Showing 1-77 of 77 Results
Alex Macario MD MBA
Professor of Anesthesiology, Perioperative and Pain Medicine
Current Research and Scholarly InterestsDr. Macario studies health care economics & outcomes, with a special focus on surgery and anesthesia. He is well known for helping develop the field of operating room management, and is keenly interested in the cost-effectiveness analyses of drugs and devices. For the past decade Dr. Macario has added medical education as a research priority to better understand methods to best teach students and residents.
M Bruce MacIver
Professor (Research) of Anesthesiology, Perioperative and Pain Medicine, Emeritus
Current Research and Scholarly InterestsWe study drug effects on the nervous system. Cellular, synaptic and molecular drug actions are investigated using electrophysiological and pharmacological tools in cortical/hippocampal brain slice preparations. We are also interested in mechanisms of neuronal integration and synchronization, especially related to patterns of EEG activity seen in vivo and in brain slices.
Ernest and Amelia Gallo Family Professor and Professor of Pediatrics and of Medicine
Current Research and Scholarly InterestsRecent clinical studies, by us and others, have demonstrated that genetically engineered T cells can eradicate cancers resistant to all other therapies. We are identifying new targets for these therapeutics, exploring pathways of resistance to current cell therapies and creating next generation platforms to overcome therapeutic resistance. We have discovered novel insights into the biology of human T cell exhaustion and developed approaches to prevent and reverse this phenomenon.
Sean Mackey, M.D., Ph.D.
Redlich Professor, Professor of Anesthesiology, Perioperative, and Pain Medicine and, by courtesy, of Neurology
Current Research and Scholarly InterestsMultiple NIH funded projects to characterize CNS mechanisms of human pain. Comparative effectiveness of cognitive behavioral therapy and chronic pain self-management within the context of opioid reduction (PCORI funded). Single session pain catastrophizing treatment: comparative efficacy & mechanisms (NIH R01). Development and implementation of an open-source learning healthcare system, CHOIR (http://choir/stanford.edu), to optimize pain care and innovative research in real-world patients.
Daniel V. Madison
Associate Professor of Molecular and Cellular Physiology
Current Research and Scholarly InterestsOur underlying forms of activity-dependent synaptic plasticity such as long-term potentiation and long-term depression, and in particular the function and plasticity of Parvalbumin-containing interneurons in neocortex. In the past few years, we have used a combinatorial approach to comparing physiological and anatomical plasticity-induced changes in synapses using electrode recording and Array Tomography in the same neurons.
Associate Professor of Molecular and Cellular Physiology
Current Research and Scholarly InterestsMolecular mechanisms of ion chnanels & transporters studied by integration of structural and electrophysiological methods.
Professor (Research) of Microbiology and Immunology
Current Research and Scholarly InterestsI'm interested in immune monitoring of T cell responses to chronic pathogens and cancer, and the correlation of T cell response signatures with disease protection.
Vinit B. Mahajan, MD, PhD
Professor of Ophthalmology
Current Research and Scholarly InterestsOur focus is the development of personalized medicine for eye diseases through translation of our discoveries in proteomics, genomics, and phenomics in humans, mice and tissue culture models.
Assistant Professor of Neurosurgery
BioDr. Mahaney is a Pediatric Neurosurgeon with clinical interest in Hydrocephalus, Craniovertebral Junction abnormalities, Spasticity, Spinal dysraphism and Myelomeningocele, Central Nervous System tumors, and Pediatric Epilepsy surgery. She completed residency training at the University of Iowa Hospitals and Clinics and subspecialty Pediatric Neurosurgery training at The Hospital for Sick Children in Toronto and the Barrow Neurologic Institute at Phoenix Children's Hospital. She is interested in advancing Neuro-endoscopic techniques in Pediatric Neurosurgical practice. Dr. Mahaney's research focuses on delineating the role of iron in the development of post-hemorrhagic hydrocephalus.
Assistant Professor of Chemical Engineering and, by courtesy, of Materials Science and Engineering
BioDanielle J. Mai joined the Department of Chemical Engineering at Stanford in January 2020. She earned her B.S.E. in Chemical Engineering from the University of Michigan and her M.S. and Ph.D. in Chemical Engineering from the University of Illinois at Urbana-Champaign under the guidance of Prof. Charles M. Schroeder. Dr. Mai was an Arnold O. Beckman Postdoctoral Fellow in Prof. Bradley D. Olsen's group at MIT, where she engineered materials with selective biomolecular transport properties, elucidated mechanisms of toughness and extensibility in entangled associative hydrogels, and developed high-throughput methods for the discovery of polypeptide materials. The Mai Lab engineers biopolymers, which are the building blocks of life. Specifically, the group integrates precise biopolymer engineering with multi-scale experimental characterization to advance biomaterials development and to enhance fundamental understanding of soft matter physics. Dr. Mai's work has been recognized through the AIChE 35 Under 35 Award (2020), APS DPOLY/UKPPG Lecture Exchange (2021), Air Force Office of Scientific Research Young Investigator Program Award (2022), ACS PMSE Arthur K. Doolittle Award (2023), and MIT Technology Review List of 35 Innovators Under 35 (2023).
Ravi Majeti MD, PhD
Director, Stanford Institute for Stem Cell Biology and Regenerative Medicine, Virginia and D. K. Ludwig Professor and Professor of Medicine (Hematology)
Current Research and Scholarly InterestsThe Majeti lab focuses on the molecular/genomic characterization and therapeutic targeting of leukemia stem cells in human hematologic malignancies, particularly acute myeloid leukemia (AML). Our lab uses experimental hematology methods, stem cell assays, genome editing, and bioinformatics to define and investigate drivers of leukemia stem cell behavior. As part of these studies, we have led the development and application of robust xenotransplantation assays for human hematopoietic cells.
