Wu Tsai Neurosciences Institute
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Assistant Professor of Bioengineering
BioWe are a discovery-driven research group working at the interface between developmental biology, bioengineering, and statistical physics. We combine quantitative organism-wide fluorescence imaging ("deep imaging"), functional genomics ("deep sequencing"), and physical modeling to understand the fundamental rules that control collective cell behaviors to optimize tissue regeneration, adaptation, and evolution. We also seek for opportunities for applying these rules to improve multicellular engineering systems.
Kevin Wang, MD, PhD
Assistant Professor of Dermatology
Current Research and Scholarly InterestsThe Wang lab takes an interdisciplinary approach to studying fundamental mechanisms controlling gene expression in mammalian cells, and how epigenetic mechanisms such as DNA methylation, chromatin modifications, and RNA influence chromatin dynamics to affect gene regulation.
Shan X. Wang
Leland T. Edwards Professor in the School of Engineering and Professor of Electrical Engineering and, by courtesy, of Radiology (Molecular Imaging Program at Stanford)
Current Research and Scholarly InterestsShan Wang was named the Leland T. Edwards Professor in the School of Engineering in 2018. He directs the Center for Magnetic Nanotechnology and is a leading expert in biosensors, information storage and spintronics. His research and inventions span across a variety of areas including magnetic biochips, in vitro diagnostics, cancer biomarkers, magnetic nanoparticles, magnetic sensors, magnetoresistive random access memory, and magnetic integrated inductors.
Sui Wang, PhD
Assistant Professor of Ophthalmology
Current Research and Scholarly InterestsOur research focuses on understanding the molecular mechanisms that underlie retinal development and diseases. We utilize genetic and genomic tools to uncover how different types of retinal cells, including retinal neurons, glia and the vasculature, respond to developmental cues and disease insults at the epigenomic and transcriptional levels, and how they interact and collectively contribute to the integrity of the retina.
1. Retinal cell fate specification.
We are using genetic tools and methods, such as in vivo plasmid electroporation and CRISPR, to dissect the roles of cis-regulatory elements and transcription factors in controlling retinal cell fate specification.
2. The multicellular responses elicited by diabetes in the retina.
Diabetes can induce multicellular responses in the retina, including vascular lesions, glial dysfunction and neurodegeneration, all of which contribute to retinopathy. We are using diabetic rats as models to investigate the detailed molecular mechanisms underlying the diabetes-induced multicellular responses, and the disease mechanisms of diabetic retinopathy.
3. Molecular tools that allow for cell type-specific labeling and manipulation in vivo.
Cis-regulatory elements, such as enhancers, play essential roles in directing tissue/cell type-specific and stage-specific expression. We are interested in identifying enhancers that can drive cell type-specific expression in the retina and brain, and incorporating them into plasmid or AAV based delivery systems.
Associate Professor of NeurosurgeryOn Leave from 09/01/2020 To 02/28/2021
Current Research and Scholarly InterestsMechanisms underlying mitochondrial dynamics and function, and their implications in neurological disorders.
Professor of Electrical Engineering
BioTsachy's research focuses on Information Theory, Data Compression and Communications, Statistical Signal Processing, Machine Learning, the interplay between them, and their applications, with recent focus on applications to genomic data compression and processing. He is inventor of several patents and involved in several companies as member of the technical board. IEEE fellow, he serves on the board of governors of the information theory society as well as the editorial boards of the Transactions on Information Theory and Foundations and Trends in Communications and Information Theory. He is founding Director of the Stanford Compression Forum.
Jill Saylin Wentzell
Project Manager, SNI Operations
Current Role at StanfordResearch Communities Manager
Professor of Pathology and, by courtesy, of Chemical and Systems Biology
Current Research and Scholarly InterestsEpigenetic Reprogramming, Direct conversion of fibroblasts into neurons, Pluripotent Stem Cells, Neural Differentiation: implications in development and regenerative medicine
Professor of Pathology at the Stanford University Medical Center
Current Research and Scholarly InterestsRob West, MD, PhD, is a Professor of Pathology at Stanford University Medical Center. He is a clinician scientist with experience in translational genomics research to identify new prognostic and therapeutic markers in cancer. His research focus is on the progression of neoplasia to carcinoma. His lab has developed spatially oriented in situ methods to study archival specimens. He also serves as a surgical pathologist specializing in breast pathology.
