Wu Tsai Neurosciences Institute
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Shan X. Wang
Leland T. Edwards Professor in the School of Engineering and Professor of Electrical Engineering and, by courtesy, of Radiology (Molecular Imaging Program at Stanford)
Current Research and Scholarly InterestsShan Wang was named the Leland T. Edwards Professor in the School of Engineering in 2018. He directs the Center for Magnetic Nanotechnology and is a leading expert in biosensors, information storage and spintronics. His research and inventions span across a variety of areas including magnetic biochips, in vitro diagnostics, cancer biomarkers, magnetic nanoparticles, magnetic sensors, magnetoresistive random access memory, and magnetic integrated inductors.
Sui Wang, PhD
Assistant Professor of Ophthalmology
Current Research and Scholarly InterestsOur research focuses on unraveling the molecular mechanisms underlying retinal development and diseases. We employ genetic and genomic tools to explore how various retinal cell types, including neurons, glia, and the vasculature, respond to developmental cues and disease insults at the epigenomic and transcriptional levels. In addition, we investigate their interactions and collective contributions to maintain retinal integrity.
1. Investigating retinal development:
We utilize genetic tools and methods such as in vivo plasmid electroporation and CRISPR to dissect the roles of cis-regulatory elements and transcription factors in controlling retinal development.
2. Understanding diabetes-induced cell-type-specific responses in the retina:
Diabetes triggers a range of multicellular responses in the retina, such as vascular lesions, glial dysfunction, and neurodegeneration, all of which contribute to retinopathy. We delve into the detailed molecular mechanisms underlying these diabetes-induced cell-type-specific responses and the pathogenesis of diabetic retinopathy.
3. Developing molecular tools for labeling and manipulation of specific cell types in vivo:
Cis-regulatory elements, particularly enhancers, play pivotal roles in directing tissue- and cell-type-specific expression. Our interest lies in identifying enhancers that can drive cell type-specific expression in the retina and brain. We incorporate these enhancers into plasmid or AAV-based delivery systems, enabling precise labeling and manipulation of specific cell types in vivo.
Associate Professor of Neurosurgery
Current Research and Scholarly InterestsMechanisms underlying mitochondrial dynamics and function, and their implications in neurological disorders.
Virginia & D.K. Ludwig Professor of Clinical Investigation in Cancer Research, Professor of Pathology, and of Developmental Biology
Current Research and Scholarly InterestsStem cell and cancer stem cell biology; development of T and B lymphocytes; cell-surface receptors for oncornaviruses in leukemia. Hematopoietic stem cells; Lymphocyte homing, lymphoma invasiveness and metastasis; order of events from hematopoietic stem cells [HSC] to AML leukemia stem cells and blood diseases, and parallels in other tissues; discovery of tumor and pathogenic cell 'don't eat me' and 'eat me' signals, and translation into therapeutics.
Professor of Electrical Engineering
BioTsachy's research focuses on Information Theory, Data Compression and Communications, Statistical Signal Processing, Machine Learning, the interplay between them, and their applications, with recent focus on applications to genomic data compression and processing. He is inventor of several patents and involved in several companies as member of the technical board. IEEE fellow, he serves on the board of governors of the information theory society as well as the editorial boards of the Transactions on Information Theory and Foundations and Trends in Communications and Information Theory. He is founding Director of the Stanford Compression Forum.
Jill Saylin Wentzell
Executive Director, Wu Tsai Neurosciences Institute
Current Role at StanfordExecutive Director, Wu Tsai Neurosciences Institute
Professor of Pathology and, by courtesy, of Chemical and Systems Biology
Current Research and Scholarly InterestsEpigenetic Reprogramming, Direct conversion of fibroblasts into neurons, Pluripotent Stem Cells, Neural Differentiation: implications in development and regenerative medicine
Professor of Pathology
Current Research and Scholarly InterestsRob West, MD, PhD, is a Professor of Pathology at Stanford University Medical Center. He is a clinician scientist with experience in translational genomics research to identify new prognostic and therapeutic markers in cancer. His research focus is on the progression of neoplasia to carcinoma. His lab has developed spatially oriented in situ methods to study archival specimens. He also serves as a surgical pathologist specializing in breast pathology.