Senior Associate Dean, Faculty Development and Diversity, Taube Professor of Global Health and Infectious Diseases, Professor of Pediatrics (Infectious Diseases) and of Epidemiology and Population Health
Current Research and Scholarly InterestsMy research focuses on epidemiologic aspects of viral vaccines and perinatal HIV infection. This includes the molecular epidemiology of factors affecting the immunogenicity of oral polio vaccine (OPV) in developing areas of the world, and now the epidemiology of transmission and circulation of vaccine derived polioviruses in order to assist in global eradication of polio. I also work in development of methods to prevent breastfeeding transmission of HIV in Africa.
Nancy Friend Pritzker Professor of Psychiatry and Behavioral SciencesOn Leave from 11/01/2023 To 10/31/2025
Current Research and Scholarly InterestsLong-lasting changes in synaptic strength are important for the modification of neural circuits by experience. A major goal of my laboratory is to elucidate the molecular events that trigger various forms of synaptic plasticity and the modifications in synaptic proteins that are responsible for the changes in synaptic efficacy.
Associate Professor (Research) of Radiology (Cancer Early Detection-Canary Center)
Current Research and Scholarly InterestsThe Mallick Lab is focused on using integrative, multi-omic approaches to model the processes that govern cellular dynamics and to use those models to discover cancer biomarkers and molecular mechanisms.
Edward Manche, MD
Professor of Ophthalmology
BioEdward E. Manche, MD is Professor of Ophthalmology and Director of the Cornea and Refractive Surgery Service at Stanford University School of Medicine. He received his medical degree from Albert Einstein College of Medicine and completed residency training at the University of Medicine and Dentistry at New Jersey where he served as Chief Resident. He completed a two-year fellowship in Cornea and Refractive Surgery at the Jules Stein Eye Institute at UCLA.
Dr. Manche is a fellow of the American Academy of Ophthalmology and received its Achievement Award in 2003 and its Senior Achievement Award in 2014. He was elected to active membership in the American Ophthalmological Society in 2011, and is recognized in Best Doctors in America and Guide to America's Top Physicians. He serves on the editorial boards of the American Journal of Ophthalmology, Journal of Ophthalmology, Clinical and Experimental Ophthalmology and Journal of Refractive Surgery.
He lectures widely on topics in cornea and refractive surgery and has published over 130 peer-reviewed articles and 30 book chapters.
Thomas M. Siebel Professor of Machine Learning, Professor of Linguistics, of Computer Science and Senior Fellow at the Stanford Institute for HAIOn Leave from 10/01/2023 To 12/31/2023
BioChristopher Manning is the inaugural Thomas M. Siebel Professor in Machine Learning in the Departments of Linguistics and Computer Science at Stanford University, Director of the Stanford Artificial Intelligence Laboratory (SAIL), and an Associate Director of the Stanford Institute for Human-Centered Artificial Intelligence (HAI). His research goal is computers that can intelligently process, understand, and generate human languages. Manning was an early leader in applying Deep Learning to Natural Language Processing (NLP), with well-known research on the GloVe model of word vectors, attention, machine translation, question answering, self-supervised model pre-training, tree-recursive neural networks, machine reasoning, dependency parsing, sentiment analysis, and summarization. He also focuses on computational linguistic approaches to parsing, natural language inference and multilingual language processing, including being a principal developer of Stanford Dependencies and Universal Dependencies. Manning has coauthored leading textbooks on statistical approaches to NLP (Manning and Schütze 1999) and information retrieval (Manning, Raghavan, and Schütze, 2008), as well as linguistic monographs on ergativity and complex predicates. His online CS224N Natural Language Processing with Deep Learning videos have been watched by hundreds of thousands of people. He is an ACM Fellow, a AAAI Fellow, and an ACL Fellow, and a Past President of the ACL (2015). His research has won ACL, Coling, EMNLP, and CHI Best Paper Awards, and an ACL Test of Time Award. He has a B.A. (Hons) from The Australian National University and a Ph.D. from Stanford in 1994, and an Honorary Doctorate from U. Amsterdam in 2023, and he held faculty positions at Carnegie Mellon University and the University of Sydney before returning to Stanford. He is the founder of the Stanford NLP group (@stanfordnlp) and manages development of the Stanford CoreNLP and Stanza software.
Andrew J. Mannix
Assistant Professor of Materials Science and Engineering
Current Research and Scholarly InterestsAtomically thin 2D materials incorporated into van der Waals heterostructures are a promising platform to deterministically engineer quantum materials with atomically resolved thickness and abrupt interfaces across macroscopic length scales while retaining excellent material properties. Because 2D materials exhibit a wide range of electronic characteristics with properties that often rival conventional electronic materials — e.g., metals, semiconductors, insulators, and superconductors — it is possible to combine them in virtually infinite variety to achieve diverse heterostructures. Furthermore, the van der Waals interface enables interlayer twist engineering to modify the interlayer symmetry, periodic potential (moiré superlattice), and hybridization, which has resulted in novel quantum states of matter. Many of these heterostructures, especially those involving specific interlayer twist angles, would be otherwise infeasible through direct growth.
The Mannix Group is developing a unique set of in-house capabilities to systematically elucidate the fundamental structure-property relationships underpinning the growth of 2D materials and their inclusion into van der Waals heterostructures. Greater understanding will allow us to provide a platform for engineering the properties of matter at the atomic scale and offer guidance for emerging applications in novel electronics and in quantum information science.
To accomplish this, we employ: precise growth techniques such as chemical vapor deposition and molecular beam epitaxy; automated van der Waals assembly; and atomically-resolved microscopy including cryo-STM/AFM.
M. Peter Marinkovich, MD
Associate Professor of Dermatology
Current Research and Scholarly InterestsThe Marinkovich lab studies the function of epithelial extracellular matrix molecules, including integrins, collagens and laminins in epithelial development and carcinoma progression. We apply our discoveries in this area towards development of molecular therapies for carcinomas, hair disease and inherited epithelial adhesive disorders.
