Stanford University
Showing 301-400 of 12,875 Results
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Al'ai Alvarez, MD
Clinical Professor, Emergency Medicine
Current Research and Scholarly InterestsI am a Biodesign Faculty Fellow graduate, and my active research is on using biometrics for personalized fatigue-mitigation lifestyle coaching in high-performance teams to minimize sleep-related disruptions.
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Estephannie Alvarez
Assistant Clinical Research Coordinator, Dermatology
Current Role at StanfordAssistant Clinical Research Coordinator
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Ruben Alvero, M.D.
Clinical Professor, Obstetrics & Gynecology - Reproductive Endocrinology & Infertility
BioDr. Ruben Alvero is Professor of Obstetrics and Gynecology at Stanford Medical School and is the Division Director of Reproductive Endocrinology and Infertility at the Lucille Packard Children’s Hospital. He is Board Certified in Obstetrics and Gynecology and in Reproductive Endocrinology and Infertility. He is a fellow of the American College of Obstetrics and Gynecology and the American College of Surgeons.
Following undergraduate training at Harvard College (BA, Economics, 1980), Dr. Alvero received his medical degree from the Uniformed Services University of the Health Sciences in Bethesda, Maryland in 1986. He completed his residency in Obstetrics and Gynecology at Walter Reed Army Medical Center (1990) and a fellowship in Reproductive Endocrinology and Infertility at the National Institutes of Health (NIH, 1995).
Dr. Alvero was the Division Director for Infertility Services at the National Naval Medical Center (Bethesda) and Walter Reed Army Medical Center and faculty in the NIH-sponsored fellowship in Reproductive Endocrinology and Infertility. Dr. Alvero remained a reserve Colonel in the U.S. Army Medical Corps until 2012 and during 27 years in the Army was mobilized several times for missions around the world, including service in Iraq, Kuwait, Mongolia, Germany and various locations in the United States.
Dr. Alvero was Professor of Obstetrics and Gynecology and Vice Chair for Education at the University of Colorado Health Sciences Center and the Director of the Assisted Reproductive Technologies, and founding member of the Center for Surgical Innovation. Dr. Alvero was Residency Program Director in Obstetrics and Gynecology at the University of Colorado. He was subsequently Division and Fellowship Director at Brown University.
The Council in Residency Education in Obstetrics and Gynecology awarded him its National Faculty Award for Excellence three times. He has been NIH-funded, most recently as part of the Reproductive Medicine Network.
Dr. Alvero is currently the Vice President of the Society for Reproductive Endocrinology, the national organization of fertility specialists and will take over as President in October 2020.
Dr. Alvero’s clinical interests include IVF, polycystic ovary syndrome, endometriosis and robotic surgery. Dr. Alvero’s research interests include non-invasive evaluation of embryo quality, cost-effectiveness analysis, and the role of critical thinking in medical education. A fluent Spanish-speaker, Dr. Alvero is also dedicated to improving the health of the Latinx community.
Dr. Alvero is happiest on the water, whether sailing or singles rowing. He is also constantly attempting to improve his mastery of Latin American cuisine. Most of all, he loves spending time with his family. -
Jurgis Alvikas
Clinical Assistant Professor, Surgery - General Surgery
BioDr. Jurgis Alvikas was born in Lithuania and moved to Chicago as a teenager. He graduated magna cum laude from the University of Illinois at Urbana–Champaign with a degree in Molecular and Cellular Biology and earned his M.D. from the University of Illinois at Chicago College of Medicine, where he was inducted into Alpha Omega Alpha. He then completed his General Surgery residency and a fellowship in Complex General Surgical Oncology at the University of Pittsburgh Medical Center.
