal antibody against the core antigen of the hepatitis C virus (HCV) to develop an ELISA kit for the detection of HCV under the guidance of Dr. Rushi Liu and Minjing Liao.
Thereafter, as a Ph. D. candidate at Xiaoming Feng’s lab, my research primarily focused on understanding the biology of regulatory T cells (Treg) and CD11c+ myeloid cells using cutting-edge single-cell sequencing and conditional knockout mice under healthy and disease conditions. We first revealed the heterogeneity and bifurcated differentiation pathway of human Tregs from normal donors and transplanted patients at the single-cell transcriptome level. A subsequent first and corresponding author publication identified a key innate responsive protein in CD11c+ alveolar macrophages, NRP2, that protects mice from lung injury via promoting the phagocytosis of neutrophils. I also participated in two projects regarding the role of a serine/threonine kinase, LKB1, in mice CD11c+ dendritic cells from lymphoid tissues and adipose tissue with diet-induced obesity. These academic experiences guided me into a strong passion and independent capacities for biomedical studies.
For my postdoctoral training, I will focus on developing Treg therapies and genetic stem cell therapy to cure patients with IPEX syndrome (a severe autoimmune disease) at preclinical and clinical stages, and other immune disorders. My sponsor Dr. Rosa Bacchetta is a well-known leader in treating IPEX patients and developing Treg therapies. My co-mentor Dr. Maria Grazia Roncarolo is a well-recognized pediatric immunologist and also one of the pioneers in the stem cell and gene therapy field, who discovered the type 1 regulatory T cells or Tr1 cells and translate the scientific discoveries into novel Treg therapies. Both of them have an excellent record of training postdoctoral fellows. The proposed projects will provide me with great opportunities in cutting-edge technology and translational research and outline a set of career development including grant writing, public presentation, and lab management, which will enhance my ability to become an independent investigator and help me to reach my goal of developing efficient and safe Treg therapies for a wide range of immune disorders and associated human diseases. -
C. Jason Wang, MD, PhD
LCY: Tan Lan Lee Professor and Professor of Pediatrics (General Pediatrics) and of Health Policy
BioDr. Wang is the Director of Center for Policy, Outcomes and Prevention. Prior to coming to Stanford in 2011, he was a faculty member at Boston University Schools of Medicine and Public Health. His other professional experiences include working as a management consultant with McKinsey and Company and serving as the project manager for Taiwan's National Health Insurance Reform Task-force. His current interests include: 1) COVID-19 related policies; 2) developing tools for assessing and improving the value of healthcare; 3) facilitating the use of mobile technology in improving quality of care; 4) supporting competency-based medical education curriculum, and 5) engaging in healthcare delivery and payment reforms.
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Jinglong Wang
Postdoctoral Scholar, Radiation Biology
BioDr. Wang was trained at the Jacques Monod Institute and École Normale Supérieure in Paris, France under the mentorship of Dr. Terence Strick. and obtained his Ph.D. degree from the University of Paris in 2019. He dissected the molecular machinery of human and bacterial NHEJ, and interrogated the mechanism of SpCas9 tolerance to non-specific substrate using single-molecule nanomanipulation tools.
Jinglong’s research in the Frock Lab focuses on DSB-related chromosome topological changes and genomic interactions. -
Marie Wang
Clinical Professor, Pediatrics
Current Research and Scholarly InterestsEvaluation and management of the febrile young infant and infections in hospitalized children; promotion of appropriate antibiotic use.
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Nancy Ewen Wang
Professor of Emergency Medicine (Pediatrics), Emerita
Current Research and Scholarly Interests- Disparities in Emergency Medical Services for children.
- Efficacy of novel interventions for pediatric access to care.
- Teaching and supporting community-initiated interventions and programs internationally. -
Paul J. Wang, MD
John R. and Ai Giak L. Singleton Director, Professor of Medicine (Cardiovascular Medicine) and, by courtesy, of Bioengineering
Current Research and Scholarly InterestsDr. Wang's research centers on the development of innovative approaches to the treatment of arrhythmias, including more effective catheter ablation techniques, more reliable implantable devices, and less invasive treatments. Dr. Wang's clinical research interests include atrial fibrillation, ventricular tachycardia, syncope, and hypertrophic cardiomyopathy. Dr. Wang is committed to addressing disparities in care and is actively involved in increasing diversity in clinical trials.
