Showing 101-150 of 989 Results
Professor of Molecular and Cellular Physiology, of Neurology, of Photon Science and, by courtesy, of Structural Biology
Current Research and Scholarly InterestsOne of Axel Brunger's major goals is to decipher the molecular mechanisms of synaptic neurotransmitter release by conducting imaging and single-molecule/particle reconstitution experiments, combined with near-atomic resolution structural studies of the synaptic vesicle fusion machinery.
Douglas L. Brutlag
Professor of Biochemistry, Emeritus
Current Research and Scholarly InterestsMy primary interest is to understand the flow of information from the genome to the phenotype of an organism. This interest includes predicting the structure and function of genes and proteins from their primary sequence, predicting function from structure simulating protein folding and ligand docking, and predicitng disease from genome variations. These goals are the same as the goals of molecular biology, however, we use primarily computational approaches.
Associate Professor of Bioengineering and, by courtesy, of Structural Biology
Current Research and Scholarly InterestsMolecular motors lie at the heart of biological processes from DNA replication to vesicle transport. My laboratory seeks to understand the physical mechanisms by which these nanoscale machines convert chemical energy into mechanical work.
Professor of Pediatrics (Endocrinology) at the Lucile Salter Packard Children's Hospital, Emeritus
Current Research and Scholarly InterestsMy major interest is in type 1 diabetes mellitus, continuous glucose sensor, and the development of an artificial pancreas. Other research interests include using continuous glucose monitoring and algorithms to control blood glucose levels in intensive care units.
Paul Buckmaster, DVM, PhD
Professor of Comparative Medicine and of Neurology
Current Research and Scholarly InterestsMechanisms of epilepsy, especially temporal lobe epilepsy.
Marguerite Blake Wilbur Professor of Natural Science and Professor of Photon Science, of Applied Physics and of Physics
BioPhil Bucksbaum holds the Marguerite Blake Wilbur Chair in Natural Science at Stanford University, with appointments in Physics, Applied Physics, and in Photon Science at SLAC. He conducts his research in the Stanford PULSE Institute (https://web.stanford.edu/~phbuck). He and his wife Roberta Morris live in Menlo Park, California with their cat. Their grown daughter lives in Toronto.
Bucksbaum was born and raised in Iowa, and graduated from Harvard in 1975. He attended U.C. Berkeley on a National Science Foundation Graduate Fellowship and received his Ph.D. in 1980 for atomic parity violation experiments under Professor Eugene Commins, with whom he also has co-authored a textbook, “Weak Interactions of Leptons and Quarks.” In 1981 he joined Bell Laboratories, where he pursued new applications of ultrafast coherent radiation from terahertz to vacuum ultraviolet, including time-resolved VUV ARPES, and strong-field laser-atom physics.
He joined the University of Michigan in 1990 and stayed for sixteen years, becoming Otto Laporte Collegiate Professor and then Peter Franken University Professor. He was founding Director of FOCUS, a National Science Foundation Physics Frontier Center, where he pioneered research using ultrafast lasers to control quantum systems. He also launched the first experiments in ultrafast x-ray science at the Advanced Photon Source at Argonne National Lab. In 2006 Bucksbaum moved to Stanford and SLAC, and organized the PULSE Institute to develop research utilizing the world’s first hard x-ray free-electron laser, LCLS. In addition to directing PULSE, he has previously served as Department Chair of Photon Science and Division Director for Chemical Science at SLAC. His current research is in laser interrogation of atoms and molecules to explore and image structure and dynamics on the femtosecond scale. He currently has more than 250 publications.
Bucksbaum is a Fellow of the APS and the Optical Society, and has been elected to the National Academy of Sciences and the American Academy of Arts and Sciences. He has held Guggenheim and Miller Fellowships, and received the Norman F. Ramsey Prize of the American Physical Society for his work in ultrafast and strong-field atomic and molecular physics. He served as the Optical Society President in 2014, and also served as the President of the American Physical Society in 2020. He has led or participated in many professional service activities, including NAS studies, national and international boards, initiatives, lectureships and editorships.
