Bio-X


Showing 1-50 of 51 Results

  • Anthony Wagner

    Anthony Wagner

    Lucie Stern Professor in the Social Sciences

    Current Research and Scholarly InterestsCognitive neuroscience of memory and cognitive/executive control in young and older adults. Research interests include encoding and retrieval mechanisms; interactions between declarative, nondeclarative, and working memory; forms of cognitive control; neurocognitive aging; functional organization of prefrontal cortex, parietal cortex, and the medial temporal lobe; assessed by functional MRI, scalp and intracranial EEG, and transcranial magnetic stimulation.

  • Soichi Wakatsuki

    Soichi Wakatsuki

    Professor of Photon Science and of Structural Biology

    Current Research and Scholarly InterestsUbiquitin signaling: structure, function, and therapeutics
    Ubiquitin is a small protein modifier that is ubiquitously produced in the cells and takes part in the regulation of a wide range of cellular activities such as gene transcription and protein turnover. The key to the diversity of the ubiquitin roles in cells is that it is capable of interacting with other cellular proteins either as a single molecule or as different types of chains. Ubiquitin chains are produced through polymerization of ubiquitin molecules via any of their seven internal lysine residues or the N-terminal methionine residue. Covalent interaction of ubiquitin with other proteins is known as ubiquitination which is carried out through an enzymatic cascade composed of the ubiquitin-activating (E1), ubiquitin-conjugating (E2), and ubiquitin ligase (E3) enzymes. The ubiquitin signals are decoded by the ubiquitin-binding domains (UBDs). These domains often specifically recognize and non-covalently bind to the different ubiquitin species, resulting in distinct signaling outcomes.
    We apply a combination of the structural (including protein crystallography, small angle x-ray scattering, cryo-electron microscopy (Cryo-EM) etc.), biocomputational and biochemical techniques to study the ubiquitylation and deubiquitination processes, and recognition of the ubiquitin chains by the proteins harboring ubiquitin-binding domains. Current research interests including SARS-COV2 proteases and their interactions with polyubiquitin chains and ubiquitin pathways in host cell responses, with an ultimate goal of providing strategies for effective therapeutics with reduced levels of side effects.

    Protein self-assembly processes and applications.
    The Surface layers (S-layers) are crystalline protein coats surrounding microbial cells. S-layer proteins (SLPs) regulate their extracellular, self-assembly by crystallizing when exposed to an environmental trigger. We have demonstrated that the Caulobacter crescentus SLP readily crystallizes into sheets both in vivo and in vitro via a calcium-triggered multistep assembly pathway. Observing crystallization using a time course of Cryo-EM imaging has revealed a crystalline intermediate wherein N-terminal nucleation domains exhibit motional dynamics with respect to rigid lattice-forming crystallization domains. Rate enhancement of protein crystallization by a discrete nucleation domain may enable engineering of kinetically controllable self-assembling 2D macromolecular nanomaterials. In particular, this is inspiring designing robust novel platform for nano-scale protein scaffolds for structure-based drug design and nano-bioreactor design for the carbon-cycling enzyme pathway enzymes. Current research focuses on development of nano-scaffolds for high throughput in vitro assays and structure determination of small and flexible proteins and their interaction partners using Cryo-EM, and applying them to cancer and anti-viral therapeutics.

    Multiscale imaging and technology developments.
    Multimodal, multiscale imaging modalities will be developed and integrated to understand how molecular level events of key enzymes and protein network are connected to cellular and multi-cellular functions through intra-cellular organization and interactions of the key machineries in the cell. Larger scale organization of these proteins will be studied by solution X-ray scattering and Cryo-EM. Their spatio-temporal arrangements in the cell organelles, membranes, and cytosol will be further studied by X-ray fluorescence imaging and correlated with cryoEM and super-resolution optical microscopy. We apply these multiscale integrative imaging approaches to biomedical, and environmental and bioenergy research questions with Stanford, DOE national labs, and other domestic and international collaborators.

  • Virginia Walbot

    Virginia Walbot

    Professor of Biology, Emerita

    Current Research and Scholarly InterestsOur current focus is on maize anther development to understand how cell fate is specified. We discovered that hypoxia triggers specification of the archesporial (pre-meiotic) cells, and that these cells secrete a small protein MAC1 that patterns the adjacent soma to differentiate as endothecial and secondary parietal cell types. We also discovered a novel class of small RNA: 21-nt and 24-nt phasiRNAs that are exceptionally abundant in anthers and exhibit strict spatiotemporal dynamics.

