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Professor of Biomedical Data Science and of Statistics
Current Research and Scholarly InterestsStatistical models and reasoning are key to our understanding of the genetic basis of human traits. Modern high-throughput technology presents us with new opportunities and challenges. We develop statistical approaches for high dimensional data in the attempt of improving our understanding of the molecular basis of health related traits.
Professor of Management Science and EngineeringOn Leave from 10/01/2021 To 03/31/2022
BioAmin Saberi is an Associate Professor and 3COM faculty scholar in Stanford University. He received his B.Sc. from Sharif University of Technology and his Ph.D. from Georgia Institute of Technology in Computer Science. His research interests include algorithms, approximation algorithms, and algorithmic aspects of games, markets, and networks. Amin Saberi's research is supported by National Science Foundation (under grants CCF 0546889, 0729586, and 0915145), Library of Congress, Stanford Clean Slate Design for the Internet, and Google. His most recent awards include an Alfred Sloan Fellowship and best paper awards in FOCS 2011 and SODA 2010.
Associate Professor of Psychiatry and Behavioral Sciences (General Psychiatry and Psychology-Adult)On Partial Leave from 09/15/2021 To 03/14/2022
Current Research and Scholarly InterestsPrimary research interests include the nature and treatment of eating disorders
(particularly bulimia nervosa and binge eating disorder), the development and treatment of obesity, and the development and treatment of problematic eating patterns in patients following bariatric surgery.
Marc R. Safran, MD
Professor of Orthopaedic Surgery
Current Research and Scholarly InterestsDr. Safrans practice focuses on arthroscopic management of hip problems as well as articular cartilage regeneration, shoulder surgery and athletic shoulder and elbow problems. He is actively involved in research in these areas.
Elaine and John Chambers Professor of Pediatric Cancer and Professor of Genetics
Current Research and Scholarly InterestsWe investigate the mechanisms by which normal cells become tumor cells, and we combine genetics, genomics, and proteomics approaches to investigate the differences between the proliferative response in response to injury and the hyperproliferative phenotype of cancer cells and to identify novel therapeutic targets in cancer cells.
Assistant Professor (Research) of Psychiatry and Behavioral Sciences (Interdisciplinary Brain Science Research)
Current Research and Scholarly InterestsThe overarching goal of my research is to develop reliable computational methods that will allow for characterizing and modeling temporal dynamics of brain activity, without averaging data in either space or time. I firmly believe that the spatiotemporal richness in brain activity might hold the key to finding the person- and disorder-centric biomarkers. I am currently developing methods to model the temporal dynamics of brain activity in individuals with fragile X syndrome and healthy controls.
Kathleen M. Sakamoto
Shelagh Galligan Professor in the School of Medicine
Current Research and Scholarly InterestsMy research focuses on the molecular pathways that regulate normal and aberrant blood cell development, including acute leukemia and bone marrow failure syndromes. We are also studying novel drugs for treatment of cancer.
Professor of Medicine (Cardiovascular) and of Radiology (Cardiovascular Imaging)
BioDr. Salerno completed his BS in Biological Engineering at Cornell University, and his MD and PhD in Biomedical Engineering at the University of Virginia as part of the Medical Scientist Training Program. He then completed the American Board of Internal Medicine Research Pathway with an Internal Medicine residency at Stanford University, and his general cardiology fellowship at Duke University Medical Center. During his time at Duke he completed a dedicated year in cardiovascular MRI at the Duke Cardiovascular MR Imaging Center. He returned to UVA in 2008 to complete a 2-year advanced cardiovascular imaging fellowship where he trained in CMR and cardiovascular CTA. He achieved COCATS Level III training in all cardiovascular imaging modalities (Echo, Nuclear, CMR, CCT), and is board certified in Echocardiography and Nuclear Cardiology. He served as faculty at UVA in Cardiology, Radiology, and Biomedical Engineering from 2010-2021 where he was the Director of Cardiac MRI and the Medical Director of Echocardiography, before returning to Stanford.
His research involves the development and evaluation of novel MRI pulse sequences and techniques to improve the clinical utility of CMR imaging. The current focus of the research is on quantitative myocardial perfusion imaging, quantitative imaging of myocardial fibrosis, rapid free-breathing and self-gated imaging, and deep learning for image reconstruction and post-processing. His laboratory includes undergraduate and graduate engineering students as well as clinical cardiovascular imaging fellows to bring new advances into clinical practice. Dr. Salerno has been in the field of MRI for 25 years and holds multiple patents related to the development and application of novel pulse sequences for MRI. He has received numerous research awards, and has published extensively in the areas of MRI, cardiovascular MRI and multi-modality cardiovascular imaging. His research has been supported by the AHA and the National Institutes of health. He is a deputy editor for JACC Cardiovascular Imaging.
Outside of work, Dr. Salerno enjoys sailing, rock climbing, skiing, running, biking, hiking, and spending time with his wife Cherie, and his two boys Christopher and Joseph.
J Kenneth Salisbury, Jr.
Professor (Research) of Computer Science and of Surgery (Anatomy), Emeritus
BioSalisbury worked on the development of the Stanford-JPL Robot Hand, the JPL Force Reflecting Hand Controller, the MIT-WAM arm, and the Black Falcon Surgical Robot. His work with haptic interface technology led to the founding of SensAble Technology, producers of the PHANToM haptic interface and software. He also worked on the development of telerobotic systems for dexterity enhancement in the operating room. His current research focuses on human-machine interaction, cooperative haptics, medical robotics, and surgical simulation.
Professor of Materials Science and Engineering
Current Research and Scholarly InterestsNovel materials and processing techniques for large-area and flexible electronic/photonic devices. Polymeric materials for electronics, bioelectronics, and biosensors. Electrochemical devices for neuromorphic computing. Defects and structure/property studies of polymeric semiconductors, nano-structured and amorphous materials in thin films. Advanced characterization techniques for soft matter.
Associate Professor of Biomedical Data Science, of Biochemistry and, by courtesy, of Statistics
Current Research and Scholarly InterestsCircular RNA regulation and function; computational and experimental approaches
Peter L. Santa Maria, MD, PhD
Associate Professor of Otolaryngology - Head & Neck Surgery (OHNS)
Current Research and Scholarly InterestsWe study chronic suppurative otitis media, a chronic biofilm infection of the middle ear predominantly involving pseudomonas and staph aureus. We are investigating mechanisms of sensory hearing loss, host microbe interactions and trialling novel therapeutics.
Our work in tympanic membrane regeneration has entered clinical trials.
Novel treatments for wound healing in intra oral wounds with potential applications to prevent post tonsillectomy wound healing and oral mucositis.
