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Showing 801-900 of 956 Results

  • Edward I. Solomon

    Edward I. Solomon

    Monroe E. Spaght Professor of Chemistry and Professor of Photon Science

    Current Research and Scholarly InterestsProf. Solomon's work spans physical-inorganic, bioinorganic, and theoretical-inorganic chemistry, focusing on spectroscopic elucidation of the electronic structure of transition metal complexes and its contribution to reactivity. He has advanced our understanding of metal sites involved in electron transfer, copper sites involved in O2 binding, activation and reduction to water, structure/function correlations over non-heme iron enzymes, and correlation of biological to heterogeneous catalysis.

  • Ivan Soltesz

    Ivan Soltesz

    James R. Doty Professor of Neurosurgery and Neurosciences

    BioIvan Soltesz received his doctorate in Budapest and conducted postdoctoral research at universities at Oxford, London, Stanford and Dallas. He established his laboratory at the University of California, Irvine, in 1995. He became full Professor in 2003, and served as department Chair from 2006 to July 2015. He returned to Stanford in 2015 as the James R. Doty Professor of Neurosurgery and Neurosciences at Stanford University School of Medicine. His major research interest is focused on neuronal microcircuits, network oscillations, cannabinoid signaling and the mechanistic bases of circuit dysfunction in epilepsy.
    His laboratory employs a combination of closely integrated experimental and theoretical techniques, including closed-loop in vivo optogenetics, paired patch clamp recordings, in vivo electrophysiological recordings from identified interneurons in awake mice, 2-photon imaging, machine learning-aided 3D video analysis of behavior, video-EEG recordings, behavioral approaches, and large-scale computational modeling methods using supercomputers. He is the author of a book on GABAergic microcircuits (Diversity in the Neuronal Machine, Oxford University Press), and editor of a book on Computational Neuroscience in Epilepsy (Academic Press/Elsevier). He co-founded the first Gordon Research Conference on the Mechanisms of neuronal synchronization and epilepsy, and taught for five years in the Ion Channels Course at Cold Springs Harbor. He has over 30 years of research experience, with over 20 years as a faculty involved in the training of graduate students (total of 16, 6 of them MD/PhDs) and postdoctoral fellows (20), many of whom received fellowship awards, K99 grants, joined prestigious residency programs and became independent faculty.

  • George Somero

    George Somero

    David and Lucile Packard Professor in Marine Science, Emeritus

    Current Research and Scholarly InterestsWe examine two aspects of organism-environment interactions: How does stress from physical (e.g., temperature) and chemical (oxygen levels, pH) factors perturb organisms and how do organisms respond, adaptively, to cope with this stress? We examine evolutionary adaptation and phenotypic acclimatization using a wide variety of marine animals, including Antarctic fishes and invertebrates from intertidal habitats on the coastlines of temperate and tropical seas.

  • Geoffrey Sonn

    Geoffrey Sonn

    Assistant Professor of Urology and, by courtesy, of Radiology

    Current Research and Scholarly InterestsMy interest is in improving prostate cancer diagnosis through MRI and image-targeted prostate biopsy. In collaboration with radiologists at Stanford, we are working to define the optimal role of MRI in prostate cancer. We hope to improve cancer imaging to the point that some men with elevated PSA may safely avoid prostate biopsy. For those who need biopsy, we are evaluating novel MRI-US fusion targeted biopsy, a technique that greatly improves upon the conventional biopsy method.

  • Justin L. Sonnenburg

    Justin L. Sonnenburg

    Associate Professor of Microbiology and Immunology

    Current Research and Scholarly InterestsWe are interested in the basic principles that govern interactions within the intestinal microbiota and between the microbiota and the host. To pursue these aims, we colonize germ-free (gnotobiotic) mice with simplified, model microbial communities, apply systems approaches (e.g. functional genomics), and use genetic tools for the host and microbes to gain mechanistic insight into emergent properties of the host-microbial super-organism.

  • Andrew Spakowitz

    Andrew Spakowitz

    Professor of Chemical Engineering, of Materials Science and Engineering and, by courtesy, of Applied Physics

    Current Research and Scholarly InterestsTheory and computation of biological processes and complex materials

  • Erik Sperling

    Erik Sperling

    Assistant Professor of Geological Sciences and, by courtesy, of Biology and Center Fellow, by courtesy, at the Woods Institute for the Environment

    Current Research and Scholarly InterestsThe research interests in the Sperling Lab are Earth history and the evolution of life, and the interactions between the biosphere and the geosphere. As such this research can generally be considered paleontology, insofar as paleontology encompasses all aspects of the history of life.

    Consequently, we define our research agenda by the questions we are interested in, rather than the tools used. This research incorporates multiple lines of evidence, and multiple tools, to investigate questions in the history of life. These lines of evidence include fossil data, molecular phylogenetics, sedimentary geochemistry, and developmental and ecological data from modern organisms. Ultimately, the goal is to link environmental change with organismal and ecological response through the lens of physiology.

    Our field research takes place all over the world--current areas include:

    -NW Canada (Yukon and Northwest Territories): Research has been conducted on the early Neoproterozoic Fifteenmile Group, Cryogenian and Ediacaran Windermere Supergroup, and on the Ordovician-Devonian Road River Group in the southern Richardson Mountains
    -Southern Canadian Cordillera: Work here has focused on the early Cambrian Mural Formation and its soft-bodied fauna.
    -England and Wales: Cambrian-Silurian successions in the Welsh Basin
    -Namibia: Ediacaran Nama Group
    -Upwelling zones: We study the oxygen minimum zone offshore California as an analogue for ancient low-oxygen oceans.

  • Edda Spiekerkoetter

    Edda Spiekerkoetter

    Associate Professor of Medicine (Pulmonary and Critical Care Medicine)

    Current Research and Scholarly InterestsPulmonary Arterial Hypertension
    Pulmonary Vascular Remodeling
    Modulation of BMP signaling
    BMP signaling in health and disease in the right ventricle of the heart
    "BMP signature" in blood as a biomarker
    BMP signaling in neonatal chronic lung disease

  • Daniel Spielman

    Daniel Spielman

    Professor of Radiology (Radiological Sciences Lab) and, by courtesy, of Electrical Engineering

    Current Research and Scholarly InterestsMy research interests are in the field of medical imaging, particularly magnetic resonance imaging and in vivo spectroscopy. Current projects include MRI and MRS at high magnetic fields and metabolic imaging using hyperpolarized 13C-labeled MRS.

  • Alfred M. Spormann

    Alfred M. Spormann

    Professor of Civil and Environmental Engineering, of Chemical Engineering and, by courtesy, of Biology

    Current Research and Scholarly InterestsMetabolism of anaerobic microbes in diseases, bioenergy, and bioremediation

  • James Spudich

    James Spudich

    Douglass M. and Nola Leishman Professor of Cardiovascular Disease
    On Leave from 02/01/2020 To 01/31/2022

    Current Research and Scholarly InterestsThe general research interest of this laboratory is the molecular basis of cell motility, with a current emphasis on power output by the human heart. We have three specific research interests, the molecular basis of energy transduction that leads to ATP-driven myosin movement on actin, the biochemical basis of the regulation of actin and myosin interaction and their assembly states, and the roles these proteins play in vivo, in cell movement, changes in cell shape and muscle contraction.