Marion S. Buckwalter, MD, PhD
Professor of Neurology and of Neurosurgery
Current Research and Scholarly InterestsThe goal of the Buckwalter Lab is to improve how people recover after a stroke. We use basic and clinical research to understand the cells, proteins, and genes that lead to successful recovery of function, and also how complications develop that impact quality of life after stroke. Ongoing projects are focused on understanding how inflammatory responses are regulated after a stroke and how they affect short-term brain injury and long term outcomes like dementia and depression.
Associate Professor of Earth System Science and Senior Fellow at the Freeman Spogli Institute for International Studies, at the Woods Institute for the Environment and at the Stanford Institute for Economic Policy Research
BioMarshall Burke is an associate professor in the Department of Earth System Science, deputy director at the Center on Food Security and the Environment, and center fellow at the Freeman Spogli Institute for International Studies (FSI) at Stanford University. He is also a faculty research fellow at the National Bureau of Economic Research, and a co-founder of AtlasAI, a remote sensing start-up. His research focuses on social and economic impacts of environmental change and on measuring and understanding economic development in emerging markets. His work has appeared in both economic and scientific journals, including recent publications in Nature, Science, The Quarterly Journal of Economics, and The Lancet. He holds a PhD in agricultural and resource economics from the University of California, Berkeley and a BA in international relations from Stanford University.
Prospective students should see my personal webpage, linked at right.
Professor of Biomedical Data Science, of Genetics and, by courtesy, of BiologyOn Leave from 10/01/2021 To 08/30/2022
Current Research and Scholarly InterestsMy genetics research focuses on analyzing genome wide patterns of variation within and between species to address fundamental questions in biology, anthropology, and medicine. We focus on novel methods development for complex disease genetics and risk prediction in multi-ethnic settings. I am also interested in clinical data science and development of new diagnostics.I am also interested in disruptive innovation for healthcare including modeling long-term risk shifts and novel payment models.
Klaus Bensch Professor of Pathology
Current Research and Scholarly InterestsOur interests include:
1) The physiology and function of lymphocyte homing in local and systemic immunity;
2) Biochemical and genetic studies of molecules that direct leukocyte recruitment;
3) Chemotactic mechanisms and receptors in vascular and immune biology;
4) Vascular control of normal and pathologic inflammation and immunity;
5) Systems biology of immune cell trafficking and programming in tumor immunity.
Professor of Radiation Oncology (Radiation Therapy)
Current Research and Scholarly InterestsPatient-centered and artificial intelligence-augmented medical decision making
William R. Kenan, Jr. Professor
BioRobert L. Byer has served as President of The American Physical Society, of the Optical Society of America and of the IEEE LEOS. He has served as Vice Provost and Dean of Research at Stanford. He has been Chair of the Department of Applied Physics, Director of the Edward L. Ginzton Laboratory and Director of the Hansen Experimental Physics Laboratory. He is a founding member of the California Council on Science and Technology and served as Chair from 1995-1999. He was a member of the Air Force Scientific Advisory Board from 2002-2006 and has been a member of the National Ignition Facility since 2000.
Robert L. Byer has conducted research and taught classes in lasers and nonlinear optics at Stanford University since 1969. He has made extraordinary contributions to laser science and technology including the demonstration of the first tunable visible parametric oscillator, the development of the Q-switched unstable resonator Nd:YAG laser, remote sensing using tunable infrared sources and precision spectroscopy using Coherent Anti Stokes Raman Scattering (CARS). Current research includes precision laser measurements in support of the detection of gravitational waves and laser “Accelerator on a chip”.
Professor of Genetics, Emerita
Current Research and Scholarly InterestsMy lab is developing innovative gene and stem cell therapies for genetic diseases, with a focus on gene therapy and regenerative medicine.