Juan G. Santiago
Charles Lee Powell Foundation ProfessorOn Partial Leave from 10/01/2021 To 12/31/2021
Current Research and Scholarly Interestshttp://microfluidics.stanford.edu/Projects/Projects.html
John A. and Cynthia Fry Gunn Professor and Professor of Neurology and of Neurosurgery
Current Research and Scholarly InterestsNeuron death, stress, gene therapy
Professor of Microbiology and Immunology
Current Research and Scholarly InterestsOur laboratory studies virus-host interactions with an emphasis microRNA-mediated gene regulation and on translational control. The mechanism by which a liver-specific microRNA regulates hepatitis C virus genome replication is under intense scrutiny. In addition, the mechanism of internal ribosome entry in certain cellular and viral mRNAs and its biological role in growth and development is being investigated.
Assistant Professor of Pathology
Current Research and Scholarly InterestsOur lab works at the interface of immunology, cancer biology, and genomics to study cellular and molecular mechanisms of the immune response to cancer. In particular, we are leveraging high-throughput genomic technologies to understand the dynamics of the tumor-specific T cell response to cancer antigens and immunotherapies (checkpoint blockade, CAR-T cells, and others). We are also interested in understanding the impact of immuno-editing on the heterogeneity and clonal evolution of cancer.
We previously developed genome sequencing technologies that enable epigenetic studies in primary human immune cells from patients: 1) 3D enhancer-promoter interaction profiling (Nat Genet, 2017), 2) paired epigenome and T cell receptor (TCR) profiling in single cells (Nat Med, 2018), 3) paired epigenome and CRISPR profiling in single cells (Cell, 2019), and high-throughput single-cell ATAC-seq in droplets (Nature Biotech, 2019). We used these tools to study fundamental principles of the T cell response to cancer immunotherapy (PD-1 blockade) directly in cancer patient samples (Nature Biotech, 2019; Nat Med, 2019).
Associate Professor of Chemical Engineering
BioPlants have an extraordinary capacity to harvest atmospheric CO2 and sunlight for the production of energy-rich biopolymers, clinically used drugs, and other biologically active small molecules. The metabolic pathways that produce these compounds are key to developing sustainable biofuel feedstocks, protecting crops from pathogens, and discovering new natural-product based therapeutics for human disease. These applications motivate us to find new ways to elucidate and engineer plant metabolism. We use a multidisciplinary approach combining chemistry, enzymology, genetics, and metabolomics to tackle problems that include new methods for delignification of lignocellulosic biomass and the engineering of plant antibiotic biosynthesis.
Alan F. Schatzberg
Kenneth T. Norris, Jr. Professor of Psychiatry and Behavioral Sciences
Current Research and Scholarly InterestsBiological bases of depressive disorders;, glucocorticoid/dopamine interactions in delusional depression;, pharmacologic treatment of depressive disorders.
Professor of Microbiology and Immunology
Current Research and Scholarly InterestsWe study innate immunity and microbial pathogenesis. We have been studying models for a variety of bacterial infections including: Listeria, Mycobacteria, Salmonella and Streptococcus as well as some fungi, malaria and viruses. Our current focus is to determine how we recover from infections.
Mark J. Schnitzer
Professor of Biology and of Applied Physics
Current Research and Scholarly InterestsThe goal of our research is to advance experimental paradigms for understanding normal cognitive and disease processes at the level of neural circuits, with emphasis on learning and memory processes. To advance these paradigms, we invent optical brain imaging techniques, several of which have been widely adopted. Our neuroscience studies combine these imaging innovations with behavioral, electrophysiological, optogenetic and computational methods, enabling a holistic approach to brain science.
Associate Professor (Research) of Pathology
BioBirgitt Schüle, MD, is an Associate Professor in the Department of Pathology, Stanford University School of Medicine. Her research focuses on medical genetics and stem cell modeling to unlock disease mechanisms and pathways leading to neurodegeneration in Parkinson’s disease and related disorders, and to develop new therapeutic strategies to advance precision medicine.
She received her medical training from the Georg-August University Göttingen and Medical University Lübeck, Germany (1993 - 2001) and completed doctoral degree in medicine (Dr. med.) in neurophysiology at the Georg-August University Göttingen (2001). During her neurology internship from 2001 to 2002 at Medical University of Lübeck with Prof. Christine Klein, Dr. Schüle studied genes for inherited forms of Parkinson’s disease and dystonia. From 2003 to 2005, she completed a postdoctoral fellowship in human genetics with Prof. Uta Francke at Stanford University School of Medicine. From 2005-2019, Dr. Schüle led key clinical research programs and biospecimen repositories for neurogenetics, translational stem cell and brain donation at the Parkinson’s Institute and Clinical Center.
Dr. Schuele is the associate core leader of the Neuropathology Core with the Stanford Alzheimer Research Center (ADRC) and core leader of the Analytics Core for the Pacific Udall Center. She supports the centers with genetic characterization, biobanking, and building a human induced pluripotent stem cell and post-mortem leptomeninges tissue bank shared with the data and tissue repositories at NIH.
Professor of Medicine (Hospital Medicine) and, by courtesy, of Operations, Information and Technology at the Graduate School of Business
BioDr. Schulman was appointed as Professor of Medicine, Associate Chair of Business Development and Strategy in the Department of Medicine, Director of Industry Partnerships and Education for the Clinical Excellence Research Center (CERC) at the Stanford University School of Medicine, and, by courtesy, Professor of Economics at Stanford’s Graduate School of Business in June, 2018. Dr. Schulman is a Professor of Medicine, Clinical Excellence Research Center (CERC) at the Stanford University School of Medicine, and, by courtesy, Professor of Operations, Information and Technology at Stanford’s Graduate School of Business.
Dr. Schulman’s research interests include organizational innovation in health care, health care policy and health economics. With over 300 original articles, over 100 review articles/commentaries, and over 40 case studies/book chapters, Kevin Schulman has had a broad impact on health policy (h-index = 77). His peer-reviewed articles have appeared in the New England Journal of Medicine, JAMA, and Annals of Internal Medicine. He is a member of the editorial/advisory boards of the American Heart Journal, Health Policy, Management and Innovation (www.HMPI.Org), and Senior Associate Editor of Health Services Research.
Prior to coming to Stanford, Dr. Schulman served as a Professor of Medicine at Duke University, directed the Health Sector Management Program at Duke’s Fuqua School of Business for a dozen years, created and directed the Duke University Master’s of Management in Clinical Informatics Program, and served as a Visiting Professor and Visiting Scholar at Harvard Business School.
He is a co-founder of Bivarus (exit January, 2018), co-founder and Managing Member of Faculty Connection, LLC., and is a Board Member of Grid Therapeutics.
He is an elected member of ASCI and AAP.
He is a graduate of Dartmouth College, the New York University School of Medicine, and The Wharton Health Care Management Program.