Associate Professor of Electrical Engineering and, by courtesy, of Computer Science
BioGordon Wetzstein is an Associate Professor of Electrical Engineering and, by courtesy, of Computer Science at Stanford University. He is the leader of the Stanford Computational Imaging Lab and a faculty co-director of the Stanford Center for Image Systems Engineering. At the intersection of computer graphics and vision, artificial intelligence, computational optics, and applied vision science, Prof. Wetzstein's research has a wide range of applications in next-generation imaging, wearable computing, and neural rendering systems. Prof. Wetzstein is a Fellow of Optica and the recipient of numerous awards, including an NSF CAREER Award, an Alfred P. Sloan Fellowship, an ACM SIGGRAPH Significant New Researcher Award, a Presidential Early Career Award for Scientists and Engineers (PECASE), an SPIE Early Career Achievement Award, an Electronic Imaging Scientist of the Year Award, an Alain Fournier Ph.D. Dissertation Award as well as many Best Paper and Demo Awards.
Associate Professor of Medicine (Cardiovascular Medicine)
Current Research and Scholarly InterestsTranslational research in rare and undiagnosed diseases. Basic and clinical research in cardiomyopathy genetics, mechanisms, screening, and treatment. Investigating novel agents for treatment of hypertrophic cardiomyopathy and new mechanisms in heart failure. Cardiovascular screening and genetics in competitive athletes, disease gene discovery in cardiomyopathy and rare disease. Informatics approaches to rare disease and multiomics. Molecular transducers of physical activity bioinformatics.
Vincent V.C. Woo Professor, Professor of Psychiatry and Behavioral Sciences (Major Laboratories and Clinical Translational Neurosciences Incubator) and, by courtesy, of Psychology
Current Research and Scholarly InterestsA revolution is under way in psychiatry. We can now understand mental illness as an expression of underlying brain circuit disruptions, shaped by experience and genetics. Our lab is defining precision brain circuit biotypes for depression, anxiety and related disorders. We integrate large amounts of brain imaging, behavioral and clinical data and computational approaches. Biotypes are used in personalized intervention studies with selective drugs, neuromodulation and exploratory therapeutics.
Associate Professor of Psychiatry and Behavioral Sciences (Major Laboratories & Clinical Translational Neurosciences Incubator) and, by courtesy, of Radiology (Neuroimaging and Neurointervention)
BioDr. Williams is an Associate Professor within the Department of Psychiatry and Behavioral Sciences and the Director of the Stanford Brain Stimulation Lab. Dr. Williams has a broad background in clinical neuroscience and is triple board-certified in general neurology, general psychiatry, as well as behavioral neurology & neuropsychiatry. In addition, he has specific training and clinical expertise in the development of brain stimulation methodologies. Themes of his work include (a) examining the use of spaced learning theory in the application of neurostimulation techniques, (b) development and mechanistic understanding of rapid-acting antidepressants, and (c) identifying objective biomarkers that predict neuromodulation responses in treatment-resistant neuropsychiatric conditions. Dr. Williams' work has resulted in an FDA clearance for the world's first non-invasive, rapid-acting neuromodulation approach for treatment-resistant depression. He has published papers in high-impact peer-reviewed journals including Brain, American Journal of Psychiatry, and the Proceedings of the National Academy of Science. Results from his studies have gained widespread attention in journals such as Science and New England Journal of Medicine Journal Watch as well as in the popular press and have been featured in various news sources including Time, Smithsonian, and Newsweek. Dr. Williams received two NARSAD Young Investigator Awards in 2016 and 2018 along with the 2019 Gerald R. Klerman Award. Dr. Williams received the National Institute of Mental Health Biobehavioral Research Award for Innovative New Scientists in 2020.
Thomas J. Wilson
Clinical Associate Professor, Neurosurgery
BioDr. Thomas J. Wilson was born in Omaha, Nebraska. He attended the University of Nebraska College of Medicine, earning his MD with highest distinction. While a medical student, he was awarded a Howard Hughes Medical Institute Research Training Fellowship and spent a year in the lab of Dr. Rakesh Singh at the University of Nebraska. He was also elected to the prestigious Alpha Omega Alpha Honor Medical Society. He completed his residency training in neurological surgery at the University of Michigan and was mentored by Dr. Lynda Yang and Dr. John McGillicuddy in peripheral nerve surgery. Following his residency, he completed a fellowship in peripheral nerve surgery at the Mayo Clinic in Rochester, Minnesota, working with Dr. Robert Spinner. He is now Clinical Associate Professor and Co-Director of the Center for Peripheral Nerve Surgery at Stanford University. He also holds a Master of Public Health (MPH) degree from the Bloomberg School of Public Health at Johns Hopkins University, with focused certificates in Clinical Trials and Health Finance and Management. His research interests include peripheral nerve outcomes research, clinical trials advancing options for patients with peripheral nerve pathologies and spinal cord injuries, and translational research focused on improved imaging techniques to assist in diagnosing nerve pain and other peripheral nerve conditions. His clinical practice encompasses the treatment of all peripheral nerve pathologies, including entrapment neuropathies, nerve tumors, nerve injuries (including brachial plexus injuries, upper and lower extremity nerve injuries), and nerve pain. Dr. Wilson enjoys working in multi-disciplinary teams to solve complex problems of the peripheral nervous system. His wife, Dr. Monique Wilson, is a practicing dermatologist in the Bay Area.
