Wu Tsai Neurosciences Institute
Showing 101-150 of 531 Results
Associate Professor of Neurosurgery and of Neurology
Current Research and Scholarly InterestsNeural circuits of movement control in health and movement disorders
Senior Associate Vice Provost for Research Platforms/Shared Facilities, Associate Professor of Materials Science and Engineering, Senior Fellow at the Precourt Institute for Energy and Associate Professor, by courtesy, of Radiology
BioJennifer Dionne is the Senior Associate Vice Provost of Research Platforms/Shared Facilities and an Associate Professor of Materials Science and Engineering and of Radiology (by courtesy) at Stanford. Jen received her Ph.D. in Applied Physics at the California Institute of Technology, advised by Harry Atwater, and B.S. degrees in Physics and Systems & Electrical Engineering from Washington University in St. Louis. Prior to joining Stanford, she served as a postdoctoral researcher in Chemistry at Berkeley, advised by Paul Alivisatos. Jen's research develops nanophotonic methods to observe and control chemical and biological processes as they unfold with nanometer scale resolution, emphasizing critical challenges in global health and sustainability. Her work has been recognized with the Alan T. Waterman Award (2019), an NIH Director's New Innovator Award (2019), a Moore Inventor Fellowship (2017), the Materials Research Society Young Investigator Award (2017), Adolph Lomb Medal (2016), Sloan Foundation Fellowship (2015), and the Presidential Early Career Award for Scientists and Engineers (2014), and was featured on Oprah’s list of “50 Things that will make you say ‘Wow!'"
Associate Professor of Biology
Current Research and Scholarly InterestsMy lab is interested in the relationship between cell death and metabolism. Using techniques drawn from many disciplines my laboratory is investigating how perturbation of intracellular metabolic networks can result in novel forms of cell death, such as ferroptosis. We are interested in applying this knowledge to find new ways to treat diseases characterized by insufficient (e.g. cancer) or excessive (e.g. neurodegeneration) cell death.
Diana Do, MD
Professor of Ophthalmology
Current Research and Scholarly InterestsDr. Do's research focuses on collaborative clinical trials to investigate novel treatments for retinal vascular diseases and ocular inflammation. She performs research to develop state of the art therapies for age-related macular degeneration, diabetic eye disease, retinal vein occlusion, retinal inflammation, and retinal detachment.
Professor of Applied Physics and of Physics, Emeritus
Current Research and Scholarly InterestsStudy of changes in conformation of proteins and RNA using x-ray scattering
Les Dorfman, MD
Professor of Neurology and Neurological Sciences, Emeritus
Current Research and Scholarly InterestsClinical electrophysiology of the peripheral and central nervous systems, including nerve conduction velocity; electromyography (EMG); and visual, auditory and somatosensory evoked potentials. Multiple sclerosis (MS) diagnosis and treatment. Neurological education.
Anthony G. Doufas, M.D., Ph.D.
Professor of Anesthesiology, Perioperative and Pain Medicine
Current Research and Scholarly InterestsMy research focuses on the relationship between sleep abnormalities and pain behavior and opioid pharmacology in the postoperative, as well as chronic pain setting. More specifically, I am interested in delineating the effect of the different components of sleep-diosordered breathing, like nocturnal recurrent hypoxemia and sleep fragmentation on pain behavior in the acute and/or chronic care setting.
Associate Professor of Computer Science and, by courtesy, of Molecular and Cellular Physiology and of Structural Biology
Current Research and Scholarly InterestsMy lab’s research focuses on computational biology, with an emphasis on 3D molecular structure. We combine two approaches: (1) Bottom-up: given the basic physics governing atomic interactions, use simulations to predict molecular behavior; (2) Top-down: given experimental data, use machine learning to predict molecular structures and properties. We collaborate closely with experimentalists and apply our methods to the discovery of safer, more effective drugs.