Assistant Professor of Biology
BioMolly Schumer is an Assistant Professor in Biology. She is interested in the genetic and evolutionary consequences of hybridization. After receiving her PhD at Princeton, she did her postdoctoral work at Columbia and was a Junior Fellow in the Harvard Society of Fellows and Hanna H. Gray Fellow at Harvard Medical School. Current research in the lab focuses on understanding genetic interactions that occur in hybrids and how these impact genome evolution.
Dean of the Graduate School of Education and the Nomellini & Olivier Professor of Educational Technology
Current Research and Scholarly InterestsInstructional methods, transfer of learning and assessment, mathematical development, teachable agents, cognition, and cognitive neuroscience.
Matthew P. Scott
Professor of Developmental Biology, Emeritus
Current Research and Scholarly InterestsOur research has been focused on the genetic regulation of animal development and its relation to birth defects, cancer, and neurodegeneration. We studied mechanisms and functions of Hedgehog (Hh) signaling, which controls cell fates and growth, in the context of normal development and brain cancer. We studied a neurodegenerative disease, Niemann-Pick C syndrome, that affects intracellular organelle movements and sterol homeostasis. Due to Dr. Scott's new job, the lab is no longer active.
Associate Professor (Research) of Obstetrics and Gynecology (Reproductive and Stem Cell Biology)
Current Research and Scholarly InterestsThe thread of Ariadne that connects germ cells, preimplatation development and pluripotent stem cells is the focus of my research, with a specific interest in human development. My long-term goals are: 1. Understanding the biology of germ cells and and their ability to sustain early preimplantation development; 2. Understanding the mechanisms that regulate very early cell fate decisions in human embryos; 3. Understanding the biology of derivation and maintenance of Pluripotent Stem Cells
Zachary M. Sellers, MD, PhD
Assistant Professor of Pediatrics (Gastroenterology)
BioI am a pediatric physician-scientist striving to advance cystic fibrosis clinical care and translational research. Clinically, I am focused on gastrointestinal manifestations of cystic fibrosis, developing diagnostic and therapeutic modalities to improve the gastrointestinal and liver health of those with cystic fibrosis. I also specialize in the clinical management of pediatric pancreatitis and am involved with the international INSPPIRE consortium to study pediatric pancreatitis. My research spans the entire spectrum across basic science and translational research to clinical research and trials. In the laboratory, my projects are centered around understanding mechanisms of ion transport in cystic fibrosis tissues and determining how loss of CFTR ion transport leads to pathologic changes in human physiology. We are also very interested in the pathophysiological relationship between pancreatitis and intestinal diseases, such as inflammatory bowel disease. Our laboratory has expertise in epithelial ion transport, with specialized skills in the measurement of bicarbonate transport. We are also part of a Multi-PI collaboration pursuing CFTR gene editing and stem cell engraftment for the treatment of cystic fibrosis. We utilize a combination of immortalized and primary cell culture, organoids, mouse and human tissue, and whole animal in vivo studies.
Robert W. Shafer
Professor (Research) of Medicine (Infectious Diseases) and, by courtesy, of Pathology
Current Research and Scholarly InterestsMy group’s research is on the mechanisms and consequences of virus evolution with a focus on HIV therapy and drug resistance. We maintain a public HIV drug resistance database (http://hivdb.stanford.edu) as a resource for HIV drug resistance surveillance, interpreting HIV drug resistance tests, and HIV drug development. Our paramount goal is to inform HIV treatment and prevention policies by identifying the main factors responsible for the emergence and spread of drug resistance.
Nigam H. Shah, MBBS, PhD
Professor of Medicine (Biomedical Informatics) and of Biomedical Data Science
Current Research and Scholarly InterestsWe analyze multiple types of health data (EHR, Claims, Wearables, Weblogs, and Patient blogs), to answer clinical questions, generate insights, and build predictive models for the learning health system.
Professor of Psychiatry and Behavioral Sciences (Major Laboratories and Clinical Translational Neurosciences Incubator), of Neurobiology and, by courtesy, of Obstetrics and Gynecology
Current Research and Scholarly InterestsWe study how our brains generate social interactions that differ between the sexes. Such gender differences in behavior are regulated by sex hormones, experience, and social cues. Accordingly, we are characterizing how these internal and external factors control gene expression and neuronal physiology in the two sexes to generate behavior. We are also interested in understanding how such sex differences in the healthy brain translate to sex differences in many neuro-psychiatric illnesses.
Professor (Research) of Neurosurgery and, by courtesy, of Neurology
Current Research and Scholarly InterestsThe ultimate goal of the Shamloo laboratory is to rapidly advance our understanding of brain function at the molecular, cellular, circuit and behavioral levels, and to elucidate the pathological process underlying malfunction of the nervous system following injury and neurologic disorders such as stroke, Alzheimer's disease, Parkinson’s disease, and autism. We have been focusing on the noradrenergic system and approaches leading to restoration of brain adrenergic signaling in these disorders.
Virginia and D. K. Ludwig Professor
Current Research and Scholarly InterestsA basic question in developmental biology involves the mechanisms used to generate the three-dimensional organization of a cell from a one-dimensional genetic code. Our goal is to define these mechanisms using both molecular genetics and biochemistry.
Eric S.G. Shaqfeh
Lester Levi Carter Professor and Professor of Mechanical EngineeringOn Leave from 10/01/2021 To 12/31/2021
Current Research and Scholarly InterestsI have over 25 years experience in theoretical and computational research related to complex fluids following my PhD in 1986. This includes work in suspension mechanics of rigid partlcles (rods), solution mechanics of polymers and most recently suspensions of vesicles, capsules and mixtures of these with rigid particles. My research group is internationally known for pioneering work in all these areas.
Sapp Family Provostial Professor, The Catherine Holman Johnson Director of Stanford Bio-X and Professor of Biology and of Neurobiology
Current Research and Scholarly InterestsThe goal of research in the Shatz Laboratory is to discover how brain circuits are tuned up by experience during critical periods of development both before and after birth by elucidating cellular and molecular mechanisms that transform early fetal and neonatal brain circuits into mature connections. To discover mechanistic underpinnings of circuit tuning, the lab has conducted functional screens for genes regulated by neural activity and studied their function for vision, learning and memory.
Gary M. Shaw
NICU Nurses Professor and Professor (Research), by courtesy, of Epidemiology and Population Health and of Obstetrics and Gynecology (Maternal Fetal Medicine)
Current Research and Scholarly InterestsPrimary research interests include 1) epidemiology of birth defects, 2) gene-environment approaches to perinatal outcomes, and 3) nutrition and reproductive outcomes.
Assistant Professor of Pathology
Current Research and Scholarly InterestsGastrointestinal and pancreatobiliary pathology, with major emphasis on GI and pancreatic neoplasia, inflammatory bowel disease, biodesign innovation, and the application of machine learning to digital pathology.