Jeffrey J. Wine
Benjamin Scott Crocker Professor of Human Biology, Emeritus
Current Research and Scholarly InterestsThe goal is to understand how a defective ion channel leads to the human genetic disease cystic fibrosis. Studies of ion channels and ion transport involved in gland fluid transport. Methods include SSCP mutation detection and DNA sequencing, protein analysis, patch-clamp recording, ion-selective microelectrodes, electrophysiological analyses of transmembrane ion flows, isotopic metho
Associate Professor of Genetics and of Pathology
Current Research and Scholarly InterestsOur laboratory uses genome-wide methods to uncover alterations that drive cancer progression and metastasis in genetically-engineered mouse models of human cancers. We combine cell-culture based mechanistic studies with our ability to alter pathways of interest during tumor progression in vivo to better understand each step of metastatic spread and to uncover the therapeutic vulnerabilities of advanced cancer cells.
H.-S. Philip Wong
Willard R. and Inez Kerr Bell Professor in the School of Engineering
BioH.-S. Philip Wong is the Willard R. and Inez Kerr Bell Professor in the School of Engineering at Stanford University. He joined Stanford University as Professor of Electrical Engineering in 2004. From 1988 to 2004, he was with the IBM T.J. Watson Research Center. From 2018 to 2020, he was on leave from Stanford and was the Vice President of Corporate Research at TSMC, the largest semiconductor foundry in the world, and since 2020 remains the Chief Scientist of TSMC in a consulting, advisory role.
He is a Fellow of the IEEE and received the IEEE Electron Devices Society J.J. Ebers Award, the society’s highest honor to recognize outstanding technical contributions to the field of electron devices that have made a lasting impact, as well as the IEEE Andrew S. Grove Award, the IEEE Technical Field Award to honor individuals for outstanding contributions to solid-state devices and technology.
He is the founding Faculty Co-Director of the Stanford SystemX Alliance – an industrial affiliate program focused on building systems, the faculty director of the Stanford Non-Volatile Memory Technology Research Initiative (NMTRI), and the faculty director of the Stanford Nanofabrication Facility – a shared facility for device fabrication on the Stanford campus that serves academic, industrial, and governmental researchers across the U.S. and around the globe, sponsored in part by the National Science Foundation.
S Simon Wong
Professor of Electrical Engineering, Emeritus
Current Research and Scholarly InterestsCurrent research focuses on
Resistive Random Access Memory (RRAM) and Integration with CMOS
Energy Efficient Approximate Computing for Machine Learning
Wing Hung Wong
Stephen R. Pierce Family Goldman Sachs Professor of Science and Human Health and Professor of Biomedical Data Science
Current Research and Scholarly InterestsCurrent interest centers on the application of statistics to biology and medicine. We are particularly interested in questions concerning gene regulation, genome interpretation and their applications to precision medicine.
Albert Y. Wu, MD, PhD, FACS
Assistant Professor of Ophthalmology
Current Research and Scholarly InterestsMy translational research focuses on using autologous stem cells to recreate a patient’s ocular tissues for potential transplantation. We are generating tissue from induced pluripotent stem cells to treat limbal stem cell deficiency in patients who are bilaterally blind. By applying my background in molecular and cellular biology, stem cell biology, oculoplastic surgery, I hope to make regenerative medicine a reality for those suffering from orbital and ocular disease.
Current Research and Scholarly InterestsI am interested in how the brain matures to control the bladder and external sphincter to achieve urinary continence. Using functional MRI of the brain, we are investigating if certain patterns of activity will predict which children will respond to therapy for incontinence.