  • Ken Waldron

    Ken Waldron

    Professor (Research) of Mechanical Engineering, Emeritus

    BioKenneth J. Waldron is Professor of Mechanical and Mechatronic Engineering at UTS. He is also Professor Emeritus from the Design Group in the Department of Mechanical Engineering of Stanford University. He holds bachelors and masters degrees from the University of Sydney, and PhD from Stanford. He works in machine design, and design methodology with a particular focus on robotic and mechatronic systems.

  • Dennis Wall

    Dennis Wall

    Professor of Pediatrics (Clinical Informatics), of Biomedical Data Science and, by courtesy, of Psychiatry and Behavioral Sciences

    Current Research and Scholarly InterestsSystems biology for design of clinical solutions that detect and treat disease

  • Guenther Walther

    Guenther Walther

    Professor of Statistics

    BioGuenther Walther studied mathematics, economics, and computer science at the University of Karlsruhe in Germany and received his Ph.D. in Statistics from UC Berkeley in 1994.

    His research has focused on statistical methodology for detection problems, shape-restricted inference, and mixture analysis, and on statistical problems in astrophysics and in flow cytometry.

    He received a Terman fellowship, a NSF CAREER award, and the Distinguished Teaching Award of the Dean of Humanities and Sciences at Stanford. He has served on the editorial boards of the Journal of Computational and Graphical Statistics, the Journal of the Royal Statistical Society, the Annals of Statistics, the Annals of Applied Statistics, and Statistical Science. He was program co-chair of the 2006 Annual Meeting of the Institute of Mathematical Statistics and served on the executive committee of IMS from 1998 to 2012.

  • Brian A. Wandell

    Brian A. Wandell

    Isaac and Madeline Stein Family Professor and Professor, by courtesy, of Electrical Engineering, of Ophthalmology and of Education

    Current Research and Scholarly InterestsModels and measures of the human visual system. The brain pathways essential for reading development. Diffusion tensor imaging, functional magnetic resonance imaging and computational modeling of visual perception and brain processes. Image systems simulations of optics and sensors and image processing. Data and computation management for reproducible research.

  • Tom Wandless

    Tom Wandless

    Professor of Chemical and Systems Biology

    Current Research and Scholarly InterestsWe employ an interdisciplinary approach to studies of biological systems, combining synthetic chemistry with biochemistry, cell biology, and structural biology. We invent tools for biology and we are motivated by approaches that enable new experiments with unprecedented control. These new techniques may also provide a window into mechanisms involved in maintaining cellular homeostasis. Protein quality control is a particular interest at present.

  • Adam Wang

    Adam Wang

    Assistant Professor of Radiology and, by courtesy, of Electrical Engineering

    BioMy research group develops technologies for advanced x-ray and CT imaging, including artificial intelligence for CT acquisition, reconstruction, and image processing; spectral imaging, including photon counting CT (PCCT) and dual-layer flat-panel detectors; novel system and detector designs; and their applications in diagnostic imaging and image-guided procedures. I am also the Director of the Photon Counting CT Lab, Zeego Lab, and Tabletop X-Ray Lab.

    I completed my PhD in Electrical Engineering at Stanford, developing strategies for maximizing the information content of dual energy CT and photon counting detectors. I then pursued a postdoctoral fellowship at Johns Hopkins in the I-STAR Lab, developing reconstruction and registration methods for x-ray based image-guided surgery. I was then a Senior Scientist at Varian Medical Systems, developing x-ray/CT methods for image-guided radiation therapy, before returning to Stanford in 2018, where I now lead a comprehensive research program in advanced x-ray and CT imaging systems and methods, with funding from NIH, DOD, DOE, and industry partners.

  • Bo Wang

    Bo Wang

    Assistant Professor of Bioengineering and, by courtesy, Developmental Biology

    Current Research and Scholarly InterestsResearch interests:
    (1) Systems biology of whole-body regeneration
    (2) Cell type evolution through the lens of single-cell multiomic sequencing analysis
    (3) Quantitative biology of brain regeneration
    (4) Regeneration of animal-algal photosymbiotic systems

  • Paul  J. Wang, MD

    Paul J. Wang, MD

    John R. and Ai Giak L. Singleton Director, Professor of Medicine (Cardiovascular Medicine) and, by courtesy, of Bioengineering

    Current Research and Scholarly InterestsDr. Wang's research centers on the development of innovative approaches to the treatment of arrhythmias, including more effective catheter ablation techniques, more reliable implantable devices, and less invasive treatments. Dr. Wang's clinical research interests include atrial fibrillation, ventricular tachycardia, syncope, and hypertrophic cardiomyopathy. Dr. Wang is committed to addressing disparities in care and is actively involved in increasing diversity in clinical trials.