  • Sheri Spunt

    Sheri Spunt

    Endowed Professor of Pediatric Cancer

    Current Research and Scholarly InterestsMy research focuses primarily on the management of children, adolescents, and young adults with soft tissue sarcomas. I also have an interest in developmental therapeutics and late effects of cancer therapy,

  • Randall Stafford

    Randall Stafford

    Professor of Medicine (Stanford Center for Research in Disease Prevention)

    Current Research and Scholarly InterestsAs Director of the SPRC Program on Prevention Outcomes and Practices, my work focuses on cardiovascular disease treatment and prevention, the adoption of new technology and practices, and patterns of physician practice, particularly medication prescribing. Specific interests include measuring and improving the quality of outpatient care, disparities in health care by race, gender, age and socioeconomic status, and interventions to improve prevention outcomes.

  • Creed Stary

    Creed Stary

    Associate Professor of Anesthesiology, Perioperative and Pain Medicine (Adult MSD) and, by courtesy, of Ophthalmology

    Current Research and Scholarly InterestsMechanisms promoting neuronal survival following cerebral ischemia-reperfusion injury; utilizing microRNA's to target multiple pathways to promote mitochondrial homeostasis and cell survival; anesthetic neurotoxicity; astrocyte-neuronal interaction

  • Kristan Staudenmayer, MD, MS, FACS

    Kristan Staudenmayer, MD, MS, FACS

    Associate Professor of Surgery (General Surgery)

    Current Research and Scholarly InterestsDefining the Impact of Injuries in the Elderly

  • Tim Stearns

    Tim Stearns

    Frank Lee and Carol Hall Professor, Senior Associate Vice Provost of Research and Professor of Genetics

    Current Research and Scholarly InterestsWe use the tools of genetics, microscopy, and biochemistry to understand fundamental questions of cell biology: How are cells organized by the cytoskeleton? How do the centrosome and cilium control cell control cell signaling? How is cell division coordinated with duplication of the centrosome, and what goes wrong in cancer cells defective in this coordination?

  • Gary K. Steinberg, MD, PhD

    Gary K. Steinberg, MD, PhD

    Bernard and Ronni Lacroute-William Randolph Hearst Professor of Neurosurgery and Neurosciences and Professor, by courtesy, of Neurology

    Current Research and Scholarly InterestsOur laboratory investigates the pathophysiology and treatment of cerebral ischemia, and methods to restore neurologic function after stroke. Treatment strategies include brain hypothermia, stem cell transplantation and optogenetic stimulation. Our clinical research develops innovative surgical, endovascular and radiosurgical approaches for treating difficult intracranial aneurysms, complex vascular malformations and occlusive disease, including Moyamoya disease, as well as stem cell transplant.

  • Lawrence Steinman, MD

    Lawrence Steinman, MD

    George A. Zimmermann Professor and Professor of Pediatrics

    Current Research and Scholarly InterestsOur laboratory is dedicated to understanding the pathogenesis of autoimmune diseases, particularly multiple sclerosis. We have developed several new therapies for autoimmunity, including some in Phase 2 clinical trials, as well as one approved drug, natalizumab. We have developed microarray technology for detecting autoantibodies to myelin proteins and lipids. We employ a diverse range of molecular and celluar approaches to trying to understand multiple sclerosis.

  • Lars Steinmetz

    Lars Steinmetz

    Professor of Genetics

    Current Research and Scholarly InterestsWe apply diverse genomic approaches to understand how genetic variation affects health and disease by: 1) functional and mechanistic analyses of gene regulation, 2) studies of meiotic recombination and inheritance, 3) analyses of genetic and environmental interactions, and 4) characterization of diseases in human cells and model organisms. We integrate wet lab and computational genomic, transcriptomic, proteomic and metabolic approaches, and develop technologies to enable personalized medicine.

  • David A. Stevens

    David A. Stevens

    Professor of Medicine, Emeritus

    Current Research and Scholarly InterestsImmunology and chemotherapy of human fungal diseases, particularly coccidioidomycosis (Valley Fever) in California and aspergillosis, and the parasitic disease, trypanosomiasis.

  • David Stevenson

    David Stevenson

    Professor of Pediatrics (Genetics)

    Current Research and Scholarly InterestsMy research focuses on disorders of the RAS/MAPK pathway (eg. NF1, Noonan, CFC, and Costello syndrome). I am working on understanding the impact of RAS signaling on the musculoskeletal system. I use genomic approaches to identify somatic events and modifiers in the RASopathies. I am also involved in identifying outcome measures for use in clinical trials for the associated orthopedic manifestations. Other areas of research involve vascular anomalies, Prader-Willi syndrome, and hypophosphatasia.

  • David K. Stevenson, M.D.

    David K. Stevenson, M.D.

    Harold K. Faber Professor of Pediatrics, Senior Associate Dean, Maternal and Child Health and Professor, by courtesy, of Obstetrics and Gynecology

    Current Research and Scholarly InterestsOur research is focused on the study of the ontogeny and control of heme catabolism and bilirubin production in the developing neonate. A better understanding of the role of increased bilirubin production in neonatal jaundice and the prevention of hemolytic jaundice has remained an overall objective of our program. We are also study the causes of preterm birth and ways to prevent it.

  • Tanya Stoyanova

    Tanya Stoyanova

    Assistant Professor of Radiology (Cancer Early Detection-Canary Center)

    Current Research and Scholarly InterestsStoyanova lab develops new early cancer detection methods and therapeutic strategies for late stage cancers. The current research focus is on protein-based biomarkers for early cancer detection as well as development of new small molecule inhibitors and antibody-based therapies for prostate and other epithelial cancers. The ultimate goals of the laboratory are to improve the early diagnosis and prognosis of clinically significant cancers and guide the development of novel and effective therapeutic strategies for metastatic prostate and other epithelial cancers.

  • Aaron F. Straight

    Aaron F. Straight

    Professor of Biochemistry and, by courtesy, of Chemical and Systems Biology

    Current Research and Scholarly InterestsWe study the biology of chromosomes. Our research is focused on understanding how chromosomal domains are specialized for unique functions in chromosome segregation, cell division and cell differentiation. We are particularly interested in the genetic and epigenetic processes that govern vertebrate centromere function, in the organization of the genome in the eukaryotic nucleus and in the roles of RNAs in the regulation of chromosome structure.

  • Samuel Strober

    Samuel Strober

    Professor of Medicine (Immunology and Rheumatology)

    Current Research and Scholarly InterestsMechanisms of immune tolerance; regulatory processes in autoimmunity and transplantation and extrathymic T cell maturation.

  • Thomas Sudhof

    Thomas Sudhof

    Avram Goldstein Professor in the School of Medicine and Professor, by courtesy, of Neurology and of Psychiatry and Behavioral Sciences

    Current Research and Scholarly InterestsInformation transfer at synapses mediates information processing in brain, and is impaired in many brain diseases. Thomas Südhof is interested in how synapses are formed, how presynaptic terminals release neurotransmitters at synapses, and how synapses become dysfunctional in diseases such as autism or Alzheimer's disease. To address these questions, Südhof's laboratory employs approaches ranging from biophysical studies to the electrophysiological and behavioral analyses of mutant mice.