Assistant Professor of Computer Science
BioJiajun Wu is an Assistant Professor of Computer Science at Stanford University, working on computer vision, machine learning, and computational cognitive science. Before joining Stanford, he was a Visiting Faculty Researcher at Google Research. He received his PhD in Electrical Engineering and Computer Science from the Massachusetts Institute of Technology. Wu's research has been recognized through the Young Investigator Program (YIP) by ONR and by AFOSR, the ACM Doctoral Dissertation Award Honorable Mention, the AAAI/ACM SIGAI Doctoral Dissertation Award, the MIT George M. Sprowls PhD Thesis Award in Artificial Intelligence and Decision-Making, the 2020 Samsung AI Researcher of the Year, the IROS Best Paper Award on Cognitive Robotics, and faculty research awards from J.P. Morgan, Samsung, Amazon, and Meta.
Joseph C. Wu, MD, PhD
Director, Stanford Cardiovascular Institute, Simon H. Stertzer, MD, Professor and Professor of Radiology
Current Research and Scholarly InterestsDrug discovery, drug screening, and disease modeling using iPSC.
Courtney Wusthoff, MD
Associate Professor of Neurology and, by courtesy, of Pediatrics (Neonatology)
Current Research and Scholarly InterestsMy projects focus on clinical research in newborns with, or at risk, for brain injury. I use EEG in at-risk neonates to better understand the underlying pathophysiology of risk factors that may lead to worse outcomes. I am particularly interested in neonatal seizures and how they may exacerbate perinatal brain injury with a goal to identify treatments that might protect the vulnerable brain. I am also interested in EEG in other pediatric populations, as well as medical ethics and global health.
Lorry Lokey Professor and Professor of Developmental Biology
Current Research and Scholarly InterestsThe precise and robust regulation of gene expression is a cornerstone for complex biological life. Research in our laboratory is focused on understanding how regulatory information encoded by the genome is integrated with the transcriptional machinery and chromatin context to allow for emergence of form and function during human embryogenesis and evolution, and how perturbations in this process lead to disease.
Tony Wyss-Coray, PhD
D. H. Chen Professor II
Current Research and Scholarly InterestsUse of genetic and molecular tools to dissect immune and inflammatory pathways in Alzheimer's and neurodegeneration.
Jacob Haimson and Sarah S. Donaldson Professor and Professor, by courtesy, of Electrical Engineering
Current Research and Scholarly Interestsartificial intelligence in medicine, medical imaging, Image-guided intervention, molecular imaging, biology guided radiation therapy (BGRT), treatment plan optimization
Assistant Professor of Psychology and of Computer Science
Current Research and Scholarly InterestsOur lab's research lies at intersection of neuroscience, artificial intelligence, psychology and large-scale data analysis. It is founded on two mutually reinforcing hypotheses:
H1. By studying how the brain solves computational challenges, we can learn to build better artificial intelligence algorithms.
H2. Through improving artificial intelligence algorithms, we'll discover better models of how the brain works.
We investigate these hypotheses using techniques from computational modeling and artificial intelligence, high-throughput neurophysiology, functional brain imaging, behavioral psychophysics, and large-scale data analysis.
Associate Professor of Orthopaedic Surgery and of Bioengineering
Current Research and Scholarly InterestsOur lab’s mission is to develop therapies for regenerating human tissues lost due to diseases or aging, and to build tissue engineered 3D models for understanding disease progression and informing drug discovery. We invent biomaterials and engineering tools to elucidate and modulate biology, and also use biology to inform materials and engineering design. Our work is highly interdisciplinary, and is driven by unmet clinical needs or key gaps in biology.
Associate Professor of Neurology
Current Research and Scholarly InterestsElucidate biological functions of cytoskeletal associated proteins in neurons. Define the cellular and molecular mechanisms underlying neurodegeneration in null mice.
Yunzhi Peter Yang
Professor of Orthopaedic Surgery and, by courtesy, of Materials Science and Engineering and of Bioengineering
Current Research and Scholarly InterestsYang lab's research interests are in the areas of bio-inspired biomaterials, medical devices, and 3D printing approaches for re-creating a suitable microenvironment for cell growth and tissue regeneration for musculoskeletal disease diagnosis and treatment, including multiple tissue healing such as rotator cuff injury, orthopedic diseases such as osteoporosis and osteonecrosis, and orthopedic traumas such as massive bone and muscle injuries.