  • Shan X. Wang

    Shan X. Wang

    Leland T. Edwards Professor in the School of Engineering and Professor of Electrical Engineering and, by courtesy, of Radiology (Molecular Imaging Program at Stanford)

    Current Research and Scholarly InterestsShan Wang was named the Leland T. Edwards Professor in the School of Engineering in 2018. He directs the Center for Magnetic Nanotechnology and is a leading expert in biosensors, information storage and spintronics. His research and inventions span across a variety of areas including magnetic biochips, in vitro diagnostics, cancer biomarkers, magnetic nanoparticles, magnetic sensors, magnetoresistive random access memory, and magnetic integrated inductors.

  • Sui Wang, PhD

    Sui Wang, PhD

    Assistant Professor of Ophthalmology

    Current Research and Scholarly InterestsOur research focuses on unraveling the molecular mechanisms underlying retinal development and diseases. We employ genetic and genomic tools to explore how various retinal cell types, including neurons, glia, and the vasculature, respond to developmental cues and disease insults at the epigenomic and transcriptional levels. In addition, we investigate their interactions and collective contributions to maintain retinal integrity.

    1. Investigating retinal development:
    We utilize genetic tools and methods such as in vivo plasmid electroporation and CRISPR to dissect the roles of cis-regulatory elements and transcription factors in controlling retinal development.

    2. Understanding diabetes-induced cell-type-specific responses in the retina:
    Diabetes triggers a range of multicellular responses in the retina, such as vascular lesions, glial dysfunction, and neurodegeneration, all of which contribute to retinopathy. We delve into the detailed molecular mechanisms underlying these diabetes-induced cell-type-specific responses and the pathogenesis of diabetic retinopathy.

    3. Developing molecular tools for labeling and manipulation of specific cell types in vivo:
    Cis-regulatory elements, particularly enhancers, play pivotal roles in directing tissue- and cell-type-specific expression. Our interest lies in identifying enhancers that can drive cell type-specific expression in the retina and brain. We incorporate these enhancers into plasmid or AAV-based delivery systems, enabling precise labeling and manipulation of specific cell types in vivo.

  • Xinnan Wang

    Xinnan Wang

    Professor of Neurosurgery

    Current Research and Scholarly InterestsMechanisms underlying mitochondrial dynamics and function, and their implications in neurological disorders.

  • Robert Waymouth

    Robert Waymouth

    Robert Eckles Swain Professor of Chemistry and Professor, by courtesy, of Chemical Engineering

    BioRobert Eckles Swain Professor in Chemistry Robert Waymouth investigates new catalytic strategies to create useful new molecules, including bioactive polymers, synthetic fuels, and sustainable plastics. In one such breakthrough, Professor Waymouth and Professor Wender developed a new class of gene delivery agents.

    Born in 1960 in Warner Robins, Georgia, Robert Waymouth studied chemistry and mathematics at Washington and Lee University in Lexington, Virginia (B.S. and B.A., respectively, both summa cum laude, 1982). He developed an interest in synthetic and mechanistic organometallic chemistry during his doctoral studies in chemistry at the California Institute of Technology under Professor R.H. Grubbs (Ph.D., 1987). His postdoctoral research with Professor Piero Pino at the Institut fur Polymere, ETH Zurich, Switzerland, focused on catalytic hydrogenation with chiral metallocene catalysts. He joined the Stanford University faculty as assistant professor in 1988, becoming full professor in 1997 and in 2000 the Robert Eckles Swain Professor of Chemistry.

    Today, the Waymouth Group applies mechanistic principles to develop new concepts in catalysis, with particular focus on the development of organometallic and organic catalysts for the synthesis of complex macromolecular architectures. In organometallic catalysis, the group devised a highly selective alcohol oxidation catalyst that selectively oxidizes unprotected polyols and carbohydrates to alpha-hyroxyketones. In collaboration with Dr. James Hedrick of IBM, we have developed a platform of highly active organic catalysts and continuous flow reactors that provide access to polymer architectures that are difficult to access by conventional approaches.