  • Brian Suffoletto

    Brian Suffoletto

    Associate Professor of Emergency Medicine

    Current Research and Scholarly InterestsDr. Suffoletto is an emergency physician and NIH-funded investigator with a focus on collecting novel forms of longitudinal and remote data to inform temporal risk prediction and inform just-in-time adaptive interventions

  • Edith Vioni Sullivan

    Edith Vioni Sullivan

    Professor of Psychiatry and Behavioral Sciences (Major Laboratories and Clinical Translational Neurosciences Incubator)

    Current Research and Scholarly InterestsApplication of neuroimaging modalities and component process analysis of cognitive, sensory, and motor functions to identify brain structural and functional mechanisms disrupted in diseases affecting the brain: alcohol use disorder, HIV infection, dementia, and normal aging from adolescence to senescence.

  • Yang Sun, MD, PhD

    Yang Sun, MD, PhD

    Associate Professor of Ophthalmology

    Current Research and Scholarly InterestsWe are interested in the role of inositol phosphatases in eye development and disease, using both animal models and human disease tissue. We are a translational laboratory seeking to understand the basic function of proteins as well as developing therapeutic strategies for clinical trials.

  • Zijie Sun

    Zijie Sun

    Professor of Urology, Emeritus

    Current Research and Scholarly InterestsWe focus on understanding the molecular mechanism of transcription factors that govern the transformation of normal cells to a neoplastic state. We are especially interested in nuclear hormone action and its interactions with other signaling pathways in tumor development and progression.

  • John B. Sunwoo

    John B. Sunwoo

    Edward C. and Amy H. Sewall Professor in the School of Medicine and Professor, by courtesy, of Dermatology

    Current Research and Scholarly InterestsMy laboratory is focused on two primary areas of research: (1) the immune response to head and neck cancer and to a tumorigenic population of cells within these malignancies called cancer stem cells; (2) the developmental programs of a special lymphocyte population involved in innate immunity called natural killer (NK) cells; and (3) intra-tumor and inter-tumor heterogeneity.

  • Trisha Suppes, MD, PhD

    Trisha Suppes, MD, PhD

    Professor of Psychiatry and Behavioral Sciences (General Psychiatry and Psychology-Adult)

    Current Research and Scholarly InterestsLong-term treatment strategies for bipolar disorder, treatment for bipolar II disorder, use of treatment algorithms, and treatment of major depression.

  • Yuri Suzuki

    Yuri Suzuki

    Professor of Applied Physics and, by courtesy, of Materials Science and Engineering

    Current Research and Scholarly InterestsHer interests are focused on novel ground states and functional properties in condensed matter systems synthesized via atomically precise thin film deposition techniques with a recent emphasis has been on highly correlated electronic systems:
    • Emergent interfacial electronic & magnetic phenomena through complex oxide heteroepitaxy
    • Low dimensional electron gas systems
    • Spin current generation, propagation and control in complex oxide-based ferromagnets
    • Multifunctional behavior in complex oxide thin films and heterostructures

  • Katrin J Svensson

    Katrin J Svensson

    Assistant Professor of Pathology

    Current Research and Scholarly InterestsMolecular metabolism
    Protein biochemistry
    Cell biology and function
    Animal physiology

  • James Swartz

    James Swartz

    James H. Clark Professor in the School of Engineering and Professor of Chemical Engineering and of Bioengineering

    Current Research and Scholarly InterestsProgram Overview

    The world we enjoy, including the oxygen we breathe, has been beneficially created by biological systems. Consequently, we believe that innovative biotechnologies can also serve to help correct a natural world that non-natural technologies have pushed out of balance. We must work together to provide a sustainable world system capable of equitably improving the lives of over 10 billion people.
    Toward that objective, our program focuses on human health as well as planet health. To address particularly difficult challenges, we seek to synergistically combine: 1) the design and evolution of complex protein-based nanoparticles and enzymatic systems with 2) innovative, uniquely capable cell-free production technologies.
    To advance human health we focus on: a) achieving the 120 year-old dream of producing “magic bullets”; smart nanoparticles that deliver therapeutics or genetic therapies only to specific cells in our bodies; b) precisely designing and efficiently producing vaccines that mimic viruses to stimulate safe and protective immune responses; and c) providing a rapid point-of-care liquid biopsy that will count and harvest circulating tumor cells.
    To address planet health we are pursuing biotechnologies to: a) inexpensively use atmospheric CO2 to produce commodity biochemicals as the basis for a new carbon negative chemical industry, and b) mitigate the intermittency challenges of photovoltaic and wind produced electricity by producing hydrogen either from biomass sugars or directly from sunlight.
    More than 25 years ago, Professor Swartz began his pioneering work to develop cell-free biotechnologies. The new ability to precisely focus biological systems toward efficiently addressing new, “non-natural” objectives has proven tremendously useful as we seek to address the crucial and very difficult challenges listed above. Another critical feature of the program is the courage (or naivete) to approach important objectives that require the development and integration of several necessary-but- not-sufficient technology advances.

  • Karl G. Sylvester

    Karl G. Sylvester

    Professor of Surgery (Pediatric Surgery)

    Current Research and Scholarly InterestsScholarly interests include investigation of molecular markers of human disease that provide diagnostic function, serve as targets for possible therapeutic manipulation, or provide insight into mechanisms of human disease. Specific diseases of interest include common conditions of pregnancy, gut microbial ecology and Necrotizing Enterocolitis (NEC).

  • Daniel Sze, MD, PhD

    Daniel Sze, MD, PhD

    Professor of Radiology (Interventional Radiology)

    Current Research and Scholarly InterestsTransarterial administration of chemotherapeutics, radioactive microspheres, and biologics for the treatment of unresectable tumors; management of portal hypertension and complications of cirrhosis (TIPS); treatment of complications of organ transplantation; Venous and pulmonary arterial thrombolysis and reconstruction; Stent and Stent-graft treatment of peripheral vascular diseases, aneurysms, aortic dissections

  • Christopher N. Ta, MD

    Christopher N. Ta, MD

    Professor of Ophthalmology
    On Partial Leave from 03/01/2020 To 02/28/2022

    BioChristopher N. Ta, MD specializes in the diagnosis and medical treatment of cornea diseases. His areas of expertise are in the treatment of ocular infections, inflammation, dry eyes and ocular surface diseases. He has conducted numerous clinical trials toward the prevention and treatment of ocular infections. Dr. Ta also has extensive clinical experience in the treatment of ocular graft-versus host disease following hematopoietic stem cell transplantation.

  • William Talbot

    William Talbot

    Professor of Developmental Biology

    Current Research and Scholarly InterestsWe use genetic and cellular approaches to investigate the molecular basis of glial development and myelination in the zebrafish.

  • Hua Tang

    Hua Tang

    Professor of Genetics and, by courtesy, of Statistics

    Current Research and Scholarly InterestsDevelop statistical and computational methods for population genomics analyses; modeling human evolutionary history; genetic association studies in admixed populations.