Professor of Anesthesiology, Perioperative and Pain Medicine
Current Research and Scholarly InterestsField of clinical pharmacology. This involves analysis of what the body does to a drug (pharmacokinetics) and how exactly a specific drug affects the body (pharmacodynamics). His research starts at the level of new drug development with detailed analysis of the pharmacokinetics and pharmacodynamics of a medication.
Assistant Professor of Neurobiology, of Psychiatry and Behavioral Sciences and, by courtesy, of Electrical Engineering
Current Research and Scholarly InterestsOur research goal is to understand how dynamics in neuronal circuits relate and constrain the representation of information and computations upon it. We adopt three synergistic strategies: First, we analyze neural circuit population recordings to better understand the relation between neural dynamics and behavior, Second, we theoretically explore the types of dynamics that could be associated with particular network computations. Third, we analyze the structural properties of neural circuits.
Justin Du Bois
Henry Dreyfus Professor of Chemistry and Professor, by courtesy, of Chemical and Systems Biology
BioResearch and Scholarship
Research in the Du Bois laboratory spans reaction methods development, natural product synthesis, and chemical biology, and draws on expertise in molecular design, molecular recognition, and physical organic chemistry. An outstanding goal of our program has been to develop C–H bond functionalization processes as general methods for organic chemistry, and to demonstrate how such tools can impact the logic of chemical synthesis. A second area of interest focuses on the role of ion channels in electrical conduction and the specific involvement of channel subtypes in the sensation of pain. This work is enabled in part through the advent of small molecule modulators of channel function.
The Du Bois group has described new tactics for the selective conversion of saturated C–H to C–N and C–O bonds. These methods have general utility in synthesis, making possible the single-step incorporation of nitrogen and oxygen functional groups and thus simplifying the process of assembling complex molecules. To date, lab members have employed these versatile oxidation technologies to prepare natural products that include manzacidin A and C, agelastatin, tetrodotoxin, and saxitoxin. Detailed mechanistic studies of metal-catalyzed C–H functionalization reactions are performed in parallel with process development and chemical synthesis. These efforts ultimately give way to advances in catalyst design. A long-standing goal of this program is to identify robust catalyst systems that afford absolute control of reaction selectivity.
In a second program area, the Du Bois group is exploring voltage-gated ion channel structure and function using the tools of chemistry in combination with those of molecular biology, electrophysiology, microscopy and mass spectrometry. Much of this work has focused on studies of eukaryotic Na and Cl ion channels. The Du Bois lab is interested in understanding the biochemical mechanisms that underlie channel subtype regulation and how such processes may be altered following nerve injury. Small molecule toxins serve as lead compounds for the design of isoform-selective channel modulators, affinity reagents, and fluorescence imaging probes. Access to toxins and modified forms thereof (including saxitoxin, gonyautoxin, batrachotoxin, and veratridine) through de novo synthesis drives studies to elucidate toxin-receptor interactions and to develop new pharmacologic tools to study ion channel function in primary cells and murine pain models.
Alfredo Dubra, PhD
Professor of Ophthalmology
Current Research and Scholarly InterestsOur lab seeks to help the early diagnosing and monitoring progression of ocular, vascular, neurodegenerative and systemic diseases through novel non-invasive optical ophthalmic imaging. We pursue this goal through a multidisciplinary approach that integrates optics, computer science, vision science, electrical engineering and other engineering disciplines.
Assistant Professor of Psychiatry and Behavioral Sciences (Major Laboratories and Clinical Translational Neurosciences Incubator)
Current Research and Scholarly InterestsWe study genetic and environmental effects on mental health. Much of our work is computational and it relies upon genetic data, collected from millions of individuals, from around the world. We use genetic approaches because the overall goal of the lab is to discover fundamental information about psychiatric disorders, and ultimately to build more rational approaches to classification, prevention, and treatment.
Associate Professor of Chemical Engineering
Current Research and Scholarly InterestsMy lab is deeply interested in uncovering the physical principles that underlie the construction of complex, multicellular animal life.