    The Waymouth group has devised selective organocatalytic strategies for the synthesis of functional degradable polymers and oligomers that function as "molecular transporters" to deliver genes, drugs and probes into cells and live animals. These advances led to the joint discovery with the Wender group of a general, safe, and remarkably effective concept for RNA delivery based on a new class of synthetic cationic materials, Charge-Altering Releasable Transporters (CARTs). This technology has been shown to be effective for mRNA based cancer vaccines.

  • Katja Gabriele Weinacht, MD, PhD

    Katja Gabriele Weinacht, MD, PhD

    Assistant Professor of Pediatrics (Stem Cell Transplantation and Regenerative Medicine)

    Current Research and Scholarly InterestsPediatric Hematopoietic Stem Cell Transplantation
    DiGeorge Syndrome
    Genetic Immune Diseases
    Immune Dysregulation

  • William Weis

    William Weis

    Member, Bio-X

    Current Research and Scholarly InterestsOur laboratory studies molecular interactions that underlie the establishment and maintenance of cell and tissue structure. Our principal areas of interest are the architecture and dynamics of intercellular adhesion junctions, signaling pathways that govern cell fate determination, and determinants of cell polarity. Our overall approach is to reconstitute macromolecular assemblies with purified components in order to analyze them using biochemical, biophysical and structural methods.

  • Irving Weissman

    Irving Weissman

    Virginia & D.K. Ludwig Professor of Clinical Investigation in Cancer Research, Professor of Pathology, and of Developmental Biology

    Current Research and Scholarly InterestsStem cell and cancer stem cell biology; development of T and B lymphocytes; cell-surface receptors for oncornaviruses in leukemia. Hematopoietic stem cells; Lymphocyte homing, lymphoma invasiveness and metastasis; order of events from hematopoietic stem cells [HSC] to AML leukemia stem cells and blood diseases, and parallels in other tissues; discovery of tumor and pathogenic cell 'don't eat me' and 'eat me' signals, and translation into therapeutics.

  • Itschak Weissman

    Itschak Weissman

    Robert and Barbara Kleist Professor in the School of Engineering

    BioTsachy's research focuses on Information Theory, Data Compression and Communications, Statistical Signal Processing, Machine Learning, the interplay between them, and their applications, with recent focus on applications to genomic data compression and processing. He is inventor of several patents and involved in several companies as member of the technical board. IEEE fellow, he serves on the board of governors of the information theory society as well as the editorial boards of the Transactions on Information Theory and Foundations and Trends in Communications and Information Theory. He is founding Director of the Stanford Compression Forum.

  • Paula V. Welander

    Paula V. Welander

    Associate Dean for Integrative Initiatives in DEI and Professor of Earth System Science

    Current Research and Scholarly InterestsBiosynthesis of lipid biomarkers in modern microbes; molecular geomicrobiology; microbial physiology

  • Paul Wender

    Paul Wender

    Francis W. Bergstrom Professor and Professor, by courtesy, of Chemical and Systems Biology

    Current Research and Scholarly InterestsMolecular imaging, therapeutics, drug delivery, drug mode of action, synthesis

  • Gerlinde Wernig

    Gerlinde Wernig

    Assistant Professor of Pathology

    Current Research and Scholarly InterestsFibrotic diseases kill more people than cancer in this country and worldwide. We believe that scar-forming cells called fibroblasts are at the core of the fibrotic response in parenchymal organ fibrosis in the lung, liver, skin, bone marrow and tumor stroma. At the cellular level we think of fibrosis as a step wise process which implicates inflammation and fibrosis. We seek to identify new effective immune therapy targets to treat fibrotic diseases.

  • Marius Wernig

    Marius Wernig

    Professor of Pathology and, by courtesy, of Chemical and Systems Biology

    Current Research and Scholarly InterestsEpigenetic Reprogramming, Direct conversion of fibroblasts into neurons, Pluripotent Stem Cells, Neural Differentiation: implications in development and regenerative medicine

  • Robert West

    Robert West

    Professor of Pathology

    Current Research and Scholarly InterestsRob West, MD, PhD, is a Professor of Pathology at Stanford University Medical Center. He is a clinician scientist with experience in translational genomics research to identify new prognostic and therapeutic markers in cancer. His research focus is on the progression of neoplasia to carcinoma. His lab has developed spatially oriented in situ methods to study archival specimens. He also serves as a surgical pathologist specializing in breast pathology.