We have created novel methods for inserting therapeutic genes into the chromosomes at specific places by using homologous recombination and recombinase enzymes.
We are working on 3 forms of muscular dystrophy.
We created induced pluripotent stem cells from patient fibroblasts, added therapeutic genes, differentiated, and engrafted the cells.
Associate Professor of BioengineeringOn Leave from 04/01/2022 To 06/30/2022
BioDavid B. Camarillo is Associate Professor of Bioengineering, (by courtesy) Mechanical Engineering and Neurosurgery at Stanford University. Dr. Camarillo holds a B.S.E in Mechanical and Aerospace Engineering from Princeton University, a Ph.D. in Mechanical Engineering from Stanford University and completed postdoctoral fellowships in Biophysics at the UCSF and Biodesign Innovation at Stanford. Dr. Camarillo worked in the surgical robotics industry at Intuitive Surgical and Hansen Medical, before launching his laboratory at Stanford in 2012. His current research focuses on precision human measurement for multiple clinical and physiological areas including the brain, heart, lungs, and reproductive system. Dr. Camarillo has been awarded the Hellman Fellowship, the Office of Naval Research Young Investigator Program award, among other honors including multiple best paper awards in brain injury and robotic surgery. His research has been funded by the NIH, NSF, DoD, as well as corporations and private philanthropy. His lab’s research has been featured on NPR, the New York Times, The Washington Post, Science News, ESPN, and TED.com as well as other media outlets aimed at education of the public.
Barnum-Simons Chair of Math and Statistics, and Professor of Statistics and, by courtesy, of Electrical Engineering
BioEmmanuel Candès is the Barnum-Simons Chair in Mathematics and Statistics, a professor of electrical engineering (by courtesy) and a member of the Institute of Computational and Mathematical Engineering at Stanford University. Earlier, Candès was the Ronald and Maxine Linde Professor of Applied and Computational Mathematics at the California Institute of Technology. His research interests are in computational harmonic analysis, statistics, information theory, signal processing and mathematical optimization with applications to the imaging sciences, scientific computing and inverse problems. He received his Ph.D. in statistics from Stanford University in 1998.
Candès has received several awards including the Alan T. Waterman Award from NSF, which is the highest honor bestowed by the National Science Foundation, and which recognizes the achievements of early-career scientists. He has given over 60 plenary lectures at major international conferences, not only in mathematics and statistics but in many other areas as well including biomedical imaging and solid-state physics. He was elected to the National Academy of Sciences and to the American Academy of Arts and Sciences in 2014.
Robson Capasso, MD
Professor of Otolaryngology - Head & Neck Surgery (OHNS) and, by courtesy, of Psychiatry and Behavioral Sciences (Sleep Medicine)
Current Research and Scholarly InterestsClinically relevant outcomes for OSA Surgery.
Wearables and Digital Health Technologies for Sleep.
Innovative approaches for OSA Management.
Innovation in Sleep and Otolaryngology
Associate Professor of Microbiology and ImmunologyOn Leave from 06/01/2022 To 09/30/2022
Current Research and Scholarly InterestsOur research focuses on the identification of host genes that play critical roles in the pathogenesis of infectious agents including viruses. We use haploid genetic screens in human cells as an efficient approach to perform loss-of-function studies. Besides obtaining fundamental insights on how viruses hijack cellular processes and on host defense mechanisms, it may also facilitate the development of new therapeutic strategies.
Professor (Research) of Pediatrics (Neonatology), of Obstetrics & Gynecology (Maternal Fetal Medicine) and, by courtesy, of Epidemiology and Population Health
Current Research and Scholarly InterestsDr. Carmichael is a perinatal and nutritional epidemiologist and Professor of Pediatrics and Obstetrics and Gynecology at the Stanford University School of Medicine.