Professor of Biology and of Pathology
Current Research and Scholarly InterestsThe connectivity of a neuron (its unique constellation of synaptic inputs and outputs) is essential for its function. Neuronal connections are made with exquisite accuracy between specific types of neurons. How each neuron finds its synaptic partners has been a central question in developmental neurobiology. We utilize the relatively simple nervous system of nematode C. elegans, to search for molecules that can specify synaptic connections and understand the molecular mechanisms of synaptic as
Hong Seh and Vivian W. M. Lim Professor and Professor, by courtesy, of Neurobiology, of Bioengineering and of Neurosurgery
Current Research and Scholarly InterestsWe conduct neuroscience, neuroengineering and translational research to better understand how the brain controls movement, and to design medical systems to assist people with paralysis. These are referred to as brain-machine interfaces (BMIs), brain-computer interfaces (BCIs) and intra-cortical neural prostheses. We conduct this research as part of our Neural Prosthetic Systems Lab (NPSL) and our Neural Prosthetics Translational Lab (NPTL), which I co-direct with Prof. Jaimie Henderson, M.D.
Sheri D. Sheppard
Richard W. Weiland Professor in the School of Engineering
BioSheri Sheppard teaches both undergraduate and graduate design-related classes, and conducts research on fracture mechanics and applied finite element analysis, and on how people become engineers. From 1999-2008 she served as a Senior Scholar at the Carnegie Foundation for the Advancement of Teaching, leading the Foundation’s engineering study. In addition to publishing technical papers, reports, and textbooks, she has led or co-led several large, multi-institutional projects to build new educational research programs and related resources, such as the Center for the Advancement of Engineering Education (CAEE), The National Center for Engineering Pathways to Innovation (Epicenter), and a program on summer research experiences for high school teachers. Her industry experience includes engineering positions at Detroit's "Big Three” — Ford Motor Company, General Motors Corporation, and Chrysler Corporation. She earned her bachelors degree from the University of Wisconsin, and her PhD at the University of Michigan. At Stanford she has served a chair of the faculty senate, as associate vice provost for graduate education, and is the longtime faculty founder of and adviser to the graduate student group MEwomen. Her work has been recognized with numerous honors and awards, including the Walter J. Gores Award, Stanford University's highest award for excellence in teaching and the Chester F. Carlson and Ralph Coats Roe Awards of the American Society for Engineering Education in recognition of distinguished accomplishment in engineering education, and for outstanding teaching and notable contributions to the mechanical engineering profession.
Professor of Genetics
Current Research and Scholarly InterestsEvolution and the adaptive landscape using yeast as a model; Defining yeast transcriptomes; chromosomal evolution in hybrid yeast species
Assistant Professor of Earth System Science, by courtesy, in Geophysics and Center Fellow, by courtesy, at the Woods Institute for the Environment
BioI joined Stanford's Earth System Science department as an assistant professor 2018. Prior to this, I was a a Junior Fellow of the Simons Foundation in New York, and a postdoctoral research scientist at Columbia University’s Department of Applied Physics and Applied Math and the Lamont-Doherty Earth Observatory. I got my Ph.D. in Atmospheric Science at MIT's Department of Earth, Atmospheric, and Planetary Sciences, in the Program for Atmospheres, Oceans, and Climate, where I worked with R. Alan Plumb. I’m broadly interested in atmosphere and ocean dynamics, climate variability, and general circulation.
I'm particularly interested in fundamental questions in atmospheric dynamics, which I address using a combination of theory, observations, and both idealized and comprehensive numerical experiments. Current areas of focus include the dynamics, variability, and change of the mid-latitude jets and storm tracks and the stratospheric polar vortex.
Assistant Professor of Radiology (Body MRI)
Current Research and Scholarly InterestsMy interests are in the development and translation of imaging technologies geared toward disease detection and characterization to better guide prognosis, treatment, and improve outcomes. I’m interested in supporting the development of MRI guided focal therapy methods which can personalize treatment and reduce the risk of morbidity from more invasive therapies.
- MRI for diagnosis of pelvic floor disorders
- MRI and PET/MRI to pelvic malignancies and lymph node staging.
- Whole Body MRI
- MRI guided procedures including biopsies, cryoablation, and high intensity focused ultrasound.
Translational Research Interests
- Development and translation of magnetic resonance imaging technologies to improve both diagnostics and therapeutics
- Molecular imaging and characterization of the tumor microenvironment
- Ultrashort echo time MRI applications in the body
- Developing synergistic MRI methods to complement PET in potential applications for PET/MRI
Professor of Medicine (Blood and Marrow Transplantation and Cellular Therapy) and of Pediatrics (Stem Cell Transplantation)
Current Research and Scholarly InterestsTransplantation of defined populations of allogeneic hematopoietic cells. Specifically, the way in which hematopoietic cell grafts alter antigen specific immune responses to allo-, auto- and viral antigens. The cellular and molecular basis of resistance to engraftment of allogeneic hematopoietic stem cells.
Linda M. Dairiki Shortliffe
Stanley McCormick Memorial Professor in the School of Medicine, Emerita
Current Research and Scholarly InterestsThe timing for intervention in obstruction in the infant and child is poorly understood.Our group has been interested in trying to define the risks that may be involved in obstructive and infectious uropathies and discovering early signs of damage to the urinary tract and kidney. We have explored ways of imaging the urinary tract using nonionizing radiation (US, MRI). We have studied the relationships of sex steroid hormones, pregnancy, reflux, urinary tract infection and urinary tract function.
Professor of Cardiothoracic Surgery
Current Research and Scholarly InterestsIn clinical research, Dr. Shrager has been an innovator studying outcomes in a variety of areas within Thoracic Surgery including: parenchyma-sparing operations and minimally invasive resections for lung cancer, transcervical thymectomy for myasthenia gravis, and surgical treatment of emphysema.
In the lab, Dr. Shrager is focused on the impact of disease states upon the diaphragm. His group published the seminal paper (NEJM) describing diaphragm atrophy assoc'd with mechanical ventilation.
Surbhi Sidana, MD
Assistant Professor of Medicine (Blood and Marrow Transplantation and Cellular Therapy)
BioDr. Sidana is a hematologist/oncologist who is fellowship trained in advanced hematology with an emphasis on myeloma, amyloidosis, and dysproteinemia disorders. She is an Assistant Professor in the Department of Medicine, Division of Blood and Marrow Transplantation & Cellular Therapy, at Stanford University School of Medicine. She leads the Myeloma Cellular Immunotherapy program at Stanford.
Her areas of expertise include transplantation and novel cellular immunotherapies such as CAR-T-cell therapy for patients with multiple myeloma. For each patient, Dr. Sidana develops a personalized care plan designed to optimize outcomes and quality of life.