  • Gordon Wetzstein

    Gordon Wetzstein

    Associate Professor of Electrical Engineering and, by courtesy, of Computer Science

    BioGordon Wetzstein is an Associate Professor of Electrical Engineering and, by courtesy, of Computer Science at Stanford University. He is the leader of the Stanford Computational Imaging Lab and a faculty co-director of the Stanford Center for Image Systems Engineering. At the intersection of computer graphics and vision, artificial intelligence, computational optics, and applied vision science, Prof. Wetzstein's research has a wide range of applications in next-generation imaging, wearable computing, and neural rendering systems. Prof. Wetzstein is a Fellow of Optica and the recipient of numerous awards, including an NSF CAREER Award, an Alfred P. Sloan Fellowship, an ACM SIGGRAPH Significant New Researcher Award, a Presidential Early Career Award for Scientists and Engineers (PECASE), an SPIE Early Career Achievement Award, an Electronic Imaging Scientist of the Year Award, an Alain Fournier Ph.D. Dissertation Award as well as many Best Paper and Demo Awards.

  • Cornelia Weyand

    Cornelia Weyand

    Professor of Medicine (Immunology and Rheumatology), Emerita

    Current Research and Scholarly InterestsAutoimmunity
    Chronic inflammatory disease
    Metabolic control of immune function

  • Matthew Wheeler

    Matthew Wheeler

    Associate Professor of Medicine (Cardiovascular Medicine)

    Current Research and Scholarly InterestsTranslational research in rare and undiagnosed diseases. Basic and clinical research in cardiomyopathy genetics, mechanisms, screening, and treatment. Investigating novel agents for treatment of hypertrophic cardiomyopathy and new mechanisms in heart failure. Cardiovascular screening and genetics in competitive athletes, disease gene discovery in cardiomyopathy and rare disease. Informatics approaches to rare disease and multiomics. Molecular transducers of physical activity bioinformatics.

  • Bernard Widrow

    Bernard Widrow

    Professor of Electrical Engineering, Emeritus

    Current Research and Scholarly InterestsProf. Widrow's research focuses on adaptive signal processing, adaptive control systems, adaptive neural networks, human memory, and human-like memory for computers. Applications include signal processing, prediction, noise cancelling, adaptive arrays, control systems, and pattern recognition. Recent work is about human learning at the synaptic level.

  • Leanne Williams

    Leanne Williams

    Vincent V.C. Woo Professor and Professor of Psychiatry and Behavioral Sciences (Major Laboratories and Clinical Translational Neurosciences Incubator)

    Current Research and Scholarly InterestsA revolution is under way in psychiatry. We can now understand mental illness as an expression of underlying brain circuit disruptions, shaped by experience and genetics. Our lab is defining precision brain circuit biotypes for depression, anxiety and related disorders. We integrate large amounts of brain imaging, behavioral and clinical data and computational approaches. Biotypes are used in personalized intervention studies with selective drugs, neuromodulation and exploratory therapeutics.

  • Nolan Williams

    Nolan Williams

    Associate Professor of Psychiatry and Behavioral Sciences (Major Laboratories & Clinical Translational Neurosciences Incubator) and, by courtesy, of Radiology (Neuroimaging and Neurointervention)

    BioNolan Williams, M.D. is an Associate Professor of Psychiatry and Behavioral Sciences at Stanford University and Director of the Stanford Brain Stimulation Lab. The long-term goals of his research program are to develop innovative technologies and therapeutics capable of modulating the neural circuitry disrupted in mood disorders, OCD, and other neuropsychiatric conditions. His team has been developing neuroimaging-based approaches to precisely target therapeutic delivery and predict treatment responses to therapeutic neuromodulation and psychedelics. Dr. Williams earned his M.D. and completed his dual residencies in neurology and psychiatry at the Medical University of South Carolina (MUSC). Triple board-certified in general neurology, general psychiatry, as well as behavioral neurology and neuropsychiatry, Dr. Williams brings a comprehensive background in clinical neuroscience to his role as a clinically active neuropsychiatrist. His expertise extends to the development and implementation of novel therapeutics, including devices and novel compounds, for central nervous system illnesses.
    Over the past decade, Dr. Williams’ laboratory alongside collaborators at Stanford University have pioneered multiple novel therapeutic and human neuroscience approaches. Notably, Stanford Accelerated Intelligent Neuromodulation Therapy (SAINT) is the world's first non-invasive, rapid-acting neuromodulation approach for treatment-resistant depression. SAINT received FDA Breakthrough Device Designation Status (2021) and FDA Clearance (2022) and is the first psychiatric treatment to be covered by Medicare New Technology Add-On Payment (NTAP). As of April 2024, SAINT has been reimbursed for patients suffering from severe depression within inpatient psychiatric units. The SAINT technology is being deployed both clinically and in research protocols in laboratories and hospitals worldwide. Dr. Williams also has an expertise in psychedelic medicines for neuropsychiatric illness and is the first investigator to conduct mechanistic clinical trials exploring the neurobiological effects of ibogaine.
    His research accomplishments have garnered international recognition, earning prestigious awards from the Pritzker Neuropsychiatric Disorders Consortium, One Mind Institute, Wellcome Leap Foundation, International Brain Stimulation Conference, National Institute of Mental Health (Biobehavioral Research Award for Innovative New Scientists), Society of Biological Psychiatry (A. E. Bennett Award), along with multiple awards from the Brain Behavior Research Foundation (most notably the Gerald L. Klerman Award and Colvin Prize). His work has been featured in Scientific American, The New York Times, The Washington Post, USA Today, CBS Sunday Morning, and the TODAY Show.