Associate Professor of Pediatrics (Developmental-Behavioral Pediatrics), of Education and of Psychology
BioDr. Jason Yeatman is an Associate Professor in the Graduate School of Education and Department of Psychology at Stanford University and the Division of Developmental and Behavioral Pediatrics at Stanford University School of Medicine. Dr. Yeatman completed his PhD in Psychology at Stanford where he studied the neurobiology of literacy and developed new brain imaging methods for studying the relationship between brain plasticity and learning. After finishing his PhD, he took a faculty position at the University of Washington’s Institute for Learning and Brain Sciences before returning to Stanford.
As the director of the Brain Development and Education Lab, the overarching goal of his research is to understand the mechanisms that underlie the process of learning to read, how these mechanisms differ in children with dyslexia, and to design literacy intervention programs that are effective across the wide spectrum of learning differences. His lab employs a collection of structural and functional neuroimaging measurements to study how a child’s experience with reading instruction shapes the development of brain circuits that are specialized for this unique cognitive function.
David C. Yeomans
Associate Professor of Anesthesiology, Perioperative and Pain Medicine
Current Research and Scholarly InterestsPhysiology of different pain types; Biomarkers of pain and inflammation; Gene Therapy for Pain
Jared and Mae Tinklenberg Professor and Professor, by courtesy, of Neurology
Current Research and Scholarly InterestsWe study cognitive processes and aging in our research center. Studies range from molecular biology to neuropsychology of cognitive processes.
Assistant Professor of Biomedical Data Science and, by courtesy, of Computer Science and of Electrical Engineering
BioDr. Serena Yeung is an Assistant Professor of Biomedical Data Science and, by courtesy, of Computer Science and of Electrical Engineering at Stanford University. Her research focus is on developing artificial intelligence and machine learning algorithms to enable new capabilities in biomedicine and healthcare. She has extensive expertise in deep learning and computer vision, and has developed computer vision algorithms for analyzing diverse types of visual data ranging from video capture of human behavior, to medical images and cell microscopy images.
Dr. Yeung leads the Medical AI and Computer Vision Lab at Stanford. She is affiliated with the Stanford Artificial Intelligence Laboratory, the Clinical Excellence Research Center, the Center for Artificial Intelligence in Medicine & Imaging, the Center for Human-Centered Artificial Intelligence, and Bio-X. She also serves on the NIH Advisory Committee to the Director Working Group on Artificial Intelligence.
Jong H. Yoon
Professor of Psychiatry and Behavioral Sciences (Public Mental Health & Population Sciences)
Current Research and Scholarly InterestsMy research seeks to discover the brain mechanisms responsible for schizophrenia and to translate this knowledge into the clinic to improve how we diagnose and treat this condition. Towards these ends, our group has been developing cutting-edge neuroimaging tools to identify neurobiological abnormalities and test novel systems-level disease models of psychosis and schizophrenia directly in individuals with these conditions.
We have been particularly interested in the role of neocortical-basal ganglia circuit dysfunction. A working hypothesis is that some of the core symptoms of schizophrenia are attributable to impairments in neocortical function that results in disconnectivity with components of the basal ganglia and dysregulation of their activity. The Yoon Lab has developed new high-resolution functional magnetic resonance imaging methods to more precisely measure the function of basal ganglia components, which given their small size and location deep within the brain has been challenging. This includes ways to measure the activity of nuclei that store and control the release of dopamine throughout the brain, a neurochemical that is one of the most important factors in the production of psychosis in schizophrenia and other neuropsychiatric conditions.
Professor of Radiology (Neuroimaging and Neurointervention)
Current Research and Scholarly InterestsImproving medical image quality using deep learning artificial intelligence
Imaging of cerebral hemodynamics with MRI and CT
Noninvasive oxygenation measurement with MRI
Clinical imaging of cerebrovascular disease
Imaging of cervical artery dissection
MR/PET in Neuroradiology
Resting-state fMRI for perfusion imaging and stroke
Natalie M. Zahr
Assistant Professor (Research) of Psychiatry and Behavioral Sciences (Major Laboratories)
BioNatalie M. Zahr received a graduate education in the basic sciences including the study of neuro- pharmacology, physiology, and anatomy. After completing her graduate training in electrophysiology, she began a postdoctoral fellowship as a magnetic resonance imaging (MRI) scientist. Her work focuses on translational approaches using in vivo MR imaging and spectroscopy in studies of human with Alcohol Use Disorders (AUD) and in rodent models of alcohol exposure with the goal of identifying mechanisms of alcohol effects on the brain. Her human studies include participants with HIV, those co-morbid for HIV and AUD and recently, aging individuals with mild cognitive impairment (MCI). Her position allows her to explore emerging MR technologies and apply them to test relevant hypotheses. Before joining Stanford, she taught at several local institutions including UC Berkeley extension and Santa Clara University where she enjoyed sharing her knowledge and enthusiasm for learning with students.