Associate Professor of Chemistry
Current Research and Scholarly InterestsOur research centers on problems at the interface of quantum and statistical mechanics. Particular themes that occur frequently in our research are hydrogen bonding, the interplay between structure and dynamics, systems with multiple time and length-scales and quantum mechanical effects. The applications of our methods are diverse, ranging from chemistry to biology to geology and materials science. Particular current interests include proton and electron transfer in fuel cells and enzymatic systems, atmospheric isotope separation and the control of catalytic chemical reactivity using electric fields.
Treatment of these problems requires a range of analytic techniques as well as molecular mechanics and ab initio simulations. We are particularly interested in developing and applying methods based on the path integral formulation of quantum mechanics to include quantum fluctuations such as zero-point energy and tunneling in the dynamics of liquids and glasses. This formalism, in which a quantum mechanical particle is mapped onto a classical "ring polymer," provides an accurate and physically insightful way to calculate reaction rates, diffusion coefficients and spectra in systems containing light atoms. Our work has already provided intriguing insights in systems ranging from diffusion controlled reactions in liquids to the quantum liquid-glass transition as well as introducing methods to perform path integral calculations at near classical computational cost, expanding our ability to treat large-scale condensed phase systems.
Lewis M. Terman Professor
BioMarkman’s research interests include the relationship between language and thought; early word learning; categorization and induction; theory of mind and pragmatics; implicit theories and conceptual change, and how theory-based explanations can be effective interventions in health domains.
Michael Marmor, MD
Professor of Ophthalmology, Emeritus
Current Research and Scholarly InterestsResearch concerns diseases of retinal function, techniques of clinical electrophysiology, and experimental studies on retinal pigment epithelial (RPE) function including fluid transport and retinal adhesiveness. Other studies consider aspects of vision and art, and ophthalmic history.
Published over 300 journal articles, chapters, books (only selected articles listed).
David J. Maron
C. F. Rehnborg Professor and Professor of Medicine (Stanford Prevention Research Center)
Current Research and Scholarly InterestsDr. Maron is the Co-Chair and Principal Investigator of the ISCHEMIA trial, and Co-Chair of the ISCHEMIA-CKD trial. These large, international, NIH-funded studies will determine whether an initial invasive strategy of cardiac catheterization and revascularization plus optimal medical therapy will reduce cardiovascular events in patients with and without chronic kidney disease and at least moderate ischemia compared to an initial conservative strategy of optimal medical therapy alone.
Douglass M. and Nola Leishman Professor of Cardiovascular Diseases, and Professor of Pediatrics (Cardiology) and of Bioengineering
Current Research and Scholarly InterestsThe Cardiovascular Biomechanics Computation Lab at Stanford develops novel computational methods for the study of cardiovascular disease progression, surgical methods, and medical devices. We have a particular interest in pediatric cardiology, and use virtual surgery to design novel surgical concepts for children born with heart defects.
Johnson and Johnson Professor of Surgery
Current Research and Scholarly InterestsHost-Pathogen interactions; EBV B cell lymphomas; pathways of immune evasion in the growth and survival of EBV B cell lymphomas; mechanisms of graft rejection and tolerance induction; stem cell and solid organ transplantation.
David Mulvane Ehrsam and Edward Curtis Franklin Professor of Chemistry and Professor of Photon Science
Current Research and Scholarly InterestsAb initio molecular dynamics, photochemistry, molecular design, mechanochemistry, graphical processing unit acceleration of electronic structure and molecular dynamics, automated reaction discovery, ultrafast (femtosecond and attosecond) chemical phenomena
Tarik F. Massoud, MD, PhD
Professor of Radiology (Neuroimaging and Neurointervention)
Current Research and Scholarly InterestsMy current interests are in molecular and translational imaging of the brain especially in neuro-oncology and cerebrovascular diseases, experimental aspects of neuroimaging, clinical neuroradiology, neuroradiological anatomy, and research education and academic training of radiologists and scientists.
Professor of Microbiology and Immunology, Emeritus
Current Research and Scholarly Interests1. Improvement of our newly discovered cancer prodrug regimen that permits noninvaisve visualization of drug activation. 2. Tracking tumors & cancer metastases using bacterial magnetite and newly developed single-cell tracking by MRI. 3. Molecular basis of bacterial planktonic and biofilm antibiotic resistance on Earth and under space microgravity -- development of new countermeasures; 4. Bioremediation.
Michaëlle Ntala Mayalu
Assistant Professor of Mechanical Engineering and, by courtesy, of Bioengineering
BioDr. Michaëlle N. Mayalu is an Assistant Professor of Mechanical Engineering. She received her Ph.D., M.S., and B.S., degrees in Mechanical Engineering at the Massachusetts Institute of Technology. She was a postdoctoral scholar at the California Institute of Technology in the Computing and Mathematical Sciences Department. She was a 2017 California Alliance Postdoctoral Fellowship Program recipient and a 2019 Burroughs Wellcome Fund Postdoctoral Enrichment Program award recipient. She is also a 2023 Hypothesis Fund Grantee.
Dr. Michaëlle N. Mayalu's area of expertise is in mathematical modeling and control theory of synthetic biological and biomedical systems. She is interested in the development of control theoretic tools for understanding, controlling, and predicting biological function at the molecular, cellular, and organismal levels to optimize therapeutic intervention.
She is the director of the Mayalu Lab whose research objective is to investigate how to optimize biomedical therapeutic designs using theoretical and computational approaches coupled with experiments. Initial project concepts include: i) theoretical and experimental design of bacterial "microrobots" for preemptive and targeted therapeutic intervention, ii) system-level multi-scale modeling of gut associated skin disorders for virtual evaluation and optimization of therapy, iii) theoretical and experimental design of "microrobotic" swarms of engineered bacteria with sophisticated centralized and decentralized control schemes to explore possible mechanisms of pattern formation. The experimental projects in the Mayalu Lab utilize established techniques borrowed from the field of synthetic biology to develop synthetic genetic circuits in E. coli to make bacterial "microrobots". Ultimately the Mayalu Lab aims to develop accurate and efficient modeling frameworks that incorporate computation, dynamical systems, and control theory that will become more widespread and impactful in the design of electro-mechanical and biological therapeutic machines.