  • Darrell Wilson

    Darrell Wilson

    Professor of Pediatrics (Endocrinology) at the Lucile Salter Packard Children's Hospital, Emeritus

    Current Research and Scholarly InterestsMy research interests cover a number of areas in Pediatric Endocrinology and Diabetes. I am PI of the Stanford Center for the NIH-funded Type-1 Diabetes TrialNet group. TrialNet conducts clinical trials directed at preventing or delaying the onset of Type 1 diabetes. I am an investigator in DirecNet, another NIH-funded study group, which is devoted to evaluating glucose sensors and the role of technology on the management of diabetes.

  • Virginia D. Winn, MD, PhD

    Virginia D. Winn, MD, PhD

    Professor of Obstetrics and Gynecology (Reproductive, Perinatal & Stem Cell Biology Research)

    Current Research and Scholarly InterestsThe Winn Laboratory seeks to understand the unique biological mechanisms of human placentation. While the placenta itself is one of the key characteristics for defining mammals, the human placenta is different from most available animal models: it is one of the most invasive placentas, and results in the formation of an organ comprised of cells from both the fetus and the mother. In addition to this fascinating chimerism, fetal cells are deeply involved in the remodeling of the maternal vasculature in order to redirect large volumes of maternal blood to the placenta to support the developing fetus. As such, the investigation of this human organ covers a large array of biological processes, and deals not only with understanding its endocrine function, but the physiologic process of immune tolerance, vascular remodeling, and cellular invasion.

  • Terry Winograd

    Terry Winograd

    Professor of Computer Science, Emeritus

    BioProfessor Winograd's focus is on human-computer interaction design and the design of technologies for development. He directs the teaching programs and HCI research in the Stanford Human-Computer Interaction Group, which recently celebrated it's 20th anniversary. He is also a founding faculty member of the Hasso Plattner Institute of Design at Stanford (the "d.school") and on the faculty of the Center on Democracy, Development, and the Rule of Law (CDDRL)

    Winograd was a founding member and past president of Computer Professionals for Social Responsibility. He is on a number of journal editorial boards, including Human Computer Interaction, ACM Transactions on Computer Human Interaction, and Informatica. He has advised a number of companies started by his students, including Google. In 2011 he received the ACM SIGCHI Lifetime Research Award.

  • Monte Winslow

    Monte Winslow

    Associate Professor of Genetics and of Pathology

    Current Research and Scholarly InterestsOur laboratory uses genome-wide methods to uncover alterations that drive cancer progression and metastasis in genetically-engineered mouse models of human cancers. We combine cell-culture based mechanistic studies with our ability to alter pathways of interest during tumor progression in vivo to better understand each step of metastatic spread and to uncover the therapeutic vulnerabilities of advanced cancer cells.

  • H.-S. Philip Wong

    H.-S. Philip Wong

    Willard R. and Inez Kerr Bell Professor in the School of Engineering

    BioH.-S. Philip Wong is the Willard R. and Inez Kerr Bell Professor in the School of Engineering at Stanford University. He joined Stanford University as Professor of Electrical Engineering in 2004. From 1988 to 2004, he was with the IBM T.J. Watson Research Center. From 2018 to 2020, he was on leave from Stanford and was the Vice President of Corporate Research at TSMC, the largest semiconductor foundry in the world, and since 2020 remains the Chief Scientist of TSMC in a consulting, advisory role.