Assistant Professor of Electrical Engineering and, by courtesy, of Computer Science
BioGordon Wetzstein is an Assistant Professor of Electrical Engineering and, by courtesy, of Computer Science at Stanford University. He is the leader of the Stanford Computational Imaging Lab and a faculty co-director of the Stanford Center for Image Systems Engineering. At the intersection of computer graphics, machine vision, optics, scientific computing, and applied vision science, Prof. Wetzstein's research has a wide range of applications in next-generation imaging, display, wearable computing, and microscopy systems. Prior to joining Stanford in 2014, Prof. Wetzstein was a Research Scientist in the Camera Culture Group at MIT. He received a Ph.D. in Computer Science from the University of British Columbia in 2011 and graduated with Honors from the Bauhaus in Weimar, Germany before that. He is the recipient of an NSF CAREER Award, an Alfred P. Sloan Fellowship, an ACM SIGGRAPH Significant New Researcher Award, a Presidential Early Career Award for Scientists and Engineers (PECASE), a Terman Fellowship, an Okawa Research Grant, the Electronic Imaging Scientist of the Year 2017 Award, an Alain Fournier Ph.D. Dissertation Award, and a Laval Virtual Award as well as Best Paper and Demo Awards at ICCP 2011, 2014, and 2016 and at ICIP 2016.
Assistant Professor of Medicine (Cardiovascular Medicine) at the Stanford University Medical Center
Current Research and Scholarly InterestsTranslational research in rare and undiagnosed diseases. Basic and clinical research in cardiomyopathy genetics, mechanisms, screening, and treatment. Investigating novel agents for treatment of hypertrophic cardiomyopathy and new mechanisms in heart failure. Cardiovascular screening and genetics in competitive athletes, disease gene discovery in cardiomyopathy and rare disease. Informatics approaches to rare disease and multiomics. Molecular transducers of physical activity bioinformatics.
Professor of Psychiatry and Behavioral Sciences (Major Laboratories and Clinical Translational Neurosciences Incubator) and, by courtesy, of Psychology
Current Research and Scholarly InterestsA revolution is under way in psychiatry. We can now understand mental illness as an expression of underlying brain circuit disruptions, shaped by experience and genetics. Our lab is defining precision brain circuit types for depression, anxiety and attention deficit. We apply computational models to large amounts of brain imaging, behavior and other data. These precision brain types inform our translational intervention studies. To close the loop, field ready insights are applied in practice.
Assistant Professor of Psychiatry and Behavioral Sciences (General Psychiatry and Psychology) at the Stanford University Medical Center
BioDr. Williams is an Assistant Professor within the Department of Psychiatry and Behavioral Sciences and the Director of the Stanford Brain Stimulation Lab. Dr. Williams has a broad background in neuropsychiatry and is double board-certified in both neurology and psychiatry. In addition, he has specific training and clinical expertise in the development of brain stimulation methodologies under Mark George, MD. Themes of his work include (a) examining the use of spaced learning theory in the application of neurostimulation techniques, (b) development and mechanistic understanding of rapid-acting antidepressants, and (c) identifying objective biomarkers that predict neuromodulation responses in treatment-resistant neuropsychiatric conditions. He has published papers in high impact peer-reviewed journals including Brain, American Journal of Psychiatry, and the Proceedings of the National Academy of Science. He has also contributed to two reviews related to novel therapeutics for neuropsychiatric conditions that have been published in the Journal of Clinical Investigation and Current Opinion in Neurobiology, which are both highly cited. Results from his studies have gained widespread attention in journals such as Science and New England Journal of Medicine Journal Watch as well as in the popular press and have been featured in various news sources including Time, Smithsonian, and Newsweek. Dr. Williams received two NARSAD Young Investigator Awards in 2016 and 2018 along with the 2019 Gerald R. Klerman Award. Dr. Williams received the National Institute of Mental Health Biobehavioral Research Award for Innovative New Scientists in 2020.