Professor of Surgery (Pediatric Surgery) and, by courtesy, of Bioengineering
Current Research and Scholarly InterestsIntestinal lengthening for short bowel syndrome
Intestinal stem cell therapy for intestinal failure
Skin derived precursor cell therapy for enteric neuromuscular dysfunction
Intestinal tissue engineering
Emmanuel During, MD
Clinical Associate Professor, Neurology & Neurological Sciences
Current Research and Scholarly InterestsImproving diagnostics and therapeutics in RBD, using home ambulatory devices including wearable actigraphy, dry-EEG, to power clinical trials based on objective outcomes of RBD activity.
Controlling symptoms of RBD testing drugs rigorously.
Predicting the course of neurodegeneration using deep phenotyping using clinical and serum biomarkers, measures of autonomic impairment, skin biopsy, microbiome
Professor of Medicine (Infectious Diseases) and of Microbiology and Immunology
Current Research and Scholarly InterestsOur basic research program focuses on understanding the roles of virus-host interactions in viral infection and disease pathogenesis via molecular and systems virology single cell approaches. This program is combined with translational efforts to apply this knowledge for the development of broad-spectrum host-centered antiviral approaches to combat emerging viral infections, including dengue, coronaviruses, encephalitic alphaviruses, and Ebola, and means to predict progression to severe disease.
Abbas El Gamal
Hitachi America Professor in the School of Engineering and Senior Fellow at the Precourt Institute for Energy
BioAbbas El Gamal is the Hitachi America Professor in the School of Engineering and Professor in the Department of Electrical Engineering at Stanford University. He received his B.Sc. Honors degree from Cairo University in 1972, and his M.S. in Statistics and Ph.D. in Electrical Engineering both from Stanford University in 1977 and 1978, respectively. From 1978 to 1980, he was an Assistant Professor of Electrical Engineering at USC. From 2003 to 2012, he was the Director of the Information Systems Laboratory at Stanford University. From 2012 to 2017 he was Chair of the Department of Electrical Engineering at Stanford University. His research contributions have been in network information theory, FPGAs, and digital imaging devices and systems. He has authored or coauthored over 230 papers and holds 35 patents in these areas. He is coauthor of the book Network Information Theory (Cambridge Press 2011). He has received several honors and awards for his research contributions, including the 2016 Richard W. Hamming Medal, the 2012 Claude E. Shannon Award, and the 2004 INFOCOM Paper Award. He is a member of the U.S. National Academy of Engineering and a Fellow of the IEEE. He has co-founded and served on the board of directors and advisory boards of several semiconductor and biotechnology startup companies.
Professor of Pathology and of Medicine (Immunology and Rheumatology)
Current Research and Scholarly InterestsDendritic cells, macrophages, NK cells and T cells; functional proteins and genes; immunotherapeutic approaches to cancer, autoimmune disease, neurodegenerative disease and metabolic disease.
Neir Eshel, MD, PhD
Assistant Professor of Psychiatry and Behavioral Sciences (Major Laboratories & Clinical Translational Neurosciences Incubator)
BioDr. Eshel (he/him/his) is a tenure-track Assistant Professor in the Department of Psychiatry & Behavioral Sciences at Stanford University School of Medicine.
His clinical focus is the full-spectrum mental health care of sexual and gender minorities, with particular interest in depression, anxiety, and the complex effects of trauma in this population. He works in collaboration with other primary care and mental health providers at the new Stanford LGBTQ+ program.
His research interests (www.staarlab.com) include the use of optogenetic, electrophysiological, neuroimaging, and behavioral approaches to probe the neural circuits of reward processing, decision making, and social behavior. He recently won multi-year grants from the National Institute of Mental Health, Burroughs-Wellcome Fund, Brain and Behavior Research Foundation, and Simons Foundation to study the neural circuits of frustration and aggression.
Dr. Eshel has published articles on topics such as the role of dopamine in learning, the neuroscience of irritability, LGBTQ health, reward and punishment processing in depression, behavioral predictors of substance use among adolescents, and the mechanism of transcranial magnetic stimulation. His work has appeared in Nature, Science, Nature Neuroscience, Annual Review of Neuroscience, JAMA, JAMA Psychiatry, Neuropsychopharmacology, Proceedings of the National Academy of Sciences, and Journal of Neuroscience. He is also the author of the book Learning: The Science Inside, a publication of the American Association for the Advancement of Science.