    He is a Fellow of the IEEE and received the IEEE Andrew S. Grove Award, the IEEE Technical Field Award to honor individuals for outstanding contributions to solid-state devices and technology, as well as the IEEE Electron Devices Society J.J. Ebers Award, the society’s highest honor to recognize outstanding technical contributions to the field of electron devices that have made a lasting impact.

    He is the founding Faculty Co-Director of the Stanford SystemX Alliance – an industrial affiliate program focused on building systems and the faculty director of the Stanford Nanofabrication Facility – a shared facility for device fabrication on the Stanford campus that serves academic, industrial, and governmental researchers across the U.S. and around the globe, sponsored in part by the National Science Foundation. He is the Principal Investigator of the Microelectronics Commons California-Pacific-Northwest AI Hardware Hub, a consortium of over 40 companies and academic institutions funded by the CHIPS Act. He is a member of the US Department of Commerce Industrial Advisory Committee on microelectronics.

  • Wing Hung Wong

    Wing Hung Wong

    Stephen R. Pierce Family Goldman Sachs Professor of Science and Human Health and Professor of Biomedical Data Science

    Current Research and Scholarly InterestsCurrent interest centers on the application of statistics to biology and medicine. We are particularly interested in questions concerning gene regulation, genome interpretation and their applications to precision medicine.

  • Gabrielle Wong-Parodi

    Gabrielle Wong-Parodi

    Assistant Professor of Earth System Science, Center Fellow at the Woods Institute for the Environment and Assistant Professor of Environmental Social Sciences

    Current Research and Scholarly InterestsTrained as an interdisciplinary social scientist theoretically grounded in psychology and decision science, my work has two aims. First, to understand how people make decisions to address the impacts of climate change. Second, to understand how robust interventions can empower people to make decisions that serve their lives, communities, and society.

  • Joseph Woo, MD, FACS, FACC, FAHA

    Joseph Woo, MD, FACS, FACC, FAHA

    Norman E. Shumway Professor, Professor of Cardiothoracic Surgery and, by courtesy, of Bioengineering

    BioDr. Woo is a board-certified, fellowship-trained cardiothoracic surgeon, cardiovascular surgeon, and transplant surgeon with Stanford Health Care. He is professor and chair of the Stanford Medicine Department of Cardiothoracic Surgery and associate director of the Stanford Cardiovascular Institute. He is also the Norman E. Shumway Professor of Cardiothoracic Surgery and professor, by courtesy, in the Department of Bioengineering.

    Dr. Woo is a nationally recognized surgeon, innovator, researcher, and educator in cardiothoracic surgery. He focuses on complex mitral and aortic valve repair, thoracic aortic surgery, heart and lung transplantation, and minimally invasive heart surgery. He was awarded the American Heart Association’s 2021 Clinical Research Prize for developing innovative and minimally invasive surgeries to repair and reconstruct heart valves.

    In 2022, Dr. Woo and his team at Stanford Health Care performed the first beating-heart transplant from a donation after circulatory death (DCD) donor and organ perfusion system. Keeping a donor heart pumping while it’s transported to the recipient and then implanting the heart while it’s beating minimizes organ damage. This groundbreaking new procedure is expected to increase the number of hearts available for transplant while improving health outcomes.

    As a physician-scientist, Dr. Woo has served as principal investigator on multiple studies funded by National Institutes of Health (NIH) grants. One explored an innovative therapy to stimulate vascular (blood-carrying) stem cells in the bone marrow and direct them to the heart to grow new blood vessels and improve blood flow to damaged heart muscle.

    Dr. Woo has also been the primary investigator for clinical trials involving the administration of stem cells during coronary artery bypass grafting (CABG) and left ventricular assist device (LVAD) implantation. In addition, Dr. Woo has served as primary investigator for multiple clinical device trials. He has filed for and holds patents for several heart-related medical devices and surgical techniques.

    Dr. Woo has co-authored more than 450 articles in peer-reviewed journals and has served as a reviewer for many of them, including the Annals of Thoracic Surgery, Journal of Thoracic and Cardiovascular Surgery, and Circulation. He has also presented his research and performed live surgery demonstrations both nationally and internationally.

    Dr. Woo serves as vice president of the American Association for Thoracic Surgery (AATS) and past president of the AATS Cardiac Surgery Biology Club. He is a fellow of the American College of Surgeons, American College of Cardiology, and American Heart Association. He is a member of many other professional societies, including the World Society of Cardiovascular and Thoracic Surgeons and International Society for Heart Research. He also serves on the leadership committee of the American Heart Association’s Council on Cardiovascular Surgery and Anesthesia.