He is passionate about caring for patients with hepato-biliary and gastrointestinal malignancies and about mentoring surgical trainees. Outside of medicine, he enjoys running, reading, and spending time with his family. -
Jennifer Alyono, MD, MS
Clinical Associate Professor, Otolaryngology (Head and Neck Surgery)
BioDr. Alyono completed her undergraduate degree in Chemistry as well as her master’s degree in Bioengineering at Stanford University. After completing medical school at the University of California, San Diego, she returned to Stanford where she completed both her residency in Otolaryngology-Head & Neck Surgery, as well as her fellowship in Otology/Neurotology and Skull base surgery. Clinically, Dr. Alyono specializes in adult and pediatric surgery for disorders of the middle ear, inner ear, ear canal, facial nerve, and skull base. This includes care for hearing loss, tympanic membrane perforations, cholesteatoma, glomus tumors, and vestibular schwannomas, among others. Her research interests lie in hearing in population health, quality of care, and technology in medicine.
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Zainab (Zaina) Alzawad
Clinical Assistant Professor, Emergency Medicine
BioDr. Zaina Alzawad is a clinical strategist with extensive experience advancing patient care through research, data-driven innovation, and interdisciplinary collaboration. She currently serves as a Clinical Development and Data Strategy Consultant in the Emergency Department at Stanford Health Care, where she leads and supports research and quality initiatives aimed at improving care delivery, operational efficiency, and clinical outcomes.
Dr. Alzawad’s research background is grounded in pediatric intensive care, with a growing focus on emergency care systems and innovation. She brings specialized expertise in psychometrics, quantitative and qualitative methodologies, and healthcare data analysis, supported by advanced training in measurement, statistics, and nursing science. She previously served as a Nurse Scientist at Stanford Health Care, where she led interdisciplinary studies and mentored clinical teams in research and evaluation. Driven by a passion for inquiry and impact, Dr. Alzawad actively mentors interdisciplinary teams and contributes to the design, implementation, and dissemination of studies that inform clinical practice. -
Derek F. Amanatullah, M.D., Ph.D.
Associate Professor of Orthopaedic Surgery
BioDerek F. Amanatullah, M.D., Ph.D., is an internationally recognized expert in hip and knee replacement. He helps patients with advanced arthritis and complex joint problems regain mobility and confidence. In addition to primary hip and knee replacements, he is frequently sought out for difficult revision surgeries, often fixing complications such as infection, instability, or persistent pain from prior procedures.
Dr. Amanatullah focuses on what truly lowers surgical risk: the skill, preparation, and coordination of the surgical team. He believes patients deserve care that relies on evidence and expert technique rather than placing the burden solely on weight or other patient factors. This patient-centered approach was highlighted by The New York Times.
As a researcher, he discovered an important new way certain infections can remain “hidden” in the body, shaping how surgeons diagnose and treat joint infections. His impact on the field earned him induction into The Knee Society, an honor held by fewer than 200 surgeons worldwide. Patients choose Dr. Amanatullah for his precision, innovation, and commitment to providing the safest, most effective joint care possible. -
Michelle Ameri, BA, RVT
Affiliate, Pediatrics - Cardiology
BioMichelle received a BA in Biology from the University of North Carolina at Asheville. Immediately after graduation, she entered the veterinary field as an assistant and thrived in the field, eventually receiving her Registered Veterinary Technician license in 2001. Prior to working at Stanford, she was the head nurse at Peninsula Equine Medical Center in Menlo Park where her duties included everything from front office work to ICU patient care to administering and monitoring anesthesia on 1000+ lb horses. She also has been an Adjunct Instructor at Foothill College in Los Altos, CA for the Veterinary Technician Program.
Since joining the Rabinovitch-Bland Lab in 2004, her role has been overseeing the day-to-day needs of the laboratory and staff. In addition to providing administrative support to the PI's and researchers, she oversees the financial and regulatory aspects of our program. Michelle really enjoys being part of a team. Her 25+ years in the veterinary field has made her proficient at working with doctors, students, and staff members. Her degree and background in the medical field are useful tools to bring to the table, and she prides herself on being proactive, organized, and having a positive attitude. When not at Stanford, you can find her at the beach, hiking with her dog, or riding her horse. -
Manuel R. Amieva
Professor of Pediatrics (Infectious Diseases) and of Microbiology and Immunology
Current Research and Scholarly InterestsMy laboratory studies how bacteria colonize our bodies for long periods of time, and how interactions between bacteria and the epithelial surfaces of the gastrointestinal tract and skin may lead to disease. Epithelial surfaces are the first barrier against infection, but they also where our bodies meet and co-evolve with the microbial world.. Several of our studies have focused on the epithelial junctions as a target for bacterial pathogens. The host epithelium uses its epithelial junctions to form a tight but dynamic barrier with an external surface that is inhospitable to microbial attachment, secretes anti-microbial compounds, and has a rapid rate of self-renewal. The balance in the microbe-epithelial relationship results in silent commensalism or symbiosis; an imbalance results in diseases ranging from acute bacterial invasive disease to chronic ulcers or carcinoma.