He has delivered presentations on anger expression in patients with PTSD, the neural circuitry of learning, dopamine prediction errors, and LGBTQ-related topics at meetings of the American College of Neuropsychopharmacology, Society of Biological Psychiatry, and Association of American Medical Colleges, among others. He is also an associate editor of the Journal of Gay and Lesbian Mental Health, and an ad-hoc reviewer for numerous publications including Science, JAMA Psychiatry, Biological Psychiatry, and Current Biology.
Dr. Eshel has won honors for his scholarship and advocacy, including the Marshall Scholarship, the Outstanding Resident Award from the National Institute of Mental Health, the Science and SciLifeLab Grand Prize for Young Scientists, and the National LGBT Health Achievement Award.
He is a member of the American Psychiatric Association, Society of Biological Psychiatry, Association of Gay & Lesbian Psychiatrists, Society for Neuroscience, and other professional associations. He is also an advocate for LGBTQ rights, recently serving as the LGBTQ Chair of the Stanford Graduate Medical Education Diversity Committee.
Prior to Stanford, Dr. Eshel trained and conducted research at the National Institutes of Health, Princeton University, the World Health Organization, University College London, and Harvard University.
Robert Michael Fairchild
Assistant Professor of Medicine (Immunology and Rheumatology)
Current Research and Scholarly InterestsDr. Fairchild’s research interests center on novel applications of ultrasonography in rheumatologic disease. Current active research endeavors include using ultrasound 1) to evaluate articular and soft tissue manifestations of systemic sclerosis, 2) to screen, detect and monitor of connective tissue disease associated interstitial lung disease, 3) and applying deep learning techniques to rheumatology ultrasound and imaging.
Assistant Professor of Neurosurgery
Current Research and Scholarly InterestsEarly neural progenitors respond to extrinsic cues that maintain and support their potency. These stem/ progenitor cells are in direct contact with the cerebrospinal fluid (CSF), which acts as part of their niche. Our research program encompasses the early neural stem cell niche, neural tube closure, CSF, metabolism, and cortical neuronal development. We are dedicated to broad collaboration focused on translating an understanding of neurodevelopment and CSF biology into regenerative strategies.
Associate Professor of Electrical Engineering
Current Research and Scholarly InterestsOptical engineering plays a major role in imaging, communications, energy harvesting, and quantum technologies. We are exploring the next frontier of optical engineering on three fronts. The first is new materials development in the growth of crystalline plasmonic materials and assembly of nanomaterials. The second is novel methods for nanofabrication. The third is new inverse design concepts based on optimization and machine learning.
C. Garrison Fathman
Professor of Medicine (Immunology and Rheumatology), Emeritus
Current Research and Scholarly InterestsMy lab of molecular and cellular immunology is interested in research in the general field of T cell activation and autoimmunity. We have identified and characterized a gene (GRAIL) that seems to control regulatory T cell (Treg) responsiveness by inhibiting the Treg IL-2 receptor desensitization. We have characterized a gene (Deaf1) that plays a major role in peripheral tolerance in T1D. Using PBC gene expression, we have provisionally identified a signature of risk and progression in T1D.
Heidi M. Feldman
Ballinger-Swindells Endowed Professor of Developmental and Behavioral Pediatrics
Current Research and Scholarly InterestsMy current research program focuses on infants born preterm, before 32 weeks gestation from two language environments: English and Spanish. The study considers how neurobiological factors, specifically properties of the white matter circuits in the brain, interact with social, psychological, and economic factors to predict language processing efficiency at 18 months of age.
Burnet C. and Mildred Finley Wohlford Professor
Current Research and Scholarly InterestsHuman genetic and cultural evolution, mathematical biology, demography of China
Associate Professor of Molecular and Cellular Physiology
Current Research and Scholarly InterestsWe are interested in the structure, dynamics and function of eukaryotic transport proteins mediating ions and major nutrients crossing the membrane, the kinetics and regulation of transport processes, the catalytic mechanism of membrane embedded enzymes and the development of small molecule modulators based on the structure and function of membrane proteins.