  • Jean Y. Tang MD PhD

    Jean Y. Tang MD PhD

    Professor of Dermatology

    Current Research and Scholarly InterestsMy research focuses on 2 main areas:

    1. Skin cancer:
    - New therapeutics to treat and prevent non-melanoma skin cancer, especially by targeting the Hedgehog signaling pathway for BCC tumors
    - Genomic analysis of drug-resistant cancers
    - Identifying risk factors for skin cancer in the Women's Health Initiative

    2. Epidermolysis Bullosa: gene therapy and protein therapy to replace defective/absent Collagen 7 in children and adults with Recessive Dystrophic EB

  • Sindy Tang

    Sindy Tang

    Associate Professor of Mechanical Engineering, Senior Fellow at the Woods Institute for the Environment and Professor, by courtesy, of Radiology (Precision Health and Integrated Diagnostics)

    Current Research and Scholarly InterestsThe long-term goal of Dr. Tang's research program is to harness mass transport in microfluidic systems to accelerate precision medicine and material design for a future with better health and environmental sustainability.

    Current research areas include: (I) Physics of droplets in microfluidic systems, (II) Interfacial mass transport and self-assembly, and (III) Applications in food allergy, single-cell wound repair, and the bottom-up construction of synthetic cell and tissues in close collaboration with clinicians and biochemists at the Stanford School of Medicine, UCSF, and University of Michigan.

    For details see https://web.stanford.edu/group/tanglab/

  • William Abraham Tarpeh

    William Abraham Tarpeh

    Assistant Professor of Chemical Engineering, by courtesy, of Civil and Environmental Engineering and Center Fellow, by courtesy, at the Woods Institute for the Environment

    BioReimagining liquid waste streams as resources can lead to recovery of valuable products and more efficient, less costly approaches to reducing harmful discharges to the environment. Pollutants in effluent streams can be captured and used as valuable inputs to other processes. For example, municipal wastewater contains resources like energy, water, nutrients, and metals. The Tarpeh Lab develops and evaluates novel approaches to resource recovery from “waste” waters at several synergistic scales: molecular mechanisms of chemical transport and transformation; novel unit processes that increase resource efficiency; and systems-level assessments that identify optimization opportunities. We employ understanding of electrochemistry, separations, thermodynamics, kinetics, and reactor design to preferentially recover resources from waste. We leverage these molecular-scale insights to increase the sustainability of engineered processes in terms of energy, environmental impact, and cost.

  • Daniel Tartakovsky

    Daniel Tartakovsky

    Professor of Energy Resources Engineering

    Current Research and Scholarly InterestsEnvironmental fluid mechanics, Applied and computational mathematics, Biomedical modeling.

  • Vivianne Tawfik

    Vivianne Tawfik

    Assistant Professor of Anesthesiology, Perioperative and Pain Medicine (Adult Pain)

    Current Research and Scholarly InterestsMy overall research interest is to understand how the immune system interacts with the nervous system after injury to promote the transition from acute to chronic pain. In my clinical practice I care for patients with persistent pain that often occurs after minor trauma such as fracture or surgery. Using basic science approaches including whole system immune phenotyping with mass cytometry and genetic manipulation of peripheral and central immune cells, we seek to dissect the temporal and tissue-specific contribution of these cells to either promotion or inhibition of healing.

  • Joyce Teng, MD, PhD

    Joyce Teng, MD, PhD

    Professor of Dermatology and, by courtesy, of Pediatrics

    BioJoyce Teng, MD, PhD is a professor in dermatology at Stanford University. She is affiliated with multiple hospitals in the area, including Lucile Salter Packard Children's Hospital (LPCH) at Stanford and Stanford Hospital and Clinics (SHC). She received her medical degree from Vanderbilt University School of Medicine and has been in practice for more than 12 years. She is one of the 5 pediatric dermatologists practicing at LPCH and one of 72 at SHC who specialize in Dermatology. She sees patients with rare genetic disorders, birthmarks, vascular anomalies and a variety of inflammatory skin diseases. She is also an experienced pediatric dermatological surgeon. Her research interests are drug discovery and novel therapy for skin disorders.

  • Avnesh Thakor

    Avnesh Thakor

    Assistant Professor of Radiology (Pediatric Radiology)

    Current Research and Scholarly InterestsOver the past decade there has been tremendous advances in the field of Interventional Oncology with the clinical utilization of multiple new innovative locoregional therapies (i.e. chemoembolization, percutaneous ablation).

    Looking forward, our ability to super-selectively deliver new therapies directly to target organs. These therapies include nanoparticles, stem cells and gene therapy and will open new pathways into the emerging field of Interventional Regenerative Medicine.

  • Suzanne Tharin

    Suzanne Tharin

    Assistant Professor of Neurosurgery
    On Leave from 08/09/2021 To 12/31/2021

    Current Research and Scholarly InterestsThe long-term goal of my research is the repair of damaged corticospinal circuitry. Therapeutic regeneration strategies will be informed by an understanding both of corticospinal motor neuron (CSMN) development and of events occurring in CSMN in the setting of spinal cord injury. MicroRNAs are small, non-coding RNAs that regulate the expression of “suites” of genes. The work in my lab seeks to identify microRNA controls over CSMN development and over the CSMN response to spinal cord injury.

  • Robert Tibshirani

    Robert Tibshirani

    Professor of Biomedical Data Science and of Statistics

    Current Research and Scholarly InterestsMy research is in applied statistics and biostatistics. I specialize in computer-intensive methods for regression and classification, bootstrap, cross-validation and statistical inference, and signal and image analysis for medical diagnosis.

  • Alice Ting

    Alice Ting

    Professor of Genetics, of Biology and, by courtesy, of Chemistry

    Current Research and Scholarly InterestsWe develop chemogenetic and optogenetic technologies for probing and manipulating protein networks, cellular RNA, and the function of mitochondria and the mammalian brain. Our technologies draw from enzyme engineering, directed evolution, chemical biology, organic synthesis, high-resolution microscopy, genetics, and computational analysis.

  • Natalie Torok

    Natalie Torok

    Professor of Medicine (Gastroenterology and Hepatology)

    Current Research and Scholarly InterestsOur laboratory has been focusing on the mechanism of liver fibrosis and the role of hepatocyte cell death in fibrogenic injury. We have demonstrated the intricate link between hepatocyte apoptosis, generation of apoptotic bodies and their efferocytosis by stellate cells triggering fibrogenic activation. Key to this was the activation of the NADPH oxidase NOX2 and production of reactive oxidative species inducing stellate cell transdifferentiation and collagen I transcription. We have expanded our work focusing on the role of non-phagocytic NOX4 in dysregulating insulin responses and precipitating ER and mitochondrial stress signaling in non-alcoholic steatohepatitis. We are particularly interested in clinical conditions that are linked to accelerated fibrosis such as during aging and T2DM. Our other major focus is on alcoholic hepatitis, and defining novel therapeutic targets based on sterile inflammatory pathways. Our ultimate goal is translation and developing new treatment approaches that reverse fibrosis and improve patient outcomes.