Jeffrey J. Wine
Benjamin Scott Crocker Professor of Human Biology
Current Research and Scholarly InterestsThe goal is to understand how a defective ion channel leads to the human genetic disease cystic fibrosis. Studies of ion channels and ion transport involved in gland fluid transport. Methods include SSCP mutation detection and DNA sequencing, protein analysis, patch-clamp recording, ion-selective microelectrodes, electrophysiological analyses of transmembrane ion flows, isotopic metho
Associate Professor of Genetics and of Pathology
Current Research and Scholarly InterestsOur laboratory uses genome-wide methods to uncover alterations that drive cancer progression and metastasis in genetically-engineered mouse models of human cancers. We combine cell-culture based mechanistic studies with our ability to alter pathways of interest during tumor progression in vivo to better understand each step of metastatic spread and to uncover the therapeutic vulnerabilities of advanced cancer cells.
Professor of Radiology (Neuroimaging and Neurointervention) and, by courtesy, of Neurology, of Neurosurgery and of Psychiatry and Behavioral Sciences at the Stanford University Medical Center
Current Research and Scholarly InterestsStroke, cerebrovascular diseases, cardiovascular diseases, carotid arteries, coronary arteries
Stroke diagnosis, stroke triage, stroke treatment
Traumatic brain injury
Traumatic brain injury diagnosis and prognosis
Psychiatric disorders, including depression and post-traumatic stress disorders
Movement disorders, including essential tremor and Parkinson’s tremor
Image-guided clinical trials
CT, multidetector-row CT, perfusion-CT, CT angiography
MRI, diffusion-weighted MRI, perfusion-weighted MRI, diffusion tensor imaging, functional MRI
Brain perfusion imaging techniques
Post-processing techniques of medical images, signal and image processing
MR-guided focused ultrasound
H.-S. Philip Wong
Willard R. and Inez Kerr Bell Professor in the School of Engineering
BioWong joined Stanford in 2004 after 16 years at IBM Research, with appointments as research staff member, Manager, and Senior Manager. While at IBM, he was responsible for shaping and executing IBM's strategy on nanoscale science and technology and silicon technology. His interests are in the area of nanoscale science and technology, semiconductor technology, solid-state devices, and electronic imaging.
His present research covers a broad range of topics including carbon electronics, 2D layered materials, wireless implantable biosensors, directed self-assembly, nanoelectromechanical relays, device modeling, brain-inspired computing, and non-volatile memory devices such as phase change memory and metal oxide resistance change memory.
S Simon Wong
Professor of Electrical EngineeringOn Partial Leave from 10/01/2020 To 06/30/2021
Current Research and Scholarly InterestsCurrent research focuses on
Resistive Random Access Memory (RRAM) and Integration with CMOS
Energy Efficient Approximate Computing for Machine Learning
Wing Hung Wong
Stephen R. Pierce Family Goldman Sachs Professor in Science and Human Health and Professor of Biomedical Data Science
Current Research and Scholarly InterestsCurrent interest centers on the application of statistics to biology and medicine. We are particularly interested in questions concerning gene regulation, genome interpretation and their applications to precision medicine.
Albert Y. Wu, MD, PhD, FACS
Assistant Professor of Ophthalmology at the Stanford University Medical Center
Current Research and Scholarly InterestsMy translational research focuses on using autologous stem cells to recreate a patient’s ocular tissues for potential transplantation. We are generating tissue from induced pluripotent stem cells to treat limbal stem cell deficiency in patients who are bilaterally blind. By applying my background in molecular and cellular biology, stem cell biology, oculoplastic surgery, I hope to make regenerative medicine a reality for those suffering from orbital and ocular disease.
Current Research and Scholarly InterestsI am interested in how the brain matures to control the bladder and external sphincter to achieve urinary continence. Using functional MRI of the brain, we are investigating if certain patterns of activity will predict which children will respond to therapy for incontinence.