Associate Professor of Psychology
Current Research and Scholarly InterestsMy research focuses on the cognitive and neural bases of social behavior, and in particular on how people respond to each other's emotions (empathy), why they conform to each other (social influence), and why they choose to help each other (prosociality).
Marguerite Blake Wilbur Professor of Natural Science and Professor, by courtesy, of Physics
Current Research and Scholarly InterestsMy research group is exploring a variety of topics that range from the basic understanding of chemical reaction dynamics to the nature of the chemical contents of single cells.
Under thermal conditions nature seems to hide the details of how elementary reactions occur through a series of averages over reagent velocity, internal energy, impact parameter, and orientation. To discover the effects of these variables on reactivity, it is necessary to carry out studies of chemical reactions far from equilibrium in which the states of the reactants are more sharply restricted and can be varied in a controlled manner. My research group is attempting to meet this tough experimental challenge through a number of laser techniques that prepare reactants in specific quantum states and probe the quantum state distributions of the resulting products. It is our belief that such state-to-state information gives the deepest insight into the forces that operate in the breaking of old bonds and the making of new ones.
Space does not permit a full description of these projects, and I earnestly invite correspondence. The following examples are representative:
The simplest of all neutral bimolecular reactions is the exchange reaction H H2 -> H2 H. We are studying this system and various isotopic cousins using a tunable UV laser pulse to photodissociate HBr (DBr) and hence create fast H (D) atoms of known translational energy in the presence of H2 and/or D2 and using a laser multiphoton ionization time-of-flight mass spectrometer to detect the nascent molecular products in a quantum-state-specific manner by means of an imaging technique. It is expected that these product state distributions will provide a key test of the adequacy of various advanced theoretical schemes for modeling this reaction.
Analytical efforts involve the use of capillary zone electrophoresis, two-step laser desorption laser multiphoton ionization mass spectrometry, cavity ring-down spectroscopy, and Hadamard transform time-of-flight mass spectrometry. We believe these methods can revolutionize trace analysis, particularly of biomolecules in cells.
Associate Professor of Radiology (Neuroimaging and Neurointervention)
BioDr. Michael Zeineh received a B.S. in Biology at Caltech in 1995 and obtained his M.D.-Ph.D. from UCLA in 2003. After internship also at UCLA, he went on to radiology residency and neuroradiology fellowship both at Stanford. He has been faculty in Stanford Neuroradiology since 2010. He spearheads many initiatives in advanced clinical imaging at Stanford, including clinical fMRI and DTI. Simultaneously, he runs a lab with the goal of discovering new imaging abnormalities in neurodegenerative disorders, with a focus on detailed microcircuitry in regions such as the hippocampal formation using advanced, multi-modal in vivo and ex vivo methods, with applications to neurodegenerative disorders such as Alzheimer’s disease and mild traumatic brain injury.
Professor (Research) of Psychiatry and Behavioral Sciences (Sleep Medicine)
Current Research and Scholarly InterestsDr. Zeitzer is a circadian physiologist specializing in the understanding of the impact of light on circadian rhythms and other aspects of non-image forming light perception.
He examines the manner in which humans respond to light and ways to manipulate this responsiveness, with direct application to jet lag, shift work, and altered sleep timing in teens. Dr. Zeitzer has also pioneered the use of actigraphy in the determination of epiphenomenal markers of psychiatric disorders.
Member, Wu Tsai Neurosciences Institute
Current Research and Scholarly InterestsMy lab is focused on developing novel therapeutic methods against stroke using rodent models. We study protective effect of postconditioning, preconditioning and mild hypothermia. The rationale for studying three means of neuroprotection is that we may discover mechanisms that these treatments have in common. Conversely, if they have differing mechanisms, we will be able to offer more than one treatment for stroke and increase a patients chance for recovery.