Her team is committed to finding ways to improve maternal and infant health outcomes and equity by leading research that identifies effective leverage points for change, from upstream 'macro' social and structural factors, to downstream clinical factors (eg, related to care and morbidities) through a collaborative research approach that integrates epidemiologic approaches with community engagement and systems thinking.
Exposure themes include social context, nutrition, care, environmental contaminants and genetics. Outcome themes include severe maternal morbidity, stillbirth, birth defects, and preterm delivery. She is particularly interested in understanding the intersectionality of these varied types of exposures and outcomes and how they interact to impact health and health disparities, for the mother-baby dyad.
Please see the team web-site for further information!
Victor G. Carrión
John A. Turner Endowed Professor for Child and Adolescent PsychiatryOn Leave from 06/01/2022 To 07/31/2022
Current Research and Scholarly InterestsExamines the interplay between brain development and stress vulnerability via a multi-method approach that includes psychophysiology, neuroimaging, neuroendocrinology and phenomenology. Treatment development that focuses on individual and community-based interventions for stress related conditions in children and adolescents that experience traumatic stress.
Dennis R Carter
Professor of Mechanical Engineering, Emeritus
Current Research and Scholarly InterestsProfessor Carter studies the influence of mechanical loading upon the growth, development, regeneration, and aging of skeletal tissues. Basic information from such studies is used to understand skeletal diseases and treatments. He has served as President of the Orthopaedic Research Society and is a Fellow of the American Institute for Medical and Biological Engineering.
Victoria and Roger Sant Director, Earth Systems Program, Professor of Earth System Science and Senior Fellow at the Woods Institute for the Environment
Current Research and Scholarly InterestsAssistant Professor in EESS, focus on marine chemistry and biogeochemistry.
Associate Professor of Chemistry and, by courtesy, of Chemical Engineering
Current Research and Scholarly InterestsOur research program is inspired by the challenge and importance of elucidating chemical structure and function in complex biological systems and the need for new strategies to treat infectious diseases. The genomics and proteomics revolutions have been enormously successful in generating crucial "parts lists" for biological systems. Yet, for many fascinating systems, formidable challenges exist in building complete descriptions of how the parts function and assemble into macromolecular complexes and whole-cell factories. We have introduced uniquely enabling problem-solving approaches integrating solid-state NMR spectroscopy with microscopy and biochemical and biophysical tools to determine atomic- and molecular-level detail in complex macromolecular assemblies and whole cells and biofilms. We are uncovering new chemistry and new chemical structures produced in nature. We identify small molecules that influence bacterial assembly processes and use these in chemical genetics approaches to learn about bacterial cell wall, amyloid and biofilm assembly.
Translationally, we have launched a collaborative antibacterial drug design program integrating synthesis, chemical biology, and mechanistic biochemistry and biophysics directed at the discovery and development of new antibacterial therapeutics targeting difficult-to-treat bacteria.
Duca Family Professor
BioChris Chafe is a composer, improvisor, and cellist, developing much of his music alongside computer-based research. He is Director of Stanford University's Center for Computer Research in Music and Acoustics (CCRMA). In 2019, he was International Visiting Research Scholar at the Peter Wall Institute for Advanced Studies The University of British Columbia, Visiting Professor at the Politecnico di Torino, and Edgard-Varèse Guest Professor at the Technical University of Berlin. At IRCAM (Paris) and The Banff Centre (Alberta), he has pursued methods for digital synthesis, music performance and real-time internet collaboration. CCRMA's jacktrip project involves live concertizing with musicians the world over. Online collaboration software and research into latency factors continue to evolve. An active performer either on the net or physically present, his music reaches audiences in sometimes novel venues. An early network project was a simultaneous five-country concert was hosted at the United Nations in 2009. Chafe’s works include gallery and museum music installations which are now into their second decade with “musifications” resulting from collaborations with artists, scientists and MD’s. Recent work includes the Earth Symphony, the Brain Stethoscope project (Gnosisong), PolarTide for the 2013 Venice Biennale, Tomato Quintet for the transLife:media Festival at the National Art Museum of China and Sun Shot played by the horns of large ships in the port of St. Johns, Newfoundland.