Dr. Sidana conducts extensive research. Currently, she is conducting clinical trials of CAR-T therapy and bispecific T-cell engagers for treatment of patients with myeloma. She is studying patients’ access to CAR-T cell therapy, the financial burden of the treatment, and its impact on patients’ quality of life and cognitive function.
Dr Sidana has received a grant from the Stanford Medicine Cancer Institute and NIH funding through the Stanford KL2 program to study adverse events of CAR-T therapy on patients and monitoring of patients undergoing CAR-T therapy using wearable devices.
In the past, Dr. Sidana received Conquer Cancer Foundation Young Investigator Award from the American Society of Clinical Oncology for her research on the impact of clinical trial participation on patients with multiple myeloma and lymphoma. She has also received grants from the Amyloidosis Foundation and International Waldenstrom’s Macrogloulinemia Foundation to understand AL amyloidosis, a rare disease caused by buildup of an abnormal protein.
Dr. Sidana has given presentations at regional and national conferences and her work has been published in high-impact journals.
Dr. Sidana has been recognized for her work with many honors, including an Outstanding Hematology/Oncology Fellow award and Outstanding Research Fellow award from the Mayo Clinic.
She is a member of the American Society of Hematology, American Society of Clinical Oncology, International Myeloma Society, International Society of Amyloidosis, and American Society of Transplantation & Cellular Therapy. Dr. Sidana is often an invited speaker at patient support groups as well as symposia and workshops for her peers.
Professor of Pathology and of Genetics
Current Research and Scholarly InterestsWe have a highly collaborative research program in the evolutionary genomics of cancer. We apply well-established principles of phylogenetics to cancer evolution on the basis of whole genome sequencing and functional genomics data of multiple tumor samples from the same patient. Introductions to our work and the concepts we apply are best found in the Newburger et al paper in Genome Research and the Sidow and Spies review in TIGS.
More information can be found here: http://www.sidowlab.org
Julia Fridman Simard
Associate Professor of Epidemiology and Population Health and, by courtesy, of Medicine (Immunology & Rheumatology)
BioJulia Fridman Simard, ScD, is an Associate Professor of Epidemiology & Population Health, and, by courtesy, of Medicine in Immunology and Rheumatology at Stanford University School of Medicine.
Dr. Simard earned her Masters and Doctorate of Science in Epidemiology degrees at the Harvard School of Public Health. During that time she trained with investigators at the Section of Clinical Sciences, Division of Rheumatology, Immunology, and Allergy at Brigham and Women’s Hospital and the Cardiovascular Epidemiology Research Unit at Beth Israel Deaconess Medical Center. In 2008, Dr. Simard relocated to Sweden to begin a Postdoctoral Fellowship in Clinical Epidemiology at the Karolinska Institutet in Stockholm. She became an Assistant Professor in their Clinical Epidemiology Unit in 2011, and was later honored with a Karolinska Institutet Teaching Award. Leveraging the population-based registers of Sweden, Dr. Simard initiated a national register linkage study to examine the utility of registers in Systemic Lupus Erythematosus (SLE) research and develop an extensive data repository for future epidemiologic investigations.
While maintaining a close collaboration with the Karolinska Institutet, she joined Stanford’s Epidemiology faculty in 2013. Dr. Simard studies outcomes such as malignancy, stroke, infection, and mortality, in patients with systemic autoimmune rheumatic diseases with a focus on systemic lupus erythematosus. Recently her primary research focus has shifted to the intersection between reproductive epidemiology and rheumatic disease fueled by a K01 career development award from the NIH (NIAMS) to study maternal and fetal outcomes in systemic lupus pregnancy. This led to collaborations with colleagues at Stanford, throughout the US, and abroad, and a series of projects focused on the diagnosis of preeclampsia and associated risks in pregnant women with systemic lupus. Dr. Simard was awarded a Peter Joseph Pappas Research Grant from the Preeclampsia Foundation for her lab's work examining preeclampsia risk in high-risk populations, and a McCormick Faculty Award from Stanford Medicine to take important steps towards disentangling preeclampsia from lupus nephritis. Dr. Simard is leading an international study of hydroxychloroquine in lupus pregnancy leveraging mixed methods in partnership with qualitative researchers, patients, clinicians, and epidemiologists in Sweden, Canada, and in the United States.
In addition to these issues of misclassification in reproductive rheumatology questions, Dr. Simard's lab is also interested in how misclassification, missed opportunities, and misdiagnosis contribute to disparities in complex conditions such as systemic lupus. In addition to methodologic issues around misclassification and bias and the largely clinical epidemiology focus of her work, Dr. Simard's work examines social determinants of health and health disparities. Dr. Simard was recently awarded an R01 from NIH (NIAID) to study the role of cognitive and unconscious bias in clinical decision making for female-predominant diseases including lupus.
Professor of Anesthesiology, Perioperative and Pain Medicine (Pediatric)
Current Research and Scholarly InterestsThe primary goal of my research is to promote the health and well being of children and adolescents with chronic pain and their families. In line with this goal, research projects focus on biological, neurological, cognitive, affective, and social risk and resiliency factors of the pain experience. Projects include brain imaging, longitudinal clinical cohort, and treatment interventions studies.
Some current research orojects include:
Learning and Memory in Pediatric Chronic Pain
Funding: NIH/NICHD R01
Description: Investigating the mechanisms underlying fear learning, extinction and disruption of fear reconsolidation in adolescents with chronic pain and health controls using behavioral and neuroimaging measures. Multi-site study with Boston Children's Hospital (Collaborator: David Borsook, MD).
Children Pain Behaviors in Context: A functional-cognitive perspective
Leading Site: University of Ghent (Collaborator: Liesbet Goubert, PhD)
Description: Identifying key antecedents and consequences that give rise to and maintain children's pain-related behaviors and investigate impact these antecedents on children's behavior and functioning through daily surveys and activity monitoring.
Charles M. Pigott Professor in the School of Engineering
BioUsing high-resolution transmission electron microscopy, Sinclair studies microelectronic and magnetic thin film microstructure.
Kuldev Singh, MD, MPH
Professor of Ophthalmology
Current Research and Scholarly InterestsGlaucoma, clinical epidemiology
Manpreet K. Singh, MD MS
Associate Professor of Psychiatry and Behavioral Sciences (Child and Adolescent Psychiatry and Child Development)
Current Research and Scholarly InterestsDr. Singh conducts research in the phenomenology, neurobiology, pharmacology, and genetic aspects of depression and bipolar disorder in children. These studies include brain imaging (MRI, MRS, fMRI), medication, and psychotherapy trials. She is particularly interested in risk factors for the development of major mood disorders and associated morbidities, and early intervention strategies to delay the onset and progression of symptoms.
Professor of Medicine (Infectious Diseases & Geographic Medicine) and of Microbiology and Immunology
Current Research and Scholarly InterestsOur lab elucidates the molecular basis of pathogenesis of the protozoan parasite Entamoeba histolytica. We use genetic and genomic approaches to identify novel virulence determinants and to characterize the global epidemiology of the parasite.