Our laboratory has developed novel microscopy applications such as quantitative 3D confocal microscopy, electron microscopy, time-lapse imaging, microinjection and micromanipulation to visualize the interaction of pathogens with epithelial cells in culture and in animal and human tissues. Many of out studies focus on the gastric pathogen Helicobacter pylori, but we have also expanded our investigations to include the intestinal pathogens Listeria monocytogenes and Salmonella enterica, and the skin pathogen and colonizer Staphylococcus aureus. I believe that elucidating how microbes communicate with and alter our epithelial cells at a molecular level will be important for finding novel therapeutic targets to control mucosal colonization and prevent invasive disease.
Using this perspective, we have uncovered several novel concepts of how bacteria colonize and breach our epithelial surfaces. For example, we discovered that Helicobacter pylori target the intercellular junctions, and in particular that the virulence factor CagA affects junction assembly and cell polarity. This confers H. pylori the ability to extract nutrients and grow directly on the epithelial surface. We also found that these properties of CagA have consequences for cellular transformation of the epithelium. For instance, we showed that H. pylori affect the activity and state of epithelial stem cells in the stomach by colonizing the epithelial surface deep in the gastric glands. This gland-associated population is essential for pathological inflammation and hyperplasia in animal models, and confers significant colonization advantages to the bacteria. Our Listeria research uncovered a new mechanism and site where bacteria can breach the gastrointestinal epithelial barrier to invade. We found that Listeria find their receptor for invasion at sites of epithelial senescence, where the epithelial junctions undergo dynamic turnover. To study Salmonella and H. pylori we have developed a human organoid model to study their interactions with human gut epithelium in vitro. To study Staphylococcus aureus pathogenesis, we have developed methods to visualize infection at the scale of a single bacterial microcolony using an organoid culture system of human keratinocytes and fibroblasts that grow into a 3D skin-equivalent. We recently identified several proteins at the eptithelial junctions as host factors involved in the pathogenesis of one of Staphylococcus aureus major toxins. -
Daniel Kwasi Amponsah
Affiliate, Department Funds
Fellow in Medicine - Med/Cardiovascular MedicineBioDr. Daniel Amponsah was born and raised in Loma Linda, California. He graduated with a BS in Biochemistry from Pacific Union College in Northern California and received his MD from Loma Linda University School of Medicine where he graduated AOA. He completed his internal medicine residency at Massachusetts General Hospital and was appointed the Simulation Chief his senior year. He is interested in pursuing an academic career in interventional cardiology with a focus on outcomes and health disparities. Prior research work has explored outcomes in ischemic time in patients with cardiogenic shock and STEMI with Dr. Anthony Hilliard, disparities in the management of aortic stenosis alongside Dr. Sammy Elmariah, defining type 2 MI using coronary CT with Dr. James Januzzi. He is presently engaged in assessing the potential applications of angiography-derived FFR and IMR across various coronary disease syndromes with Dr. Bill Fearon and investigating disparities in advanced structural interventions with Dr. Celina Yong.
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Michael Amylon
Professor of Pediatrics (Hematology/Oncology) at the Lucile Salter Packard Children's Hospital, Emeritus
Current Research and Scholarly InterestsBone marrow transplantation (BMT) is a treatment modality which is being broadly applied to a growing number of disorders. Increasing success with BMT is offering improved survival to pediatric and adult patients with acute leukemia, chronic leukemia, lymphomas, and a variety of solid tumors as well as severe aplastic anemia.