Russell D. Fernald
Benjamin Scott Crocker Professor of Human Biology, Emeritus
Current Research and Scholarly InterestsIn the course of evolution,two of the strongest selective forces in nature,light and sex, have left their mark on living organisms. I am interested in how the development and function of the nervous system reflects these events. We use the reproductive system to understand how social behavior influences the main system of reproductive action controlled by a collection of cells in the brain containing gonodotropin releasing hormone(GnRH)
Juan Carlos Fernandez-Miranda
Professor of Neurosurgery and, by courtesy, of Otolaryngology - Head & Neck Surgery (OHNS)
BioDr. Juan Fernandez-Miranda is Professor of Neurosurgery and Surgical Director of the Stanford Brain Tumor, Skull Base, and Pituitary Centers. He is internationally renowned for his expertise in minimally invasive brain surgery, endoscopic skull base and pituitary surgery, open skull base surgery, and complex brain tumor surgery. He has performed nearly 3,000 cranial operations including over 1,500 endoscopic endonasal operations for pituitary tumors and other skull base lesions. He is highly regarded for his innovative contributions to the development and refinement of endoscopic endonasal skull base surgery, for his ability to select the most effective and less invasive approach to each individual patient, and for his precise knowledge of the intricate anatomy of the white matter tracts required to maximize resection and minimize morbidity on high and low grade glioma patients. He has been recently ranked by Expertscape as World-Expert (top 0.05%) on Skull Base Surgery and #1 Neurosurgeon Expert on Skull Base Tumors (pituitary adenomas, meningiomas, craniopharyngiomas, chordomas, chondrosarcomas, schwannomas and esthesioneuroblastomas) on the US Pacific Region. He is co-founder and vice-president of the International Rhoton Society and executive member of the Board of Directors of the The Neurosurgical Atlas, the largest nonprofit organization for neurosurgical education and research in the world.
Dr. Fernandez-Miranda completed neurosurgery residency at La Paz University Hospital in Madrid, Spain. Upon completion of his residency, he was awarded the Sanitas Prize to the best medical postgraduate trainee in the country. From 2005 to 2007, he underwent fellowship training in microsurgical neuroanatomy at the University of Florida under legendary neurosurgeon Albert L. Rhoton, Jr. From 2007 to 2010 he continued subspecialty clinical training in cerebrovascular surgery at the University of Virginia, and endoscopic endonasal and open skull base surgery at University of Pittsburgh Medical Center (UPMC). During his 10-year tenure at UPMC, he pioneered endoscopic endonasal approaches to highly complex pituitary and skull base tumors, developed a world-class complex brain surgery program, and led a premier training and research program on surgical neuroanatomy and skull base surgery.
In 2018, he was recruited to bring to Stanford his unique technical expertise and to collaborate with world-renowned Stanford colleagues across multiple disciplines, leading the establishment of one of the most preeminent centers worldwide for comprehensive treatment of complex lesions in the brain, skull base, and pituitary regions. His top priority is to provide gentle, accurate, and safe surgery, in a team-based and compassionate approach to patient care.
Professor of Radiology (Molecular Imaging Program at Stanford)
Current Research and Scholarly InterestsMy focus is image-guided drug and gene delivery and I am engaged in the design of imaging devices, molecularly-targeted imaging probes and engineered delivery vehicles, drawing upon my education in biology and imaging physics and more than 20 years of experience with the synthesis and labeling of therapeutic particles. My laboratory has unique resources for and substantial experience in synthetic chemistry and ultrasound, CT, MR and PET imaging.