Assistant Professor of Medicine (Gastroenterology and Hepatology)
Current Research and Scholarly InterestsThere are two primary and overlapping emphases of my research, both of which are driven and united by needs-based innovation and translational potential:
(1) Understanding the microenvironment of the inflamed versus normal gut in order to identify better therapeutic targets for people with immune-¬mediated GI disorders. Here, our investigations include understanding the influence and interactions of pharmacologic and dietary interventions on gut microbiome/metabolomic changes and the host immune response. In the context of providing patients with new understanding and solutions for their disease, I have led and advised on the design of both pilot and large clinical trials (including new FDA approved therapies) for anti-inflammatory therapies;
(2) Applying novel approaches and technologies (including natural language processing, computer vision, and reinforcement learning) to identify and address unmet clinical needs. In this area we have ongoing and published efforts in my lab to validate and develop solutions to pressing clinical needs. We have developed/led new drug delivery technologies with a multidisciplinary team that have shown strong potential in ongoing human IBD clinical trials. My lab has utilized both supervised and unsupervised approaches to analyze social media discourse and unstructured data sets for identifying patient needs that are rarely addressed in clinical settings. We have gained insights into patient perceptions around preventative health interventions, such as health screening and diet, including the dearth of evidence-based dietary recommendations to treat IBD (despite strong patient desire for solutions in this domain).
Professor of Molecular and Cellular Physiology, of Structural Biology and of Photon Science
BioThe Skiniotis laboratory seeks to resolve structural and mechanistic questions underlying biological processes that are central to cellular physiology. Our investigations employ primarily cryo-electron microscopy (cryoEM) and 3D reconstruction techniques complemented by biochemistry, biophysics and simulation methods to obtain a dynamic view into the macromolecular complexes carrying out these processes. The main theme in the lab is the structural biology of cell surface receptors that mediate intracellular signaling and communication. Our current main focus is the exploration of the mechanisms responsible for transmembrane signal instigation in cytokine receptors and G protein coupled receptor (GPCR) complexes.
Associate Professor of Neurosurgery
Current Research and Scholarly InterestsMy research focuses on screening strategies to identify and characterize cancer stem cells (CSCs) in human gliomas. We are pursuing this in several ways: 1) a novel colony-forming antibody live cell array to identify distinct CSC surface phenotypes, 2) RNAi screens to identify kinases critical for CSC tumorigenicity, 3) high throughput small molecule and chemical screens to identify compounds that selectively kill or target CSCs, and 4) identifying CSCs using the tumor specific EGFRvIII
Professor of Biology and, by courtesy, of Chemical and Systems Biology
Current Research and Scholarly InterestsMy overarching goal is to understand how cell growth triggers cell division. Linking growth to division is important because it allows cells to maintain specific size range to best perform their physiological functions. For example, red blood cells must be small enough to flow through small capillaries, whereas macrophages must be large enough to engulf pathogens. In addition to being important for normal cell and tissue physiology, the link between growth and division is misregulated in cancer.
Robert Lane Smith
Professor (Research) of Orthopedic Surgery, Emeritus
Current Research and Scholarly InterestsOur group is interested in the molecular and cell biology underlying bone and cartilage metabolism in health and disease. Normal daily activities are linked to the ability of the articular cartilage to withstand normal joint forces that may reach 5-7 times body weight and bone homeostasis depends on daily mechanical loading histories.
Stephen J Smith
Professor of Molecular and Cellular Physiology, Emeritus
Current Research and Scholarly InterestsResearch in the Smith Laboratory addresses basic mechanisms and and disorders of brain function. Present efforts are focused on the development and application of new proteomic imaging methods to explore the circuit and molecular architectures of memory storage and retrieval in cerebral cortex.
BioProfessor Smolke's research program focuses on developing modular genetic platforms for programming information processing and control functions in living systems, resulting in transformative technologies for engineering, manipulating, and probing biological systems. She has pioneered the design and application of a broad class of RNA molecules, called RNA devices, that process and transmit user-specified input signals to targeted protein outputs, thereby linking molecular computation to gene expression. This technology has been extended to efficiently construct multi-input devices exhibiting various higher-order information processing functions, demonstrating combinatorial assembly of many information processing, transduction, and control devices from a smaller number of components. Her laboratory is applying these technologies to addressing key challenges in cellular therapeutics, targeted molecular therapies, and green biosynthesis strategies.
Matthew Smuck, MD
Professor of Orthopaedic Surgery
Current Research and Scholarly InterestsI direct the Wearable Health Lab at Stanford, investigating medical applications of mobile technology to improve musculoskeletal and neurologic disease detection, treatment and prevention.
Stanford W. Ascherman, MD, FACS, Professor of Genetics
Current Research and Scholarly InterestsOur laboratory use different omics approaches to study a) regulatory networks, b) intra- and inter-species variation which differs primarily at the level of regulatory information c) human health and disease. For the later we have established integrated Personal Omics Profiling (iPOP), an analysis that combines longitudinal analyses of genomic, transcriptomic, proteomic, metabolomic, DNA methylation, microbiome and autoantibody profiles to monitor healthy and disease states
Samuel So, MD
Lui Hac Minh Professor in the School of Medicine
Current Research and Scholarly InterestsThrough a 4 pronged comprehensive program: translational and clinical research, early detection and treatment, promoting education, awareness and immunization and building partnership, we are working towards the development of new strategies that will lead to the elimination of hepatitis B worldwide and reduce the threat and incidence of liver cancer. Current research efforts focus on evaluating potential new diagnostic and treatment markers and novel targeted therapy for primary liver cancer.
Yuen So, MD, PhD
Professor of Neurology
Current Research and Scholarly InterestsResearch in the diagnosis, pathophysiology and treatment of peripheral neuropathy, myasthenia gravis, motor neuron diseases including ALS and SMA, nerve injuries and muscle diseases. Application of clinical neurophysiological methods to neurological diagnosis. Development of evidence-based medicine pertaining to the practice of neurology.
Hyongsok Tom Soh
Professor of Radiology (Early Detection), of Electrical Engineering and, by courtesy, of Chemical Engineering and of Bioengineering
BioDr. Soh received his B.S. with a double major in Mechanical Engineering and Materials Science with Distinction from Cornell University and his Ph.D. in Electrical Engineering from Stanford University. From 1999 to 2003, Dr. Soh served as the technical manager of MEMS Device Research Group at Bell Laboratories and Agere Systems. He was a faculty member at UCSB before joining Stanford in 2015. His current research interests are in analytical biotechnology, especially in high-throughput screening, directed evolution, and integrated biosensors.