Harley H McAdams
Professor (Research) of Developmental Biology, Emeritus
Current Research and Scholarly InterestsExperimental and theoretical analysis and modeling of genetic regulatory circuits, particularly bacterial regulation and with emphasis on global regulation of Caulobacter crescentus. Bioinformatic analysis of bacterial genomes, global patterns of gene transcription and translation.
Lucie Stern Professor in the Social Sciences, Professor of Psychology and, by courtesy, of Linguistics and of Computer Science
Current Research and Scholarly InterestsMy research addresses topics in perception and decision making; learning and memory; language and reading; semantic cognition; and cognitive development. I view cognition as emerging from distributed processing activity of neural populations, with learning occurring through the adaptation of connections among neurons. A new focus of research in the laboratory is mathematical cognition and reasoning in humans and contemporary AI systems based on neural networks.
Michael V. McConnell, MD, MSEE
Clinical Professor, Medicine - Cardiovascular Medicine
Current Research and Scholarly InterestsMy imaging research has involved clinical and molecular Imaging of cardiovascular disease, with a focus on coronary and vascular diseases, including atherosclerosis, aortic aneurysms, and vascular inflammation.
My prevention research has involved innovative technologies to reduce coronary and vascular disease, including early disease detection plus leveraging mobile health to enhance heart-healthy activities in patients and populations.
Susan K. McConnell
Susan B. Ford Professor, EmeritaOn Leave from 10/01/2023 To 12/31/2023
Current Research and Scholarly InterestsSusan McConnell has studied the cellular and molecular mechanisms that underlie the development of the mammalian cerebral cortex. Her work focused on the earliest events that pattern the developing forebrain, enable neural progenitors to divide asymmetrically to generate young neurons, propel the migration of postmitotic neurons outward into their final positions, and sculpt the fates and phenotypes of the neurons as they differentiate.
Rick and Melinda Reed Professor, Professor of Photon Science and Senior Fellow at the Precourt Institute for Energy
BioMcIntyre's group performs research on nanostructured inorganic materials for applications in electronics, energy technologies and sensors. He is best known for his work on metal oxide/semiconductor interfaces, ultrathin dielectrics, defects in complex metal oxide thin films, and nanostructured Si-Ge single crystals. His research team synthesizes materials, characterizes their structures and compositions with a variety of advanced microscopies and spectroscopies, studies the passivation of their interfaces, and measures functional properties of devices.
David B. McKay
Professor of Structural Biology, Emeritus
Current Research and Scholarly InterestsThree-dimensional structure determination and biophysical studies of macromolecules.
Professor of Medicine (Endocrinology)
Current Research and Scholarly InterestsDr. McLaughlin conducts clinical research related to obesity, insulin resistance, diabetes, and cardiovascular disease (CVD). Current studies include: 1) the impact of macronutrient composition on metabolism, DM2 and CVD; 2) comparison of different weight loss diets on metabolism and CVD risk reduction ; 3) role of adipocytes and adipose tissue immune cells in modulating insulin resistance; 4) use of continuous glucose monitoring and multi-omics to define metabolic phenotype and precision diets
Uel Jackson McMahan
Professor of Neurobiology and of Structural Biology, Emeritus
Current Research and Scholarly InterestsWe are currently investigating mechanisms involved in synaptic transmission and synaptogenesis using electron microscope tomography in ways that provide in situ 3D structural information at macromolecular resolution.
Jennifer A McNab
Associate Professor (Research) of Radiology (Radiological Sciences Laboratory)
Current Research and Scholarly InterestsMy research is focused on developing magnetic resonance imaging (MRI) methods that probe brain tissue microstructure. This requires new MRI contrast mechanisms, strategic encoding and reconstruction schemes, physiological monitoring, brain tissue modeling and validation. Applications of these methods include neuronavigation, neurosurgical planning and the development of improved biomarkers for brain development, degeneration, disease and injury.
Kimford Meador, MD
Professor of Neurology
BioDr. Meador is a Professor of Neurology and Neurosciences at Stanford University, and Clinical Director, Stanford Comprehensive Epilepsy Center. Dr. Meador graduated from the Georgia Institute of Technology in Applied Biology (with high honor) and received his MD from the Medical College of Georgia. After an internship at the University of Virginia and service as an officer in the Public Health Corps, he completed a residency in Neurology at the Medical College of Georgia and a fellowship in Behavioral Neurology at the University of Florida. Dr. Meador joined the faculty at the Medical College of Georgia (1984-2002) where he became the Charbonnier Professor of Neurology. He was the Chair of Neurology at Georgetown University (2002-2004), the Melvin Greer Professor of Neurology and Neuroscience at the University of Florida (2004-2008) where he served as Director of Epilepsy Program and Director of the Clinical Alzheimer Research Program, and Professor of Neurology and Pediatrics at Emory University (2008-2013) where he served as Director of Epilepsy and of Clinical Neurocience Research. He joined the faculty of Stanford University in 2013. Dr. Meador has authored over 400 peer-reviewed publications. His research interests include: cognitive mechanisms (e.g., memory and attention); cerebral lateralization; pharmacology and physiology of cognition; mechanisms of perception, consciousness and memory; EEG; epilepsy; epilepsy and pregnancy; preoperative evaluation for epilepsy surgery; intracarotid amobarbital procedure (i.e., Wada test); functional imaging; therapeutic drug trials; neurodevelopmental effects of antiepileptic drugs; psychoimmunology; behavioral disorders (e.g., aphasia, neglect, dementia); and neuropsychiatric disorders. Dr. Meador has served as the PI for a long running NIH multicenter study of pregnancy outcomes in women with epilepsy and their children. Dr. Meador has served on the editorial boards for Clinical Neurophysiology, Epilepsy and Behavior, Epilepsy Currents, Journal of Clinical Neurophysiology, Neurology, Cognitive and Behavioral Neurology, and Epilepsy.com. His honors include Resident Teaching Award Medical College of Georgia; Outstanding Young Faculty Award in Clinical Sciences Medical College of Georgia; Distinguished Faculty Award for Clinical Research Medical College of Georgia Lawrence C. McHenry History Award American Academy of Neurology; Dreifuss Abstract Award American Epilepsy Society; Fellow of the American Neurological Association; Diplomat of American Neurologic Association; past Chair of the Section of Behavioral Neurology of American Academy of Neurology; past President of Society for Cognitive and Behavioral Neurology; past President of the Society for Behavioral & Cognitive Neurology; past President of the Southern EEG & Epilepsy Society; ranking in the top 10 experts in epilepsy worldwide by Expertscape; Distinguished Alumnus Award for Professional Achievement, Medical College of Georgia, Georgia Regents University 2015; American Epilepsy Society Clinical Research Award; and named award by the American Epilepsy Society: “Kimford J. Meador Research in Women with Epilepsy Award,” and ranked in the top 500 neuroscientist in the world and top 300 in USA by Research.com in 2022.
