Stanford University
Showing 3,201-3,300 of 13,043 Results
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Jeffrey A. Feinstein, MD, MPH
Dunlevie Family Professor of Pulmonary Vascular Disease and Professor, by courtesy, of Bioengineering
Current Research and Scholarly InterestsResearch interests include (1) computer simulation and modeling of cardiovascular physiology with specific attention paid to congenital heart disease and its treatment, (2) the evaluation and treatment of pulmonary hypertension/pulmonary vascular diseases, and (3) development and testing of medical devices/therapies for the treatment of congenital heart disease and pulmonary vascular diseases.
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David Feldman
Professor of Medicine (Endocrinology, Gerontology and Metabolism), Emeritus
Current Research and Scholarly InterestsStudies of the role of the vitamin D receptor in the action of 1,25-dihydroxyvitamin D, the active vitamin D hormone. Current efforts are evaluating the vitamin D receptor in breast and prostate cancer, osteoporosis and rickets.
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Heidi M. Feldman
Ballinger-Swindells Endowed Professor of Developmental and Behavioral Pediatrics
Current Research and Scholarly InterestsMy current research program focuses on infants born preterm, before 32 weeks gestation from two language environments: English and Spanish. The study considers how neurobiological factors, specifically properties of the white matter circuits in the brain, interact with social, psychological, and economic factors to predict language processing efficiency at 18 months of age.
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Marcus Feldman
Burnet C. and Mildred Finley Wohlford Professor
Current Research and Scholarly InterestsHuman genetic and cultural evolution, mathematical biology, demography of China
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Dean W. Felsher
Professor of Medicine (Oncology) and of Pathology
Current Research and Scholarly InterestsMy laboratory studies the molecular basis of cancer with a focus on understanding when cancer can be reversed through targeted oncogene inactivation.
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Stephen Felt, DVM, MPH
Professor of Comparative Medicine
Current Research and Scholarly InterestsHis research interests include infectious diseases, particularly zoonoses, and exploring techniques which promote the health and welfare of laboratory animals.
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Michelle Feltes
Clinical Associate Professor, Emergency Medicine
BioDr Michelle Feltes is a Clinical Assistant Professor of Emergency Medicine. She received her medical degree from Washington University in St Louis and completed residency in the George Washington University Emergency Medicine residency program in Washington DC. She completed the Global EM Fellowship at Stanford and the Masters of Academic Medicine degree at the University of Southern California in 2018. She then stayed on as faculty at Stanford University in the department of Emergency Medicine with a focus on global health. Her academic work focuses on the development of global emergency medicine and medical education.
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Scott Fendorf
Terry Huffington Professor, Senior Associate Dean for Research, Senior Fellow at the Woods Institute for the Environment and Professor of Photon Science
Current Research and Scholarly InterestsSoil and environmental biogeochemistry
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Liang Feng
Associate Professor of Molecular and Cellular Physiology and, by courtesy, of Structural Biology
Current Research and Scholarly InterestsWe are interested in the structure, dynamics and function of eukaryotic transport proteins mediating ions and major nutrients crossing the membrane, the kinetics and regulation of transport processes, the catalytic mechanism of membrane embedded enzymes and the development of small molecule modulators based on the structure and function of membrane proteins.
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Yanan Feng
Sr. Research Scientist - Basic Life, Genetics
Current Role at StanfordSenior Research Scientist, Department of Genetics, Dr. Stanley N. Cohen's lab
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Howard H Fenn MD
Adjunct Clinical Associate Professor, Psychiatry and Behavioral Sciences
BioCurrent CV available on request to
hhfenn@aol.com
CLINICAL:
Inpatient psychiatry attending at VA HCS Palo Alto for over 30 years.
Medical Director, Geriatric Psychiatry unit, VA HCSC Palo Alto/Menlo Park for 10 years
Outpatient psychiatrist at Palo Alto Medical foundation/Sutter for 15 years
CURRENT PUBLICATIONS:
Lead Editor, Inpatient Geriatric Psychiatry, Springer, 2019
LEGAL/FORENSIC:
Consultation practice on legal issues and court testimony for >40 years
Expert consultant/witness for Coleman vs. California Department of Corrections for 4 years
Qualified Medical Examiner (QME) for Division of Worker's Compensation for 15 years
Compensation and Pension Unit, VA HCS Palo Alto for 5 years
SEMINAR LEADER:
Psychiatric Issues in Cognitive Impairment -- Stanford/VA Alzheimer's Center (SVAAC)
Legal Aspects of Geriatric Psychiatry (Stanford/VA Geriatric Psychiatry Fellowship
Didactic topics on inpatient psychiatry rotation for Stanford Geriatric Psychiatry fellows
EDUCATIONAL/ADMINISTRATIVE:
Program Director, Stanford/VA Geriatric Psychiatry Fellowship, 3 years
Site Director, Inpatient Psychiatry Rotation/Geriatric Medicine Fellowship --6 years
SCHOLARSHIP:
Lead Editor of textbook, Inpatient Geriatric Psychiatry, published by Springer in 2019.