Director, Edward L. Ginzton Laboratory and Professor of Electrical EngineeringOn Leave from 10/01/2021 To 12/31/2021
BioThe Solgaard group focus on design and fabrication of nano-photonics and micro-optical systems. We combine photonic crystals, optical meta-materials, silicon photonics, and MEMS, to create efficient and reliable systems for communication, sensing, imaging, and optical manipulation.
Edward I. Solomon
Monroe E. Spaght Professor of Chemistry and Professor of Photon Science
Current Research and Scholarly InterestsProf. Solomon's work spans physical-inorganic, bioinorganic, and theoretical-inorganic chemistry, focusing on spectroscopic elucidation of the electronic structure of transition metal complexes and its contribution to reactivity. He has advanced our understanding of metal sites involved in electron transfer, copper sites involved in O2 binding, activation and reduction to water, structure/function correlations over non-heme iron enzymes, and correlation of biological to heterogeneous catalysis.
James R. Doty Professor of Neurosurgery and Neurosciences
BioIvan Soltesz received his doctorate in Budapest and conducted postdoctoral research at universities at Oxford, London, Stanford and Dallas. He established his laboratory at the University of California, Irvine, in 1995. He became full Professor in 2003, and served as department Chair from 2006 to July 2015. He returned to Stanford in 2015 as the James R. Doty Professor of Neurosurgery and Neurosciences at Stanford University School of Medicine. His major research interest is focused on neuronal microcircuits, network oscillations, cannabinoid signaling and the mechanistic bases of circuit dysfunction in epilepsy.
His laboratory employs a combination of closely integrated experimental and theoretical techniques, including closed-loop in vivo optogenetics, paired patch clamp recordings, in vivo electrophysiological recordings from identified interneurons in awake mice, 2-photon imaging, machine learning-aided 3D video analysis of behavior, video-EEG recordings, behavioral approaches, and large-scale computational modeling methods using supercomputers. He is the author of a book on GABAergic microcircuits (Diversity in the Neuronal Machine, Oxford University Press), and editor of a book on Computational Neuroscience in Epilepsy (Academic Press/Elsevier). He co-founded the first Gordon Research Conference on the Mechanisms of neuronal synchronization and epilepsy, and taught for five years in the Ion Channels Course at Cold Springs Harbor. He has over 30 years of research experience, with over 20 years as a faculty involved in the training of graduate students (total of 16, 6 of them MD/PhDs) and postdoctoral fellows (20), many of whom received fellowship awards, K99 grants, joined prestigious residency programs and became independent faculty.
David and Lucile Packard Professor in Marine Science, Emeritus
Current Research and Scholarly InterestsWe examine two aspects of organism-environment interactions: How does stress from physical (e.g., temperature) and chemical (oxygen levels, pH) factors perturb organisms and how do organisms respond, adaptively, to cope with this stress? We examine evolutionary adaptation and phenotypic acclimatization using a wide variety of marine animals, including Antarctic fishes and invertebrates from intertidal habitats on the coastlines of temperate and tropical seas.
Assistant Professor of Urology and, by courtesy, of Radiology
Current Research and Scholarly InterestsMy interest is in improving prostate cancer diagnosis through MRI and image-targeted prostate biopsy. In collaboration with radiologists at Stanford, we are working to define the optimal role of MRI in prostate cancer. We hope to improve cancer imaging to the point that some men with elevated PSA may safely avoid prostate biopsy. For those who need biopsy, we are evaluating novel MRI-US fusion targeted biopsy, a technique that greatly improves upon the conventional biopsy method.
Justin L. Sonnenburg
Associate Professor of Microbiology and Immunology
Current Research and Scholarly InterestsWe are interested in the basic principles that govern interactions within the intestinal microbiota and between the microbiota and the host. To pursue these aims, we colonize germ-free (gnotobiotic) mice with simplified, model microbial communities, apply systems approaches (e.g. functional genomics), and use genetic tools for the host and microbes to gain mechanistic insight into emergent properties of the host-microbial super-organism.
Professor of Chemical Engineering, of Materials Science and Engineering and, by courtesy, of Applied Physics
Current Research and Scholarly InterestsTheory and computation of biological processes and complex materials
Assistant Professor of Geological Sciences and, by courtesy, of Biology and Center Fellow, by courtesy, at the Woods Institute for the Environment
Current Research and Scholarly InterestsThe research interests in the Sperling Lab are Earth history and the evolution of life, and the interactions between the biosphere and the geosphere. As such this research can generally be considered paleontology, insofar as paleontology encompasses all aspects of the history of life.
Consequently, we define our research agenda by the questions we are interested in, rather than the tools used. This research incorporates multiple lines of evidence, and multiple tools, to investigate questions in the history of life. These lines of evidence include fossil data, molecular phylogenetics, sedimentary geochemistry, and developmental and ecological data from modern organisms. Ultimately, the goal is to link environmental change with organismal and ecological response through the lens of physiology.
Our field research takes place all over the world--current areas include:
-NW Canada (Yukon and Northwest Territories): Research has been conducted on the early Neoproterozoic Fifteenmile Group, Cryogenian and Ediacaran Windermere Supergroup, and on the Ordovician-Devonian Road River Group in the southern Richardson Mountains
-Southern Canadian Cordillera: Work here has focused on the early Cambrian Mural Formation and its soft-bodied fauna.
-England and Wales: Cambrian-Silurian successions in the Welsh Basin
-Namibia: Ediacaran Nama Group
-Upwelling zones: We study the oxygen minimum zone offshore California as an analogue for ancient low-oxygen oceans.
Associate Professor of Medicine (Pulmonary and Critical Care Medicine)
Current Research and Scholarly InterestsPulmonary Arterial Hypertension
Pulmonary Vascular Remodeling
Modulation of BMP signaling
BMP signaling in health and disease in the right ventricle of the heart
"BMP signature" in blood as a biomarker
BMP signaling in neonatal chronic lung disease
Professor of Radiology (Radiological Sciences Lab) and, by courtesy, of Electrical Engineering
Current Research and Scholarly InterestsMy research interests are in the field of medical imaging, particularly magnetic resonance imaging and in vivo spectroscopy. Current projects include MRI and MRS at high magnetic fields and metabolic imaging using hyperpolarized 13C-labeled MRS.
Alfred M. Spormann
Professor of Civil and Environmental Engineering, of Chemical Engineering and, by courtesy, of Biology
Current Research and Scholarly InterestsMetabolism of anaerobic microbes in diseases, bioenergy, and bioremediation
Douglass M. and Nola Leishman Professor of Cardiovascular DiseaseOn Leave from 02/01/2020 To 01/31/2022
Current Research and Scholarly InterestsThe general research interest of this laboratory is the molecular basis of cell motility, with a current emphasis on power output by the human heart. We have three specific research interests, the molecular basis of energy transduction that leads to ATP-driven myosin movement on actin, the biochemical basis of the regulation of actin and myosin interaction and their assembly states, and the roles these proteins play in vivo, in cell movement, changes in cell shape and muscle contraction.