Professor of Geological SciencesOn Leave from 01/01/2022 To 06/30/2022
Current Research and Scholarly InterestsResearch
I use stable and radiogenic isotopes to understand Earth system history. These studies examine the link between climate, tectonics, biological, and surface processes. Projects include: 1) examining the terrestrial climate history of the Earth focusing on periods of time in the past that had CO 2-levels similar to the present and to future projections; and 2) addressing how the chemical weathering of the Earth's crust affects both the long- and short-term carbon cycle. Field areas for these studies are in the Cascades, Rocky Mountains, Sierra Nevada, the European Alps, Tibet and the Himalaya and the Southern Alps of New Zealand.
Much of the research that I do has an international component. Specifically, I have collaborations with: 1) the Senckenberg Biodiversity and Climate Research Center in Frankfurt Germany as a Humboldt Fellow and 2) the Chinese University of Geosciences in Bejiing China where I collaborate with Professor Yuan Gao.
I teach courses at the undergraduate and graduate level in isotope biogeochemistry, Earth system history, and the relationship between climate, surface processes and tectonics.
Editor American Journal of Science; Co-Director Stanford Stable Isotope Biogeochemistry Laboratory (present);Chair, Department of Geological and Environmental Sciences (2004-07); Co-Director Stanford/USGS SHRIMP Ion microprobe facility (2001-04)
Sue and Bob McCollum Professor
Current Research and Scholarly InterestsI specialize in the treatment of gastrointestinal malignancies. I am interested in developing stereotactic body radiotherapy for tumors of the liver, both primary and metastatic. I am interested in developing functional imaging as a means of determining treatment response with radiation. I am also interested in developing image-guided radiotherapy to improve radiation delivery for GI cancers to reduce toxicity and improve disease outcome.
Professor of Aeronautics and AstronauticsOn Leave from 04/01/2022 To 06/30/2022
BioProfessor Chang's primary research interest is in the areas of multi-functional materials and intelligent structures with particular emphases on structural health monitoring, intelligent self-sensing diagnostics, and multifunctional energy storage composites for transportation vehicles as well as safety-critical assets and medical devices. His specialties include embedded sensors and stretchable sensor networks with built-in self-diagnostics, integrated diagnostics and prognostics, damage tolerance and failure analysis for composite materials, and advanced multi-physics computational methods for multi-functional structures. Most of his work involves system integration and multi-disciplinary engineering in structural mechanics, electrical engineering, signal processing, and multi-scale fabrication of materials. His recent research topics include: Multifunctional energy storage composites, Integrated health management for aircraft structures, bio-inspired intelligent sensory materials for fly-by-feel autonomous vehicles, active sensing diagnostics for composite structures, self-diagnostics for high-temperature materials, etc.
Howard Y. Chang, MD, PhD
Virginia and D. K. Ludwig Professor of Cancer Research and Professor of Genetics
Current Research and Scholarly InterestsOur research is focused on how the activities of hundreds or even thousands of genes (gene parties) are coordinated to achieve biological meaning. We have pioneered methods to predict, dissect, and control large-scale gene regulatory programs; these methods have provided insights into human development, cancer, and aging.
James Chang, MD
Johnson and Johnson Professor of Surgery and Professor, by courtesy, of Orthopaedic Surgery
Current Research and Scholarly InterestsMy role in research is to apply novel advances in tissue engineering and microsurgery to the clinical problems of hand trauma, peripheral nerve injuries, and congenital hand problems. I am interested in developing new tissues and techniques that will allow optimal reconstruction of form and function to those patients requiring reconstructive surgery.