Slide presentations published by the American Society of Clinical Pharmacology (ASCP), editor Ira Glick, MD, entitled:
--Pharmacological Treatment of PTSD
--Behavioral and Psychological symptoms of Dementia
Chapters, review articles on topics of Medication management for Major Neurocognitive Disorder with Behavioral Disturbance
Chapter in Inpatient Geriatric Psychiatry, in On-Call Geriatric Psychiatry (2016), Springer.
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Emily Ferguson, PhD
Postdoctoral Scholar, Psychiatry
BioEmily Ferguson, Ph.D., is a postdoctoral academic researcher and clinician within Stanford University’s Autism and Developmental Disorders Research Program (https://med.stanford.edu/autism.html) within the Department of Psychiatry and Behavioral Sciences. She earned her doctoral degree in Clinical Psychology from the University of California Santa Barbara and completed her clinical internship at the University of California Los Angeles. Dr. Ferguson's research focuses on advancing understanding of mechanisms of challenging behaviors in autistic youth and adults to inform treatment development. Her work takes a comprehensive perspective, integrating methods from implementation science to improve the accessibility and quality of clinical care for underserved autistic populations, especially those with higher support needs (or "profound autism"). She is also interested in developing methods to improve self-regulation in individuals with profound autism to effectively manage self-injurious behaviors and aggression. Dr. Ferguson is currently supporting research in the Preschool Autism Lab (https://med.stanford.edu/autismcenter/pre-school-autism-lab-program.html), and exploring profiles of challenging behaviors with the Program for Psychometrics and Measurement-Based Care (https://med.stanford.edu/sppmc.html) in a diverse range of autistic and non-autistic youth to inform treatment approaches.
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Jessica Ferguson Toll
Clinical Assistant Professor, Medicine - Infectious Diseases
BioDr. Ferguson is a board certified Infectious Disease specialist. She specializes in the treatment of immunocompromised patients, including patients who have undergone bone marrow or solid organ transplantation and patients with hematologic or solid malignancies on chemotherapy.
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Jacqueline Ferguson Solanki
Instructor (Affiliated), Health Policy
Staff, Health PolicyBioDr. Jacqueline Ferguson is a Research Investigator at the Palo Alto VA (Veterans Health Administration) and is a researcher with the Center for Population Health Sciences at Stanford Medicine.
She specializes in using secondary data sources such as occupational records, insurance claims, and electronic health records to study the relationship between environmental, social exposures and population health. Her research interests are widespread, but all center around methodology to handle time-varying exposures affected by prior exposure and methodology to account for multiple co-exposures or exposure mixtures. Her most recent work has focused on improving access to care for Veterans by examining patient characteristics associated with the frequency, quantity, and proportion of video-based care used by Veterans.
Jacqueline’s doctoral research at UC Berkeley and the Center for Population Health Sciences at Stanford Medicine has examined the impact of specific components of shift work on worker health, and identified night and rotational work as risk factors for hypertension and Type II diabetes. Jacqueline's current research seeks to understand how multiple social determinants of health can simultaneously influence Veteran care and health within the Veterans Health Administration.
Complete List of Published Work: https://www.ncbi.nlm.nih.gov/myncbi/1xKgynf_jII5z/bibliography/public/ -
Anne Fernald
Josephine Knotts Knowles Professor of Human Biology, Emerita
Current Research and Scholarly InterestsWorking with English- and Spanish-learning children from diverse socioeconomic and cultural backgrounds, our research examines the importance of early language experience in supporting language development. We are deeply involved in community-based research in San Jose, designing an innovative parent-engagement program for low-resource Latino families with young children. We are also conducting field studies of beliefs about child development and caregiver-child interaction in rural villages in Senegal. A central goal of this translational research is to help parents understand their vital role in facilitating children’s language and cognitive growth.