  • Philip S. Tsao, PhD

    Philip S. Tsao, PhD

    Professor (Research) of Medicine (Cardiovascular Medicine)

    Current Research and Scholarly InterestsOur primary interests are in the molecular underpinnings of vascular disease as well as assessing disease risk. In addition to targeted investigation of specific signaling molecules, we utilize global genomic analysis to identify gene expression networks and regulatory units. We are particularly interested in the role of microRNAs in gene expression pathways associated with disease.

  • Richard Tsien

    Richard Tsien

    George D. Smith Professor, Emeritus

    Current Research and Scholarly InterestsWe study synaptic communication between brain cells with the goal of understanding neuronal computations and memory mechanisms. Main areas of focus include: presynaptic calcium channels, mechanisms of vesicular fusion and recycling. Modulation of synaptic strength through changes in postsynaptic receptors and dendritic morphology. Signaling that links synaptic activity to nuclear transcription and local protein translation. Techniques include imaging, electrophysiology, molecular biology.

  • Shripad Tuljapurkar

    Shripad Tuljapurkar

    The Dean and Virginia Morrison Professor of Population Studies

    Current Research and Scholarly InterestsStochastic dynamics of human and natural populations; prehistoric societies; probability forecasts including sex ratios, mortality, aging and fiscal balance; life history evolution.

  • Minang (Mintu) Turakhia

    Minang (Mintu) Turakhia

    Associate Professor of Medicine (Cardiovascular Medicine)

    Current Research and Scholarly InterestsDr. Turakhia has an active clinical research program, with funding from AHA, VA, NIH, the medical device industry, and foundations. His research program aims to improve the treatment of heart rhythm disorders, with an emphasis on atrial fibrillation, by evaluating quality and variation of care, comparative and cost-effectiveness of therapies, and risk prediction. Dr. Turakhia has extensive expertise in using large administrative and claims databases for this work. His TREAT-AF retrospective study of over 500,000 patients with newly-diagnosed AF is the largest known research cohort of AF patients. He has served as study PI or chairman of several prominent single- and multicenter trials in atrial fibrillation, investigational devices for electrophysiology procedures, digital health interventions, and sensor technologies.

    His other research interests include technology assessment of new device-based therapies and the impact of changing health policy and reform on the delivery of arrhythmia care. Dr. Turakhia is a Fellow of the American Heart Association, American College of Cardiology, and Heart Rhythm Society.

  • Alexander Eckehart Urban

    Alexander Eckehart Urban

    Associate Professor of Psychiatry and Behavioral Sciences (Major Laboratories and Clinical Translational Neurosciences Incubator) and of Genetics
    On Leave from 10/01/2021 To 08/31/2022

    Current Research and Scholarly InterestsComplex behavioral and neuropsychiatric phenotypes often have a strong genetic component. This genetic component is often extremely complex and difficult to dissect. The current revolution in genome technology means that we can avail ourselves to tools that make it possible for the first time to begin understanding the complex genetic and epigenetic interactions at the basis of the human mind.

  • PJ Utz

    PJ Utz

    Professor of Medicine (Immunology and Rheumatology)

    Current Research and Scholarly InterestsThe long-term research goal of the Utz laboratory is to understand autoimmunity, autoantibodies, and how tolerance is broken and can be reestablished.

  • Tulio Valdez

    Tulio Valdez

    Associate Professor of Otolaryngology - Head & Neck Surgery (OHNS) and, by courtesy, of Pediatrics

    BioDr. Tulio A Valdez is a surgeon scientist born and raised in Colombia with a subspecialty interest in Pediatric Otolaryngology. He attended medical school at Universidad Javeriana in Bogota Colombia before undertaking his residency in Otolaryngology, Head and Neck Surgery in Boston. He completed his Pediatric Otolaryngology Fellowship at Texas Children’s Hospital (2007), Houston and obtained his Master’s in Clinical and Translational Research at the University of Connecticut.

    Clinically, Dr. Valdez has an interest in airway surgery and swallowing disorders. He has a special interest in the management of sinus disease in cystic fibrosis. Dr. Valdez has co-authored one textbook and numerous book chapters and scientific manuscripts. Dr. Valdez continues his clinical research in these areas, particularly with a focus on aerodigestive disorders.

    Scientifically, Dr. Valdez has developed various imaging methods to diagnose otitis media and cholesteatoma a middle ear condition that can lead to hearing loss. He was part of the Laser Biomedical Research Center at Massachusetts Institute of Technology. His research includes novel imaging modalities to better diagnose ear infections one of the most common pediatric problems. His research has now expanded to include better intraoperative imaging modalities in pediatric patients to improve surgical outcomes without the need for radiation exposure. 

    Dr. Valdez believes in the multi-disciplinary collaborations to tackle medical problems and has co-invented various medical devices and surgical simulation models.

  • Gregory Valiant

    Gregory Valiant

    Associate Professor of Computer Science

    Current Research and Scholarly InterestsMy primary research interests lie at the intersection of algorithms, learning, applied probability, and statistics. I am particularly interested in understanding the algorithmic and information theoretic possibilities and limitations for many fundamental information extraction tasks that underly real-world machine learning and data-centric applications.

  • Matt van de Rijn

    Matt van de Rijn

    Sabine Kohler, MD, Professor of Pathology

    Current Research and Scholarly InterestsOur research focuses on molecular analysis of human soft tissue tumors (sarcomas) with an emphasis on leiomyosarcoma and desmoid tumors. In addition we study the role of macrophages in range of malignant tumors.

  • Capucine van Rechem

    Capucine van Rechem

    Assistant Professor of Pathology (Pathology Research)

    Current Research and Scholarly InterestsMy long-term interest lies in understanding the impact chromatin modifiers have on disease development and progression so that more optimal therapeutic opportunities can be achieved. My laboratory explores the direct molecular impact of chromatin-modifying enzymes during cell cycle progression, and characterizes the unappreciated and unconventional roles that these chromatin factors have on cytoplasmic function such as protein synthesis.

  • Benjamin Van Roy

    Benjamin Van Roy

    Professor of Electrical Engineering, of Management Science and Engineering

    BioBenjamin Van Roy is a Professor at Stanford University, where he has served on the faculty since 1998. His research focuses on understanding how an agent interacting with a poorly understood environment can learn over time to make effective decisions. He is interested in the design of efficient reinforcement learning algorithms, understanding what is possible or impossible in this domain, and applying the technology toward the benefit of society. Beyond academia, he leads a DeepMind Research team in Mountain View, and has also led research programs at Unica (acquired by IBM), Enuvis (acquired by SiRF), and Morgan Stanley.

    He is a Fellow of INFORMS and IEEE and has served on the editorial boards of Machine Learning, Mathematics of Operations Research, for which he co-edits the Learning Theory Area, Operations Research, for which he edited the Financial Engineering Area, and the INFORMS Journal on Optimization.

    He received the SB in Computer Science and Engineering and the SM and PhD in Electrical Engineering and Computer Science, all from MIT. He has been a recipient of the MIT George C. Newton Undergraduate Laboratory Project Award, the MIT Morris J. Levin Memorial Master's Thesis Award, the MIT George M. Sprowls Doctoral Dissertation Award, the National Science Foundation CAREER Award, the Stanford Tau Beta Pi Award for Excellence in Undergraduate Teaching, and the Management Science and Engineering Department's Graduate Teaching Award. He has held visiting positions as the Wolfgang and Helga Gaul Visiting Professor at the University of Karlsruhe, the Chin Sophonpanich Foundation Professor and the InTouch Professor at Chulalongkorn University, a Visiting Professor at the National University of Singapore, and a Visiting Professor at the Chinese University of Hong Kong, Shenzhen.