Robert Chang, MD
Associate Professor of Ophthalmology
Current Research and Scholarly InterestsI'm interested in developing a best in class glaucoma registry, utilizing modern algorithm techniques on imaging, text, and biologic data for precision health predictive analytics in glaucoma diagnosis and treatment, validating new medical devices and technologies, especially portable ones, and working on implementation science
Steven D. Chang, MD
Robert C. and Jeannette Powell Neurosciences Professor and, by courtesy, of Otolaryngology - Head & Neck Surgery (OHNS) and of Neurology
Current Research and Scholarly InterestsClinical research includes studies in the treatment of cerebrovascular disorders, such as aneurysms and AVMs, as well as the use of radiosurgery to treat tumors and vascular malformations of the brain and spine.
Dr. Chang is C0-Director of the Cyberknife Radiosurgery Program.
Dr. Chang is also the head of the The Stanford Neuromolecular Innovation Program with the goal of developing new technologies to improve the diagnosis and treatment of patients affected by neurological conditions.
Assistant Professor (Research) of Radiology (Integrative Biomedical Imaging Informatics at Stanford) and, by courtesy, of Biomedical Data Science
Current Research and Scholarly InterestsDr. Chaudhari is interested in the application of artificial intelligence techniques to all aspects of medical imaging, including automated schedule and reading prioritization, image reconstruction, quantitative analysis, and prediction of patient outcomes. His interests range from developing novel data-efficient machine learning algorithms to clinical deployment and validation of patient outcomes. He is also exploring combining imaging with clinical, natural language, and time series data.
Associate Professor of Mechanical Engineering
BioOur group's research is focused at the intersection of mechanics and biology. We are interested in elucidating the underlying molecular mechanisms that give rise to the complex mechanical properties of cells, extracellular matrices, and tissues . Conversely, we are investigating how complex mechanical cues influence important biological processes such as cell division, differentiation, or cancer progression. Our approaches involve using force measurement instrumentation, such as atomic force microscopy, to exert and measure forces on materials and cells at the nanoscale, and the development of material systems for 3D cell culture that allow precise and independent manipulation of mechanical properties.
Bertha Chen, MD
Professor of Obstetrics and Gynecology (Gynecology - Urogynecology) and, by courtesy, of Urology
Current Research and Scholarly InterestsDr. Chen’s research examines the molecular causes of urinary incontinence and pelvic floor dysfunction. Recognizing that urinary incontinence linked to demise of smooth muscle sphincter function, she is investigating the potential use of stem cell regeneration to restore muscle capacity.
James K. Chen
Jauch Professor and Professor of Chemical and Systems Biology, of Developmental Biology and of Chemistry
Current Research and Scholarly InterestsOur laboratory combines chemistry and developmental biology to investigate the molecular events that regulate embryonic patterning, tissue regeneration, and tumorigenesis. We are currently using genetic and small-molecule approaches to study the molecular mechanisms of Hedgehog signaling, and we are developing chemical technologies to perturb and observe the genetic programs that underlie vertebrate development.
Jonathan H. Chen, MD, PhD
Assistant Professor of Medicine (Biomedical Informatics)
Current Research and Scholarly InterestsInformatics solutions ares the only credible approach to systematically address challenges of escalating complexity in healthcare. Tapping into real-world clinical data streams like electronic medical records will reveal the community's latent knowledge in a reproducible form. Delivering this back as clinical decision support will uniquely close the loop on a continuously learning health system.
Professor of Neurosurgery and of Psychiatry and Behavioral Sciences
Current Research and Scholarly InterestsWhat distinguishes us humans from other animals is our ability to undergo complex behavior. The synapses are the structural connection between neurons that mediates the communication between neurons, which underlies our various cognitive function. My research program aims to understand the cellular and molecular mechanisms that underlie synapse function during behavior in the developing and mature brain, and how synapse function is altered during mental retardation.