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Russell D. Fernald
Benjamin Scott Crocker Professor of Human Biology, Emeritus
Current Research and Scholarly InterestsIn the course of evolution,two of the strongest selective forces in nature,light and sex, have left their mark on living organisms. I am interested in how the development and function of the nervous system reflects these events. We use the reproductive system to understand how social behavior influences the main system of reproductive action controlled by a collection of cells in the brain containing gonodotropin releasing hormone(GnRH)
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Nielsen Fernandez-Becker
Clinical Professor, Medicine - Gastroenterology & Hepatology
BioI am the director of the Celiac Disease Program at Stanford and I am highly experienced in diagnosis and management of celiac disease and gluten associated disorders.
My objective is to provide excellent and compassionate clinical care for my patients while seeking a better understanding of diseases I treat, particularly Celiac disease (CeD), eosinophilic esophagitis (EoE). My top priorities are patient care and translational research to make new discoveries and improve the care my patients. -
Marcelo Fernandez Vina
Professor of Pathology
On Leave from 03/02/2026 To 06/10/2026BioMarcelo Fernández-Viña, Ph.D., D (ABHI) is a Professor for the Department of Pathology at Stanford University Medical School and serves as Director of the Histocompatibility, Immunogenetics and Disease Profiling Laboratory at this institution. He has been working in the fields of Histocompatibility and Immunogenetics since 1982. He earned a degree in Biochemistry from the School of Basic Sciences in Rosario, Argentina, and his Ph.D. in Internal Medicine from the University of Buenos Aires Medical School in Argentina. Previously he held a position as a Professor in the Department of Laboratory Medicine at the University of Texas M.D. Anderson Cancer Center in Houston. He has more than 180 peer reviewed publications, many of them focusing on HLA variation in multiple world populations, identifying susceptibility and resistance factors for diseases and in the impact of HLA mismatches in allogeneic transplantation; and 59 book chapters. He served as expert Consultant for Donor Searches for NMDP and as President Elect, President and Past President of the American Society for Histocompatibility and Immunogenetics. He served as a member of the Board of Directors and the Executive Committee for the United Network for Organ Sharing. He served as Co-Chair of the Immunobiology Committee of the CIBMTR; He also served as a member of the HHS Advisory Council on Blood Stem Cell Transplantation (ACBSCT).He serves as HLA Expert Consultant for the NMDP for the HRSA contract and is a member of the Histocompatibility Advisory Group for NMDP. He is Councilor of the International Histocompatibility Workshop and a member of the WHO Nomenclature Committee for Factors of the HLA System and was Chairman of the (17th) International HLA & Immunogenetics Workshop, and Past President of the International HLA & Immunogenetics Workshop.
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Juan Carlos Fernandez-Miranda, MD, FACS
Professor of Neurosurgery and, by courtesy, of Otolaryngology - Head & Neck Surgery (OHNS)
BioDr. Juan Fernandez-Miranda is Professor of Neurosurgery and Surgical Director of the Stanford Brain Tumor, Skull Base, and Pituitary Centers. He is internationally renowned for his expertise in minimally invasive brain surgery, endoscopic skull base and pituitary surgery, open skull base surgery, and complex brain tumor surgery. He has performed over 4,000 cranial operations including more than 2,000 endoscopic endonasal operations for pituitary tumors and other skull base lesions. He is highly regarded for his innovative contributions to the development and refinement of endoscopic endonasal skull base surgery, for his ability to select the most effective and less invasive approach to each individual patient, and for his precise knowledge of the intricate anatomy of the white matter tracts required to maximize resection and minimize morbidity on high and low grade glioma patients. He has been recently ranked by Expertscape as World-Expert (top 0.05%) on Skull Base Surgery and #1 Neurosurgeon Expert on Skull Base Tumors (pituitary adenomas, meningiomas, craniopharyngiomas, chordomas, chondrosarcomas, schwannomas and esthesioneuroblastomas) on the US Pacific Region. He is co-founder and vice-president of the International Rhoton Society and executive member of the Board of Directors of the The Neurosurgical Atlas, the largest nonprofit organization for neurosurgical education and research in the world.