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Shivesh Anand
Postdoctoral Scholar, Cardiothoracic Surgery
BioDr. Shivesh Anand is an NWO Rubicon Postdoctoral Fellow in the Department of Cardiothoracic Surgery at Stanford University, specializing in tissue engineering and regenerative medicine. He completed his PhD at the MERLN Institute (Maastricht, Netherlands), where he applied biomaterials, biofabrication, and biomodulation strategies to develop nano-engineered scaffolds for tympanic membrane regeneration. His global research trajectory is deeply interdisciplinary, including research appointments at Harvard-MIT Health Sciences and Technology (United States), A*STAR (Singapore), IBEC Barcelona (Spain), and Aarhus University (Denmark). Currently focused on active regenerative engineering, he investigates how multimodal biophysical cues modulate cell fate and tissue regeneration.
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Shuchi Anand
Associate Professor - University Medical Line, Medicine - Nephrology
Current Research and Scholarly InterestsManagement of CKD and ESRD in low-resource settings
Tubulointerstitial disease
Chronic kidney disease of unknown etiology
ESRD and physical activity
ESRD and vitamin D deficiency -
Kanwaljeet S. Anand
Professor of Pediatrics (Pediatric Critical Care) and of Anesthesiology, Perioperative and Pain Medicine
Current Research and Scholarly InterestsDr. Anand is a translational clinical researcher who pioneered research on the endocrine-metabolic stress responses of infants undergoing surgery and developed the first-ever scientific rationale for pain perception in early life. This provided a framework for newer methods of pain assessment, numerous clinical trials of analgesia/anesthesia in newborns, infants and older children. His research focus over the past 30+ years has contributed fundamental knowledge about pediatric pain/stress, long-term effects of pain in early life, management of pain, mechanisms for opioid tolerance and withdrawal. Current projects in his laboratory are focused on developing biomarkers for repetitive pain/stress in critically ill children and the mechanisms underlying sedative/anesthetic neurotoxicity in the immature brain. He designed and directed many randomized clinical trials (RCT), including the largest-ever pediatric analgesia trial studying morphine therapy in ventilated preterm neonates. He has extensive experience in clinical and translational research from participating in collaborative networks funded by NIMH, NINDS, or NICHD, a track-record of excellent collaboration across multiple disciplines, while achieving success with large research teams like the Collaborative Pediatric Critical Care Research Network (CPCCRN). He played a leadership roles in CANDLE (Condition Affecting Neuro-Development & Learning in Early infancy) and other activities of the Urban Child Institute and UT Neuroscience Institute. More recently, he led the NeoOpioid Consortium funded by the European Commission, which collected data from 243 NICUs in 18 European countries.
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Nidharshan Anandasivam
Affiliate, Department Funds
Fellow in Medicine - Med/NephrologyBioNidharshan Anandasivam is a fellow in the Stanford University Nephrology Fellowship Program. He received a Bachelor of Science in Biological Engineering at MIT, an MD from Yale School of Medicine, and an MBA from Yale School of Management. He completed his Internal Medicine Residency at University of Texas at Austin Dell Medical School.
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Christine Anastasiou, MD, MAS
Clinical Assistant Professor, Medicine - Immunology & Rheumatology
BioDr. Anastasiou is a board-certified, fellowship-trained rheumatologist with the Stanford Health Care Immunology and Rheumatology Clinic. She is also a clinical assistant professor in the Department of Medicine, Division of Immunology and Rheumatology at Stanford University School of Medicine.
Dr. Anastasiou specializes in diagnosing and treating patients with rheumatic diseases. She has a special interest in ankylosing spondylitis, systemic lupus erythematosus, rheumatoid arthritis, and idiopathic inflammatory myopathies.
Her scholarly work includes epidemiologic studies and clinical trials focused on improving safety and health outcomes for people with chronic rheumatic diseases. Dr. Anastasiou has served as an investigator and collaborator for clinical trials of new therapies to treat rheumatic disease. She is actively involved in medical education through developing and leading patient, medical student, resident, and fellow educational programs.