Assistant Professor of Computer Science
BioJiajun Wu is an Assistant Professor of Computer Science at Stanford University, working on computer vision, machine learning, and computational cognitive science. Before joining Stanford, he was a Visiting Faculty Researcher at Google Research. He received his PhD in Electrical Engineering and Computer Science at Massachusetts Institute of Technology. Wu's research has been recognized through the ACM Doctoral Dissertation Award Honorable Mention, the AAAI/ACM SIGAI Doctoral Dissertation Award, the MIT George M. Sprowls PhD Thesis Award in Artificial Intelligence and Decision-Making, the 2020 Samsung AI Researcher of the Year, the IROS Best Paper Award on Cognitive Robotics, and fellowships from Facebook, Nvidia, Samsung, and Adobe.
Courtney Wusthoff, MD
Associate Professor of Neurology and, by courtesy, of Pediatrics (Neonatology) at the Stanford University Medical Center
Current Research and Scholarly InterestsMy projects focus on clinical research in newborns with, or at risk, for brain injury. I use EEG in at-risk neonates to better understand the underlying pathophysiology of risk factors that may lead to worse outcomes. I am particularly interested in neonatal seizures and how they may exacerbate perinatal brain injury with a goal to identify treatments that might protect the vulnerable brain. I am also interested in EEG in other pediatric populations, as well as medical ethics and global health.
Lorry Lokey Professor and Professor of Developmental Biology
Current Research and Scholarly InterestsThe precise and robust regulation of gene expression is a cornerstone for complex biological life. Research in our laboratory is focused on understanding how regulatory information encoded by the genome is integrated with the transcriptional machinery and chromatin context to allow for emergence of form and function during human embryogenesis and evolution, and how perturbations in this process lead to disease.
Tony Wyss-Coray, PhD
D. H. Chen Professor II
Current Research and Scholarly InterestsUse of genetic and molecular tools to dissect immune and inflammatory pathways in Alzheimer's and neurodegeneration.
Assistant Professor of Psychology and of Computer Science
Current Research and Scholarly InterestsOur lab's research lies at intersection of neuroscience, artificial intelligence, psychology and large-scale data analysis. It is founded on two mutually reinforcing hypotheses:
H1. By studying how the brain solves computational challenges, we can learn to build better artificial intelligence algorithms.
H2. Through improving artificial intelligence algorithms, we'll discover better models of how the brain works.
We investigate these hypotheses using techniques from computational modeling and artificial intelligence, high-throughput neurophysiology, functional brain imaging, behavioral psychophysics, and large-scale data analysis.
Associate Professor of Orthopaedic Surgery and of Bioengineering
Current Research and Scholarly InterestsOur research seeks to understand how microenvironmental cues regulate stem cell fate, and to develop novel biomaterials and stem cell-based therapeutics for tissue engineering and regenerative medicine. Our work spans from fundamental science, technology development, to translational research.We are particularly interested in developing better therapies for treating musculoskeletal diseases, cardiovascular diseases and cancer.
Associate Professor of Neurology
Current Research and Scholarly InterestsElucidate biological functions of cytoskeletal associated proteins in neurons. Define the cellular and molecular mechanisms underlying neurodegeneration in null mice.
Yunzhi Peter Yang
Professor of Orthopaedic Surgery
Current Research and Scholarly InterestsYang lab's research interests are in the areas of bio-inspired biomaterials, medical devices, and 3D printing approaches for re-creating a suitable microenvironment for cell growth and tissue regeneration for musculoskeletal disease diagnosis and treatment, including multiple tissue healing such as rotator cuff injury, orthopedic diseases such as osteoporosis and osteonecrosis, and orthopedic traumas such as massive bone and muscle injuries.
David C. Yeomans
Associate Professor of Anesthesiology, Perioperative and Pain Medicine
Current Research and Scholarly InterestsPhysiology of different pain types; Biomarkers of pain and inflammation; Gene Therapy for Pain
Jared and Mae Tinklenberg Professor and Professor, by courtesy, of Neurology
Current Research and Scholarly InterestsWe study cognitive processes and aging in our research center. Studies range from molecular biology to neuropsychology of cognitive processes.