Professor of Pediatrics (Human Gene Therapy)
Current Research and Scholarly InterestsMolecular mechanisms and intracellular pathways of MHC class II antigen processing and presentation, with a focus on B cells; mechanisms underlying HLA allele association with disease; disease mechanisms in systemic juvenile idiopathic arthritis, including an HLA-linked complication; monocytes as drivers or suppressors of auto-inflammation in systemic juvenile idiopathic arthritis and pediatric acute neuropsychiatric syndrome.
Professor of Materials Science and Engineering
BioThe Melosh group explores how to apply new methods from the semiconductor and self-assembly fields to important problems in biology, materials, and energy. We think about how to rationally design engineered interfaces to enhance communication with biological cells and tissues, or to improve energy conversion and materials synthesis. In particular, we are interested in seamlessly integrating inorganic structures together with biology for improved cell transfection and therapies, and designing new materials, often using diamondoid molecules as building blocks.
My group is very interested in how to design new inorganic structures that will seamless integrate with biological systems to address problems that are not feasible by other means. This involves both fundamental work such as to deeply understand how lipid membranes interact with inorganic surfaces, electrokinetic phenomena in biologically relevant solutions, and applying this knowledge into new device designs. Examples of this include “nanostraw” drug delivery platforms for direct delivery or extraction of material through the cell wall using a biomimetic gap-junction made using nanoscale semiconductor processing techniques. We also engineer materials and structures for neural interfaces and electronics pertinent to highly parallel data acquisition and recording. For instance, we have created inorganic electrodes that mimic the hydrophobic banding of natural transmembrane proteins, allowing them to ‘fuse’ into the cell wall, providing a tight electrical junction for solid-state patch clamping. In addition to significant efforts at engineering surfaces at the molecular level, we also work on ‘bridge’ projects that span between engineering and biological/clinical needs. My long history with nano- and microfabrication techniques and their interactions with biological constructs provide the skills necessary to fabricate and analyze new bio-electronic systems.
Molecular materials at interfaces
Self-Assembly and Nucleation and Growth
Reid Weaver Dennis Professor in Electrical Engineering and Professor of Computer Science, Emerita
BioTeresa H. Meng is the Reid Weaver Dennis Professor of Electrical Engineering, Emerita, at Stanford University. Her research activities in the first 10 years focused on low-power circuit and system design, video signal processing, and wireless communications. In 1998, Prof. Meng took leave from Stanford and founded Atheros Communications, Inc., which developed semiconductor system solutions for wireless network communications products. After returning to Stanford in 2000 to continue her teaching and research, Prof. Meng turned her research interest to applying signal processing and IC design to bio-medical engineering. She collaborated with Prof. Krishna Shenoy on neural signal processing and neural prosthetic systems. She also directed a research group exploring wireless power transfer and implantable bio-medical devices. Prof. Meng retired from Stanford in 2013.
Rachael L. and Walter F. Nichols, MD, Professor and Professor, by courtesy, of Education and of NeurologyOn Leave from 11/29/2023 To 12/29/2023
Current Research and Scholarly InterestsEXPERIMENTAL, CLINICAL AND THEORETICAL SYSTEMS NEUROSCIENCE
Cognitive neuroscience; Systems neuroscience; Cognitive development; Psychiatric neuroscience; Functional brain imaging; Dynamical basis of brain function; Nonlinear dynamics of neural systems.
Professor of Medicine (Cardiovascular) and, by courtesy, of Chemical and Systems Biology
BioDr. Mercola is Professor of Medicine and Professor in the Stanford Cardiovascular Institute. He completed postdoctoral training at the Dana-Farber Cancer Institute and Harvard Medical School, was on the faculty in the Department of Cell Biology at Harvard Medical School for 12 years, and later at the Sanford-Burnham-Prebys Institute and Department of Bioengineering at the University of California, San Diego before relocating to Stanford in 2015.
Prof. Mercola is known for identifying many of the factors that are responsible for inducing and forming the heart, including the discovery that Wnt inhibition is a critical step in cardiogenesis that provided the conceptual basis and reagents for the large-scale production of cardiovascular tissues from pluripotent stem cells. He has collaborated with medicinal chemists, optical engineers and software developers to pioneer the use of patient iPSC-cardiomyocytes for disease modeling, safety pharmacology and drug development. His academic research is focused on developing and using quantitative high throughput assays of patient-specific cardiomyocyte function to discover druggable targets for preserving contractile function in heart failure and promoting regeneration following ischemic injury. He co-established drug screening and assay development at the Conrad Prebys Drug Discovery Center (San Diego), which operated as one of 4 large screening centers of the US National Institutes of Health (NIH) Molecular Libraries screening initiative and continues as one of the largest academic drug screening centers.