  • Sherry M. Wren, MD, FACS, FCS(ECSA), FISS

    Sherry M. Wren, MD, FACS, FCS(ECSA), FISS

    Professor of Surgery (General Surgery)

    Current Research and Scholarly InterestsOur research interests are primarily in global surgery,robotics,surgical oncology, especially gastrointestinal cancers.

  • Albert Y. Wu, MD, PhD, FACS

    Albert Y. Wu, MD, PhD, FACS

    Assistant Professor of Ophthalmology

    Current Research and Scholarly InterestsMy translational research focuses on using autologous stem cells to recreate a patient’s ocular tissues for potential transplantation. We are generating tissue from induced pluripotent stem cells to treat limbal stem cell deficiency in patients who are bilaterally blind. By applying my background in molecular and cellular biology, stem cell biology, oculoplastic surgery, I hope to make regenerative medicine a reality for those suffering from orbital and ocular disease.

  • Hsi-Yang Wu

    Hsi-Yang Wu

    Member, Bio-X

    Current Research and Scholarly InterestsI am interested in how the brain matures to control the bladder and external sphincter to achieve urinary continence. Using functional MRI of the brain, we are investigating if certain patterns of activity will predict which children will respond to therapy for incontinence.

  • Jiajun Wu

    Jiajun Wu

    Assistant Professor of Computer Science and, by courtesy, of Psychology

    BioJiajun Wu is an Assistant Professor of Computer Science and, by courtesy, of Psychology at Stanford University, working on computer vision, machine learning, and computational cognitive science. Before joining Stanford, he was a Visiting Faculty Researcher at Google Research. He received his PhD in Electrical Engineering and Computer Science from the Massachusetts Institute of Technology. Wu's research has been recognized through the Young Investigator Programs (YIP) by ONR and by AFOSR, the NSF CAREER award, the Okawa research grant, paper awards and finalists at ICCV, CVPR, SIGGRAPH Asia, CoRL, and IROS, dissertation awards from ACM, AAAI, and MIT, the 2020 Samsung AI Researcher of the Year, and faculty research awards from J.P. Morgan, Samsung, Amazon, and Meta.

  • Joseph  C. Wu, MD, PhD

    Joseph C. Wu, MD, PhD

    Director, Stanford Cardiovascular Institute, Simon H. Stertzer, MD, Professor and Professor of Radiology

    Current Research and Scholarly InterestsDrug discovery, drug screening, and disease modeling using iPSC.

  • Joy Wu

    Joy Wu

    Gerald M. Reaven, MD Professor of Endocrinology

    Current Research and Scholarly InterestsMy laboratory focuses on the pathways that regulate the differentiation of mesenchymal stem cells into the osteoblast and adipocyte lineages. We are also studying the role of osteoblasts in the hematopoietic and cancer niches in the bone marrow microenvironment.

  • Sean M. Wu

    Sean M. Wu

    Professor of Medicine (Cardiovascular Medicine) and, by courtesy, of Pediatrics

    Current Research and Scholarly InterestsMy lab seeks to identify mechanisms regulating cardiac lineage commitment during embryonic development and the biology of cardiac progenitor cells in development and disease. We believe that by understanding the transcriptional and epigenetic basis of cardiomyocyte growth and differentiation, we can identify the most effective ways to repair diseased adult hearts. We employ mouse and human embryonic and induced pluripotent stem cells as well as rodents as our in vivo models for investigation.

  • Courtney Wusthoff, MD

    Courtney Wusthoff, MD

    Professor of Neurology and Neurological Sciences (Pediatric Neurology)

    Current Research and Scholarly InterestsMy projects focus on clinical research in newborns with, or at risk, for brain injury. I use EEG in at-risk neonates to better understand the underlying pathophysiology of risk factors that may lead to worse outcomes. I am particularly interested in neonatal seizures and how they may exacerbate perinatal brain injury with a goal to identify treatments that might protect the vulnerable brain. I am also interested in EEG in other pediatric populations, as well as medical ethics and global health.

  • Joanna Wysocka

    Joanna Wysocka

    Lorry Lokey Professor and Professor of Developmental Biology

    Current Research and Scholarly InterestsThe precise and robust regulation of gene expression is a cornerstone for complex biological life. Research in our laboratory is focused on understanding how regulatory information encoded by the genome is integrated with the transcriptional machinery and chromatin context to allow for emergence of form and function during human embryogenesis and evolution, and how perturbations in this process lead to disease.