Endowed Professor of Pediatric Cancer
Current Research and Scholarly InterestsMy research focuses primarily on the management of children, adolescents, and young adults with soft tissue sarcomas. I also have an interest in developmental therapeutics and late effects of cancer therapy,
Professor of Medicine (Stanford Center for Research in Disease Prevention)
Current Research and Scholarly InterestsAs Director of the SPRC Program on Prevention Outcomes and Practices, my work focuses on cardiovascular disease treatment and prevention, the adoption of new technology and practices, and patterns of physician practice, particularly medication prescribing. Specific interests include measuring and improving the quality of outpatient care, disparities in health care by race, gender, age and socioeconomic status, and interventions to improve prevention outcomes.
Associate Professor of Anesthesiology, Perioperative and Pain Medicine (Adult MSD) and, by courtesy, of Ophthalmology
Current Research and Scholarly InterestsMechanisms promoting neuronal survival following cerebral ischemia-reperfusion injury; utilizing microRNA's to target multiple pathways to promote mitochondrial homeostasis and cell survival; anesthetic neurotoxicity; astrocyte-neuronal interaction
Kristan Staudenmayer, MD, MS, FACS
Associate Professor of Surgery (General Surgery)
Current Research and Scholarly InterestsDefining the Impact of Injuries in the Elderly
Frank Lee and Carol Hall Professor, Senior Associate Vice Provost of Research and Professor of Genetics
Current Research and Scholarly InterestsWe use the tools of genetics, microscopy, and biochemistry to understand fundamental questions of cell biology: How are cells organized by the cytoskeleton? How do the centrosome and cilium control cell control cell signaling? How is cell division coordinated with duplication of the centrosome, and what goes wrong in cancer cells defective in this coordination?
Gary K. Steinberg, MD, PhD
Bernard and Ronni Lacroute-William Randolph Hearst Professor of Neurosurgery and Neurosciences and Professor, by courtesy, of Neurology
Current Research and Scholarly InterestsOur laboratory investigates the pathophysiology and treatment of cerebral ischemia, and methods to restore neurologic function after stroke. Treatment strategies include brain hypothermia, stem cell transplantation and optogenetic stimulation. Our clinical research develops innovative surgical, endovascular and radiosurgical approaches for treating difficult intracranial aneurysms, complex vascular malformations and occlusive disease, including Moyamoya disease, as well as stem cell transplant.
Lawrence Steinman, MD
George A. Zimmermann Professor and Professor of Pediatrics
Current Research and Scholarly InterestsOur laboratory is dedicated to understanding the pathogenesis of autoimmune diseases, particularly multiple sclerosis. We have developed several new therapies for autoimmunity, including some in Phase 2 clinical trials, as well as one approved drug, natalizumab. We have developed microarray technology for detecting autoantibodies to myelin proteins and lipids. We employ a diverse range of molecular and celluar approaches to trying to understand multiple sclerosis.
Professor of Genetics
Current Research and Scholarly InterestsWe apply diverse genomic approaches to understand how genetic variation affects health and disease by: 1) functional and mechanistic analyses of gene regulation, 2) studies of meiotic recombination and inheritance, 3) analyses of genetic and environmental interactions, and 4) characterization of diseases in human cells and model organisms. We integrate wet lab and computational genomic, transcriptomic, proteomic and metabolic approaches, and develop technologies to enable personalized medicine.
David A. Stevens
Professor of Medicine, Emeritus
Current Research and Scholarly InterestsImmunology and chemotherapy of human fungal diseases, particularly coccidioidomycosis (Valley Fever) in California and aspergillosis, and the parasitic disease, trypanosomiasis.
Professor of Pediatrics (Genetics)
Current Research and Scholarly InterestsMy research focuses on disorders of the RAS/MAPK pathway (eg. NF1, Noonan, CFC, and Costello syndrome). I am working on understanding the impact of RAS signaling on the musculoskeletal system. I use genomic approaches to identify somatic events and modifiers in the RASopathies. I am also involved in identifying outcome measures for use in clinical trials for the associated orthopedic manifestations. Other areas of research involve vascular anomalies, Prader-Willi syndrome, and hypophosphatasia.
David K. Stevenson, M.D.
Harold K. Faber Professor of Pediatrics, Senior Associate Dean, Maternal and Child Health and Professor, by courtesy, of Obstetrics and Gynecology
Current Research and Scholarly InterestsOur research is focused on the study of the ontogeny and control of heme catabolism and bilirubin production in the developing neonate. A better understanding of the role of increased bilirubin production in neonatal jaundice and the prevention of hemolytic jaundice has remained an overall objective of our program. We are also study the causes of preterm birth and ways to prevent it.
Assistant Professor of Radiology (Cancer Early Detection-Canary Center)
Current Research and Scholarly InterestsStoyanova lab develops new early cancer detection methods and therapeutic strategies for late stage cancers. The current research focus is on protein-based biomarkers for early cancer detection as well as development of new small molecule inhibitors and antibody-based therapies for prostate and other epithelial cancers. The ultimate goals of the laboratory are to improve the early diagnosis and prognosis of clinically significant cancers and guide the development of novel and effective therapeutic strategies for metastatic prostate and other epithelial cancers.
Aaron F. Straight
Professor of Biochemistry and, by courtesy, of Chemical and Systems Biology
Current Research and Scholarly InterestsWe study the biology of chromosomes. Our research is focused on understanding how chromosomal domains are specialized for unique functions in chromosome segregation, cell division and cell differentiation. We are particularly interested in the genetic and epigenetic processes that govern vertebrate centromere function, in the organization of the genome in the eukaryotic nucleus and in the roles of RNAs in the regulation of chromosome structure.
Professor of Medicine (Immunology and Rheumatology)
Current Research and Scholarly InterestsMechanisms of immune tolerance; regulatory processes in autoimmunity and transplantation and extrathymic T cell maturation.
Avram Goldstein Professor in the School of Medicine and Professor, by courtesy, of Neurology and of Psychiatry and Behavioral Sciences
Current Research and Scholarly InterestsInformation transfer at synapses mediates information processing in brain, and is impaired in many brain diseases. Thomas Südhof is interested in how synapses are formed, how presynaptic terminals release neurotransmitters at synapses, and how synapses become dysfunctional in diseases such as autism or Alzheimer's disease. To address these questions, Südhof's laboratory employs approaches ranging from biophysical studies to the electrophysiological and behavioral analyses of mutant mice.
Associate Professor of Emergency Medicine
Current Research and Scholarly InterestsDr. Suffoletto is an emergency physician and NIH-funded investigator with a focus on collecting novel forms of longitudinal and remote data to inform temporal risk prediction and inform just-in-time adaptive interventions