Dr. Anastasiou is a member of the American College of Rheumatology (ACR). She has published her research in peer-reviewed journals, including Arthritis Care & Research and Lupus Science & Medicine. She has delivered lectures and presentations across the country and abroad on various topics related to rheumatology. -
David Anders
Director of Research, Rad/Molecular Imaging Program at Stanford
Current Role at StanfordDirector of the Cyclotron and Radiochemistry Facility
The CRF team is excited to be designing our second cyclotron facility where we will expand production into radiometals. -
Chad Anderson
Clinical Assistant Professor, Medicine - Primary Care and Population Health
BioChad Anderson is a Physician Assistant at Stanford ValleyCare and a Clinical Assistant Professor with the Stanford School of Medicine MSPA program. He is the Assistant Director of PA education at ValleyCare. He is dual credentialed as a Family Nurse Practitioner and a Physician Assistant. He completed his FNP/PA training at the Stanford School of Medicine and his graduate studies at A.T. Still University – Arizona School of Health Sciences. He is passionate about improving our patients hospital experience as well as educating our future providers.
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Jamie Anderson
Senior Research Process Manager, Institutional Official, School of Medicine - Research Management Group
Current Role at StanfordResearch Process Manager, Research Management Group - School of Medicine
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Kenton Anderson
Clinical Professor, Emergency Medicine
Current Research and Scholarly InterestsCardiopulmonary Resuscitation
Cardiac Arrest
Emergency Ultrasound -
Leah Anderson
Manager Access Services, School of Medicine - Lane Medical Library
Current Role at StanfordManager, Access Services
-- Manages Access Services, the public-facing department at Lane Library
-- Manages DocXpress Document Delivery Service
-- Manages access and storage of the library's physical collections -
Rodney U. Anderson, MD FACS
Professor (Clinical) of Urology, Emeritus
Current Research and Scholarly InterestsClinical Medical Research devoted to tertiary level application of treatment modalities for neurologic and functional disturbances of the genitourinary tract. Problems such as urinary incontinence, urinary retention, urinary flow dysfunction (BPH), impotence, and chronic pelvic pain syndromes are addressed. New medical devices and technology for treating these disorders are investigated
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Thomas Anthony ("Tony") Anderson
Clinical Professor, Anesthesiology, Perioperative and Pain Medicine
Current Research and Scholarly InterestsMy lab's research focuses on two areas:
1. Focused ultrasound for peripheral nervous system modulation- We are interested in the potential of focused ultrasound to modulate peripheral nerves and improve both acute and chronic pain.
2. Pediatric perioperative outcomes- Our goals are to understand A) how various perioperative pain management strategies affect outcomes in children who undergo surgery and B) whether disparities in the perioperative pain management of children occur. -
Kazuo Ando
Clinical Associate Professor, Anesthesiology, Perioperative and Pain Medicine
BioBorn and raised in Japan, Dr. Ando received an MD-PhD degree from the Aichi Medical University. After anesthesia training, Dr. Ando came to Stanford to pursue clinical and basic research experience. During his postdoctoral fellowship in Dr. Gaudilliere's laboratory, Dr. Ando worked on publication of “A next-generation single-cell technology (mass cytometry) to study the feto-maternal immune system,” a project designed to evaluate the immune response associated with preterm birth. In addition, Dr. Ando performs research in Obstetric Anesthesia, such as respiratory monitoring after cesarean sections and labor satisfaction, to obtain clinical research experience and to understand the key differences in medicine between the United States and Japan.
After his postdoctoral fellowship, Dr. Ando has maintained his status as a researcher in Dr. Gaudilliere's laboratory, continuing work relating to pregnancy and preterm birth.
Dr. Ando divides his efforts between laboratory research and the clinic. -
Dev Andra
Affiliate, Pediatrics - Adolescent Medicine
BioI'm a rising sophomore at Monta Vista High School and a member of the Stanford REACH Lab Youth Action Board. As part of the Communications Subcommittee, I contribute to marketing and social media outreach for YAB initiatives and am currently co-leading the launch of Reaching Beyond, a new podcast by the REACH Lab YAB. In my free time, I enjoy coding, building and tinkering with AI projects, playing guitar, and competing in badminton.