Professor of Chemical and Systems Biology and of BiochemistryOn Leave from 05/08/2023 To 07/31/2023
Current Research and Scholarly InterestsMy lab has two main goals: to understand the regulation of mitosis and to understand the systems-level logic of simple signaling circuits. We often make use of Xenopus laevis oocytes, eggs, and cell-free extracts for both sorts of study. We also carry out single-cell fluorescence imaging studies on mammalian cell lines. Our experimental work is complemented by computational and theoretical studies aimed at understanding the design principles and recurring themes of regulatory circuits.
George D. Smith Professor of Molecular and Genetic Medicine and Professor of Pathology and of GeneticsOn Leave from 05/15/2023 To 06/25/2023
Current Research and Scholarly InterestsWe study natural cellular mechanisms for adapting to genetic change. These include systems activated during normal development and those for detecting and responding to foreign or unwanted genetic activity. Underlying these studies are questions of how a cells can distinguish information as "self" versus "nonself" or "wanted" versus "unwanted".
David Starr Jordan ProfessorOn Leave from 10/01/2022 To 06/30/2023
Current Research and Scholarly InterestsEvolutionary & ecological dynamics & diversity, microbial, expt'l, & cancer
Paul Graham Fisher, MD
Beirne Family Professor of Pediatric Neuro-Oncology, Professor of Pediatrics and, by courtesy, of Neurosurgery and of Epidemiology and Population Health
Current Research and Scholarly InterestsClinical neuro-oncology: My research explores the epidemiology, natural history, and disease patterns of brain tumors in childhood, as well as prospective clinical trials for treating these neoplasms. Research interests also include neurologic effects of cancer and its therapies, and childhood headaches.
Robert Fisher, MD, PhD
The Maslah Saul, MD, Professor and Professor, by courtesy, of Neurosurgery
Current Research and Scholarly InterestsDr. Fisher is interested in clincal, laboratory and translational aspects of epilepsy research. Prior work has included: electrical deep brain stimulation for epilepsy, studied in laboratory models and clinical trials; drug delivery to a seizure focus; mechanisms of absence epilepsy studied with in vitro slices of brain thalamus; hyperthermic seizures; diagnosis and treatment of non-epileptic seizures, the post-ictal state; driving and epilepsy; new antiepileptic drugs; surgery for epilepsy.
Matthew Fitzgerald, PhD
Assistant Professor of Otolaryngology - Head & Neck Surgery (OHNS)
Current Research and Scholarly InterestsMy research encompasses several translational projects. One focus is to modify the routine audiologic test battery such that it places equal weight on hearing acuity and hearing function. This work includes measures of speech in noise, or electrophysiologic responses such as the FFR. I also explore tools to better assess and maximize performance in users of hearing aids and cochlear implants. Finally, I am also investigating the benefits of telemedicine, and new treatments for tinnitus.
Adjunct Clinical Professor, Anesthesiology, Perioperative and Pain Medicine
BioDr. Flood is a Professor at Stanford University who is fellowship trained in Pain Medicine and Obstetric Anesthesiology. She specializes in the treatment of chronic pelvic pain and multiple aspects of women's health including the prevention of chronic pain after childbirth. Research interests include the role of multimodal treatment in chronic pain conditions and prevention of persistent opioid use. Her research has spanned from detailed pharmacodynamic analysis, clinical trials to population health.
Associate Professor of Bioengineering and of Genetics
Current Research and Scholarly InterestsThe Fordyce Lab is focused on developing new instrumentation and assays for making quantitative, systems-scale biophysical measurements of molecular interactions. Current research in the lab is focused on three main platforms: (1) arrays of valved reaction chambers for high-throughput protein expression and characterization, (2) spectrally encoded beads for multiplexed bioassays, and (3) sortable droplets and microwells for single-cell assays.
Professor of Statistics and of Computer Science
BioEmily Fox is a Professor in the Department of Statistics and, by courtesy, Computer Science at Stanford University. Prior to Stanford, she was the Amazon Professor of Machine Learning in the Paul G. Allen School of Computer Science & Engineering and Department of Statistics at the University of Washington. From 2018-2021, Emily led the Health AI team at Apple, where she was a Distinguished Engineer. Before joining UW, Emily was an Assistant Professor at the Wharton School Department of Statistics at the University of Pennsylvania. She earned her doctorate from Electrical Engineering and Computer Science (EECS) at MIT where her thesis was recognized with EECS' Jin-Au Kong Outstanding Doctoral Thesis Prize and the Leonard J. Savage Award for Best Thesis in Applied Methodology.