Associate Professor of Biology
Current Research and Scholarly InterestsOur goal is to understand how brain circuits mediate motivated behaviors and how maladaptive changes in these circuits cause mood disorders. To achieve this goal, we focus on studying the neural circuits for pain and addiction, as both trigger highly motivated behaviors, whereas, transitioning from acute to chronic pain or from recreational to compulsive drug use involves maladaptive changes of the underlying neuronal circuitry.
Alan G. Cheng, MD
Edward C. and Amy H. Sewall Professor in the School of Medicine, Professor of Otolaryngology - Head & Neck Surgery (OHNS) and, by courtesy, of Pediatrics
Current Research and Scholarly InterestsActive Wnt signaling maintains somatic stem cells in many organ systems. Using Wnt target genes as markers, we have characterized distinct cell populations with stem cell behavior in the inner ear, an organ thought to be terminally differentiated. Ongoing work focuses on delineating the developing significance of these putative stem/progenitor cells and their behavior after damage.
Professor (Research) of GeneticsOn Leave from 06/20/2022 To 08/12/2022
Current Research and Scholarly InterestsMy research involves identifying, validating and integrating scientific facts into encyclopedic databases essential for research and scientific education. Published results of scientific experimentation are a foundation of our understanding of the natural world and provide motivation for new experiments. The combination of in-depth understanding reported in the literature with computational analyses is an essential ingredient of modern biological research.
Glenn M. Chertow
Norman S. Coplon/Satellite Healthcare Professor of Medicine and Professor, by courtesy, of Epidemiology and Population Health
Current Research and Scholarly Interestsclinical epidemiology, health services research, decision sciences, clinical trials in acute and chronic kidney disease
Emilie Cheung, MD
Associate Professor of Orthopaedic Surgery
Current Research and Scholarly InterestsPyrocarbon humeral head replacement
Clinical outcome after shoulder replacement
Clinical outcome after elbow replacement
Clinical outcomes following complex reconstruction of the shoulder and elbow,
Bone mineral density in the shoulder,
3D kinematics of the shoulder girdle after arthroplasty
John R. Adler Professor, Professor of Neurosurgery and of Ophthalmology and, by courtesy, of Electrical EngineeringOn Partial Leave from 03/01/2022 To 08/31/2022
Current Research and Scholarly InterestsFunctional circuitry of the retina and design of retinal prostheses
Professor of Microbiology & Immunology
Current Research and Scholarly InterestsContribution of T cells to immunocompetence and autoimmunity; how the immune system clears infection, avoids autoimmunity and how infection impacts on the development of immune responses.
Assistant Professor of Chemical and Systems Biology
Current Research and Scholarly InterestsResearch in my laboratory is aimed at understanding how eukaryotes replicate their DNA despite numerous challenges (collectively known as replication stress), and more generally – how eukaryotic cells safeguard genome integrity. Specifically, we are investigating: (i) mechanisms that regulate the activity of the replicative helicase during replication stress, (ii) mechanisms that control the inheritance of epigenetic information during replication, and (iii) mechanisms of ubiquitin-mediated regulation of genome maintenance. We utilize single-molecule microscopy to directly image fluorescently-labeled replication factors and track them in real time in Xenopus egg extracts. I developed this system as a postdoctoral fellow, and used it to monitor how the eukaryotic replicative helicase copes with DNA damage. We plan to further extend the capabilities of this platform to directly visualize other essential replication factors, nucleosomes, and regulatory post-translational modifications like ubiquitin chains. By elucidating molecular mechanisms responsible for maintaining genome stability, we aim to better understand the link between genome instability and cancer, and how these mechanisms can be harnessed to improve disease treatment.
Associate Professor of Surgery (Pediatric Surgery)
BioDr. Chiu obtained his B.S. degree in Biological Sciences and graduated with Honors from Stanford University. After graduating, he received his Medical Degree at Northwestern University Feinberg School of Medicine, where he remained for his internship and General Surgery residency training. Dr. Chiu completed his Pediatric Surgery training at The Children’s Hospital of Philadelphia. He is an Associate Professor at Stanford University School of Medicine where he has an active research program studying innovative approaches to treat patients with neuroblastoma.