Dr. Fernandez-Miranda completed neurosurgery residency at La Paz University Hospital in Madrid, Spain. Upon completion of his residency, he was awarded the Sanitas Prize to the best medical postgraduate trainee in the country. From 2005 to 2007, he underwent fellowship training in microsurgical neuroanatomy at the University of Florida under legendary neurosurgeon Albert L. Rhoton, Jr. From 2007 to 2010 he continued subspecialty clinical training in cerebrovascular surgery at the University of Virginia, and endoscopic endonasal and open skull base surgery at University of Pittsburgh Medical Center (UPMC). During his 10-year tenure at UPMC, he pioneered endoscopic endonasal approaches to highly complex pituitary and skull base tumors, developed a world-class complex brain surgery program, and led a premier training and research program on surgical neuroanatomy and skull base surgery.
In 2018, he was recruited to bring to Stanford his unique technical expertise and to collaborate with world-renowned Stanford colleagues across multiple disciplines, leading the establishment of one of the most preeminent centers worldwide for comprehensive treatment of complex lesions in the brain, skull base, and pituitary regions. His top priority is to provide gentle, accurate, and safe surgery, in a team-based and compassionate approach to patient care. -
Sebastian Fernandez-Pol
Clinical Associate Professor, Pathology
BioDr. Sebastian Fernandez-Pol is an academic hematopathologist with fellowship training in hematopathology and dermatopathology. He has a particular interest in improving diagnostic accuracy for cutaneous lymphoproliferative disorders. Dr. Fernandez-Pol received his B.A. in chemistry with a concentration in biochemistry from the Washington University in St. Louis in 2003, his MD and PhD from Northwestern University in 2013, and completed his anatomic pathology and clinical pathology residency, hematopathology fellowship, and dermatopathology fellowship at Stanford University in 2019.
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Michael S. Fernandopulle
Affiliate, Department Funds
Resident in PathologyBioMichael Fernandopulle, M.D., Ph.D., is a resident in clinical pathology at Stanford University. During his graduate work at the NIH with Dr. Michael Ward and at Cambridge with Dr. Peter St. George-Hyslop, he uncovered novel pathways for mRNA localization and local protein synthesis in neurons. He is interested in combining biochemistry, metabolism, and high-throughput cell and subcellular profiling technologies to uncover fundamental principles of aging and neurodegeneration, and to apply these discoveries toward novel diagnostics and therapeutics.
Michael holds an Sc.B. in Chemistry from Brown University, an M.D. from Northwestern University, and a Ph.D. in Neuroscience from the University of Cambridge, Darwin College. -
Katherine Ferrara
Professor of Radiology (Molecular Imaging Program at Stanford)
Current Research and Scholarly InterestsMy focus is image-guided drug and gene delivery and I am engaged in the design of imaging devices, molecularly-targeted imaging probes and engineered delivery vehicles, drawing upon my education in biology and imaging physics and more than 20 years of experience with the synthesis and labeling of therapeutic particles. My laboratory has unique resources for and substantial experience in synthetic chemistry and ultrasound, CT, MR and PET imaging.
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Lorenzo Ferrari
Postdoctoral Scholar, Cardiothoracic Surgery
BioLorenzo Ferrari, PhD, is a biomedical engineer interested in cardiovascular flows and in developing benchtop systems for in vitro evaluation of cardiac devices. His current postdoctoral research in the Department of Cardiothoracic Surgery at Stanford University focuses on simulating and testing transcatheter valves implanted in the right ventricular outflow tract using 4D Flow MRI, working with Doff B. McElhinney, Daniel B. Ennis, and Alison L. Marsden. He obtained his PhD summa cum laude in Biomedical Engineering from the University of Bern, where he investigated the influence of heart valve design and size under different hemodynamic conditions using particle velocimetry techniques. During his PhD, he completed a secondment at the University of Twente in the Physics of Fluids group at the Max Planck Center for Complex Fluid Dynamics, collaborating with Michel Versluis and Guillaume Lajoinie to assess the stability of flow fields past valve prostheses.
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James Ferrell
Professor of Chemical and Systems Biology and of Biochemistry
Current Research and Scholarly InterestsMy lab has two main goals: to understand the regulation of mitosis and to understand the systems-level logic of simple signaling circuits. We often make use of Xenopus laevis oocytes, eggs, and cell-free extracts for both sorts of study. We also carry out single-cell fluorescence imaging studies on mammalian cell lines. Our experimental work is complemented by computational and theoretical studies aimed at understanding the design principles and recurring themes of regulatory circuits.