Prof. Mercola received an NIH MERIT award for his work on heart formation. He holds numerous patents, including describing the invention of the first engineered dominant negative protein and small molecules for stem cell and cancer applications. He serves on multiple editorial and advisory boards, including Vala Sciences, Regencor, The Ted Rogers Centre for Heart Research and the Human Biomolecular Research Institute. His laboratory is funded by the National Institutes of Health (NIH), California Institute for Regenerative Medicine, Phospholamban Foundation and Fondation Leducq.
Associate Professor of Medicine (Blood and Marrow Transplantation and Cellular Therapy), of Pediatrics (Stem Cell Transplantation) and, by courtesy, of Surgery (Abdominal Transplantation)
Current Research and Scholarly InterestsResearch focus in T cell immunotherapy and T cell immune monitoring using high-throughput sequencing and genomic approaches, with an emphasis on hematopoietic stem cell transplantation, the treatment of graft-versus-host disease and immune tolerance induction.
Stanford University Professor of Nephrology, Emeritus
Current Research and Scholarly InterestsInadequate removal of uremic solutes contributes to widespread illness in the more than 500,000 Americans maintained on dialysis. But we know remarkably little about these solutes. Dr. Meyer's research efforts are focused on identifying which uremic solutes are toxic, how these solutes are made, and how their production could be decreased or their removal could be increased. We should be able to improve treatment if we knew more about what we are trying to remove.
Professor of Pathology (Research), Emerita
Current Research and Scholarly InterestsLymphocyte/endothelial cell adhesion mechanisms involved in lymphocyte migration to sites of inflammation; regulation of expression of endothelial cell adhesion molecules.
Emmanuel Mignot, MD, PhD
Craig Reynolds Professor of Sleep Medicine and Professor, by courtesy, of Genetics and of Neurology
Current Research and Scholarly InterestsThe research focus of the laboratory is the study of sleep and sleep disorders such as narcolepsy and Kleine Levin syndrome. We also study the neurobiological and genetic basis of the EEG and develop new tools to study sleep using nocturnal polysomnography. Approaches mostly involve human genetic studies (GWAS, sequencing), EEG signal analysis, and immunology (as narcolepsy is an autoimmune disease of the brain).
Professor of Pediatrics (Pulmonary Medicine) and, by courtesy, of Medicine (Pulmonary and Critical Care Medicine)
Current Research and Scholarly InterestsAt Stanford University I developed and currently direct the CF Translational Research Center. The overarching goal of the center is to provide the groundwork to streamline, accelerate, and promote the translation of basic discoveries into effective therapies and interventions to benefit patients affected by cystic fibrosis. My laboratory group currently has three main lines of investigation: respiratory cell biology in CF; remote biochemical monitoring; and lung physiology in young children.
D. Craig Miller, M.D.
Thelma and Henry Doelger Professor of Cardiovascular Surgery, Emeritus
Current Research and Scholarly InterestsCardiac and heart valve disease with experimental laboratory large animal projects focused on the investigation of left ventricular and cardiac mechanics, bioenergetics, and LV and mitral valve physiology and pathophysiology. Current thrust is aimed at understanding the mitral valve and subvalvular mitral apparatus and transmural LV wall strains, thickening, and myolaminar fiber-sheet mechanics.
Clinical research interests include thoracic aortic diseases (aortic dissection, aneurysm) and cardiac valvular disease, including surgical treatment, endovascular thoracic aortic stent-graft repair, mitral valve repair, and valve-sparing aortic root replacement.
Professor of Civil and Environmental Engineering
BioBill Mitch received a B.A. in Anthropology (Archaeology) from Harvard University in 1993. During his studies, he excavated at Mayan sites in Belize and surveyed sites dating from 2,000 B.C. in Louisiana. He switched fields by receiving a M.S. degree in Civil and Environmental Engineering at UC Berkeley. He worked for 3 years in environmental consulting, receiving his P.E. license in Civil Engineering in California. Returning to UC Berkeley in 2000, he received his PhD in Civil and Environmental Engineering in 2003. He moved to Yale as an assistant professor after graduation. His dissertation received the AEESP Outstanding Doctoral Dissertation Award in 2004. At Yale, he serves as the faculty advisor for the Yale Student Chapter of Engineers without Borders. In 2007, he won a NSF CAREER Award. He moved to Stanford University as an associate professor in 2013.
Employing a fundamental understanding of organic chemical reaction pathways, his research explores links between public health, engineering and sustainability. Topics of current interest include:
Public Health and Emerging Carcinogens: Recent changes to the disinfection processes fundamental to drinking and recreational water safety are creating a host of highly toxic byproducts linked to bladder cancer. We seek to understand how these compounds form so we can adjust the disinfection process to prevent their formation.
Global Warming and Oceanography: Oceanic dissolved organic matter is an important global carbon component, and has important impacts on the net flux of CO2 between the ocean and atmosphere. We seek to understand some of the important abiotic chemical reaction pathways responsible for carbon turnover.
Sustainability and Persistent Organic Pollutants (POPs): While PCBs have been banned in the US, we continue to produce a host of structurally similar chemicals. We seem to understand important chemical pathways responsible for POP destruction in the environment, so we can design less persistent and problematic chemicals in the future.
Engineering for Sustainable Wastewater Recycling: The shortage of clean water represents a critical challenge for the next century, and has necessitated the recycling of wastewater. We seek to understand ways of engineer this process in ways to minimize harmful byproduct formation.