Wallenberg-Bienenstock Professor and Professor of Bioengineering and of Microbiology and Immunology
Current Research and Scholarly InterestsMy research includes methodology improvements in single particle cryo-EM for atomic resolution structure determination of molecules and molecular machines, as well as in cryo-ET of cells and organelles towards subnanometer resolutions. We collaborate with many researchers around the country and outside the USA on understanding biological processes such as protein folding, virus assembly and disassembly, pathogen-host interactions, signal transduction, and transport across cytosol and membranes.
Danny Hung-Chieh Chou
Assistant Professor of Pediatrics (Endocrinology) and, by courtesy, of Chemical and Systems Biology
Current Research and Scholarly InterestsOur research program integrates concepts of chemical biology, protein engineering and structure biology to design new therapeutic leads and generate probes to study biological processes. A key focus of our lab is insulin, an essential hormone in our body to reduce blood glucose levels. We generate synthetic libraries of insulin analogs to select for chemical probes, and investigate natural insulin molecules (e.g. from the venom of fish-hunting cone snails!) to develop novel therapeutic candidates. We are especially interested in using chemical and enzymatic synthesis to create novel chemical entities with enhanced properties, and leverage the strong expertise of our collaborators to apply our skill sets in the fields of cancer biology, immunology and pain research. Our ultimate goal is to translate our discovery into therapeutic interventions in human diseases.
Constance Chu, MD
Professor of Orthopaedic Surgery (Sports Medicine)
BioDr. Constance R. Chu is Professor and Vice Chair Research, in the Department of Orthopedic Surgery at Stanford University. She is also Director of the Joint Preservation Center and Chief of Sports Medicine at the VA Palo Alto. Previously, she was the Albert Ferguson Endowed Chair and Professor of Orthopaedic Surgery at the University of Pittsburgh. She is a clinician-scientist who is both principal investigator of several projects funded by the National Institutes of Health and who has been recognized as a Castle-Connelly/US News and World Report “Top Doctor” in Orthopedic Surgery as well as on Becker’s list of Top Knee Surgeons in the United States. Her clinical practice focuses on the knee: primarily restoration and reconstruction of the ACL, menisci and cartilage. She graduated from the U.S. Military Academy at West Point and earned her medical degree from Harvard Medical School.
As Director of the multi-disciplinary Joint Preservation Center structured to seamlessly integrate the latest advances in biologics, mechanics, and imaging with comprehensive patient centered musculoskeletal and orthopedic care, Dr. Chu aims to develop a new model for health care delivery, research and education with an emphasis on health promotion and prevention. Cornerstones of this program include teamwork and a focus on personalized medicine. A central goal is to transform the clinical approach to osteoarthritis from palliation to prevention. In addition to optimizing clinical operations, outstanding research is critical to developing more effective new treatments. Towards this end, Dr. Chu is leading innovative translational research from bench to bedside in three main areas: quantitative imaging and biomarker development for early diagnosis and staging of joint and cartilage injury and degeneration; cartilage tissue engineering and stem cell based cartilage repair; and molecular and biological therapies for joint restoration and joint rejuvenation. Her research efforts have led to more than 30 professional awards and honors to include a Kappa Delta Award, considered to be the highest research honor in Orthopedic Surgery.
Dr. Chu also regularly holds leadership and committee positions in major professional organizations such as the American Association of Orthopedic Surgeons (AAOS) and the American Orthopedic Association (AOA). In her subspecialty of Orthopedic Sports Medicine, she is a past President of the Forum Sports Focus Group, a member of the Herodicus Society of leaders in Sports Medicine, and immediate past Chair of the American Orthopedic Society for Sports Medicine (AOSSM) Research Council. She is alumnus of the AOA American, British, Canadian (ABC) and the AOSSM Traveling Fellowships.