  • Shreyas Vasanawala, MD/PhD

    Shreyas Vasanawala, MD/PhD

    William R. Brody Professor of Pediatric Radiology and Child Health

    Current Research and Scholarly InterestsOur group is focused on developing new fast and quantitative MRI techniques.

  • Anand Veeravagu

    Anand Veeravagu

    Assistant Professor of Neurosurgery and, by courtesy, of Orthopaedic Surgery

    Current Research and Scholarly InterestsThe focus of my laboratory is to utilize precision medicine techniques to improve the diagnosis and treatment of neurologic conditions. From traumatic brain injury to spinal scoliosis, the ability to capture detailed data regarding clinical symptoms and treatment outcomes has empowered us to do better for patients. Utilize data to do better for patients, that’s what we do.

    Stanford Neurosurgical Ai and Machine Learning Lab
    http://med.stanford.edu/neurosurgery/research/AILab.html

  • Jose Vilches-Moure

    Jose Vilches-Moure

    Assistant Professor of Comparative Medicine

    BioDr. José G. Vilches-Moure, DVM, PhD, Assistant Professor, received his DVM degree from Purdue University in Indiana in 2007. He completed his residency training in Anatomic Pathology (with emphasis in pathology of laboratory animal species) and his PhD in Comparative Pathology at the University of California-Davis. He joined Stanford in 2015, and is the Director of the Animal Histology Services (AHS). Dr. Vilches-Moure is a diplomate of the American College of Veterinary Pathologists, and his collaborative research interests include cardiac development and pathology, developmental pathology, and refinement of animal models in which to study early cancer detection techniques. His teaching interests include comparative anatomy/histology, general pathology, comparative pathology, and pathology of laboratory animal species.

  • Anne Villeneuve

    Anne Villeneuve

    Professor of Developmental Biology and of Genetics

    Current Research and Scholarly InterestsMechanisms underlying homologous chromosome pairing, DNA recombination and chromosome remodeling during meiosis, using the nematode Caenorhabditis elegans as an experimental system. High-resolution 3-D imaging of dynamic reorganization of chromosome architecture. Role of protease inhibitors in regulating sperm activation.

  • Hannes Vogel MD

    Hannes Vogel MD

    Professor of Pathology and of Pediatrics (Pediatric Genetics) and, by courtesy, of Neurosurgery and of Comparative Medicine

    Current Research and Scholarly InterestsMy research interests include nerve and muscle pathology, mitochondrial diseases, pediatric neurooncology, and transgenic mouse pathology.

  • Douglas Vollrath

    Douglas Vollrath

    Associate Professor of Genetics and, by courtesy, of Ophthalmology
    On Partial Leave from 07/01/2021 To 08/15/2022

    Current Research and Scholarly InterestsThe Vollrath lab works to uncover molecular mechanisms relevant to the health and pathology of the outer retina. We study the retinal pigment epithelium (RPE), a cell monolayer adjacent to photoreceptors that performs a variety of tasks crucial for retinal homeostasis. Specific areas of interest include the circadian regulation of RPE phagocytosis of photoreceptor outer segment tips, and how RPE metabolic dysfunction contributes to retinal degenerative diseases.

  • Jelena Vuckovic

    Jelena Vuckovic

    Jensen Huang Professor of Global Leadership and Professor, by courtesy, of Applied Physics

    Current Research and Scholarly Interestsphotonics, quantum technologies, quantum optics, inverse design

  • Anthony Wagner

    Anthony Wagner

    Lucie Stern Professor in the Social Sciences
    On Leave from 10/01/2021 To 12/31/2021

    Current Research and Scholarly InterestsCognitive neuroscience of memory and cognitive/executive control in young and older adults. Research interests include encoding and retrieval mechanisms; interactions between declarative, nondeclarative, and working memory; forms of cognitive control; neurocognitive aging; functional organization of prefrontal cortex, parietal cortex, and the medial temporal lobe; assessed by functional MRI, scalp and intracranial EEG, and transcranial magnetic stimulation.

  • Soichi Wakatsuki

    Soichi Wakatsuki

    Professor of Photon Science and of Structural Biology

    Current Research and Scholarly InterestsUbiquitin signaling: structure, function, and therapeutics
    Ubiquitin is a small protein modifier that is ubiquitously produced in the cells and takes part in the regulation of a wide range of cellular activities such as gene transcription and protein turnover. The key to the diversity of the ubiquitin roles in cells is that it is capable of interacting with other cellular proteins either as a single molecule or as different types of chains. Ubiquitin chains are produced through polymerization of ubiquitin molecules via any of their seven internal lysine residues or the N-terminal methionine residue. Covalent interaction of ubiquitin with other proteins is known as ubiquitination which is carried out through an enzymatic cascade composed of the ubiquitin-activating (E1), ubiquitin-conjugating (E2), and ubiquitin ligase (E3) enzymes. The ubiquitin signals are decoded by the ubiquitin-binding domains (UBDs). These domains often specifically recognize and non-covalently bind to the different ubiquitin species, resulting in distinct signaling outcomes.
    We apply a combination of the structural (including protein crystallography, small angle x-ray scattering, cryo-electron microscopy (Cryo-EM) etc.), biocomputational and biochemical techniques to study the ubiquitylation and deubiquitination processes, and recognition of the ubiquitin chains by the proteins harboring ubiquitin-binding domains. Current research interests including SARS-COV2 proteases and their interactions with polyubiquitin chains and ubiquitin pathways in host cell responses, with an ultimate goal of providing strategies for effective therapeutics with reduced levels of side effects.

    Protein self-assembly processes and applications.
    The Surface layers (S-layers) are crystalline protein coats surrounding microbial cells. S-layer proteins (SLPs) regulate their extracellular, self-assembly by crystallizing when exposed to an environmental trigger. We have demonstrated that the Caulobacter crescentus SLP readily crystallizes into sheets both in vivo and in vitro via a calcium-triggered multistep assembly pathway. Observing crystallization using a time course of Cryo-EM imaging has revealed a crystalline intermediate wherein N-terminal nucleation domains exhibit motional dynamics with respect to rigid lattice-forming crystallization domains. Rate enhancement of protein crystallization by a discrete nucleation domain may enable engineering of kinetically controllable self-assembling 2D macromolecular nanomaterials. In particular, this is inspiring designing robust novel platform for nano-scale protein scaffolds for structure-based drug design and nano-bioreactor design for the carbon-cycling enzyme pathway enzymes. Current research focuses on development of nano-scaffolds for high throughput in vitro assays and structure determination of small and flexible proteins and their interaction partners using Cryo-EM, and applying them to cancer and anti-viral therapeutics.