Jong H. Yoon
Associate Professor of Psychiatry and Behavioral Sciences (General Psychiatry and Psychology-Adult) at the Palo Alto Veterans Affairs Health Care System
Current Research and Scholarly InterestsMy research seeks to discover the brain mechanisms responsible for schizophrenia and to translate this knowledge into the clinic to improve how we diagnose and treat this condition. Towards these ends, our group has been developing cutting-edge neuroimaging tools to identify neurobiological abnormalities and test novel systems-level disease models of psychosis and schizophrenia directly in individuals with these conditions.
We have been particularly interested in the role of neocortical-basal ganglia circuit dysfunction. A working hypothesis is that some of the core symptoms of schizophrenia are attributable to impairments in neocortical function that results in disconnectivity with components of the basal ganglia and dysregulation of their activity. The Yoon Lab has developed new high-resolution functional magnetic resonance imaging methods to more precisely measure the function of basal ganglia components, which given their small size and location deep within the brain has been challenging. This includes ways to measure the activity of nuclei that store and control the release of dopamine throughout the brain, a neurochemical that is one of the most important factors in the production of psychosis in schizophrenia and other neuropsychiatric conditions.
Professor of Radiology (Neuroimaging and Neurointervention)
Current Research and Scholarly InterestsImproving medical image quality using deep learning artificial intelligence
Imaging of cerebral hemodynamics with MRI and CT
Noninvasive oxygenation measurement with MRI
Clinical imaging of cerebrovascular disease
Imaging of cervical artery dissection
MR/PET in Neuroradiology
Resting-state fMRI for perfusion imaging and stroke
Associate Professor of Psychology
Current Research and Scholarly InterestsMy research focuses on the cognitive and neural bases of social behavior, and in particular on how people respond to each other's emotions (empathy), why they conform to each other (social influence), and why they choose to help each other (prosociality).
Marguerite Blake Wilbur Professor in Natural Science and Professor, by courtesy, of Physics
Current Research and Scholarly InterestsMy research group is exploring a variety of topics that range from the basic understanding of chemical reaction dynamics to the nature of the chemical contents of single cells.
Under thermal conditions nature seems to hide the details of how elementary reactions occur through a series of averages over reagent velocity, internal energy, impact parameter, and orientation. To discover the effects of these variables on reactivity, it is necessary to carry out studies of chemical reactions far from equilibrium in which the states of the reactants are more sharply restricted and can be varied in a controlled manner. My research group is attempting to meet this tough experimental challenge through a number of laser techniques that prepare reactants in specific quantum states and probe the quantum state distributions of the resulting products. It is our belief that such state-to-state information gives the deepest insight into the forces that operate in the breaking of old bonds and the making of new ones.
Space does not permit a full description of these projects, and I earnestly invite correspondence. The following examples are representative:
The simplest of all neutral bimolecular reactions is the exchange reaction H H2 -> H2 H. We are studying this system and various isotopic cousins using a tunable UV laser pulse to photodissociate HBr (DBr) and hence create fast H (D) atoms of known translational energy in the presence of H2 and/or D2 and using a laser multiphoton ionization time-of-flight mass spectrometer to detect the nascent molecular products in a quantum-state-specific manner by means of an imaging technique. It is expected that these product state distributions will provide a key test of the adequacy of various advanced theoretical schemes for modeling this reaction.
Analytical efforts involve the use of capillary zone electrophoresis, two-step laser desorption laser multiphoton ionization mass spectrometry, cavity ring-down spectroscopy, and Hadamard transform time-of-flight mass spectrometry. We believe these methods can revolutionize trace analysis, particularly of biomolecules in cells.
Associate Professor of Radiology (Neuroimaging and Neurointervention) at the Stanford University Medical Center
BioDr. Michael Zeineh received a B.S. in Biology at Caltech in 1995 and obtained his M.D.-Ph.D. from UCLA in 2003. After internship also at UCLA, he went on to radiology residency and neuroradiology fellowship both at Stanford. He has been an assistant professor of radiology since 2010. Combining clinical acumen in neuroradiology with advanced MRI acquisition and image processing as well as histologic validation, Dr. Zeineh hopes to advance the care of patients with neurodegenerative disorders. In particular, he is interested in Alzheimer's disease, sports-related mild traumatic brain injury, and chronic fatigue syndrome. Additionally, he is specifically interested and has over 20 years of experience studying hippocampal anatomy and pathology.