Carbon Sequestration: We are evaluating the formation of nitrosamine and nitraminecarcinogens from amine-based carbon capture, as well as techniques to destroy any of these byproducts that form.
George D. Smith Professor of Translational MedicineOn Leave from 09/25/2023 To 12/24/2023
Current Research and Scholarly InterestsTwo areas: 1. Using rationally-designed peptide inhibitors to study protein-protein interactions in cell signaling. Focus: protein kinase C in heart and large GTPases regulating mitochondrial dynamics in neurodegdenration. 2. Using small molecules (identified in a high throughput screens and synthetic chemistry) as activators and inhibitors of aldehyde dehydrogenases, a family of detoxifying enzymes, and glucose-6-phoshate dehydrogenase, in normal cells and in models of human diseases.
W. E. Moerner
Harry S. Mosher Professor and Professor, by courtesy, of Applied Physics
Current Research and Scholarly InterestsLaser spectroscopy and microscopy of single molecules to probe biological systems, one biomolecule at a time. Primary thrusts: fluorescence microscopy far beyond the optical diffraction limit (PALM/STORM/STED), methods for 3D optical microscopy in cells, and trapping of single biomolecules in solution for extended study. We explore protein localization patterns in bacteria, structures of amyloid aggregates in cells, signaling proteins in the primary cilium, and dynamics of DNA and RNA.
Matteo Amitaba Mole'
Assistant Professor of Obstetrics and Gynecology (Dunlevie Maternal-Fetal Medicine Center for Discovery, Innovation and Clinical Impact)
Current Research and Scholarly InterestsThe research focus of our laboratory is centered on investigating the complex process of human embryo implantation. Due to the limited availability of suitable model systems and inability to directly observe this process in vivo, this has been traditionally referred to as the enigmatic stage of human embryonic development.
The successful implantation of an embryo is crucial for the establishment of a healthy pregnancy. During the transition between the first and second week of gestation, the human embryo must securely implant into the maternal uterus, initiating development of the placenta to receive necessary nutrients and oxygen for its growth until birth.
However, the process of implantation in humans is highly susceptible to failure, with a significant percentage of embryos unable to develop beyond this stage leading to early miscarriages. This clinically observed "implantation barrier" often requires patients to undergo numerous cycles of IVF treatment, with no guarantee of a successful pregnancy outcome.
The primary objective is to increase the understanding of maternal-embryo interactions initiated at implantation, with the goal of developing clinical interventions to address the high incidence of implantation failures underlying pre-clinical miscarriages.
Denise M. Monack
Martha Meier Weiland Professor in the School of Medicine
Current Research and Scholarly InterestsThe primary focus of my research is to understand the genetic and molecular mechanisms of intracellular bacterial pathogenesis. We use several model systems to study complex host-pathogen interactions in the gut and in immune cells such as macrophages and dendritic cells. Ultimately we would like to understand how Salmonella persists within certain hosts for years in the face of a robust immune response.
Obayashi Professor in the School of Engineering and Professor of OceansOn Leave from 10/01/2023 To 12/31/2023
Current Research and Scholarly InterestsHydrodynamics of lakes, estuaries, coral reefs, kelp forests and the coastal ocean
Milan Gambhir Professor of Pediatric Neuro-Oncology and Professor, by courtesy, of Neurosurgery, of Pediatrics, of Pathology and of Psychiatry and Behavioral Sciences
Current Research and Scholarly InterestsThe Monje Lab studies the molecular and cellular mechanisms of postnatal neurodevelopment. This includes microenvironmental influences on neural precursor cell fate choice in normal neurodevelopment and in disease states.
Stephen B. Montgomery
Professor of Pathology, of Genetics and of Biomedical Data Science
Current Research and Scholarly InterestsWe focus on understanding the effects of genome variation on cellular phenotypes and cellular modeling of disease through genomic approaches such as next generation RNA sequencing in combination with developing and utilizing state-of-the-art bioinformatics and statistical genetics approaches. See our website at http://montgomerylab.stanford.edu/
Thomas Montine, MD, PhD
Stanford Medicine Professor of Pathology
BioDr. Montine received his education at Columbia University (BA in Chemistry), the University of Rochester (PhD in Pharmacology), and McGill University (MD and CM). His postgraduate medical training was at Duke University, and he was junior faculty at Vanderbilt University where he was awarded the Thorne Professorship in Pathology. In 2002, Dr. Montine was appointed as the Alvord Endowed Professor in Neuropathology and Director of the Division of Neuropathology at the University of Washington. He was Director of the University of Washington Alzheimer’s Disease Research Center, one of the original 10 Centers in the US, and passed that responsibility to able colleagues. Dr. Montine was the founding Director of the Pacific Udall Center, a NINDS-funded Morris K. Udall Centers of Excellence for Parkinson’s Disease Research. In 2010, Dr. Montine was appointed Chair of the Department of Pathology at the University of Washington. In 2016, Dr. Montine was appointed Chair of the Department of Pathology at Stanford University where he is the Stanford Medicine Endowed Professor in Pathology.
The focus of the Montine Laboratory is on the structural and molecular bases of cognitive impairment. The Montine Laboratory addresses this prevalent, unmet medical need through a combination of neuropathology, biomarkers for detection and progression of early disease, and experimental studies that test hypotheses concerning specific mechanisms of neuron injury and then develop novel approaches to neuroprotection. Our current approaches include small molecule precision therapeutics and cell replacement strategies for brain.
Ben Barres Professor
Current Research and Scholarly InterestsWe study neural mechanisms of visual-motor integration and the neural basis of cognition (e.g. attention). We study the activity of single neurons in visual and motor structures within the brain, examine how perturbing that activity affects neurons in other brain structures, and also how it affects the perceptual and
Associate Professor of Biology and Senior Fellow at the Woods Institute for the Environment
Current Research and Scholarly InterestsOur research focuses on the ecology of infectious disease. We are interested in how climate, species interactions, and global change drive infectious disease dynamics in humans and natural ecosystems. This research combines mathematical modeling and empirical work. Our main study systems include vector-borne diseases in humans and fungal pathogens in California grasses.