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Katrin Andreasson
Edward F. and Irene Thiele Pimley Professor of Neurology and Neurological Sciences
Current Research and Scholarly InterestsOur research focuses on understanding how immune responses initiate and accelerate synaptic and neuronal injury in age-related neurodegeneration, including models of Alzheimer's disease and Parkinson's disease. We also focus on the role of immune responses in aggravating brain injury in models of stroke. Our goal is the identification of critical immune pathways that function in neurologic disorders and that can be targeted to elicit disease modifying effects.
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Jason Andrews
Professor of Medicine (Infectious Diseases) and, by courtesy, of Epidemology
On Partial Leave from 04/01/2026 To 09/30/2026Current Research and Scholarly InterestsOur laboratory aims to develop and test innovative approaches to the diagnosis, treatment and control of infectious diseases in resource-limited settings. We draw upon multiple fields including mathematical modeling, microbial genetics, field epidemiology, statistical inference and biodesign to work on challenging problems in infectious diseases, with an emphasis on tuberculosis and tropical diseases.
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Lay Teng Ang
Assistant Professor of Urology
BioAs a stem cell biologist, I aim to understand the mechanisms through which stem cells differentiate into progressively specialized cell types and to harness this knowledge to artificially generate pure populations of desired cell types from stem cells. My work over the past ten years has centered on pluripotent stem cells (PSCs, which include embryonic and pluripotent stem cells), which can generate any of the hundreds of diverse cell types in the body. However, it has been notoriously challenging to guide PSCs to differentiate into a pure population of a given cell type. Current differentiation strategies typically generate heterogeneous cell populations unsuitable for basic research or clinical applications. To address this challenge, I mapped the cascade of branching lineage choices through which PSCs differentiate into various endodermal and mesodermal cell types. I then developed effective methods to differentiate PSCs into specific lineages by providing the extracellular signal(s) that specify a given lineage while inhibiting the signals that induce the alternate fate(s), enabling the generation of highly-pure human heart and bone (Loh & Chen et al., 2016; Cell) and liver (Loh & Ang et al., 2014; Cell Stem Cell) from PSCs. My laboratory currently focuses on differentiating human PSCs into liver progenitors (Ang et al., 2018; Cell Reports) and blood vessel cells (Ang et al., 2022; Cell).
I earned my Ph.D. jointly from the University of Cambridge and A*STAR and was subsequently appointed as a Research Fellow and, later, a Senior Research Fellow at the Genome Institute of Singapore. I then moved my laboratory to Stanford University as a Siebel Investigator and Instructor at the Stanford Institute for Stem Cell Biology & Regenerative Medicine. In 2024, I am jointly appointed in the Stanford Department of Urology and Stem Cell Institute as an Assistant Professor. My laboratory has been supported by the Stanford Maternal & Child Health Research Institute, California Institute for Regenerative Medicine, Siebel Investigatorship, Additional Ventures, and other sources. -
Michael Angelo
Associate Professor of Pathology
BioMichael Angelo, MD PhD is a board-certified pathologist and assistant professor in the department of Pathology at Stanford University School of Medicine. Dr. Angelo is a leader in high dimensional imaging with expertise in tissue homeostasis, tumor immunology, and infectious disease. His lab has pioneered the construction and development of Multiplexed Ion Beam Imaging by time of flight (MIBI-TOF). MIBI-TOF uses secondary ion mass spectrometry and metal-tagged antibodies to achieve rapid, simultaneous imaging of dozens of proteins at subcellular resolution. In recognition of this achievement, Dr. Angelo received the NIH Director’s Early Independence award in 2014. His lab has since used this novel technology to discover previously unknown rule sets governing the spatial organization and cellular composition of immune, stromal, and tumor cells within the tumor microenvironment in triple negative breast cancer. These findings were found to be predictive of single cell expression of several immunotherapy drug targets and of 10-year overall survival. This effort has led to ongoing work aimed at elucidating structural mechanisms in the TME that promote recruitment of cancer associated fibroblasts, tumor associated macrophages, and extracellular matrix remodeling. Dr. Angelo is the recipient of the 2020 DOD Era of Hope Award and a principal investigator on multiple extramural awards from the National Cancer Institute, Breast Cancer Research Foundation, Parker Institute for Cancer Immunotherapy, the Bill and Melinda Gates Foundation, and the Human Biomolecular Atlas (HuBMAP) initiative.