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Margaret S. Ferris, MD
Clinical Assistant Professor, Adult Neurology
Clinical Assistant Professor (By courtesy), NeurosurgeryBioDr. Ferris is a fellowship-trained neurologist and Clinical Assistant Professor in the Department of Neurology, Division of Movement Disorders.
She diagnoses and treats a breath of movement disorders such as Parkinson’s disease and essential tremor. She recognizes the broad effects of these conditions on daily living and aims to develop personalized, comprehensive treatment plans that optimize health and quality of life.
Dr. Ferris research interests focus on access to interventional therapies for movement disorders. She has participated in investigations sponsored by the National Institutes of to evaluate advanced treatments for complications of Parkinson’s disease.
She has co-authored articles in publications such as Nature, The Neurohospitalist, and BioMed Central (BMC) Genomics. She has presented her insights about innovations in the understanding, detection, and management of movement disorders at conferences including, the Society for Neuroscience Annual Meeting, Pan American Parkinson’s Disease and Movement Disorders Congress.
She is a member of the American Academy of Neurology and the Movement Disorder Society.
Essential tremor patient story: https://www.youtube.com/watch?v=fV6BzyU9b3c -
Dorien Feyaerts
Instructor, Anesthesiology, Perioperative and Pain Medicine
Current Research and Scholarly InterestsBiomedical scientist and immunologist with a strong background in fetal-maternal immunology that aims to conduct impactful translational research in women’s health to improve the health of mothers and their children.
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Priya Fielding-Singh
Postdoctoral Scholar, SCRDP/ Heart Disease Prevention
BioI am a Sociologist and Postdoctoral Fellow in Cardiovascular Disease Prevention at the Stanford Prevention Research Center. My research examines health, gender, and social inequality.
My primary research agenda investigates health disparities across class, race, and gender in the United States. I draw on both qualitative and quantitative methods to understand how neighborhoods, schools, and families shape our health behaviors and outcomes. My work has been published in journals such as Social Science & Medicine, Obesity, Sociological Science, and the Journal of Adolescent Health.
I hold a Ph.D. in Sociology from Stanford University, a M.A. in Anthropology from the University of Bremen, and a B.S. in Education and Social Policy from Northwestern University. -
Vikram Fielding-Singh, MD, JD, MS
Clinical Associate Professor, Anesthesiology, Perioperative and Pain Medicine
Current Research and Scholarly InterestsImproving perioperative care of patients with end stage kidney disease, using biomarkers to aid early diagnosis of acute kidney injury, and evaluating the performance of risk prediction models in perioperative medicine.
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Caroline Figueroa, MD PhD
Affiliate, Pediatrics - General Pediatrics
Visiting Postdoctoral Scholar, Pediatrics - General PediatricsBioCaroline Figueroa, MD, PhD, is a visiting scholar at Stanford University. She is the 2025–26 Dutch Commonwealth Fund Harkness Fellow in Health Care Policy and Practice. She is an assistant professor at Delft University of Technology (TU Delft) in the Netherlands, where she leads the Research on Inclusive Solutions and Empowerment in Digital Health (RISE) group. Her work focuses on making digital mental health solutions — such as apps and AI-chatbots — safe, effective, and accessible, particularly for adolescents, young adults, and women. Figueroa’s research on digital health equity has directly informed policy documents by global organizations such as the World Health Organization and the United Nations, and has been published in leading journals including Lancet Digital Health, Journal of the American Medical Informatics Association, and Human Brain Mapping.
Figueroa is a medical doctor with a PhD in the neuroscience of depression from the University of Amsterdam and the University of Oxford; she also has several years of experience in clinical psychiatry. Before joining TU Delft, she was a postdoctoral scholar at the University of California, Berkeley. -
Marcos Figueroa
Access Service Specialist, School of Medicine - Lane Medical Library
Current Role at StanfordStanford University - School of Medicine - Lane Medical Library
Library Specialist-Circulation Evening Supervisor; Bills & Fines Coordinator -
Andrey Finegersh, MD, PhD
Assistant Professor of Otolaryngology - Head & Neck Surgery (OHNS)
BioDr. Finegersh is a fellowship-trained head and neck surgical oncologist with board certification in otolaryngology and an Assistant Professor with the Stanford School of Medicine Department of Otolaryngology.
He specializes in treatment of benign and malignant tumors of the head and neck and has received additional training in microvascular reconstruction and transoral robotic surgery. He takes tremendous pride in providing compassionate care for patients and managing challenging diagnoses.