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Samantha Wang
Clinical Assistant Professor, Medicine
BioSamantha Wang earned her Bachelors degree in Molecular & Cell Biology from the University of California, Berkeley, followed by MD and Masters in Health Science degrees from Yale University School of Medicine. After completing her internal medicine residency at Stanford, Dr. Wang served as Chief Resident for the Internal Medicine Residency and subsequently joined the Division of Hospital Medicine, where she now contributes her expertise in the care of acutely ill adult patients.
Outside her clinical work, Dr. Wang is deeply committed to medical education, health equity, and patient-centered communication. She has been recognized for her exceptional teaching with the David A. Rytand Teaching Award, and subsequently completed a Rathmann Family Foundation Fellowship in Medical Education in Patient-Centered Care. With leadership roles in both undergraduate and graduate medical education programs, Dr. Wang is actively engaged and committed in shaping the future of health care professionals.
Dr. Wang is deeply passionate about health equity and has spoken nationally on the topic of racial justice in clinical decision-making. She has received institutional and national funding to develop and study health equity curricula across the continuum of medical education, and is the course director for the "5-Minute Moment for Racial Justice", which advocates for justice, equity, diversity, and inclusion in medical decision making. As a member of the Stanford 25 Bedside Medicine and Presence Groups, she strives to create a more equitable and inclusive learning environment. In her research endeavors, Samantha employs a comprehensive approach, utilizing quantitative and qualitative methodologies, alongside participatory qualitative approaches with community partners. Her focus is on understanding how to effectively teach health equity in the clinical learning environment.
Her quality improvement work is centered on improving communication skills around serious illness diagnoses, and she has trained students, residents, and other faculty members in these skills. Dr. Wang believes that the best doctors combine intellectual acumen with the ability to connect with patients on a personal level, bringing thoughtfulness, kindness, and authenticity to the bedside. In her care of complex patients with serious diagnoses, she consistently advocates for incorporating loved ones' and the patient's values into the care plan, ensuring a holistic and patient-centered approach. -
Shan X. Wang
Leland T. Edwards Professor in the School of Engineering and Professor of Electrical Engineering and, by courtesy, of Radiology (Molecular Imaging Program at Stanford)
Current Research and Scholarly InterestsShan Wang was named the Leland T. Edwards Professor in the School of Engineering in 2018. He directs the Center for Magnetic Nanotechnology and is a leading expert in biosensors, information storage and spintronics. His research and inventions span across a variety of areas including magnetic biochips, in vitro diagnostics, cancer biomarkers, magnetic nanoparticles, magnetic sensors, magnetoresistive random access memory, and magnetic integrated inductors.
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Sui Wang, PhD
Assistant Professor of Ophthalmology
Current Research and Scholarly InterestsOur research focuses on unraveling the molecular mechanisms underlying retinal development and diseases. We employ genetic and genomic tools to explore how various retinal cell types, including neurons, glia, and the vasculature, respond to developmental cues and disease insults at the epigenomic and transcriptional levels. In addition, we investigate their interactions and collective contributions to maintain retinal integrity.
1. Investigating retinal development:
We utilize genetic tools and methods such as in vivo plasmid electroporation and CRISPR to dissect the roles of cis-regulatory elements and transcription factors in controlling retinal development.
2. Understanding diabetes-induced cell-type-specific responses in the retina:
Diabetes triggers a range of multicellular responses in the retina, such as vascular lesions, glial dysfunction, and neurodegeneration, all of which contribute to retinopathy. We delve into the detailed molecular mechanisms underlying these diabetes-induced cell-type-specific responses and the pathogenesis of diabetic retinopathy.