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Timothy Angelotti MD, PhD
Clinical Associate Professor, Anesthesiology, Perioperative and Pain Medicine
Current Research and Scholarly InterestsMy research efforts are focused on investigating the pharmacological and physiological interface of the autonomic nervous system with effector organs. Utilizing molecular, cellular, and electrophysiological techniques, we are examining alpha2 adrenergic receptor function in cultured sympathetic neurons. Future research aims will be directed toward understanding neurotransmitter release in general.
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Martin S. Angst
Professor of Anesthesiology, Perioperative and Pain Medicine (MSD)
Current Research and Scholarly InterestsOur laboratory studies biological and clinical determinants of human resilience using surgery as an injury model.
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Justin P. Annes M.D., Ph.D.
Associate Professor of Medicine (Endocrinology)
Current Research and Scholarly InterestsThe ANNES LABORATORY of Molecular Endocrinology: Leveraging Chemical Biology to Treat Endocrine Disorders
DIABETES
The prevalence of diabetes is increasing at a staggering rate. By the year 2050 an astounding 25% of Americans will be diabetic. The goal of my research is to uncover therapeutic strategies to stymie the ensuing diabetes epidemic. To achieve this goal we have developed a variety of innovate experimental approaches to uncover novel approaches to curing diabetes.
(1) Beta-Cell Regeneration: Diabetes results from either an absolute or relative deficiency in insulin production. Our therapeutic strategy is to stimulate the regeneration of insulin-producing beta-cells to enhance an individual’s insulin secretion capacity. We have developed a unique high-throughput chemical screening platform which we use to identify small molecules that promote beta-cell growth. This work has led to the identification of key molecular pathways (therapeutic targets) and candidate drugs that promote the growth and regeneration of islet beta-cells. Our goal is to utilize these discoveries to treat and prevent diabetes.
(2) The Metabolic Syndrome: A major cause of the diabetes epidemic is the rise in obesity which leads to a cluster of diabetes- and cardiovascular disease-related metabolic abnormalities that shorten life expectancy. These physiologic aberrations are collectively termed the Metabolic Syndrome (MS). My laboratory has developed an original in vivo screening platform t to identify novel hormones that influence the behaviors (excess caloric consumption, deficient exercise and disrupted sleep-wake cycles) and the metabolic abnormalities caused by obesity. We aim to manipulate these hormone levels to prevent the development and detrimental consequences of the MS.
HEREDIATY PARAGAGLIOMA SYNDROME
The Hereditary Paraganglioma Syndrome (hPGL) is a rare genetic cancer syndrome that is most commonly caused by a defect in mitochondrial metabolism. Our goal is to understand how altered cellular metabolism leads to the development of cancer. Although hPGL is uncommon, it serves as an excellent model for the abnormal metabolic behavior displayed by nearly all cancers. Our goal is to develop novel therapeutic strategies that target the abnormal behavior of cancer cells. In the laboratory we have developed hPGL mouse models and use high throughput chemical screening to identify the therapeutic susceptibilities that result from the abnormal metabolic behavior of cancer cells.
As a physician scientist trained in clinical genetics I have developed expertise in hereditary endocrine disorders and devoted my efforts to treating families affected by the hPGL syndrome. By leveraging our laboratory expertise in the hPGL syndrome, our care for individuals who have inherited the hPGL syndrome is at the forefront of medicine. Our goal is to translate our laboratory discoveries to the treatment of affected families. -
Arash Anoshiravani
Clinical Professor, Pediatrics - Adolescent Medicine
Current Research and Scholarly InterestsResearch interests include high-risk youth, adolescent health services, and the juvenile justice system.
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Alexandra Sasha Anronikov
Life Science Research Professional 2, Multispecialty Anesthesiology
Current Role at StanfordResearcher in the Gaudillière Lab, Department of Anesthesia. Currently conducting CyTOF experiments, clinical research coordination, sample processing, and data analysis to integrate clinical findings with experimental results and advance understanding of immune adaptation. Current studies look at how the human immune system responds to physiological stressors like traumatic injury, stroke, pregnancy and pregnancy-related complications.