Dr. Finegersh completed his MD and PhD degrees at the University of Pittsburgh School of Medicine's combined Medical Scientist Training Program. He went on to complete residency in otolaryngology at the University of California San Diego (UCSD) and his fellowship at Stanford University, where he stayed on as faculty.
He has extensive research experience in head and neck cancer epigenetics and completed post-doctoral research at the University of Pittsburgh and UCSD. He has received grants from the NIH and American Academy of Otolaryngology and has an active research lab studying molecular mechanisms of cancer. Dr. Finegersh has additional clinical interests in studying the role of minimally invasive surgery to improve outcomes for head and neck cancer patients. -
Anna Finley Caulfield, MD
Clinical Professor, Adult Neurology
Current Research and Scholarly InterestsDr. Finley joined the Stanford Stroke Center in 2004 from Beth Israel Deaconess Medical Center in Boston. She cares for acute stroke patients and other neurologically critical ill patients in the intensive care unit. Currently, her research interests include hypothermia after cardiac arrest and comparing health care provider's predications of future neurological function in neurologically critical ill patients to their 6-month outcome.
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David Fiorentino, MD, PhD
Professor of Dermatology
Current Research and Scholarly InterestsFrom a clinical standpoint, I am particularly focused in the care of patients with myositis or systemic sclerosis. We offer clinical trials, including novel, cutting-edge cellular-based (e.g. chimeric antigen receptor, or, CAR T) therapies for these diseases. We are particularly interested in understanding the role of auto antigens in providing windows into disease pathogenesis, as well as their potential direct role of autoantibodies in causing disease.
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Andrew Fire
George D. Smith Professor of Molecular and Genetic Medicine and Professor of Pathology and of Genetics
Current Research and Scholarly InterestsWhile chromosomal inheritance provides cells with one means for keeping and transmitting genetic information, numerous other mechanisms have (and remain to be) discovered. We study novel cellular mechanisms that enforce genetic constancy and permit genetic change. Underlying our studies are questions of the diversity of inheritance mechanisms, how cells distinguish such mechanisms as "wanted" versus "unwanted", and of the consequences and applications of such mechanisms in health and disease.
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Michael Fischbach
Liu (Liao) Family Professor
Current Research and Scholarly InterestsThe microbiome carries out extraordinary feats of biology: it produces hundreds of molecules, many of which impact host physiology; modulates immune function potently and specifically; self-organizes biogeographically; and exhibits profound stability in the face of perturbations. Our lab studies the mechanisms of microbiome-host interactions. Our approach is based on two technologies we recently developed: a complex (119-member) defined gut community that serves as an analytically manageable but biologically relevant system for experimentation, and new genetic systems for common species from the microbiome. Using these systems, we investigate mechanisms at the community level and the strain level.
1) Community-level mechanisms. A typical gut microbiome consists of 200-250 bacterial species that span >6 orders of magnitude in relative abundance. As a system, these bacteria carry out extraordinary feats of metabolite consumption and production, elicit a variety of specific immune cell populations, self-organize geographically and metabolically, and exhibit profound resilience against a wide range of perturbations. Yet remarkably little is known about how the community functions as a system. We are exploring this by asking two broad questions: How do groups of organisms work together to influence immune function? What are the mechanisms that govern metabolism and ecology at the 100+ strain scale? Our goal is to learn rules that will enable us to design communities that solve specific therapeutic problems.
2) Strain-level mechanisms. Even though gut and skin colonists live in communities, individual strains can have an extraordinary impact on host biology. We focus on two broad (and partially overlapping) categories:
Immune modulation: Can we redirect colonist-specific T cells against an antigen of interest by expressing it on the surface of a bacterium? How do skin colonists induce high levels of Staphylococcus-specific antibodies in mice and humans?
Abundant microbiome-derived molecules: By constructing single-strain/single-gene knockouts in a complex defined community, we will ask: What are the effects of bacterially produced molecules on host metabolism and immunology? Can the molecular output of low-abundance organisms impact host physiology?
3) Cell and gene therapy. We have begun two new efforts in mammalian cell and gene therapies. First, we are developing methods that enable cell-type specific delivery of genome editing payloads in vivo. We are especially interested in delivery vehicles that are customizable and easy to manufacture. Second, we have begun a comprehensive genome mining effort with an emphasis on understudied or entirely novel enzyme systems with utility in mammalian genome editing.