Emily has been awarded a CZ Biohub Investigator Award, Presidential Early Career Award for Scientists and Engineers (PECASE), a Sloan Research Fellowship, ONR Young Investigator Award, and NSF CAREER Award. Her research interests are in large-scale Bayesian dynamic modeling, interpretability and computations, with applications in health and computational neuroscience.
David and Lucile Packard Foundation Professor of Human Biology and Professor, by courtesy, of Linguistics
Current Research and Scholarly InterestsHow do we learn to communicate using language? I study children's language learning and how it interacts with their developing understanding of the social world. I use behavioral experiments, computational tools, and novel measurement methods like large-scale web-based studies, eye-tracking, and head-mounted cameras.
Professor of Biology
Current Research and Scholarly InterestsWe study the evolution of complex traits by developing new experimental and computational methods.
Our work brings together quantitative genetics, genomics, epigenetics, and evolutionary biology to achieve a deeper understanding of how genetic variation shapes the phenotypic diversity of life. Our main focus is on the evolution of gene expression, which is the primary fuel for natural selection. Our long-term goal is to be able to introduce complex traits into new species via genome editing.
Professor of Medicine (Gastroenterology and Hepatology)
Current Research and Scholarly Interests1. Gastrointestinal Endoscopy- Techniques and Outcomes
2. Noninvasive colorectal cancer screening
3. Medical device development in gastroenterology
Donald Kennedy Chair in the School of Humanities and Sciences and Professor of GeneticsOn Leave from 04/01/2023 To 06/30/2023
Current Research and Scholarly InterestsThe long term goal of our research is to understand how proteins fold in living cells. My lab uses a multidisciplinary approach to address fundamental questions about molecular chaperones, protein folding and degradation. In addition to basic mechanistic principles, we aim to define how impairment of cellular folding and quality control are linked to disease, including cancer and neurodegenerative diseases and examine whether reengineering chaperone networks can provide therapeutic strategies.
Associate Professor of Music
BioResearch topics include neural oscillations for auditory perception, auditory-motor coupling, brain plasticity in development and aging, and recovery from stroke with music-supported therapy.
Her post-doctoral and research-associate work at Rotman Research Institute in Toronto was supported by awards from the Canadian Institutes of Health Research. Her research continues to explore the biological nature of human musical ability by examining brain activities with non-invasive human neurophysiological measures such as magnetoencephalography (MEG) and electroencephalography (EEG).
Sanjiv Sam Gambhir, MD, PhD
Current Research and Scholarly InterestsMy laboratory focuses on merging advances in molecular biology with those in biomedical imaging to advance the field of molecular imaging. Imaging for the purpose of better understanding cancer biology and applications in gene and cell therapy, as well as immunotherapy are all being studied. A key long-term focus is the earlier detection of cancer by combining in vitro diagnostics and molecular imaging.
Associate Professor of Applied Physics and, by courtesy, of Neurobiology and of Electrical Engineering
Current Research and Scholarly InterestsTheoretical / computational neuroscience
Assistant Professor of Chemical Engineering
Current Research and Scholarly InterestsHow do we design biological systems as “smart medicine” that sense patients’ states, process the information, and respond accordingly? To realize this vision, we will tackle fundamental challenges across different levels of complexity, such as (1) protein components that minimize their crosstalk with human cells and immunogenicity, (2) biomolecular circuits that function robustly in different cells and are easy to deliver, (3) multicellular consortia that communicate through scalable channels, and (4) therapeutic modules that interface with physiological inputs/outputs. Our engineering targets include biomolecules, molecular circuits, viruses, and cells, and our approach combines quantitative experimental analysis with computational simulation. The molecular tools we build will be applied to diverse fields such as neurobiology and cancer therapy.