Instructor, Psychiatry and Behavioral Sciences
BioI am interested in using machine learning and computational approaches to analyze longitudinal and multi-modal MRI to characterize how the white-matter architecture develops during adolescence to support coordinated neural activity for developing higher-order executive functions. My research also extends to characterizing the predisposing and detrimental effects of alcohol and substance use on brain structure and function. My broad interest lies in image analysis and statistical learning for the detection, diagnosis and treatment of diseases.
Assistant Professor of Mechanical Engineering and, by courtesy, of Materials Science and Engineering
BioRuike Renee Zhao is an Assistant Professor of Mechanical Engineering at Stanford University where she directs the Soft Intelligent Materials Laboratory. Renee received her BS degree from Xi'an Jiaotong University in 2012, and her MS and PhD degrees from Brown University in 2014 and 2016, respectively. She was a postdoc associate at MIT during 2016-2018 prior to her appointment as an Assistant Professor in the Department of Mechanical and Aerospace Engineering at The Ohio State University from 2018 to 2021.
Renee’s research focuses on the development of stimuli-responsive soft composites for multifunctional robotic systems with integrated shape-changing, assembling, sensing, and navigation. By combining mechanics, polymer engineering, and advanced material manufacturing techniques, the functional soft composites enable applications in soft robotics, miniaturized biomedical devices, flexible electronics, and deployable and morphing structures.
Renee is a recipient of the ARO Early Career Program (ECP) Award (2023), AFOSR Young Investigator Research Program (YIP) Award (2023), Eshelby Mechanics Award for Young Faculty (2022), ASME Henry Hess Early Career Publication Award (2022), ASME Pi Tau Sigma Gold Medal (2022), ASME Applied Mechanics Division Journal of Applied Mechanics Award (2021), NSF Career Award (2020), and ASME Applied Mechanics Division Haythornthwaite Research Initiation Award (2018).
Professor of Mechanical Engineering, of Energy Science Engineering, Senior Fellow at the Precourt Institute for Energy and Professor, by courtesy, of Materials Science and Engineering
BioProfessor Zheng received her Ph.D. in Mechanical & Aerospace Engineering from Princeton University (2006), B.S. in Thermal Engineering from Tsinghua University (2000). Prior to joining Stanford in 2007, Professor Zheng did her postdoctoral work in the Department of Chemistry and Chemical Biology at Harvard University. Professor Zheng is a member of MRS, ACS and combustion institute. Professor Zheng received the TR35 Award from the MIT Technology Review (2013), one of the 100 Leading Global Thinkers by the Foreign Policy Magazine (2013), 3M Nontenured Faculty Grant Award (2013), the Presidential Early Career Award (PECASE) from the white house (2009), Young Investigator Awards from the ONR (2008), DARPA (2008), Terman Fellowship from Stanford (2007), and Bernard Lewis Fellowship from the Combustion Institute (2004).
Assistant Professor of Biomedical Data Science and, by courtesy, of Computer Science and of Electrical Engineering
Current Research and Scholarly InterestsMy group works on both foundations of statistical machine learning and applications in biomedicine and healthcare. We develop new technologies that make ML more accountable to humans, more reliable/robust and reveals core scientific insights.
We want our ML to be impactful and beneficial, and as such, we are deeply motivated by transformative applications in biotech and health. We collaborate with and advise many academic and industry groups.
J. Bradley Zuchero
Assistant Professor of Neurosurgery
Current Research and Scholarly InterestsGlia are a frontier of neuroscience, and overwhelming evidence from the last decade shows that they are essential regulators of all aspects of the nervous system. The Zuchero Lab aims to uncover how glial cells regulate neural development and how their dysfunction contributes to diseases like multiple sclerosis (MS) and in injuries like stroke.
Although glia represent more than half of the cells in the human brain, fundamental questions remain to be answered. How do glia develop their highly specialized morphologies and interact with neurons to powerfully control form and function of the nervous system? How is this disrupted in neurodegenerative diseases and after injury? By bringing cutting-edge cell biology techniques to the study of glia, we aim to uncover how glia help sculpt and regulate the nervous system and test their potential as novel, untapped therapeutic targets for disease and injury.
We are particularly interested in myelin, the insulating sheath around neuronal axons that is lost in diseases like MS. How do oligodendrocytes- the glial cell that produces myelin in the central nervous system- form and remodel myelin, and why do they fail to regenerate myelin in disease? Our current projects aim to use cell biology and neuroscience approaches to answer these fundamental questions. Ultimately we hope our work will lead to much-needed therapies to promote remyelination in patients.