    Multiscale imaging and technology developments.
    Multimodal, multiscale imaging modalities will be developed and integrated to understand how molecular level events of key enzymes and protein network are connected to cellular and multi-cellular functions through intra-cellular organization and interactions of the key machineries in the cell. Larger scale organization of these proteins will be studied by solution X-ray scattering and Cryo-EM. Their spatio-temporal arrangements in the cell organelles, membranes, and cytosol will be further studied by X-ray fluorescence imaging and correlated with cryoEM and super-resolution optical microscopy. We apply these multiscale integrative imaging approaches to biomedical, and environmental and bioenergy research questions with Stanford, DOE national labs, and other domestic and international collaborators.

  • Virginia Walbot

    Virginia Walbot

    Professor of Biology

    Current Research and Scholarly InterestsOur current focus is on maize anther development to understand how cell fate is specified. We discovered that hypoxia triggers specification of the archesporial (pre-meiotic) cells, and that these cells secrete a small protein MAC1 that patterns the adjacent soma to differentiate as endothecial and secondary parietal cell types. We also discovered a novel class of small RNA: 21-nt and 24-nt phasiRNAs that are exceptionally abundant in anthers and exhibit strict spatiotemporal dynamics.

  • Ken Waldron

    Ken Waldron

    Professor (Research) of Mechanical Engineering, Emeritus

    BioKenneth J. Waldron is Professor of Mechanical and Mechatronic Engineering at UTS. He is also Professor Emeritus from the Design Group in the Department of Mechanical Engineering of Stanford University. He holds bachelors and masters degrees from the University of Sydney, and PhD from Stanford. He works in machine design, and design methodology with a particular focus on robotic and mechatronic systems.

  • Dennis Wall

    Dennis Wall

    Professor of Pediatrics (Systems Medicine), of Biomedical Data Science and, by courtesy, of Psychiatry and Behavioral Sciences

    Current Research and Scholarly InterestsSystems biology for design of clinical solutions that detect and treat disease

  • Guenther Walther

    Guenther Walther

    Professor of Statistics
    On Leave from 10/01/2021 To 12/31/2021

    BioGuenther Walther studied mathematics, economics, and computer science at the University of Karlsruhe in Germany and received his Ph.D. in Statistics from UC Berkeley in 1994.

    His research has focused on statistical methodology for detection problems, shape-restricted inference, and mixture analysis, and on statistical problems in astrophysics and in flow cytometry.

    He received a Terman fellowship, a NSF CAREER award, and the Distinguished Teaching Award of the Dean of Humanities and Sciences at Stanford. He has served on the editorial boards of the Journal of Computational and Graphical Statistics, the Journal of the Royal Statistical Society, the Annals of Statistics, the Annals of Applied Statistics, and Statistical Science. He was program co-chair of the 2006 Annual Meeting of the Institute of Mathematical Statistics and served on the executive committee of IMS from 1998 to 2012.

  • Brian A. Wandell

    Brian A. Wandell

    Isaac and Madeline Stein Family Professor and Professor, by courtesy, of Electrical Engineering, of Ophthalmology and at the Graduate School of Education

    Current Research and Scholarly InterestsModels and measures of the human visual system. The brain pathways essential for reading development. Diffusion tensor imaging, functional magnetic resonance imaging and computational modeling of visual perception and brain processes. Image systems simulations of optics and sensors and image processing. Data and computation management for reproducible research.

  • Tom Wandless

    Tom Wandless

    Professor of Chemical and Systems Biology and, by courtesy, of Chemistry

    Current Research and Scholarly InterestsWe employ an interdisciplinary approach to studies of biological systems, combining synthetic chemistry with biochemistry, cell biology, and structural biology. We invent tools for biology and we are motivated by approaches that enable new experiments with unprecedented control. These new techniques may also provide a window into mechanisms involved in maintaining cellular homeostasis. Protein quality control is a particular interest at present.

  • Adam Wang

    Adam Wang

    Assistant Professor of Radiology and, by courtesy, of Electrical Engineering

    BioMy group develops technologies for advanced x-ray and CT imaging, including artificial intelligence for CT acquisition, reconstruction, and image processing; novel system and detector designs; spectral imaging; model-based image reconstruction; and radiation transport methods. I am also the Director of the Zeego Lab and the Tabletop X-Ray Lab.

    I completed my PhD in Electrical Engineering at Stanford under the supervision of Dr. Norbert Pelc, developing strategies for maximizing the information content of dual energy CT and photon counting detectors. I then pursued a postdoc at Johns Hopkins with Dr. Jeff Siewerdsen in Biomedical Engineering, developing reconstruction and registration methods for x-ray based image-guided surgery. Prior to returning to Stanford in 2018, I was a Senior Scientist at Varian Medical Systems, developing x-ray/CT methods for image-guided radiation therapy.

  • Bo Wang

    Bo Wang

    Assistant Professor of Bioengineering

    BioWe are a discovery-driven research group working at the interface between developmental biology, bioengineering, and statistical physics. We combine quantitative organism-wide fluorescence imaging, functional genomics, and physical modeling to understand the fundamental rules that control collective cell behaviors to optimize tissue regeneration, adaptation, and evolution.

  • Kevin Wang, MD, PhD

    Kevin Wang, MD, PhD

    Assistant Professor of Dermatology

    Current Research and Scholarly InterestsThe Wang lab takes an interdisciplinary approach to studying fundamental mechanisms controlling gene expression in mammalian cells, and how epigenetic mechanisms such as DNA methylation, chromatin modifications, and RNA influence chromatin dynamics to affect gene regulation.

  • Paul  J. Wang, MD

    Paul J. Wang, MD

    John R. and Ai Giak L. Singleton Director, Professor of Medicine (Cardiovascular Medicine) and, by courtesy, of Bioengineering

    Current Research and Scholarly InterestsDr. Wang's research centers on the development of innovative approaches to the treatment of arrhythmias, including more effective catheter ablation techniques, more reliable implantable devices, and less invasive treatments. Dr. Wang's clinical research interests include atrial fibrillation, ventricular tachycardia, syncope, and hypertrophic cardiomyopathy. Dr. Wang has active collaborations with Bioengineering, Mechanical Engineering, and Electrical Engineering Departments at Stanford.

  • Shan X. Wang

    Shan X. Wang

    Leland T. Edwards Professor in the School of Engineering and Professor of Electrical Engineering and, by courtesy, of Radiology (Molecular Imaging Program at Stanford)

    Current Research and Scholarly InterestsShan Wang was named the Leland T. Edwards Professor in the School of Engineering in 2018. He directs the Center for Magnetic Nanotechnology and is a leading expert in biosensors, information storage and spintronics. His research and inventions span across a variety of areas including magnetic biochips, in vitro diagnostics, cancer biomarkers, magnetic nanoparticles, magnetic sensors, magnetoresistive random access memory, and magnetic integrated inductors.

  • Sui Wang, PhD

    Sui Wang, PhD

    Assistant Professor of Ophthalmology

    Current Research and Scholarly InterestsOur research focuses on understanding the molecular mechanisms that underlie retinal development and diseases. We utilize genetic and genomic tools to uncover how different types of retinal cells, including retinal neurons, glia and the vasculature, respond to developmental cues and disease insults at the epigenomic and transcriptional levels, and how they interact and collectively contribute to the integrity of the retina.