Assistant Professor (Research) of Neurology
BioDr. Beth Mormino completed a PhD in Neuroscience at UC Berkeley in the laboratory of Dr. William Jagust, where she performed some of the initial studies applying Amyloid PET with the tracer PIB to clinically normal older individuals. This initial work provided evidence that the pathophysiological processes of Alzheimer’s disease begin years before clinical symptoms and are associated with subtle changes to brain regions critical for memory. During her postdoctoral fellowship with Drs. Reisa Sperling and Keith Johnson at Massachusetts General Hospital she used multimodal imaging techniques to understand longitudinal cognitive changes among individuals classified as preclinical AD. In 2017, Dr. Mormino joined the faculty at Stanford University in the department of Neurology and Neurological Sciences. Her research program focuses on combining imaging and genetics to predict cognitive trajectories over time, and the integration of novel PET scans to better understand human aging and neurodegenerative diseases.
Associate Professor of Biology
Current Research and Scholarly InterestsOur research interests are to elucidate the contribution of chromatin to mechanisms that promote genomic integrity.
Professor of Radiology (Radiological Sciences Lab)
Current Research and Scholarly InterestsMR physics into tissue contrast mechanisms such as diffusion, perfusion, and functional imaging describes the research direction. Applications of cerebral stroke (brain attacks) and neurocognitive disorders are also being developed from these methods
Darius M. Moshfeghi, MD
Professor of Ophthalmology
Current Research and Scholarly InterestsDr. Moshfeghi leads the Stanford University Network for Diagnosis of Retinopathy of Prematurity (SUNDROP network) and the Pediatrix-Stanford collaboration TeleROP. Between these 2 screening programs, nearly 2% of United States neonatal intensive care units are being provided telemedicine screening services through Stanford University.
Heather E. Moss, MD, PhD
Associate Professor of Ophthalmology and of Neurology
Current Research and Scholarly InterestsI am a clinician scientist with a background in engineering, epidemiology and neuro-ophthalmology. In my research, I combine tools from these disciplines with the goal of understanding and preventing vision loss from optic nerve diseases. My focus is on papilledema, the swelling of the optic nerve head due to elevation in intracranial pressure, which we are characterizing using electrophysiological and imaging techniques. Other areas of interest are peri-operative vision loss and optic neuritis.
Associate Professor of Psychiatry and Behavioral Sciences (Major Laboratories and Clinical Translational Neurosciences Incubator)
BioExpertise: Neurobiology, Sleep sciences, Molecular Genetics, Developmental Biology, Gene Silencing/Epigenetics
Methodology: Synapse Imaging (Two photon microscopy, Array Tomography), Calcium Imaging (Light Sheet Microscopy/SPIM, Light Field Microscopy), Optogenetics, CLARITY, Tol2 transgenesis, TALENs, CRISPR/Cas9, Video tracking and behavior computation.
Prithvi Mruthyunjaya, MD, MHS
Professor of Ophthalmology and, by courtesy, of Radiation Oncology
Current Research and Scholarly InterestsDr Mruthyunjaya has maintained a broad research interest with publications in both ocular oncology and retinal diseases.
His focus is on multi-modal imaging of ocular tumors and understanding imaging clues that may predict vision loss after ocular radiation therapy. He coordinates multi-center research on the role of genetic testing and outcomes of treatments of ocular melanoma.
In the field of retinal diseases, his interests are in intra-operative imaging to enhance surgical accuracy.
Mary Beth Mudgett
Senior Associate Dean for the Natural Sciences and Professor of Biology
Current Research and Scholarly InterestsMy laboratory investigates how bacterial pathogens employ proteins secreted by the type III secretion system (TTSS) to manipulate eukaryotic signaling to promote disease. We study TTSS effectors in the plant pathogen Xanthomonas euvesicatoria, the causal agent of bacterial spot disease of pepper and tomato. For these studies, we apply biochemical, cell biological, and genetic approaches using the natural hosts and model pathosystems.
Assistant Professor of Materials Science and Engineering
BioKunal Mukherjee is an assistant professor in Materials Science and Engineering at Stanford. He has been an assistant professor in the Materials department at UC Santa Barbara (2016-2020), held postdoctoral appointments at IBM TJ Watson Research Center (2016) and MIT (2015), and worked as a transceiver engineer at Finisar (2009-2010).
The Mukherjee group specializes in semiconductors that emit and detect light in the infrared. Our research enables better materials for data transmission, sensing, manufacturing, and environmental monitoring. We make high-quality thin films with IV-VI (PbSnSe) and III-V (GaAs-InAs/GaSb) material systems and spend much of our time understanding how imperfections in the crystalline structure such as dislocations and point defects impact their electronic and optical properties. This holds the key to directly integrating these semiconductors with silicon and germanium substrates for new hybrid circuits that combine infrared photonics and conventional electronics.
Stanford Medicine Professor of Biomedical Informatics Research, Professor of Medicine (Biomedical Informatics) and of Biomedical Data Science
Current Research and Scholarly InterestsModern science requires that experimental data—and descriptions of the methods used to generate and analyze the data—are available online. Our laboratory studies methods for creating comprehensive, machine-actionable descriptions both of data and of experiments that can be processed by other scientists and by computers. We are also working to "clean up" legacy data and metadata to improve adherence to standards and to facilitate open science broadly.
David Myung, MD, PhD
Associate Professor of Ophthalmology and, by courtesy, of Chemical Engineering
Current Research and Scholarly InterestsNovel biomaterials to reconstruct the wounded cornea
Mesenchymal stem cell therapy for corneal and ocular surface regeneration
Engineered biomolecule therapies for promote corneal wound healing
Telemedicine in ophthalmology