Associate Professor (Research) of Psychiatry and Behavioral Sciences (Sleep Medicine)
Current Research and Scholarly InterestsDr. Zeitzer is a circadian physiologist specializing in the understanding of the impact of light on circadian rhythms and other aspects of non-image forming light perception.
He examines the manner in which humans respond to light and ways to manipulate this responsiveness, with direct application to jet lag, shift work, and altered sleep timing in teens. Dr. Zeitzer has also pioneered the use of actigraphy in the determination of epiphenomenal markers of psychiatric disorders.
Professor (Research) of NeurosurgeryOn Leave from 07/15/2020 To 06/04/2021
Current Research and Scholarly InterestsMy lab is focused on developing novel therapeutic methods against stroke using rodent models. We study protective effect of postconditioning, preconditioning and mild hypothermia. The rationale for studying three means of neuroprotection is that we may discover mechanisms that these treatments have in common. Conversely, if they have differing mechanisms, we will be able to offer more than one treatment for stroke and increase a patients chance for recovery.
Professor of Mechanical Engineering
BioProfessor Zheng received her Ph.D. in Mechanical & Aerospace Engineering from Princeton University (2006), B.S. in Thermal Engineering from Tsinghua University (2000). Prior to joining Stanford in 2007, Professor Zheng did her postdoctoral work in the Department of Chemistry and Chemical Biology at Harvard University. Professor Zheng is a member of MRS, ACS and combustion institute. Professor Zheng received the TR35 Award from the MIT Technology Review (2013), one of the 100 Leading Global Thinkers by the Foreign Policy Magazine (2013), 3M Nontenured Faculty Grant Award (2013), the Presidential Early Career Award (PECASE) from the white house (2009), Young Investigator Awards from the ONR (2008), DARPA (2008), Terman Fellowship from Stanford (2007), and Bernard Lewis Fellowship from the Combustion Institute (2004).
Roseanna N. Zia
Assistant Professor of Chemical Engineering and, by courtesy, of Mechanical Engineering
Current Research and Scholarly InterestsThe Zia group seeks to unite the deeply connected fields of suspension mechanics and cell biology, to show the role of physics in biological cell fitness. With theory and computation we ask:
1. Is Brownian motion alone sufficient to power life-essential processes in biological cells, and how does this connect cell fitness or even to the origin of life?
2. Do colloidal phase transitions really arrest?
3. Can Einstein's fluctuation-dissipation theory be expanded well beyond equilibrium?
Assistant Professor of Biomedical Data Science and, by courtesy, of Computer Science and of Electrical Engineering
Current Research and Scholarly InterestsMy group works on both foundations of statistical machine learning and applications in biomedicine and healthcare. We develop new technologies that make ML more accountable to humans, more reliable/robust and reveals core scientific insights.
We want our ML to be impactful and beneficial, and as such, we are deeply motivated by transformative applications in biotech and health. We collaborate with and advise many academic and industry groups.
J. Bradley Zuchero
Assistant Professor of Neurosurgery
Current Research and Scholarly InterestsGlia are a frontier of neuroscience, and overwhelming evidence from the last decade shows that they are essential regulators of all aspects of the nervous system. The Zuchero Lab aims to uncover how glial cells regulate neural development and how their dysfunction contributes to diseases like multiple sclerosis (MS) and in injuries like stroke.
Although glia represent more than half of the cells in the human brain, fundamental questions remain to be answered. How do glia develop their highly specialized morphologies and interact with neurons to powerfully control form and function of the nervous system? How is this disrupted in neurodegenerative diseases and after injury? By bringing cutting-edge cell biology techniques to the study of glia, we aim to uncover how glia help sculpt and regulate the nervous system and test their potential as novel, untapped therapeutic targets for disease and injury.
We are particularly interested in myelin, the insulating sheath around neuronal axons that is lost in diseases like MS. How do oligodendrocytes- the glial cell that produces myelin in the central nervous system- form and remodel myelin, and why do they fail to regenerate myelin in disease? Our current projects aim to use cell biology and neuroscience approaches to answer these fundamental questions. Ultimately we hope our work will lead to much-needed therapies to promote remyelination in patients.