3. Developing molecular tools for labeling and manipulation of specific cell types in vivo:
Cis-regulatory elements, particularly enhancers, play pivotal roles in directing tissue- and cell-type-specific expression. Our interest lies in identifying enhancers that can drive cell type-specific expression in the retina and brain. We incorporate these enhancers into plasmid or AAV-based delivery systems, enabling precise labeling and manipulation of specific cell types in vivo. -
Taia T. Wang, MD, PhD, MSCI
Assistant Professor of Medicine (Infectious Diseases) and of Microbiology and Immunology
Current Research and Scholarly InterestsLaboratory of Mechanisms in Human Immunity and Disease Pathogenesis
Antibodies are a critical component of host defense. While the importance of humoral immunity has been recognized for decades, substantial gaps in knowledge remain around how antibodies function, and how their function is regulated, in vivo. Our laboratory performs studies designed to fill in these gaps, with the goal of enabling new vaccine and therapeutic strategies to prevent human disease. My interest in this area culminated from training in medicine, RNA virus biology (PhD), and molecular antibody biology (postdoctoral training). The intersection of these topics, viral immunity and disease pathogenesis, is the focus of our work. The essential question driving our research is why a small subset of people develop severe or fatal disease during viral infection while most infections result in a subclinical or mild outcome, even in at-risk populations. Our hypothesis is that the antibody signaling pathways that are engaged during viral infection through Fc gamma receptors (FcγRs) are a key driver of these distinct outcomes. We are focused on several major unknowns to address this hypothesis: How are antibody effector functions regulated in vivo and does this change in disease? How do distinct signaling pathways engaged by IgG immune complex-FcγR interactions impact host cell genetic regulation and the ultimate inflammatory/immune response? What are the tissue-specific functions that antibodies engage? How does the heterogeneity in post-translational modifications (PTMs) of human antibodies contribute to heterogeneity in viral immunity?
Current clinical studies:
Recruiting:
An Open Label Study of IgG Fc Glycan Composition in Human Immunity
Principal Investigator: Taia T. Wang, MD, PhD
ClinicalTrials.gov Identifier:
NCT01967238 -
Wenjun Wang
Postdoctoral Scholar, Stem Cell Transplantation
Current Research and Scholarly InterestsMy postdoctoral research focuses on investigating novel therapy for childhood leukemias.
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Xinnan Wang
Associate Professor of Neurosurgery
Current Research and Scholarly InterestsMechanisms underlying mitochondrial dynamics and function, and their implications in neurological disorders.
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Victoria Ward
Clinical Associate Professor, Pediatrics
Current Research and Scholarly InterestsGlobal child health, digital health, preterm birth, human trafficking
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Katja Gabriele Weinacht, MD, PhD
Assistant Professor of Pediatrics (Stem Cell Transplantation and Regenerative Medicine)
Current Research and Scholarly InterestsPediatric Hematopoietic Stem Cell Transplantation
DiGeorge Syndrome
Genetic Immune Diseases
Immune Dysregulation -
Alexis Thomas Weiner
Postdoctoral Scholar, Pathology
Current Research and Scholarly InterestsThe planar cell polarity (PCP) signaling pathway polarizes animal cells along an axis parallel to the tissue plane, and in so doing generates long-range organization that can span entire tissues. Although its core proteins and much about their interactions are known, how PCP signaling occurs at a mechanistic level remains fundamentally mysterious. In my current project I will employ novel genetic methods to dissect the logic underlying how cellular asymmetry arises at a molecular level.
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Dana Weintraub
Clinical Associate Professor, Pediatrics - General Pediatrics
Current Research and Scholarly InterestsResearch interests include: 1) Childhood obesity, community-based interventions to increase physical activity 2) Impact of medical-legal collaboration on child and family health.
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Irving Weissman
Virginia & D.K. Ludwig Professor of Clinical Investigation in Cancer Research, Professor of Pathology, and of Developmental Biology
Current Research and Scholarly InterestsStem cell and cancer stem cell biology; development of T and B lymphocytes; cell-surface receptors for oncornaviruses in leukemia. Hematopoietic stem cells; Lymphocyte homing, lymphoma invasiveness and metastasis; order of events from hematopoietic stem cells [HSC] to AML leukemia stem cells and blood diseases, and parallels in other tissues; discovery of tumor and pathogenic cell 'don't eat me' and 'eat me' signals, and translation into therapeutics.