    1. Retinal cell fate specification.
    We are using genetic tools and methods, such as in vivo plasmid electroporation and CRISPR, to dissect the roles of cis-regulatory elements and transcription factors in controlling retinal cell fate specification.

    2. The multicellular responses elicited by diabetes in the retina.
    Diabetes can induce multicellular responses in the retina, including vascular lesions, glial dysfunction and neurodegeneration, all of which contribute to retinopathy. We are using diabetic rats as models to investigate the detailed molecular mechanisms underlying the diabetes-induced multicellular responses, and the disease mechanisms of diabetic retinopathy.

    3. Molecular tools that allow for cell type-specific labeling and manipulation in vivo.
    Cis-regulatory elements, such as enhancers, play essential roles in directing tissue/cell type-specific and stage-specific expression. We are interested in identifying enhancers that can drive cell type-specific expression in the retina and brain, and incorporating them into plasmid or AAV based delivery systems.

  • Xinnan Wang

    Xinnan Wang

    Associate Professor of Neurosurgery

    Current Research and Scholarly InterestsMechanisms underlying mitochondrial dynamics and function, and their implications in neurological disorders.

  • Robert Waymouth

    Robert Waymouth

    Robert Eckles Swain Professor of Chemistry and Professor, by courtesy, of Chemical Engineering

    BioRobert Eckles Swain Professor in Chemistry Robert Waymouth investigates new catalytic strategies to create useful new molecules, including bioactive polymers, synthetic fuels, and sustainable plastics. In one such breakthrough, Professor Waymouth and Professor Wender developed a new class of gene delivery agents.

    Born in 1960 in Warner Robins, Georgia, Robert Waymouth studied chemistry and mathematics at Washington and Lee University in Lexington, Virginia (B.S. and B.A., respectively, both summa cum laude, 1982). He developed an interest in synthetic and mechanistic organometallic chemistry during his doctoral studies in chemistry at the California Institute of Technology under Professor R.H. Grubbs (Ph.D., 1987). His postdoctoral research with Professor Piero Pino at the Institut fur Polymere, ETH Zurich, Switzerland, focused on catalytic hydrogenation with chiral metallocene catalysts. He joined the Stanford University faculty as assistant professor in 1988, becoming full professor in 1997 and in 2000 the Robert Eckles Swain Professor of Chemistry.

    Today, the Waymouth Group applies mechanistic principles to develop new concepts in catalysis, with particular focus on the development of organometallic and organic catalysts for the synthesis of complex macromolecular architectures. In organometallic catalysis, the group devised a highly selective alcohol oxidation catalyst that selectively oxidizes unprotected polyols and carbohydrates to alpha-hyroxyketones. In collaboration with Dr. James Hedrick of IBM, we have developed a platform of highly active organic catalysts and continuous flow reactors that provide access to polymer architectures that are difficult to access by conventional approaches.

    The Waymouth group has devised selective organocatalytic strategies for the synthesis of functional degradable polymers and oligomers that function as "molecular transporters" to deliver genes, drugs and probes into cells and live animals. These advances led to the joint discovery with the Wender group of a general, safe, and remarkably effective concept for RNA delivery based on a new class of synthetic cationic materials, Charge-Altering Releasable Transporters (CARTs). This technology has been shown to be effective for mRNA based cancer vaccines.

  • Katja Gabriele Weinacht, MD, PhD

    Katja Gabriele Weinacht, MD, PhD

    Assistant Professor of Pediatrics (Stem Cell Transplantation and Regenerative Medicine)

    Current Research and Scholarly InterestsPediatric Hematopoietic Stem Cell Transplantation
    DiGeorge Syndrome
    Genetic Immune Diseases
    Immune Dysregulation

  • William Weis

    William Weis

    William M. Hume Professor in the School of Medicine, Professor of Structural Biology, of Molecular and Cellular Physiology and of Photon Science
    On Partial Leave from 09/01/2021 To 08/31/2022

    Current Research and Scholarly InterestsOur laboratory studies molecular interactions that underlie the establishment and maintenance of cell and tissue structure. Our principal areas of interest are the architecture and dynamics of intercellular adhesion junctions, signaling pathways that govern cell fate determination, and determinants of cell polarity. Our overall approach is to reconstitute macromolecular assemblies with purified components in order to analyze them using biochemical, biophysical and structural methods.

  • Irving Weissman

    Irving Weissman

    Director, Stanford Institute for Stem Cell Biology and Regenerative Medicine, Virginia & D.K. Ludwig Professor of Clinical Investigation in Cancer Research, Professor of Developmental Biology and, by courtesy, of Biology

    Current Research and Scholarly InterestsStem cell and cancer stem cell biology; development of T and B lymphocytes; cell-surface receptors for oncornaviruses in leukemia. Hematopoietic stem cells; Lymphocyte homing, lymphoma invasiveness and metastasis.

  • Itschak Weissman

    Itschak Weissman

    Professor of Electrical Engineering
    On Partial Leave from 10/01/2021 To 06/30/2022

    BioTsachy's research focuses on Information Theory, Data Compression and Communications, Statistical Signal Processing, Machine Learning, the interplay between them, and their applications, with recent focus on applications to genomic data compression and processing. He is inventor of several patents and involved in several companies as member of the technical board. IEEE fellow, he serves on the board of governors of the information theory society as well as the editorial boards of the Transactions on Information Theory and Foundations and Trends in Communications and Information Theory. He is founding Director of the Stanford Compression Forum.

  • Paula V. Welander

    Paula V. Welander

    Associate Professor of Environmental Earth System Science

    Current Research and Scholarly InterestsBiosynthesis of lipid biomarkers in modern microbes; molecular geomicrobiology; microbial physiology

  • Paul Wender

    Paul Wender

    Francis W. Bergstrom Professor and Professor, by courtesy, of Chemical and Systems Biology

    Current Research and Scholarly InterestsMolecular imaging, therapeutics, drug delivery, drug mode of action, synthesis

  • Gerlinde Wernig

    Gerlinde Wernig

    Assistant Professor of Pathology

    Current Research and Scholarly InterestsFibrotic diseases kill more people than cancer in this country and worldwide. We believe that scar-forming cells called fibroblasts are at the core of the fibrotic response in parenchymal organ fibrosis in the lung, liver, skin, bone marrow and tumor stroma. At the cellular level we think of fibrosis as a step wise process which implicates inflammation and fibrosis. We seek to identify new effective immune therapy targets to treat fibrotic diseases.

  • Marius Wernig

    Marius Wernig

    Professor of Pathology and, by courtesy, of Chemical and Systems Biology

    Current Research and Scholarly InterestsEpigenetic Reprogramming, Direct conversion of fibroblasts into neurons, Pluripotent Stem Cells, Neural Differentiation: implications in development and regenerative medicine

  • Robert West

    Robert West

    Professor of Pathology

    Current Research and Scholarly InterestsRob West, MD, PhD, is a Professor of Pathology at Stanford University Medical Center. He is a clinician scientist with experience in translational genomics research to identify new prognostic and therapeutic markers in cancer. His research focus is on the progression of neoplasia to carcinoma. His lab has developed spatially oriented in situ methods to study archival specimens. He also serves as a surgical pathologist specializing in breast pathology.